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General Information
Symbol
Dmel\fzhs.PP
Species
D. melanogaster
Name
heat shock construct of Park
FlyBase ID
FBal0049593
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
hs-fz
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Expression of a fz cDNA is driven by an Hsp70 promoter.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Late overexpression of fzhs.PP induces multiple wing hairs.

When hot wax is applied to the wing tip - causing a gradient of fz activity - wing hairs show reversed polarity and point distal-to-proximal. When expressed late, just prior to hair initiation in pupae a multiple hair cell phenotype results.

Induces wing cells to form multiple wing hairs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

fzhs.PP has visible | heat sensitive phenotype, enhanceable by Rab23[+]/Rab23T69A

fzhs.PP has visible | heat sensitive phenotype, enhanceable by Rab23[+]/Rab2351

Suppressed by
Statement
Reference

fzhs.PP has planar polarity defective | heat sensitive phenotype, suppressible by fy2

Phenotype Manifest In
Enhanced by
Statement
Reference

fzhs.PP has wing hair | heat sensitive phenotype, enhanceable by Rab23[+]/Rab23T69A

fzhs.PP has wing hair | heat sensitive phenotype, enhanceable by Rab23[+]/Rab2351

fzhs.PP has wing hair | heat sensitive phenotype, enhanceable by dshhs.PA

fzhs.PP has wing hair | heat sensitive phenotype, enhanceable by inhs.PP

fzhs.PP has wing hair phenotype, enhanceable by stan3

Suppressed by
Statement
Reference

fzhs.PP has wing hair | heat sensitive phenotype, suppressible by fy2

NOT suppressed by
Statement
Reference

fzhs.PP has wing hair | heat sensitive phenotype, non-suppressible by fy6

fzhs.PP has wing hair | heat sensitive phenotype, non-suppressible by in1/inII53

Enhancer of
Statement
Reference

fzhs.PP is an enhancer of wing hair phenotype of fy6

fzhs.PP is an enhancer of wing hair & 1st posterior cell phenotype of inII53

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Rab23T69A dominantly enhances the multiple hair phenotype induced by late fzhs.PP overexpression.

Rab2351 dominantly enhances the multiple hair phenotype induced by late fzhs.PP overexpression.

Late gain of function phenotype of fzhs.PP is not suppressible by inII53/in1 or fy6.

The addition of nkdScer\UAS.cZa and Scer\GAL4hs.PB completely suppresses the wing hair polarity phenotype seen in fzhs.PP flies.

The addition of nkdScer\UAS.T:Hsap\MYC and Scer\GAL4hs.PB completely suppresses the wing hair polarity phenotype seen in fzhs.PP flies.

stan3 does not block the ability of fzhs.PP to form multiple hairs, it rather enhances the fzhs.PP multiple hair phenotype slightly.

When expressed just before prehair initiation, in a Vang mutant background, cells are still induced to form multiple hairs. Indeed, the Vang mutant background slightly enhances the formation of multiple hairs. Vang function is required for the ability of a gradient of fz expression (induced by distal waxing) to repolarize wing hairs.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Carried in a plasmid and transfected into S2 cells.

Carried in plasmid "hs-fz" and expressed in Schneider cells.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
fzhs.PP
Name Synonyms
heat shock construct of Park
Secondary FlyBase IDs
    References (8)