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General Information
Symbol
Dmel\araDFM1
Species
D. melanogaster
Name
FlyBase ID
FBal0049305
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
iroDFM1
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Distal breakpoint maps between the second and third exon.

Deficiency breakpoint maps to an intron in the protein coding region of the ara transcription unit (at the ararF209 insertion site).

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

When homozygous, in wing clones, differentiation of L5 and the alula fail. Dorsal clones remove L5 dorsally, and ventral clones remove L5 ventrally. No other site in the wing showed a requirement for ara-caup. Notum cells lacking ara and caup are inviable.

araDFM1/ara1 flies have a strong iroquois phenotype. araDFM1/Df(3L)iro-2 flies die as embryos.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Homozygous caupDFM1 somatic clones (containing the alleles caupDFM1 and araDFM1) in the abdomen are normal, except for lateral ones. The clones found in the lateral domains of the tergite are often depigmented; usually not all parts of the clones are affected to the same extent. These clones tend to be roundish.

Homozygous Df(3L)iro-DFM1 (containing araDFM1 and removing caup) clones cause a series of phenotypes, adding progressively more 'ventral-type' tissue in the following order: dorsal eye overgrowth or ectopic dorsal eyes, overgrowth of ventral type of cuticle (ptilinum and rostral membrane) ectopic antennal pouches, antenna and maxillary palps. The extra head structures are produced autonomously, but the eyes can be composed of both mutant and wild-type ommatidia. The ectopic ventral structures, all grow from the orbital region of the head. The rest of the dorsal head is displaced by the over-grown tissue.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Phenotype may be less extreme than for araDFM3 because of the ectopic expression of a gene related to those of the Iroquois complex.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)