eye, with Scer\GAL4GMR.PF
rprGMR.PW flies have an eye ablation phenotype and show signs of cell death in the eye disc.
Eyes are highly ablated and abnormally shaped.
Expression of rprGMR.PW in the eye causes apoptosis in the developing retina that results in a small-eye phenotype.
Flies expressing rprGMR.PW have a rough eye phenotype.
rprGMR.PW mutants results in increased photoreceptor apoptotic cell death.
Adults expressing rprGMR.PW show a reduction in eye size compared to wild type.
rprGMR.PW flies show an eye ablation phenotype.
Expression of rprGMR.PW in the eye reduces the overall size and pigmentation of the eye.
Mosaic animals in which the eyes are expressing rprGMR.PW have an small eye phenotype.
Flies carrying rprGMR.PW have rough and reduced eyes.
Flies expressing rprGMR.PW have small, rough eyes.
Flies expressing rprGMR.PW have a small eye phenotype.
Expression of rprGMR.PW results in widespread ectopic apoptosis in the developing eye, resulting in mis-patterning of the ommatidial rows and a reduction in size of the adult eye field.
rprGMR.PW results in a dosage dependent eye degeneration phenotype.
rprGMR.PW flies have very small, rough eyes.
Flies expressing rprGMR.PW show an eye ablation phenotype.
flies exhibit moderate loss of eye tissue.
Flies expressing rprGMR.PW have a severely ablated eye.
Causes dose-dependent elimination of the eye due to ectopic apotosis. Eye is small and roughened.
Mutants have eyes that are severely reduced in size. The addition of BacA\p35GMR.PH to rprGMR.PW flies, completely suppresses the eye phenotype seen in those flies. The addition of Df(3L)AC1 to rprGMR.PW flies shows a significant suppression of the eye phenotype seen in these eyes.
Flies carrying rprGMR.PW have an ablated eye phenotype.
rprGMR.PW flies have a mild but easily detectable eye phenotype.
Flies carrying rprGMR.PW have a small eye phenotype and show increased numbers of dying cells posterior to the morphogenetic furrow.
Wild-type larvae reduce their path lengths show increased head swinging when exposed to light. These responses are not altered in larvae carrying rprGMR.PW. Wild-type larvae show a greater change in direction when lights are turned on or off (light (L) to dark (D), or D to L transition) than in the absence of a light transition (D to D). The amplitude of change of direction is greater for the D to L than for the L to D transition. The difference in the amplitude of change of direction at all transitions is abolished in larvae carrying rprGMR.PW.
Two copies of rprGMR.PW in an otherwise wild-type background result in a severely roughened eye.
Causes a dose-dependent mild eye ablation phenotype.
Flies carrying two copies of rprGMR.PW have noticeably roughened eyes with many fused or small ommatidia and extra bristles.
Eye is ablated due to apoptosis in a dose-dependent manner.
The eye is ablated, in a dose-dependent manner. Two doses of P{GMR-rpr.W} causes a rough eye, three doses decreases the size of the eye, four doses eliminates the eye completely. Examination of developing eye discs reveals that increased cell death causes the loss of the eye.
rprGMR.PW has increased cell death | larval stage phenotype, enhanceable by DriceC1/Drice[+]
rprGMR.PW has increased cell death | larval stage phenotype, enhanceable by Drice[+]/DriceC2
Scer\GAL4GMR.PF, rprGMR.PW has visible phenotype, enhanceable by CG3251GD10916, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, rprGMR.PW has increased cell death phenotype, enhanceable by CG3251GD10916, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, rprGMR.PW has visible phenotype, enhanceable by CG3251KK106465, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, rprGMR.PW has increased cell death phenotype, enhanceable by CG3251KK106465, Scer\GAL4GMR.PF
rprGMR.PW has visible phenotype, enhanceable by Df(2R)PC66/+
rprGMR.PW has visible phenotype, enhanceable by Diap133-1s
rprGMR.PW has visible phenotype, enhanceable by Diap121-4s
rprGMR.PW has abnormal cell death phenotype, enhanceable by Diap1109.07
rprGMR.PW has abnormal cell death phenotype, enhanceable by Diap14
rprGMR.PW has abnormal cell death phenotype, enhanceable by Diap15
rprGMR.PW has abnormal cell death phenotype, enhanceable by Diap16B
rprGMR.PW has abnormal cell death phenotype, enhanceable by Diap17
rprGMR.PW has abnormal cell death phenotype, enhanceable by Diap181.03
rprGMR.PW has abnormal cell death phenotype, enhanceable by Diap19
rprGMR.PW has abnormal cell death phenotype, enhanceable by Df(3L)brm11
rprGMR.PW has abnormal cell death phenotype, enhanceable by SEF2-1
rprGMR.PW has abnormal cell death phenotype, enhanceable by SEM2-4
rprGMR.PW has abnormal cell death phenotype, non-enhanceable by Ras85DN17.sev
rprGMR.PW has abnormal cell death phenotype, non-enhanceable by Ras85DV12.sev
rprGMR.PW has increased cell death | larval stage phenotype, suppressible | partially by Drice[+]/DriceL1
rprGMR.PW has increased cell death phenotype, suppressible by Cdk7S164A.T170A
rprGMR.PW has increased cell death phenotype, suppressible by Diap1αTub84B.WT
rprGMR.PW has increased cell death phenotype, suppressible by Diap1N.21-438.αTub84B
rprGMR.PW has visible phenotype, suppressible | partially by Hr4EP1232/Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
rprGMR.PW has visible phenotype, suppressible | partially by mir-278EP2316/Scer\GAL4GMR.PF/EP1229EP2316/Scer\GAL4GMR.PF
rprGMR.PW has visible phenotype, suppressible | partially by Scer\GAL4GMR.PF/Scer\GAL4GMR.PF/ImpEP1433
rprGMR.PW has visible | somatic clone phenotype, suppressible by DroncL32/DroncL32
rprGMR.PW has visible | somatic clone phenotype, suppressible by DroncI24/DroncI24
rprGMR.PW has visible phenotype, suppressible | partially by klu[+]/kluunspecified
rprGMR.PW has visible phenotype, suppressible by morgue[+]/morgueEP1184/Scer\GAL4[-]
rprGMR.PW has increased cell death phenotype, suppressible by morgue[+]/morgueEP1184/Scer\GAL4[-]
Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, rprGMR.PW, sklUAS.cWa has increased cell death phenotype, suppressible by BacA\p35UAS.cHa, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, rprGMR.PW, sklUAS.cWa has abnormal eye color phenotype, suppressible by BacA\p35UAS.cHa, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
rprGMR.PW has visible phenotype, suppressible by Df(2L)morgue19/+
rprGMR.PW has abnormal cell death phenotype, suppressible by Diap1SL
rprGMR.PW has abnormal cell death phenotype, suppressible | partially by Diap1UAS.cLa/Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
rprGMR.PW has abnormal cell death phenotype, suppressible by Scer\GAL4GMR.PF/Diap1V85M.UAS/Scer\GAL4GMR.PF
rprGMR.PW has abnormal cell death phenotype, suppressible by clnSF3-2
rprGMR.PW has abnormal cell death phenotype, suppressible by clnSF3-3
rprGMR.PW has abnormal cell death phenotype, suppressible by SM3-2SM3-2
rprGMR.PW has visible phenotype, suppressible by Darkk11502
rprGMR.PW has visible phenotype, suppressible by Df(1)su(s)R194
rprGMR.PW has increased cell death phenotype, non-suppressible by Diap1D20A.αTub84B
rprGMR.PW has increased cell death phenotype, non-suppressible by Diap1N21M.21-438.αTub84B
rprGMR.PW has increased cell death phenotype, non-suppressible by Diap1C406Y.αTub84B
rprGMR.PW has visible phenotype, non-suppressible by Darkunspecified/Ark[+]
rprGMR.PW has visible phenotype, non-suppressible by DammC156G.GMR.Tag:FLAG
rprGMR.PW has abnormal cell death phenotype, non-suppressible by Ras85DN17.sev
rprGMR.PW has abnormal cell death phenotype, non-suppressible by Ras85DV12.sev
rprGMR.PW is an enhancer of visible phenotype of Dcp-1fl.GMR
rprGMR.PW is an enhancer of visible phenotype of Dricefl.GMR
Df(1)su(s)R194, Dredd+tCa, rprGMR.PW has visible phenotype
rprGMR.PW has eye disc | larval stage phenotype, enhanceable by DriceC1/Drice[+]
rprGMR.PW has eye disc | larval stage phenotype, enhanceable by Drice[+]/DriceC2
Scer\GAL4GMR.PF, rprGMR.PW has eye phenotype, enhanceable by CG3251GD10916, Scer\GAL4GMR.PF
Scer\GAL4GMR.PF, rprGMR.PW has eye phenotype, enhanceable by CG3251KK106465, Scer\GAL4GMR.PF
rprGMR.PW has eye phenotype, enhanceable by lncRNA:HsrωEP3037/Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
rprGMR.PW has eye phenotype, enhanceable by Diap1dsRNA.UAS.cLa/Scer\GAL4GMR.PF/Scer\GAL4GMR.PF/Diap1dsRNA.Scer\UAS.cLa
rprGMR.PW has eye phenotype, enhanceable by Df(2R)PC66/+
rprGMR.PW has phenotype, enhanceable by Bruceunspecified/Bruce[+]
rprGMR.PW has phenotype, enhanceable by Df(3R)faf-BP/+
rprGMR.PW has eye phenotype, enhanceable by Diap133-1s
rprGMR.PW has eye phenotype, enhanceable by Diap121-4s
rprGMR.PW has phenotype, enhanceable by Diap111-3e
rprGMR.PW has eye phenotype, enhanceable by Diap1109.07
rprGMR.PW has eye phenotype, enhanceable by Diap181.03
rprGMR.PW has eye phenotype, enhanceable by Dcp-1GMR.PS
rprGMR.PW has phenotype, non-enhanceable by Ubc2k13206
rprGMR.PW has phenotype, non-enhanceable by lwrunspecified
rprGMR.PW has phenotype, non-enhanceable by SM2-1SM2-1
rprGMR.PW has phenotype, non-enhanceable by SM3-3SM3-3
rprGMR.PW has phenotype, non-enhanceable by SM3-6SM3-6
rprGMR.PW has phenotype, non-enhanceable by SM3-8SM3-8
rprGMR.PW has eye phenotype, non-enhanceable by Ras85DN17.sev
rprGMR.PW has eye phenotype, non-enhanceable by Ras85DV12.sev
rprGMR.PW has eye disc | larval stage phenotype, suppressible | partially by Drice[+]/DriceL1
rprGMR.PW has eye phenotype, suppressible by Cdk7S164A.T170A
rprGMR.PW has eye phenotype, suppressible by Scer\GAL4GMR.PF/Hsrωa.Sym.Scer\UAS/lncRNA:HsrωdsRNA.Sym.UAS/Scer\GAL4GMR.PF
lncRNA:HsrωEP3037, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, rprGMR.PW has eye phenotype, suppressible by Hsrωa.Sym.Scer\UAS/lncRNA:HsrωdsRNA.Sym.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
rprGMR.PW has eye phenotype, suppressible | partially by Scer\GAL4GMR.PF/Scer\GAL4GMR.PF/Diap1UAS.cHa
Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, rprGMR.PW, Diap1UAS.cHa has eye phenotype, suppressible by Hsrωa.Sym.Scer\UAS/lncRNA:HsrωdsRNA.Sym.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
rprGMR.PW has eye phenotype, suppressible by Diap1N.21-438.αTub84B
rprGMR.PW has eye phenotype, suppressible by Diap1αTub84B.WT
rprGMR.PW has eye phenotype, suppressible | partially by Scer\GAL4GMR.PF/Scer\GAL4GMR.PF/CskdsRNA.UAS
rprGMR.PW has eye phenotype, suppressible | partially by Hr4EP1232/Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
rprGMR.PW has eye phenotype, suppressible | partially by mir-278EP2316/Scer\GAL4GMR.PF/EP1229EP2316/Scer\GAL4GMR.PF
rprGMR.PW has eye phenotype, suppressible | partially by Scer\GAL4GMR.PF/Scer\GAL4GMR.PF/ImpEP1433
rprGMR.PW has eye | somatic clone phenotype, suppressible by DroncL32/DroncL32
rprGMR.PW has eye | somatic clone phenotype, suppressible by DroncI24/DroncI24
rprGMR.PW has ommatidium phenotype, suppressible | partially by klu[+]/kluunspecified
rprGMR.PW has eye phenotype, suppressible by morgue[+]/morgueEP1184/Scer\GAL4[-]
rprGMR.PW has ommatidium phenotype, suppressible by morgue[+]/morgueEP1184/Scer\GAL4[-]
rprGMR.PW has eye phenotype, suppressible | partially by Df(2L)M24F-B/+
rprGMR.PW has ommatidium phenotype, suppressible | partially by Df(2L)M24F-B/+
rprGMR.PW has eye phenotype, suppressible | partially by Df(2L)dp-h25/+
rprGMR.PW has ommatidium phenotype, suppressible | partially by Df(2L)dp-h25/+
rprGMR.PW has eye phenotype, suppressible | partially by Df(2L)ed-dp/+
rprGMR.PW has ommatidium phenotype, suppressible | partially by Df(2L)ed-dp/+
rprGMR.PW has eye phenotype, suppressible | partially by Df(3R)H-B79/+
rprGMR.PW has ommatidium phenotype, suppressible | partially by Df(3R)H-B79/+
rprGMR.PW has ommatidium phenotype, suppressible | partially by bsk2/bsk[+]
rprGMR.PW has ommatidium phenotype, suppressible | partially by hep[+]/hep1
rprGMR.PW has ommatidium phenotype, suppressible | partially by Df(2L)sc19-8/+
rprGMR.PW has eye phenotype, suppressible | partially by Df(2L)sc19-8/+
Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, rprGMR.PW, sklUAS.cWa has eye phenotype, suppressible by BacA\p35UAS.cHa, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
rprGMR.PW has eye phenotype, suppressible by Df(2L)morgue19/+
rprGMR.PW has phenotype, suppressible by Diap121-2s
rprGMR.PW has phenotype, suppressible by Diap123-4s
rprGMR.PW has phenotype, suppressible by Diap123-8s
rprGMR.PW has phenotype, suppressible by Diap145-2s
rprGMR.PW has eye phenotype, suppressible | partially by Diap1UAS.cLa/Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
rprGMR.PW has eye phenotype, suppressible by Scer\GAL4GMR.PF/Diap1V85M.UAS/Scer\GAL4GMR.PF
rprGMR.PW has phenotype, suppressible | partially by Droncpro.C-A.UAS/Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
rprGMR.PW has phenotype, suppressible | partially by Scer\GAL4GMR.PF/Scer\GAL4GMR.PF/DroncCARD.UAS
rprGMR.PW has phenotype, suppressible by BacA\p35GMR.PH
rprGMR.PW has eye phenotype, suppressible by Darkk11502
rprGMR.PW has ommatidium phenotype, suppressible by DarkCD4
rprGMR.PW has eye phenotype, suppressible by Df(1)su(s)R194
rprGMR.PW has ommatidium phenotype, suppressible by Df(1)su(s)R194
rprGMR.PW has eye phenotype, suppressible by Ras85DV12.sev
Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, rprGMR.PW, Diap1dsRNA.UAS.cLa/Diap1dsRNA.Scer\UAS.cLa has eye phenotype, non-suppressible by Hsrωa.Sym.Scer\UAS/lncRNA:HsrωdsRNA.Sym.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
rprGMR.PW has eye phenotype, non-suppressible by Diap1D20A.αTub84B
rprGMR.PW has eye phenotype, non-suppressible by Diap1N21M.21-438.αTub84B
rprGMR.PW has eye phenotype, non-suppressible by Diap1C406Y.αTub84B
rprGMR.PW has eye phenotype, non-suppressible by Darkunspecified/Ark[+]
rprGMR.PW has phenotype, non-suppressible by lwrunspecified
rprGMR.PW has phenotype, non-suppressible by Ubc2k13206
rprGMR.PW has eye phenotype, non-suppressible by DammC156G.GMR.Tag:FLAG
rprGMR.PW has phenotype, non-suppressible by SM2-1SM2-1
rprGMR.PW has phenotype, non-suppressible by SM3-3SM3-3
rprGMR.PW has phenotype, non-suppressible by SM3-6SM3-6
rprGMR.PW has phenotype, non-suppressible by SM3-8SM3-8
rprGMR.PW has eye phenotype, non-suppressible by Darkk11502
rprGMR.PW has eye phenotype, non-suppressible by Ras85DN17.sev
rprGMR.PW has eye phenotype, non-suppressible by Ras85DV12.sev
rprGMR.PW is an enhancer of eye phenotype of Dcp-1fl.GMR
rprGMR.PW is an enhancer of eye phenotype of Dricefl.GMR
rprGMR.PW is an enhancer of eye phenotype of Dcp-1GMR.PS
Df(1)su(s)R194, Dredd+tCa, rprGMR.PW has eye phenotype
Drice17/DriceΔ1, DriceΔ1/DriceL1, DriceΔ1/DriceL2, DriceΔ1/DriceC1, DriceΔ1/DriceC2, DriceΔ1/DriceS1, DriceΔ1/DriceS2 (but not DriceΔ1/+) significantly suppresses the eye ablation phenotype in rprGMR.PW flies.
DriceC1/+ or DriceC2/+ significantly enhance and DriceL1/+, DriceL2/+, DriceS1/+ or DriceS2/+ weakly suppress the eye ablation phenotype in rprGMR.PW flies; Drice17/+ does not suppress the phenotype. DriceL1/+ significantly suppresses and DriceC1/+ or DriceC2/+ significantly enhance the increased cell death seen in rprGMR.PW larval eye discs.
Expression of CG3251GD10916 under the control of Scer\GAL4GMR.PF enhances the rprGMR.PW-induced cell death in the eye.
Expression of CG3251KK106465 under the control of Scer\GAL4GMR.PF enhances the rprGMR.PW-induced cell death in the eye.
A Cdk7S164A.T170A mutant background significantly suppresses the partial eye ablation found upon expression of rprGMR.PW in the developing eye.
Ras85DR68Q very mildly suppresses rprGMR.PW-induced cell death although this is suspected to be due to suppression of endogenous W activity and not grim or rpr activity.
Scer\GAL4GMR.PF-mediated expression of P{Sym-UAS-Hsrω} significantly rescues the rprGMR.PW eye phenotype.
Scer\GAL4GMR.PF-mediated expression of HsrωEP3037 significantly enhances the rprGMR.PW eye phenotype.
Scer\GAL4GMR.PF-mediated expression of P{Sym-UAS-Hsrω} eliminates the enhancing effect of HsrωEP3037 on rprGMR.PW eyes as well as reversing the level of degeneration seen in eyes expressing rprGMR.PW alone.
Expression of thScer\UAS.cHa using Scer\GAL4GMR.PF rescues the rprGMR.PW small eye phenotype.
Co-expression of P{Sym-UAS-Hsrω} in the rprGMR.PW, thScer\UAS.cHa, Scer\GAL4GMR.PF background improves eye morphology such that eyes are indistinguishable from wild type.
Expression of thdsRNA.Scer\UAS.cLa using Scer\GAL4GMR.PF enhances the rprGMR.PW small eye phenotype.
Co-expression of P{Sym-UAS-Hsrω} fails to suppress the eye damage in the rprGMR.PW, thdsRNA.Scer\UAS.cLa, Scer\GAL4GMR.PF background.
Expression of thαTub84B.WT or thN.21-438.αTub84B suppresses the small-eye phenotype observed in rprGMR.PW mutants.
Expression of thD20A.αTub84B or thN21M.21-438.αTub84B fails to suppress the small-eye phenotype observed in rprGMR.PW mutants.
Expression of thC406Y.αTub84B, which lacks a functional RING domain, fails to inhibit the small-eye phenotype observed in rprGMR.PW mutants.
Expression of scramb1Scer\UAS.cAa, scramb2Scer\UAS.cAa, or both, under the control of Scer\GAL4Act does not affect rprGMR.PW-induced photoreceptor apoptosis. The eye sizes are not significantly different in the three mutant backgrounds compared with control flies.
CskIR.Scer\UAS; Scer\GAL4GMR.PF partially suppresses the reduction in eye size due to rprGMR.PW.
The severity of the rprGMR.PW eye phenotype is suppressed by "dronc[d5]" animals (Df(3L)NcZ in which CG6685 function, but not Nc function, is rescued by P{CG6685+tDa}).
The reduced eye phenotype caused by expression of rprGMR.PW is significantly suppressed by pnut1/+ or pnutXP/+, but Arkunspecified/+ has little effect.
The eye phenotype caused by rprGMR.PW is mildly but consistently suppressed by kluunspecified/+.
The rprGMR.PW eye phenotypes are significantly suppressed by heterozygosity for Df(2L)sc19-8, Df(2L)ed-dp, Df(2L)dp-h25, Df(2L)M24F-B, Traf1EP578, Df(3R)H-B79, bsk2 or hep1, but not Df(2L)tkv3 or Df(2L)ed1.
The addition of sklScer\UAS.cWa (driven by Scer\GAL4GMR.PF) to rprGMR.PW flies enhances the eye phenotype. Flies exhibit much more severe eye cell death, with greatly reduced size and pigmentation. The subsequent addition of BacA\p35Scer\UAS.cHa represses these phenotypes.
The eye cell death phenotype caused by rprGMR.PW is suppressed by Df(2L)morgue19/+.
The rprGMR.PW severely ablated eye phenotype is not suppressed by DammC156G.GMR.T:Zzzz\FLAG.
The addition of rprGMR.PW to Dcp-1fl.GMR flies show a strong enhancement of the eye phenotype seen in Dcp-1fl.GMR flies. The addition of rprGMR.PW to Icefl.GMR flies show a strong enhancement of the eye phenotype seen in Icefl.GMR flies.
Arkk11502 has little effect on the eye phenotype caused by rprGMR.PW. A strong synergism in cell ablation is seen when Dcp-1GMR.PS and rprGMR.PW are coexpressed in the eye. This phenotype is not modified by Arkk11502.
The grimGMR.PC eye ablation phenotype is not particularly affected by either Ras85DV12.sev and Ras85DN17.sev.
The rprGMR.PW rough eye phenotype is suppressed if the flies are also heterozygous for Df(1)su(s)R194. The rough eye phenotype is restored in flies carrying rprGMR.PW, heterozygous for Df(1)su(s)R194 and also carrying Dredd+tCa.
Expression of BacA\p35 abrogates the effects of ectopic rpr; flies carrying both P{GMRP35} and P{GMR-rpr.W} (two copies) show the same slightly rough eye phenotype as flies carrying P{GMRP35} alone.