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General Information
Symbol
Dmel\HDAC15-5
Species
D. melanogaster
Name
FlyBase ID
FBal0049831
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Rpd3m5-5, Hdac1M5-5
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C4627779T

Amino acid change:

Q109term | HDAC1-PA

Reported amino acid change:

Q109term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Q109term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Rpd35-5 heterozygotes exhibit an extension in lifespan from a median of 49 to 56 days, compared to control lines.

Rpd35-5 homozygous and Rpd35-5/Rpd33-10 transheterozygous mutants fail to survive beyond the end of the second instar larval stage.

When homozygous mutant clones are made in the follicle cells of stage 10B ovaries, the mutant cells have nucleus wide hyper-acetylation. In clones of five or fewer cells, 20% appear to have undergone an extra genome reduplication rather than the developmental delay in replication that normally occurs before stage 10B.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

HDAC15-5, ttkrM730 has visible phenotype, enhanceable by Mi-24/Mi-2[+]

Enhancer of
Statement
Reference

HDAC15-5/Rpd3[+] is an enhancer of visible | dominant phenotype of Snr1E1

Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference

HDAC15-5/Rpd3[+] is a non-suppressor of short lived | calorie restriction conditional phenotype of Hsap\HTTQ93.ex1.UAS, Scer\GAL4elav-C155

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

HDAC15-5, ttkrM730 has wing sensillum | ectopic phenotype, enhanceable by Mi-24/Mi-2[+]

Enhancer of
Statement
Reference

HDAC15-5/Rpd3[+] is an enhancer of wing vein | ectopic phenotype of Snr1E1

HDAC15-5/Rpd3[+] is an enhancer of wing phenotype of Snr1E1

Suppressor of
Statement
Reference
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Heterozygosity for Rpd35-5 has little effect on In(1)wm4 eye colour variegation.

At 29oC, Rpd35-5/+ enhances the ectopic wing vein phenotype of Snr1E1/+; 8% of flies have ectopic veins emanating from the posterior crossvein and posterior to the L5 longitudinal vein of the wing.

ttkrM730 Rpd35-5 double mutants have ectopic sensory bristles on the wing veins.

Xenogenetic Interactions
Statement
Reference

A heterozygous Rpd35-5 background markedly increases the survival rate of flies neuronally-expressing Hsap\HTTQ93.ex1p.Scer\UAS flies (from <10% to nearer 35% survival to eclosion). In addition, the level of neurodegeneration, as measured by the ratio of rhabdomeres per ommatidia, is also lowered in a Rpd35-5 heterozygous background.

A Rpd35-5 heterozygous background does not affect the short lifespan found in flies expressing Hsap\HTTQ93.ex1p.Scer\UAS under the control of Scer\GAL4elav-C155.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)