Allele Dmel\dib^unspecified

General Information
Symbol	Dmel\dib^unspecified	Species	D. melanogaster
Name		FlyBase ID	FBal0049409
Feature type	allele	Associated gene	Dmel\dib

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Tearle and Nusslein-Volhard, 1987) lethal \| recessive (Harrison et al., 1995)
Phenotype Manifest In
	commissure (Giesen et al., 2003) dorsal closure embryo (Giesen et al., 2003) embryonic/first instar larval cuticle (Tearle and Nusslein-Volhard, 1987) embryonic/larval foregut (Giesen et al., 2003) embryonic/larval hindgut (Giesen et al., 2003) embryonic/larval midgut (Giesen et al., 2003) embryonic head (Tearle and Nusslein-Volhard, 1987) embryonic ventral epidermis (Giesen et al., 2003) glial cell (Giesen et al., 2003) longitudinal connective (Giesen et al., 2003) midline glial cell \| ectopic (Giesen et al., 2003) ventral nerve cord (Giesen et al., 2003)
Detailed Description
	Statement Reference Mutant embryos have alterations in embryonic morphology. No epidermal folds are found below the ventral nerve cord. Instead of stretching dorsally, the ectoderm appears to fold like an accordion in the anterior-posterior axis. As a consequence the gut is frequently pushed outside the embryo. By the end of embryogenesis the ventral folding of the epidermis pushes the ventral nerve cord further deep into the embryo. Beside the dorsal closure phenotypes, defects are also seen during head involution and in gut morphology. Mutant embryos also typically have fused commissure phenotypes where anterior and posterior commissures are not separated. Longitudinal connectives are also often reduced and frequent gaps may be seen in tracts. Glial cell organisation is severely affected in mutants. Mutants have a significant increase in the number of midline glial cells. About 6 cells are seen per neuromere. (Giesen et al., 2003) Cuticle and head structures are undifferentiated in dib^unspecified mutant embryos. (Tearle and Nusslein-Volhard, 1987)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement Reference dib^unspecified has midline glial cell \| ectopic phenotype, enhanceable by Scer\GAL4^sim.PS/BacA\p35^Scer\UAS.cHa (Giesen et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference In dib^unspecified, BacA\p35^Scer\UAS.cHa, Scer\GAL4^sim.PS embryos, about 10 midline glial cells are seen per neuromere. (Giesen et al., 2003)
Xenogenetic Interactions
Statement Reference In dib^unspecified, BacA\p35^Scer\UAS.cHa, Scer\GAL4^sim.PS embryos, about 10 midline glial cells are seen per neuromere. (Giesen et al., 2003)
Complementation & Rescue Data
Rescued by	dib^unspecified is rescued by dib^+tHS (Chavez et al., 2000) dib^unspecified is rescued by dib^+tSE9 (Chavez et al., 2000) dib^unspecified is rescued by dib^+tSE20 (Chavez et al., 2000)
Not rescued by	dib^unspecified is not rescued by dib^tSE32 (Chavez et al., 2000)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Eleven alleles have been isolated. (Harrison et al., 1995)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	dib^unspecified unspecified (Harrison et al., 1995)
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Palanker et al., 2006, Development 133(18): 3549--3562 Dynamic regulation of Drosophila nuclear receptor activity in vivo. [FBrf0193912] Giesen et al., 2003, Mech. Dev. 120(4): 401--413 Regulation of glial cell number and differentiation by ecdysone and Fos signaling. [FBrf0157169] Chavez et al., 2000, Development 127(19): 4115--4126 The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels. [FBrf0129760] Harrison et al., 1995, Genetics 139(4): 1701--1709 A genetic analysis of the 63E-64A genomic region of Drosophila melanogaster: Identification of mutations in a replication factor C subunit. [FBrf0080079]
Stock list	Tearle and Nusslein-Volhard, 1987, D. I. S. 66: 209--269 Tubingen mutants and stock list. [FBrf0045941]

Allele Dmel\dibunspecified

Allele Dmel\dib^unspecified