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General Information
Symbol
Dmel\aubN11
Species
D. melanogaster
Name
FlyBase ID
FBal0049313
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Location of a 154bp deletion beginning in codon G741, which leads to a frameshift and early translation termination. The resulting predicted protein has 16 novel amino acids added after residue 740.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

As a result of the deletion the frame is changed after E740.

154bp deletion, resulting in a frameshift which is predicted to add 16 novel amino acids after residue 740. Nucleotide substitution: G5549A (silent polymorphism).

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Germline stem cells and cystoblasts of aubN11/aubHN ovaries show delays in prometaphase and chromosome segregation defects.

No embryos derived from aubN11/aubHN2 females produce a cuticle.

No embryos derived from aubN11/aubQC42 females produce a cuticle.

2% of eggs from homozygous mothers are fertilized and embryos lack abdominal segments and pole cells, i.e. show a classic posterior group mutant phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

aub[+]/aubN11 is an enhancer of abnormal meiotic cell cycle phenotype of RanGAPSd

NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference

aubHN2/aubN11 is a non-suppressor of eye phenotype of wdsRNA.GMR/wdsRNA.GMR

Additional Comments
Genetic Interactions
Statement
Reference

The segregation distortion seen in males carrying either the SD-5 or SD-Mad-ltcn Dp(2;2)RanGAPSD chromosome variant is enhanced (the k[[c]] value, or proportion of Dp(2;2)RanGAPSD-bearing progeny as the fraction of total progeny (corrected for viability), is significantly increased) if the males are also carrying a single copy of aubN11.

The yellowish eye colour caused by expression of one copy of wdsRNA.GMR in a wild-type background is not altered if the flies are also carrying aubHN2/aubN11.

Ectopic pole cells are not produced at the anterior of embryos derived from aubN11/aubHN ; oskshort.bcd females.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 4 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
Synonyms and Secondary IDs (1)
References (24)