FB2025_01 , released February 20, 2025
Allele: Dmel\para74
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General Information
Symbol
Dmel\para74
Species
D. melanogaster
Name
FlyBase ID
FBal0050240
Feature type
allele
Associated gene
Dmel\para
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Pittendrigh et al., 1997, Stern et al., 1990)
Progenitor genotype
Cytology
Description

Mutation in S6 in domain III.

(ffrench-Constant et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:16,473,789..16,473,789 [-]
Nucleotide change:

G16473789H

Amino acid change:

M1536I | para-PA; M1489I | para-PAA; M1491I | para-PAB; M1489I | para-PAC; M1491I | para-PAD; M1513I | para-PAE; M1515I | para-PAF; M1494I | para-PAG; M1512I | para-PAH; M1491I | para-PAI; M1537I | para-PAJ; M1502I | para-PAK; M1516I | para-PAL; M1488I | para-PAM; M1548I | para-PAN; M1518I | para-PAO; M1502I | para-PAP; M1494I | para-PAQ; M1472I | para-PAS; M1461I | para-PAT; M1467I | para-PAW; M1504I | para-PAX; M1537I | para-PAY; M1516I | para-PAZ; M1536I | para-PB; M1537I | para-PBA; M1471I | para-PBB; M1461I | para-PBD; M1536I | para-PBF; M1536I | para-PBG; M1460I | para-PBH; M1536I | para-PC; M1519I | para-PD; M1513I | para-PE; M1513I | para-PF; M1492I | para-PG; M1502I | para-PH; M1484I | para-PI; M1505I | para-PJ; M1481I | para-PK; M1492I | para-PL; M1505I | para-PM; M1505I | para-PN; M1497I | para-PO; M1526I | para-PP; M1481I | para-PQ; M1484I | para-PR; M1505I | para-PS; M1515I | para-PT; M1523I | para-PU; M1502I | para-PV; M1507I | para-PW; M1530I | para-PX; M1543I | para-PY; M1494I | para-PZ

Reported amino acid change:

M?I

Comment:

The nature of the nucleotide substitution in the mutant was inferred by a FlyBase curator based on the reported amino acid change. The location of the amino acid change was reported in the context of the surrounding amino acid sequence.

(Pittendrigh et al., 1997)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      para74 mutant larvae do not display any resistance to picrotoxin (PTX)-induced seizures.

      (Stilwell et al., 2006)

      para74 and para74/paraDN7 flies show increased resistance to allethrin compared to wild type lifes in a lethality assay. para74 neurons isolated from embryos and maintained in culture have sodium currents that are kinetically similar to wild-type currents in activation, inactivation and time to peak. Application of 500nM allethrin has little effect on para74 mutant sodium channels, in contrast to wild type, where it causes removal of inactivation and prolonged tail currents.

      (Martin et al., 2000)

      Homozygous flies show significant resistance to dichloro-diphenyl-trichloro ethane (DDT) compared to wild-type flies. Homozygous flies have a modest level of resistance (2.58 fold) to deltamethrin compared to wild-type flies. para74/paraDN7 transheterozygotes have a 105 fold resistance to deltamethrin compared to wild-type flies. This high level of resistance is not altered if the flies also carry Tp(1;2)r+75c.

      (Pittendrigh et al., 1997)

      para74/paralk5 flies show temperature sensitive paralysis and reduced viability.

      (Stern et al., 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      para74 is a suppressor of phenotype of Sh14

      (Stern et al., 1990)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Suppresses the leg shaking phenotype of Sh14.

      (Stern et al., 1990)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      para74
      (Stilwell et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)