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Allele Dmel\oc^uvi

General Information
Symbol	Dmel\ocuvi	Species	D. melanogaster
Name	UV-insensitive	FlyBase ID	FBal0050218
Feature type	allele	Associated gene	Dmel\oc
Also Known As	otduvi
Allele class	hypomorphic allele - genetic evidence
Mutagen	X ray
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (van den Dries et al., 1996)
Mutagen	X ray (van den Dries et al., 1996)
Mutations Mapped to the Genome
Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion	Statement Reference 1.5kb deletion in intron 3. (van den Dries et al., 1996)
Cytology
Phenotypic Data
Phenotypic Class
	visual behavior defective | recessive (van den Dries et al., 1996)
Phenotype Manifest In
	cone cell (van den Dries et al., 1996) ommatidium (McDonald et al., 2010, Terrell et al., 2012) photoreceptor, with Scer\GAL4oc.1.6 (Fichelson et al., 2012) photoreceptor cell (van den Dries et al., 1996) rhabdomere (van den Dries et al., 1996, McDonald et al., 2010, Terrell et al., 2012) rhabdomere, with Scer\GAL4oc.1.6 (Fichelson et al., 2012) rhabdomere of eye photoreceptor cell (Mishra et al., 2010) rhabdomere R1 (Tahayato et al., 2003) rhabdomere R2 (Tahayato et al., 2003) rhabdomere R3 (Tahayato et al., 2003) rhabdomere R4 (Tahayato et al., 2003) rhabdomere R5 (Tahayato et al., 2003) rhabdomere R6 (Tahayato et al., 2003) rhabdomere R7 (Tahayato et al., 2003) rhabdomere R8 (Tahayato et al., 2003)
Detailed Description
	Statement Reference Remodelling of the photoreceptor zona adherens occurs 60h after puparium formation (APF)in oc[uvi] mutants compared to 44 hours APF in wild type. Photoreceptors exhibit defective elongation along the lens to brain axis. Rhabdomere morphogenesis defects are also seen; on average 1.8 cells per ommatidium harbour a split rhabdomere and 1.2 cells lack a rhabdomere altogether. An increased number of stalk membranes are shorter than 2500nm compared to wild type. (Fichelson et al., 2012) Rhabdomeres are misshapen (they are often split and/or duplicated) and are restricted to the distal-most third of the retina in mutant flies. The organisation of the ommatidia is disrupted. (Terrell et al., 2012) Rhabdomeres fail to extend more than one-third of the depth of the retina in mutant flies and are often misshapen or duplicated. Ommatidial organisation is disrupted. (McDonald et al., 2010) The process of rhabdomere initiation has begun in mutant photoreceptor cells at 60 hours after puparium formation (APF), as in wild-type photoreceptors. However, the mutant photoreceptors show clear disorganisation of the initial stages of rhabdomere elaboration. At 72 hours APF, continuing defects in rhabdomere morphogenesis are seen. At 96 hours APF discernible rhabdomere structures are present, but they are smaller than normal and misshapen. The rhabdomeres of the ocelli in mutant flies show little difference from those in wild-type controls. (Mishra et al., 2010) The shape of the rhabdomeres of all eight photoreceptor cells is abnormal in ocuvi mutants. (Tahayato et al., 2003) Flies are preferentially attracted to visible light over UV light. Rhabdomeres are disorganised and often appear duplicated. The rhabdomere phenotype becomes progressively worse in more proximal sections, resulting in premature rhabdomere termination. The R8 photoreceptor is frequently abnormally localized. Heterozygotes with oc1 show neither an R-cell nor an ocellar phenotype. (van den Dries et al., 1996)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement Reference ocuvi has rhabdomere of eye photoreceptor cell phenotype, enhanceable by ocuvi (Mishra et al., 2010, Mishra et al., 2010)
Suppressed by
Statement Reference ocuvi has ommatidium phenotype, suppressible | partially by Hsap\OTX1Scer\UAS.T:Zzzz\FLAG/Scer\GAL4oc.1.6 (Terrell et al., 2012) ocuvi has ommatidium phenotype, suppressible | partially by Scer\GAL4oc.1.6/Hsap\CRXE80A.Scer\UAS.T:Zzzz\FLAG (Terrell et al., 2012) ocuvi has ommatidium phenotype, suppressible | partially by Scer\GAL4oc.1.6/Hsap\OTX2Scer\UAS.T:Zzzz\FLAG (Terrell et al., 2012) ocuvi has ommatidium phenotype, suppressible by Hsap\CRXR90W.Scer\UAS.T:Zzzz\FLAG/Scer\GAL4oc.1.6 (Terrell et al., 2012) ocuvi has ommatidium phenotype, suppressible by Hsap\CRXScer\UAS.T:Zzzz\FLAG/Scer\GAL4oc.1.6 (Terrell et al., 2012) ocuvi has ommatidium phenotype, suppressible by Scer\GAL4oc.1.6/Hsap\CRXI138fs48.Scer\UAS.T:Zzzz\FLAG (Terrell et al., 2012) ocuvi has rhabdomere phenotype, suppressible | partially by Hsap\OTX1Scer\UAS.T:Zzzz\FLAG/Scer\GAL4oc.1.6 (Terrell et al., 2012) ocuvi has rhabdomere phenotype, suppressible | partially by Scer\GAL4oc.1.6/Hsap\CRXE80A.Scer\UAS.T:Zzzz\FLAG (Terrell et al., 2012) ocuvi has rhabdomere phenotype, suppressible | partially by Scer\GAL4oc.1.6/Hsap\OTX2Scer\UAS.T:Zzzz\FLAG (Terrell et al., 2012) ocuvi has rhabdomere phenotype, suppressible by Hsap\CRXR90W.Scer\UAS.T:Zzzz\FLAG/Scer\GAL4oc.1.6 (Terrell et al., 2012) ocuvi has rhabdomere phenotype, suppressible by Hsap\CRXScer\UAS.T:Zzzz\FLAG/Scer\GAL4oc.1.6 (Terrell et al., 2012) ocuvi has rhabdomere phenotype, suppressible by Scer\GAL4oc.1.6/Hsap\CRXI138fs48.Scer\UAS.T:Zzzz\FLAG (Terrell et al., 2012) Scer\GAL4oc.1.6, ocuvi has photoreceptor phenotype, suppressible | partially by Kr-h1GD4367, Scer\GAL4oc.1.6 (Fichelson et al., 2012) Scer\GAL4oc.1.6, ocuvi has photoreceptor phenotype, suppressible | partially by Kr-h1KK112003, Scer\GAL4oc.1.6 (Fichelson et al., 2012) Scer\GAL4oc.1.6, ocuvi has rhabdomere phenotype, suppressible | partially by Kr-h1GD4367, Scer\GAL4oc.1.6 (Fichelson et al., 2012) Scer\GAL4oc.1.6, ocuvi has rhabdomere phenotype, suppressible | partially by Kr-h1KK112003, Scer\GAL4oc.1.6 (Fichelson et al., 2012)
NOT suppressed by
Statement Reference ocuvi has ommatidium phenotype, non-suppressible by Scer\GAL4oc.1.6/Hsap\CRXK88N.Scer\UAS.T:Zzzz\FLAG (Terrell et al., 2012) ocuvi has rhabdomere phenotype, non-suppressible by Scer\GAL4oc.1.6/Hsap\CRXK88N.Scer\UAS.T:Zzzz\FLAG (Terrell et al., 2012)
Enhancer of
Statement Reference ocuvi is an enhancer of rhabdomere of eye photoreceptor cell phenotype of ocuvi (Mishra et al., 2010, Mishra et al., 2010) ocuvi is an enhancer of rhabdomere of eye photoreceptor cell phenotype of Pph13hazy (Mishra et al., 2010)
Other
Statement Reference Pph13hazy, ocuvi has eye photoreceptor cell phenotype (Mishra et al., 2010) Pph13hazy, ocuvi has ocellus rhabdomere phenotype (Mishra et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference Expression of Kr-h1[GD4367] under the control of Scer\GAL4[oc.1.6] partially suppresses the apical membrane maturation defects seen in oc[uvi] mutant photoreceptors. The photoreceptor elongation defects, rhabdomere loss and stalk membrane length are all also partially suppressed. Expression of Kr-h1[KK112003] under the control of Scer\GAL4[oc.1.6] partially suppresses the apical membrane maturation defects seen in oc[uvi] mutant photoreceptors. (Fichelson et al., 2012) The process of rhabdomere initiation has begun in photoreceptor cells at 60 hours after puparium formation (APF) in oc[uvi] ; Pph13[hazy] double mutants, as in wild-type photoreceptors. However, the mutant photoreceptors show clear disorganisation of the initial stages of rhabdomere elaboration. At 72 hours APF the defects in rhabdomere morphogenesis in the double mutant are more severe than in either single mutant; the apical rhabdomeric membrane lacks any definable shape and organisation in the double mutant. By 96 hours APF no rhabdomere is recognisable in the double mutants. Instead, there is a region of apical membrane that extends out into the inter-rhabdomeral space in distal portions of the retina, but this membrane lacks any organised structure. This membrane structure is visible along the entire length of the photoreceptor cell. No photoreceptor cell structures can be discerned beyond approximately 20μm from the surface of the retina, compared with 100μm for a wild-type photoreceptor cell. oc[uvi] ; Pph13[hazy] double mutants lack rhabdomeres in the ocelli photoreceptor cells. (Mishra et al., 2010)
Xenogenetic Interactions
Statement Reference Expression of Hsap\OTX1[Scer\UAS.T:Zzzz\FLAG] or Hsap\OTX2[Scer\UAS.T:Zzzz\FLAG] under the control of Scer\GAL4[oc.1.6] rescues rhabdomere elongation in oc[uvi] flies (so that the rhabdomeres extend the entire depth of the retina in the rescued animals). However, misshapen rhabdomeres are seen in the rescued flies and ommatidia are frequently disorganised. Expression of Hsap\CRX[Scer\UAS.T:Zzzz\FLAG] under the control of Scer\GAL4[oc.1.6] rescues rhabdomere elongation in oc[uvi] flies (so that the rhabdomeres extend the entire depth of the retina in the rescued animals). Almost all ommatidia form well-organised trapezoids. Expression of Hsap\CRX[K88N.Scer\UAS.T:Zzzz\FLAG] under the control of Scer\GAL4[oc.1.6] does not rescue rhabdomere or ommatidial morphology in oc[uvi] flies. Expression of either Hsap\CRX[R90W.Scer\UAS.T:Zzzz\FLAG] or Hsap\CRX[I138fs48.Scer\UAS.T:Zzzz\FLAG] under the control of Scer\GAL4[oc.1.6] largely rescues rhabdomere and ommatidial morphology in oc[uvi] flies. Expression of Hsap\CRX[E80A.Scer\UAS.T:Zzzz\FLAG] under the control of Scer\GAL4[oc.1.6] partially rescues rhabdomere and ommatidial morphology in oc[uvi] flies. (Terrell et al., 2012)
Complementation & Rescue Data
Rescued by	ocuvi is rescued by Scer\GAL4oc.1.6/ocScer\UAS.FL (McDonald et al., 2010) ocuvi is rescued by Scer\GAL4oc.1.6/ocScer\UAS.T:Zzzz\FLAG (Terrell et al., 2012) ocuvi is rescued by Scer\GAL4oc.1.6/ocΔN.Scer\UAS (McDonald et al., 2010)
Partially rescued by	ocuvi is partially rescued by ochs.PF (Tahayato et al., 2003) ocuvi is partially rescued by ocΔABC.Scer\UAS/Scer\GAL4oc.1.6 (McDonald et al., 2010) ocuvi is partially rescued by ocΔC.Scer\UAS/Scer\GAL4oc.1.6 (McDonald et al., 2010) ocuvi is partially rescued by ocΔNC.Scer\UAS/Scer\GAL4oc.1.6 (McDonald et al., 2010) ocuvi is partially rescued by Scer\GAL4oc.1.6/ocHD.Scer\UAS (McDonald et al., 2010) ocuvi is partially rescued by Scer\GAL4oc.1.6/ocΔA.Scer\UAS (McDonald et al., 2010) ocuvi is partially rescued by Scer\GAL4oc.1.6/ocΔAB.Scer\UAS (McDonald et al., 2010) ocuvi is partially rescued by Scer\GAL4oc.1.6/ocΔB.Scer\UAS (McDonald et al., 2010)
Comments	Expression of oc[Scer\UAS.T:Zzzz\FLAG] under the control of Scer\GAL4[oc.1.6] rescues rhabdomere elongation in oc[uvi] flies (so that the rhabdomeres extend the entire depth of the retina in the rescued animals). The rescued rhabdomeres have normal morphology and ommatidial organisation is wild type. (Terrell et al., 2012) Expression of oc[Scer\UAS.FL] or oc[ΔN.Scer\UAS] under the control of Scer\GAL4[oc.1.6] rescues rhabdomere elongation and ommatidial organisation in oc[uvi] flies. Expression of either oc[ΔC.Scer\UAS], oc[ΔNC.Scer\UAS], oc[ΔA.Scer\UAS], oc[ΔB.Scer\UAS], oc[ΔAB.Scer\UAS] or oc[ΔABC.Scer\UAS] under the control of Scer\GAL4[oc.1.6] partially rescues rhabdomere elongation and ommatidial organisation in oc[uvi] flies. Expression of oc[HD.Scer\UAS] under the control of Scer\GAL4[oc.1.6] weakly rescues rhabdomere elongation and ommatidial organisation in oc[uvi] flies. (McDonald et al., 2010) Almost complete rescue of ocuvi phenotypes is seen after five successive heat shocks before 48 hours after puparium formation (APF). The rhabdomeres appear normal in shape and are not split. Heat shocks later than 48 hours APF fail to rescue the rhabdomeric defects. (Tahayato et al., 2003)
Stocks ( 0 )
Notes on Origin
Discoverer
External Crossreferences & Linkouts
Other Crossreferences
Linkouts
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	ocuvi   otduvi (Tahayato et al., 2003, van den Dries et al., 1996, Sprecher et al., 2007, Mishra et al., 2010, McDonald et al., 2010, Terrell et al., 2012) otdUVI (Fichelson et al., 2012) otduvi (McDonald et al., 2006)
Name Synonym	UV-insensitive (van den Dries et al., 1996)
Secondary FlyBase IDs
References ( 9 )
Research paper	Fichelson et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(20): 7893--7898 Orthodenticle and Kruppel homolog 1 regulate Drosophila photoreceptor maturation. [FBrf0218313] Terrell et al., 2012, Dev. Dyn. 241(1): 215--228 OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye. [FBrf0216943] McDonald et al., 2010, Dev. Biol. 347(1): 122--132 Separable transcriptional regulatory domains within Otd control photoreceptor terminal differentiation events. [FBrf0211936] Mishra et al., 2010, Development 137(17): 2895--2904 Pph13 and Orthodenticle define a dual regulatory pathway for photoreceptor cell morphogenesis and function. [FBrf0211519] Sprecher et al., 2007, Genes Dev. 21(17): 2182--2195 Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates. [FBrf0205916] Tahayato et al., 2003, Dev. Cell 5(3): 391--402 Otd/Crx, a dual regulator for the specification of ommatidia subtypes in the Drosophila retina. [FBrf0162062] van den Dries et al., 1996, Dev. Biol. 173(1): 243--255 orthodenticle is required for photoreceptor cell development in the Drosophila eye. [FBrf0086078]
Abstract	McDonald et al., 2006, Dev. Biol. 295(1): 407 Mapping the functional domains of Otd during eye development in Drosophila. [FBrf0195315] Vandendries and Reinke, 1993, Davis, Zipursky, 1993: 133 Regulation of photoreceptor cell differentiation by the orthodenticle gene. [FBrf0079555]