Allele Dmel\aop^e2d

General Information
Symbol	Dmel\aop^e2d	Species	D. melanogaster
Name		FlyBase ID	FBal0049301
Feature type	allele	Associated gene	Dmel\aop
Also Known As	yan^e2D

Allele class	amorphic allele - genetic evidence
Mutagen
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Rogge et al., 1995, Gabay et al., 1996)
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Rogge et al., 1995) partially lethal - majority die (with aop^pok-x8) (Rogge et al., 1995) partially lethal - majority die (with aop^yan-1) (Rogge et al., 1995) planar polarity defective (with aop^yan-1) (Weber et al., 2008) visible (with aop^yan-1) (Rogge et al., 1995)
Phenotype Manifest In
	Bolwig organ (Rogge et al., 1995) cephalopharyngeal skeleton \| embryonic stage (Rogge et al., 1995) dorsal pouch \| embryonic stage (Rogge et al., 1995) embryonic/first instar larval cuticle \| anterior \| dorsal (Rogge et al., 1995) eye-antennal disc \| embryonic stage (Rogge et al., 1995) ommatidium (Rogge et al., 1995) ommatidium (with aop^pok-x8) (Rogge et al., 1995) ommatidium (with aop^yan-1) (Rogge et al., 1995, Weber et al., 2008) photoreceptor cell R1 (Rogge et al., 1995) photoreceptor cell R2 (Rogge et al., 1995) photoreceptor cell R3 (Rogge et al., 1995) photoreceptor cell R4 (Rogge et al., 1995) photoreceptor cell R5 (Rogge et al., 1995) photoreceptor cell R6 (Rogge et al., 1995) photoreceptor cell R7 (Rogge et al., 1995) photoreceptor cell R7 \| ectopic (with aop^pok-x8) (Rogge et al., 1995) photoreceptor cell R8 (Rogge et al., 1995) pigment cell (with aop^pok-x8) (Rogge et al., 1995) stomatogastric nervous system \| embryonic stage (Rogge et al., 1995) visual primordium (Rogge et al., 1995)
Detailed Description
	Statement Reference aop[yan-1]/aop[e2d] eye discs show chirality defects in ommatidial clusters. (Weber et al., 2008) Heterozygotes with aop^pok-x8 or aop^yan-1 are semi-lethal and the adult escapers have small rough eyes due to fusion of ommatidia, loss of the regular pigment cell array and ectopic R7 cells. (Rogge et al., 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference aop[+]/aop^e2d is an enhancer of planar polarity defective phenotype of Scer\GAL4^hs.2sev, dgo^Scer\UAS.cFa (Weber et al., 2012)
Suppressor of
Statement Reference aop[+]/aop^e2d is a suppressor \| partially of planar polarity defective phenotype of dsh^hs.sev.B (Weber et al., 2008)
Other
Statement Reference aop[+]/aop^e2d, kay² has planar polarity defective \| somatic clone phenotype (Weber et al., 2008)
Phenotype Manifest In
Enhancer of
Statement Reference aop[+]/aop^e2d is an enhancer of ommatidium phenotype of Egfr^E1 (Rogge et al., 1995) aop[+]/aop^e2d is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, dgo^Scer\UAS.cFa (Weber et al., 2012)
NOT Enhancer of
Statement Reference aop[+]/aop^e2d is a non-enhancer of wing hair phenotype of Scer\GAL4^hs.2sev, dgo^Scer\UAS.cFa (Weber et al., 2012)
Suppressor of
Statement Reference aop[+]/aop^e2d is a suppressor \| partially of ommatidium phenotype of dsh^hs.sev.B (Weber et al., 2008) aop^e2d is a suppressor \| partially of denticle belt phenotype of Egfr^f1 (Rogge et al., 1995) aop^e2d is a suppressor of photoreceptor cell R7 phenotype of Sos^JC2, sev⁶ (Rogge et al., 1995)
NOT Suppressor of
Statement Reference aop[+]/aop^e2d is a non-suppressor of wing hair phenotype of Scer\GAL4^hs.2sev, dgo^Scer\UAS.cFa (Weber et al., 2012)
Other
Statement Reference aop[+]/aop^e2d, kay² has eye photoreceptor cell \| somatic clone phenotype (Weber et al., 2008) aop[+]/aop^e2d, kay² has ommatidium \| somatic clone phenotype (Weber et al., 2008)
Additional Comments
Genetic Interactions
Statement Reference aop[e2d]/+ enhances the planar cell polarity (PCP) defects in the eye induced by the overexpression of dgo[Scer\UAS.cFa] under the control of Scer\GAL4[hs.2sev]. (Weber et al., 2012) Homozygous kay[2] clones in the eye in a aop[e2d]/+ background show ommatidial chirality, rotation and photoreceptor number defects (kay[2] single mutant clones do not show tissue polarity defects by themselves). One copy of aop[e2d] partially suppresses the formation of symmetrical ommatidia that is seen in animals expressing dsh[hs.sev.B]. (Weber et al., 2008) Loss of wild type ttk promotes the formation of rare ectopic R7 cells. (Lai et al., 1997) Heterozygotes with aop^pok-x8 or aop^yan-1 are semi-lethal and the adult escapers have small rough eyes due to fusion of ommatidia, loss of the regular pigment cell array and ectopic R7 cells. sev⁶/sev⁺;Sos^JC2/aop^e2d mutants exhibit an increase in the number of R7 cells compared to sev⁶/Sos^JC2 mutants with two functional aop copies. (Rogge et al., 1995) sev⁶/sev⁺;Sos^JC2/aop^e2d mutants exhibit an increase in the number of R7 cells compared to sev⁶/Sos^JC2 mutants with two functional aop copies. (Rogge et al., 1995)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially complements	aop^pok-x8 (Rogge et al., 1995) aop^yan-1 (Rogge et al., 1995)
Fails to complement	aop¹ (Rogge et al., 1995) aop² (Rogge et al., 1995)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	aop^e2d aop^E2d (Weber et al., 2012) e2d (Rogge et al., 1995) yan^e2D (Chang et al., 2003, Flores et al., 2000) yan^e2d (Dumstrei et al., 1998, Lai et al., 1997, Gabay et al., 1996, Rogge et al., 1995, zur Lage et al., 2004) yan^E2d (Weber et al., 2008)
Name Synonym
Secondary FlyBase IDs

References ( 9 )
Research paper	Weber et al., 2012, Genetics 191(1): 145--162 Novel regulators of planar cell polarity: a genetic analysis in Drosophila. [FBrf0218210] Weber et al., 2008, Dev. Biol. 316(1): 110--123 Combinatorial signaling by the Frizzled/PCP and Egfr pathways during planar cell polarity establishment in the Drosophila eye. [FBrf0204109] zur Lage et al., 2004, Dev. Cell 7(5): 687--696 EGF receptor signaling triggers recruitment of Drosophila sense organ precursors by stimulating proneural gene autoregulation. [FBrf0180128] Chang et al., 2003, Dev. Biol. 263(1): 103--113 Antagonistic relationship between Dpp and EGFR signaling in Drosophila head patterning. [FBrf0173075] Flores et al., 2000, Cell 103(1): 75--85 Combinatorial signaling in the specification of unique cell fates. [FBrf0131288] Dumstrei et al., 1998, Development 125(17): 3417--3426 EGFR signaling is required for the differentiation and maintenance of neural progenitors along the dorsal midline of the Drosophila embryonic head. [FBrf0104745] Lai et al., 1997, Genetics 147(3): 1131--1137 Repression of Drosophila photoreceptor cell fate through cooperative action of two transcriptional repressors Yan and Tramtrack. [FBrf0099341] Gabay et al., 1996, Development 122(11): 3355--3362 EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm. [FBrf0090562] Rogge et al., 1995, Development 121(12): 3947--3958 The role of yan in mediating the choice between cell division and differentiation. [FBrf0085837]

Allele Dmel\aope2d

Allele Dmel\aop^e2d