FlyBase Allele Report: Dmel\ksr[S-627]

General Information

Symbol

Dmel\ksr^S-627

Species

D. melanogaster

Name

FlyBase ID

FBal0049700

Feature type

allele

Associated gene

Dmel\ksr

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Karim et al., 1996)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q163term.

(Wolfstetter et al., 2017)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:5,483,151..5,483,151 [-]

Nucleotide change:

C5483151T

Reported nucleotide change:

:C5483151T

Amino acid change:

Q163term | ksr-PA; Q163term | ksr-PB; Q163term | ksr-PC; Q163term | ksr-PD

Reported amino acid change:

Q163term

(Wolfstetter et al., 2017)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by Alk^UAS.cLa

(Wolfstetter et al., 2020)

modeled by Hsap\ALK^F1174L.UAS

(Wolfstetter et al., 2020)

modeled by Hsap\ALKAL1^UAS.cGa

(Wolfstetter et al., 2020)

modeled by Hsap\ALK::Hsap\NPM1^UAS.cWa

(Wolfstetter et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Karim et al., 1996)

Phenotype Manifest In

larval visceral muscle cell | embryonic stage | maternal effect

(Wolfstetter et al., 2017)

larval visceral muscle cell | embryonic stage | maternal effect (with ksr^S-638)

(Wolfstetter et al., 2017)

Detailed Description

Statement

Reference

ksr^S-627 embryos derived from mothers bearing ksr^S-627 mutant germline clones and thus lacking both maternal and zygotic ksr do not show any loss of muscle founder cells at late embryonic stages and only display rather mild visceral muscle phenotypes such as myotube stretching defects at stage 13/14 and incomplete midgut constriction at the end of embryogenesis.

(Wolfstetter et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

ksr^S-627 is an enhancer of visible phenotype of Dsor1^XS520

(Karim et al., 1996)

ksr^S-627 is an enhancer of lethal phenotype of Raf¹²

(Karim et al., 1996)

NOT Enhancer of

Statement

Reference

ksr^S-627 is a non-enhancer of visible phenotype of Ret^GMR.PR

(Read et al., 2005)

ksr^S-627 is a non-enhancer of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

ksr^S-627 is a non-enhancer of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Suppressor of

Statement

Reference

ksr^S-627 is a suppressor of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

NOT Suppressor of

Statement

Reference

ksr^S-627 is a non-suppressor of visible phenotype of Ret^GMR.PR

(Read et al., 2005)

ksr^S-627 is a non-suppressor of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

ksr^S-627 is a non-suppressor of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Phenotype Manifest In

Enhancer of

Statement

Reference

ksr^S-627 is an enhancer of eye phenotype of Dsor1^XS520

(Karim et al., 1996)

ksr^S-627 is an enhancer of eye phenotype of Raf¹²

(Karim et al., 1996)

NOT Enhancer of

Statement

Reference

ksr^S-627 is a non-enhancer of eye phenotype of Ret^GMR.PR

(Read et al., 2005)

ksr^S-627 is a non-enhancer of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

ksr^S-627 is a non-enhancer of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Suppressor of

Statement

Reference

ksr^S-627 is a suppressor of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

ksr^S-627 is a suppressor of phenotype of Ras85D^V12.sev

(Karim et al., 1996)

NOT Suppressor of

Statement

Reference

ksr^S-627 is a non-suppressor of eye phenotype of Ret^GMR.PR

(Read et al., 2005)

ksr^S-627 is a non-suppressor of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

ksr^S-627 is a non-suppressor of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Suppresses the rough eye phenotype of Ras85D^V12.sev. Enhances the phenotype of Ras85D^N17.sev. Has little or no effect on the phenotype of phl::tor^13D.hs.sev. Suppresses the phenotype of Ras85D::Src64B^{V12.ΔCAAX.sev}. Enhances the lethality of phl¹². Enhances the phl¹² eye phenotype. Enhances the Dsor1^XS520 eye phenotype. Enhances the aop^S2382 eye phenotype.

(Karim et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

5683

ksr^S-627/TM3, P{sevRas1.V12}FK2, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ksr⁶²⁷

(Sullivan and Rubin, 2002)

ksr^S-627

(Sawyer et al., 2020, Wolfstetter et al., 2020, Wolfstetter et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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