FlyBase Allele Report: Dmel\rpr[GMR.PW]

General Information

Symbol

Dmel\rpr^GMR.PW

Species

D. melanogaster

Name

glass multimer reporter construct of White

FlyBase ID

FBal0050351

Feature type

allele

Associated gene

Dmel\rpr

Associated Insertion(s)

Carried in Construct

P{GMR-rpr.W}

Also Known As

GMR-rpr, GMR-reaper, P^GMR-reaper

Allele class

Mutagen

in vitro construct - regulatory fusion

Nature of the Allele

Allele class

Mutagen

in vitro construct - regulatory fusion

(Chen et al., 1998, White et al., 1996)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{GMR-rpr.W}

Cytology

Nature of the lesion

Statement

Reference

GMR regulatory sequences drive expression of a rpr cDNA.

(White et al., 1996)

Allele components

Product class / Tool use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

rpr

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

behavior defective | larval stage | recessive

(Busto et al., 1999)

cell death defective

(Bergmann et al., 1998)

increased cell death

(Morishita et al., 2013, Ditzel et al., 2008, Acharya et al., 2006, Hays et al., 2002, Wing et al., 2002, Lisi et al., 2000, Taguchi et al., 2000, Kurada and White, 1998, White et al., 1996)

increased cell death, with Scer\GAL4^GMR.PF

(Louis et al., 2015)

increased cell death | larval stage

(Wu et al., 2016)

visible

visible, with Scer\GAL4^GMR.PF

(Louis et al., 2015)

visible | dominant

(Lisi et al., 2000, Kurada and White, 1998)

visible | somatic clone

(Xu et al., 2005)

Phenotype Manifest In

eye

eye, with Scer\GAL4^GMR.PF

(Louis et al., 2015)

eye | somatic clone

(Xu et al., 2005)

eye disc

(Taguchi et al., 2000)

eye disc | larval stage

(Wu et al., 2016)

eye photoreceptor cell

(Acharya et al., 2006)

interommatidial bristle

(Chen et al., 1998)

ommatidium

(Gottfried et al., 2004, Rusconi et al., 2004, Hays et al., 2002, Kuranaga et al., 2002, Rodriguez et al., 1999, Chen et al., 1998)

Detailed Description

Statement

Reference

rpr^GMR.PW flies have an eye ablation phenotype and show signs of cell death in the eye disc.

(Wu et al., 2016)

Eyes are highly ablated and abnormally shaped.

(Mallik and Lakhotia, 2009)

Expression of rpr^GMR.PW in the eye causes apoptosis in the developing retina that results in a small-eye phenotype.

(Ditzel et al., 2008)

Flies expressing rpr^GMR.PW have a rough eye phenotype.

(Krieser et al., 2007)

rpr^GMR.PW mutants results in increased photoreceptor apoptotic cell death.

(Acharya et al., 2006)

Adults expressing rpr^GMR.PW show a reduction in eye size compared to wild type.

(Kondo et al., 2006)

rpr^GMR.PW flies show an eye ablation phenotype.

(Xu et al., 2006)

Expression of rpr^GMR.PW in the eye reduces the overall size and pigmentation of the eye.

(Wildonger et al., 2005)

Mosaic animals in which the eyes are expressing rpr^GMR.PW have an small eye phenotype.

(Xu et al., 2005)

Flies carrying rpr^GMR.PW have rough and reduced eyes.

(Gottfried et al., 2004)

Flies expressing rpr^GMR.PW have small, rough eyes.

(Rusconi et al., 2004)

Flies expressing rpr^GMR.PW have a small eye phenotype.

(Ditzel et al., 2003, Wilson et al., 2002)

Expression of rpr^GMR.PW results in widespread ectopic apoptosis in the developing eye, resulting in mis-patterning of the ommatidial rows and a reduction in size of the adult eye field.

(Hays et al., 2002)

rpr^GMR.PW results in a dosage dependent eye degeneration phenotype.

(Higashiyama et al., 2002)

rpr^GMR.PW flies have very small, rough eyes.

(Kuranaga et al., 2002)

Flies expressing rpr^GMR.PW show an eye ablation phenotype.

(Ryoo et al., 2002)

flies exhibit moderate loss of eye tissue.

(Wing et al., 2002)

Flies expressing rpr^GMR.PW have a severely ablated eye.

(Harvey et al., 2001)

Causes dose-dependent elimination of the eye due to ectopic apotosis. Eye is small and roughened.

(Lisi et al., 2000)

Mutants have eyes that are severely reduced in size. The addition of BacA\p35^GMR.PH to rpr^GMR.PW flies, completely suppresses the eye phenotype seen in those flies. The addition of Df(3L)AC1 to rpr^GMR.PW flies shows a significant suppression of the eye phenotype seen in these eyes.

(Meier et al., 2000)

Flies carrying rpr^GMR.PW have an ablated eye phenotype.

(Quinn et al., 2000)

rpr^GMR.PW flies have a mild but easily detectable eye phenotype.

(Song et al., 2000)

Flies carrying rpr^GMR.PW have a small eye phenotype and show increased numbers of dying cells posterior to the morphogenetic furrow.

(Taguchi et al., 2000)

Wild-type larvae reduce their path lengths show increased head swinging when exposed to light. These responses are not altered in larvae carrying rpr^GMR.PW. Wild-type larvae show a greater change in direction when lights are turned on or off (light (L) to dark (D), or D to L transition) than in the absence of a light transition (D to D). The amplitude of change of direction is greater for the D to L than for the L to D transition. The difference in the amplitude of change of direction at all transitions is abolished in larvae carrying rpr^GMR.PW.

(Busto et al., 1999)

Two copies of rpr^GMR.PW in an otherwise wild-type background result in a severely roughened eye.

(Rodriguez et al., 1999)

Causes a dose-dependent mild eye ablation phenotype.

(Bergmann et al., 1998)

Flies carrying two copies of rpr^GMR.PW have noticeably roughened eyes with many fused or small ommatidia and extra bristles.

(Chen et al., 1998)

Eye is ablated due to apoptosis in a dose-dependent manner.

(Kurada and White, 1998)

The eye is ablated, in a dose-dependent manner. Two doses of P{GMR-rpr.W} causes a rough eye, three doses decreases the size of the eye, four doses eliminates the eye completely. Examination of developing eye discs reveals that increased cell death causes the loss of the eye.

(White et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

rpr^GMR.PW has visible phenotype, enhanceable by Drice^C1/Drice[+]

(Wu et al., 2016)

rpr^GMR.PW has increased cell death | larval stage phenotype, enhanceable by Drice^C1/Drice[+]

(Wu et al., 2016)

rpr^GMR.PW has visible phenotype, enhanceable by Drice[+]/Drice^C2

(Wu et al., 2016)

rpr^GMR.PW has increased cell death | larval stage phenotype, enhanceable by Drice[+]/Drice^C2

(Wu et al., 2016)

Scer\GAL4^GMR.PF, rpr^GMR.PW has visible phenotype, enhanceable by CG3251^GD10916, Scer\GAL4^GMR.PF

(Louis et al., 2015)

Scer\GAL4^GMR.PF, rpr^GMR.PW has increased cell death phenotype, enhanceable by CG3251^GD10916, Scer\GAL4^GMR.PF

(Louis et al., 2015)

Scer\GAL4^GMR.PF, rpr^GMR.PW has visible phenotype, enhanceable by CG3251^KK106465, Scer\GAL4^GMR.PF

(Louis et al., 2015)

Scer\GAL4^GMR.PF, rpr^GMR.PW has increased cell death phenotype, enhanceable by CG3251^KK106465, Scer\GAL4^GMR.PF

(Louis et al., 2015)

rpr^GMR.PW has visible phenotype, enhanceable by PSR[+]/PSR^FM1

(Krieser et al., 2007)

rpr^GMR.PW has visible phenotype, enhanceable by PSR^FM1/PSR^FM1

(Krieser et al., 2007)

rpr^GMR.PW has visible phenotype, enhanceable by Df(2R)017/+

(Ditzel et al., 2003)

rpr^GMR.PW has visible phenotype, enhanceable by Df(2R)PC66/+

(Ditzel et al., 2003)

rpr^GMR.PW has visible phenotype, enhanceable by Diap1^33-1s

(Wilson et al., 2002)

rpr^GMR.PW has visible phenotype, enhanceable by Diap1^21-4s

(Wilson et al., 2002)

rpr^GMR.PW has cell death defective phenotype, enhanceable by Diap1^109.07

(Lisi et al., 2000)

rpr^GMR.PW has cell death defective phenotype, enhanceable by Diap1⁴

(Lisi et al., 2000)

rpr^GMR.PW has cell death defective phenotype, enhanceable by Diap1⁵

(Lisi et al., 2000)

rpr^GMR.PW has cell death defective phenotype, enhanceable by Diap1^6B

(Lisi et al., 2000)

rpr^GMR.PW has cell death defective phenotype, enhanceable by Diap1⁷

(Lisi et al., 2000)

rpr^GMR.PW has cell death defective phenotype, enhanceable by Diap1^81.03

(Lisi et al., 2000)

rpr^GMR.PW has cell death defective phenotype, enhanceable by Diap1⁹

(Lisi et al., 2000)

rpr^GMR.PW has cell death defective phenotype, enhanceable by Df(3L)brm11

(Lisi et al., 2000)

rpr^GMR.PW has cell death defective phenotype, enhanceable by S^EF2-1

(Taguchi et al., 2000)

rpr^GMR.PW has cell death defective phenotype, enhanceable by S^EM2-4

(Taguchi et al., 2000)

NOT Enhanced by

Statement

Reference

rpr^GMR.PW has cell death defective phenotype, non-enhanceable by Ras85D^N17.sev

(Bergmann et al., 1998)

rpr^GMR.PW has cell death defective phenotype, non-enhanceable by Ras85D^V12.sev

(Bergmann et al., 1998)

Suppressed by

Statement

Reference

rpr^GMR.PW has visible phenotype, suppressible by Drice^Δ1/Drice¹⁷

(Wu et al., 2016)

rpr^GMR.PW has visible phenotype, suppressible by Drice^Δ1/Drice^L1

(Wu et al., 2016)

rpr^GMR.PW has visible phenotype, suppressible by Drice^Δ1/Drice^L2

(Wu et al., 2016)

rpr^GMR.PW has visible phenotype, suppressible by Drice^C1/Drice^Δ1

(Wu et al., 2016)

rpr^GMR.PW has visible phenotype, suppressible by Drice^Δ1/Drice^C2

(Wu et al., 2016)

rpr^GMR.PW has visible phenotype, suppressible by Drice^Δ1/Drice^S1

(Wu et al., 2016)

rpr^GMR.PW has visible phenotype, suppressible by Drice^Δ1/Drice^S2

(Wu et al., 2016)

rpr^GMR.PW has visible phenotype, suppressible | partially by Drice[+]/Drice^L1

(Wu et al., 2016)

rpr^GMR.PW has increased cell death | larval stage phenotype, suppressible | partially by Drice[+]/Drice^L1

(Wu et al., 2016)

rpr^GMR.PW has visible phenotype, suppressible | partially by Drice[+]/Drice^L2

(Wu et al., 2016)

rpr^GMR.PW has visible phenotype, suppressible | partially by Drice^S1/Drice[+]

(Wu et al., 2016)

rpr^GMR.PW has increased cell death phenotype, suppressible by Cdk7^S164A.T170A

(Morishita et al., 2013)

rpr^GMR.PW has increased cell death phenotype, suppressible by Diap1^αTub84B.WT

(Ditzel et al., 2008)

rpr^GMR.PW has increased cell death phenotype, suppressible by Diap1^{N.21-438.αTub84B}

(Ditzel et al., 2008)

rpr^GMR.PW has visible phenotype, suppressible | partially by Drice¹⁷/Drice¹⁷

(Xu et al., 2006)

rpr^GMR.PW has visible phenotype, suppressible | partially by Hr4^EP1232/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Müller et al., 2005)

rpr^GMR.PW has visible phenotype, suppressible | partially by mir-278^EP2316/Scer\GAL4^GMR.PF/EP1229^EP2316/Scer\GAL4^GMR.PF

(Müller et al., 2005)

rpr^GMR.PW has visible phenotype, suppressible | partially by Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF/Imp^EP1433

(Müller et al., 2005)

rpr^GMR.PW has visible | somatic clone phenotype, suppressible by Dronc^L32/Dronc^L32

(Xu et al., 2005)

rpr^GMR.PW has visible | somatic clone phenotype, suppressible by Dronc^I24/Dronc^I24

(Xu et al., 2005)

rpr^GMR.PW has visible phenotype, suppressible by pnut[+]/pnut^XP

(Gottfried et al., 2004)

rpr^GMR.PW has visible phenotype, suppressible by pnut[+]/pnut¹

(Gottfried et al., 2004)

rpr^GMR.PW has visible phenotype, suppressible | partially by klu[+]/klu^unspecified

(Rusconi et al., 2004)

rpr^GMR.PW has visible phenotype, suppressible by morgue[+]/morgue^EP1184/Scer\GAL4[-]

(Hays et al., 2002)

rpr^GMR.PW has increased cell death phenotype, suppressible by morgue[+]/morgue^EP1184/Scer\GAL4[-]

(Hays et al., 2002)

rpr^GMR.PW has visible phenotype, suppressible | partially by eff⁵⁹⁸/eff[+]

(Ryoo et al., 2002)

rpr^GMR.PW has visible phenotype, suppressible | partially by eff[+]/eff^D73

(Ryoo et al., 2002)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, rpr^GMR.PW, skl^UAS.cWa has increased cell death phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Wing et al., 2002)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, rpr^GMR.PW, skl^UAS.cWa has eye color defective phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Wing et al., 2002)

rpr^GMR.PW has visible phenotype, suppressible by Df(2L)morgue¹⁹/+

(Wing et al., 2002)

rpr^GMR.PW has cell death defective phenotype, suppressible by Diap1^SL

(Lisi et al., 2000)

rpr^GMR.PW has cell death defective phenotype, suppressible | partially by Diap1^UAS.cLa/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Lisi et al., 2000)

rpr^GMR.PW has cell death defective phenotype, suppressible by Scer\GAL4^GMR.PF/Diap1^V85M.UAS/Scer\GAL4^GMR.PF

(Lisi et al., 2000)

rpr^GMR.PW has visible phenotype, suppressible | partially by Df(3L)AC1

(Quinn et al., 2000)

rpr^GMR.PW has cell death defective phenotype, suppressible by cln^SF3-2

(Taguchi et al., 2000)

rpr^GMR.PW has visible phenotype, suppressible by cln^SF3-2

(Taguchi et al., 2000)

rpr^GMR.PW has cell death defective phenotype, suppressible by cln^SF3-3

(Taguchi et al., 2000)

rpr^GMR.PW has cell death defective phenotype, suppressible by SM3-2^SM3-2

(Taguchi et al., 2000)

rpr^GMR.PW has visible phenotype, suppressible by Dark^k11502

(Kanuka et al., 1999)

rpr^GMR.PW has visible phenotype, suppressible by Dark^CD4

(Rodriguez et al., 1999)

rpr^GMR.PW has visible phenotype, suppressible by Df(1)su(s)R194

(Chen et al., 1998)

NOT suppressed by

Statement

Reference

rpr^GMR.PW has visible phenotype, non-suppressible by Drice^Δ1/Drice[+]

(Wu et al., 2016)

rpr^GMR.PW has visible phenotype, non-suppressible by Drice[+]/Drice¹⁷

(Wu et al., 2016)

rpr^GMR.PW has increased cell death phenotype, non-suppressible by Diap1^{D20A.αTub84B}

(Ditzel et al., 2008)

rpr^GMR.PW has increased cell death phenotype, non-suppressible by Diap1^{N21M.21-438.αTub84B}

(Ditzel et al., 2008)

rpr^GMR.PW has increased cell death phenotype, non-suppressible by Diap1^{C406Y.αTub84B}

(Ditzel et al., 2008)

rpr^GMR.PW has visible phenotype, non-suppressible by Dark^unspecified/Ark[+]

(Gottfried et al., 2004)

rpr^GMR.PW has visible phenotype, non-suppressible by TER94[+]/TER94^26-8

(Higashiyama et al., 2002)

rpr^GMR.PW has visible phenotype, non-suppressible by Damm^{C156G.GMR.Tag:FLAG}

(Harvey et al., 2001)

rpr^GMR.PW has cell death defective phenotype, non-suppressible by Ras85D^N17.sev

(Bergmann et al., 1998)

rpr^GMR.PW has cell death defective phenotype, non-suppressible by Ras85D^V12.sev

(Bergmann et al., 1998)

Enhancer of

Statement

Reference

rpr^GMR.PW is an enhancer of visible phenotype of Dcp-1^fl.GMR

(Song et al., 2000)

rpr^GMR.PW is an enhancer of visible phenotype of Drice^fl.GMR

(Song et al., 2000)

Other

Statement

Reference

Df(1)su(s)R194, Dredd^+tCa, rpr^GMR.PW has visible phenotype

(Chen et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

rpr^GMR.PW has eye phenotype, enhanceable by Drice^C1/Drice[+]

(Wu et al., 2016)

rpr^GMR.PW has eye disc | larval stage phenotype, enhanceable by Drice^C1/Drice[+]

(Wu et al., 2016)

rpr^GMR.PW has eye phenotype, enhanceable by Drice[+]/Drice^C2

(Wu et al., 2016)

rpr^GMR.PW has eye disc | larval stage phenotype, enhanceable by Drice[+]/Drice^C2

(Wu et al., 2016)

Scer\GAL4^GMR.PF, rpr^GMR.PW has eye phenotype, enhanceable by CG3251^GD10916, Scer\GAL4^GMR.PF

(Louis et al., 2015)

Scer\GAL4^GMR.PF, rpr^GMR.PW has eye phenotype, enhanceable by CG3251^KK106465, Scer\GAL4^GMR.PF

(Louis et al., 2015)

rpr^GMR.PW has eye phenotype, enhanceable by lncRNA:Hsrω^EP3037/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

rpr^GMR.PW has eye phenotype, enhanceable by Diap1^{dsRNA.UAS.cLa}/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF/Diap1^{dsRNA.Scer\UAS.cLa}

(Mallik and Lakhotia, 2009)

rpr^GMR.PW has eye phenotype, enhanceable by PSR[+]/PSR^FM1

(Krieser et al., 2007)

rpr^GMR.PW has eye phenotype, enhanceable by PSR^FM1/PSR^FM1

(Krieser et al., 2007)

rpr^GMR.PW has eye phenotype, enhanceable by Df(2R)017/+

(Ditzel et al., 2003)

rpr^GMR.PW has eye phenotype, enhanceable by Df(2R)PC66/+

(Ditzel et al., 2003)

rpr^GMR.PW has phenotype, enhanceable by Bruce^unspecified/Bruce[+]

(Ryoo et al., 2002)

rpr^GMR.PW has phenotype, enhanceable by Df(3R)faf-BP/+

(Ryoo et al., 2002)

rpr^GMR.PW has phenotype, enhanceable by Pros26[+]/Prosβ6¹

(Ryoo et al., 2002)

rpr^GMR.PW has eye phenotype, enhanceable by Diap1^33-1s

(Wilson et al., 2002)

rpr^GMR.PW has eye phenotype, enhanceable by Diap1^21-4s

(Wilson et al., 2002)

rpr^GMR.PW has phenotype, enhanceable by Diap1⁴

(Goyal et al., 2000)

rpr^GMR.PW has phenotype, enhanceable by Diap1⁵

(Goyal et al., 2000)

rpr^GMR.PW has phenotype, enhanceable by Diap1^11-3e

(Goyal et al., 2000)

rpr^GMR.PW has eye phenotype, enhanceable by Diap1^109.07

(Lisi et al., 2000)

rpr^GMR.PW has eye phenotype, enhanceable by Diap1⁴

(Lisi et al., 2000)

rpr^GMR.PW has eye phenotype, enhanceable by Diap1⁵

(Lisi et al., 2000)

rpr^GMR.PW has eye phenotype, enhanceable by Diap1^6B

(Lisi et al., 2000)

rpr^GMR.PW has eye phenotype, enhanceable by Diap1⁷

(Lisi et al., 2000)

rpr^GMR.PW has eye phenotype, enhanceable by Diap1^81.03

(Lisi et al., 2000)

rpr^GMR.PW has eye phenotype, enhanceable by Diap1⁹

(Lisi et al., 2000)

rpr^GMR.PW has eye phenotype, enhanceable by Dcp-1^GMR.PS

(Zhou et al., 1999)

rpr^GMR.PW has eye phenotype, enhanceable by Ras85D^e2F

(Kurada and White, 1998)

rpr^GMR.PW has eye phenotype, enhanceable by Raf⁷

(Kurada and White, 1998)

NOT Enhanced by

Statement

Reference

rpr^GMR.PW has phenotype, non-enhanceable by Ubc2^k13206

(Ryoo et al., 2002)

rpr^GMR.PW has phenotype, non-enhanceable by lwr^unspecified

(Ryoo et al., 2002)

rpr^GMR.PW has phenotype, non-enhanceable by SM2-1^SM2-1

(Taguchi et al., 2000)

rpr^GMR.PW has phenotype, non-enhanceable by SM3-3^SM3-3

(Taguchi et al., 2000)

rpr^GMR.PW has phenotype, non-enhanceable by SM3-6^SM3-6

(Taguchi et al., 2000)

rpr^GMR.PW has phenotype, non-enhanceable by SM3-8^SM3-8

(Taguchi et al., 2000)

rpr^GMR.PW has phenotype, non-enhanceable by bul^SF3-1

(Taguchi et al., 2000)

rpr^GMR.PW has phenotype, non-enhanceable by sty^SM3-5

(Taguchi et al., 2000)

rpr^GMR.PW has phenotype, non-enhanceable by sty^SM3-9

(Taguchi et al., 2000)

rpr^GMR.PW has phenotype, non-enhanceable by osa^E65

(Staehling-Hampton et al., 1999)

rpr^GMR.PW has eye phenotype, non-enhanceable by Ras85D^N17.sev

(Bergmann et al., 1998)

rpr^GMR.PW has eye phenotype, non-enhanceable by Ras85D^V12.sev

(Bergmann et al., 1998)

Suppressed by

Statement

Reference

rpr^GMR.PW has eye phenotype, suppressible by Drice^Δ1/Drice¹⁷

(Wu et al., 2016)

rpr^GMR.PW has eye phenotype, suppressible by Drice^Δ1/Drice^L1

(Wu et al., 2016)

rpr^GMR.PW has eye phenotype, suppressible by Drice^Δ1/Drice^L2

(Wu et al., 2016)

rpr^GMR.PW has eye phenotype, suppressible by Drice^C1/Drice^Δ1

(Wu et al., 2016)

rpr^GMR.PW has eye phenotype, suppressible by Drice^Δ1/Drice^C2

(Wu et al., 2016)

rpr^GMR.PW has eye phenotype, suppressible by Drice^Δ1/Drice^S1

(Wu et al., 2016)

rpr^GMR.PW has eye phenotype, suppressible by Drice^Δ1/Drice^S2

(Wu et al., 2016)

rpr^GMR.PW has eye phenotype, suppressible | partially by Drice[+]/Drice^L1

(Wu et al., 2016)

rpr^GMR.PW has eye disc | larval stage phenotype, suppressible | partially by Drice[+]/Drice^L1

(Wu et al., 2016)

rpr^GMR.PW has eye phenotype, suppressible | partially by Drice[+]/Drice^L2

(Wu et al., 2016)

rpr^GMR.PW has eye phenotype, suppressible | partially by Drice^S1/Drice[+]

(Wu et al., 2016)

rpr^GMR.PW has eye phenotype, suppressible by Cdk7^S164A.T170A

(Morishita et al., 2013)

rpr^GMR.PW has eye phenotype, suppressible by Scer\GAL4^GMR.PF/Hsrω^{a.Sym.Scer\UAS}/lncRNA:Hsrω^{dsRNA.Sym.UAS}/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

lncRNA:Hsrω^EP3037, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, rpr^GMR.PW has eye phenotype, suppressible by Hsrω^{a.Sym.Scer\UAS}/lncRNA:Hsrω^{dsRNA.Sym.UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

rpr^GMR.PW has eye phenotype, suppressible | partially by Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF/Diap1^UAS.cHa

(Mallik and Lakhotia, 2009)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, rpr^GMR.PW, Diap1^UAS.cHa has eye phenotype, suppressible by Hsrω^{a.Sym.Scer\UAS}/lncRNA:Hsrω^{dsRNA.Sym.UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

rpr^GMR.PW has eye phenotype, suppressible by Diap1^{N.21-438.αTub84B}

(Ditzel et al., 2008)

rpr^GMR.PW has eye phenotype, suppressible by Diap1^αTub84B.WT

(Ditzel et al., 2008)

rpr^GMR.PW has eye phenotype, suppressible | partially by Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF/Csk^dsRNA.UAS

(Vidal et al., 2006)

rpr^GMR.PW has eye phenotype, suppressible | partially by Drice¹⁷/Drice¹⁷

(Xu et al., 2006)

rpr^GMR.PW has eye phenotype, suppressible | partially by Hr4^EP1232/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Müller et al., 2005)

rpr^GMR.PW has eye phenotype, suppressible | partially by mir-278^EP2316/Scer\GAL4^GMR.PF/EP1229^EP2316/Scer\GAL4^GMR.PF

(Müller et al., 2005)

rpr^GMR.PW has eye phenotype, suppressible | partially by Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF/Imp^EP1433

(Müller et al., 2005)

rpr^GMR.PW has eye phenotype, suppressible | partially by lz^ts1

(Wildonger et al., 2005)

rpr^GMR.PW has eye | somatic clone phenotype, suppressible by Dronc^L32/Dronc^L32

(Xu et al., 2005)

rpr^GMR.PW has eye | somatic clone phenotype, suppressible by Dronc^I24/Dronc^I24

(Xu et al., 2005)

rpr^GMR.PW has eye phenotype, suppressible by pnut[+]/pnut^XP

(Gottfried et al., 2004)

rpr^GMR.PW has eye phenotype, suppressible by pnut[+]/pnut¹

(Gottfried et al., 2004)

rpr^GMR.PW has ommatidium phenotype, suppressible | partially by klu[+]/klu^unspecified

(Rusconi et al., 2004)

rpr^GMR.PW has eye phenotype, suppressible by morgue[+]/morgue^EP1184/Scer\GAL4[-]

(Hays et al., 2002)

rpr^GMR.PW has ommatidium phenotype, suppressible by morgue[+]/morgue^EP1184/Scer\GAL4[-]

(Hays et al., 2002)

rpr^GMR.PW has eye phenotype, suppressible | partially by Df(2L)M24F-B/+

(Kuranaga et al., 2002)

rpr^GMR.PW has ommatidium phenotype, suppressible | partially by Df(2L)M24F-B/+

(Kuranaga et al., 2002)

rpr^GMR.PW has eye phenotype, suppressible | partially by Df(2L)dp-h25/+

(Kuranaga et al., 2002)

rpr^GMR.PW has ommatidium phenotype, suppressible | partially by Df(2L)dp-h25/+

(Kuranaga et al., 2002)

rpr^GMR.PW has eye phenotype, suppressible | partially by Df(2L)ed-dp/+

(Kuranaga et al., 2002)

rpr^GMR.PW has ommatidium phenotype, suppressible | partially by Df(2L)ed-dp/+

(Kuranaga et al., 2002)

rpr^GMR.PW has eye phenotype, suppressible | partially by Df(3R)H-B79/+

(Kuranaga et al., 2002)

rpr^GMR.PW has ommatidium phenotype, suppressible | partially by Df(3R)H-B79/+

(Kuranaga et al., 2002)

rpr^GMR.PW has eye phenotype, suppressible | partially by bsk²/bsk[+]

(Kuranaga et al., 2002)

rpr^GMR.PW has ommatidium phenotype, suppressible | partially by bsk²/bsk[+]

(Kuranaga et al., 2002)

rpr^GMR.PW has eye phenotype, suppressible | partially by hep[+]/hep¹

(Kuranaga et al., 2002)

rpr^GMR.PW has ommatidium phenotype, suppressible | partially by hep[+]/hep¹

(Kuranaga et al., 2002)

rpr^GMR.PW has ommatidium phenotype, suppressible | partially by Df(2L)sc19-8/+

(Kuranaga et al., 2002)

rpr^GMR.PW has eye phenotype, suppressible | partially by Df(2L)sc19-8/+

(Kuranaga et al., 2002)

rpr^GMR.PW has eye phenotype, suppressible | partially by eff⁵⁹⁸/eff[+]

(Ryoo et al., 2002)

rpr^GMR.PW has eye phenotype, suppressible | partially by eff[+]/eff^D73

(Ryoo et al., 2002)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, rpr^GMR.PW, skl^UAS.cWa has eye phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Wing et al., 2002)

rpr^GMR.PW has eye phenotype, suppressible by Df(2L)morgue¹⁹/+

(Wing et al., 2002)

rpr^GMR.PW has phenotype, suppressible by Diap1^21-2s

(Goyal et al., 2000)

rpr^GMR.PW has phenotype, suppressible by Diap1^23-4s

(Goyal et al., 2000)

rpr^GMR.PW has phenotype, suppressible by Diap1^23-8s

(Goyal et al., 2000)

rpr^GMR.PW has phenotype, suppressible by Diap1^45-2s

(Goyal et al., 2000)

rpr^GMR.PW has phenotype, suppressible by Diap1^6-3s

(Goyal et al., 2000)

rpr^GMR.PW has eye phenotype, suppressible by Diap1^SL

(Lisi et al., 2000)

rpr^GMR.PW has eye phenotype, suppressible | partially by Diap1^UAS.cLa/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Lisi et al., 2000)

rpr^GMR.PW has eye phenotype, suppressible by Scer\GAL4^GMR.PF/Diap1^V85M.UAS/Scer\GAL4^GMR.PF

(Lisi et al., 2000)

rpr^GMR.PW has phenotype, suppressible | partially by Df(3L)AC1

(Meier et al., 2000)

rpr^GMR.PW has phenotype, suppressible | partially by Dronc^pro.C-A.UAS/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Meier et al., 2000)

rpr^GMR.PW has phenotype, suppressible | partially by Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF/Dronc^CARD.UAS

(Meier et al., 2000)

rpr^GMR.PW has phenotype, suppressible by BacA\p35^GMR.PH

(Meier et al., 2000)

rpr^GMR.PW has eye phenotype, suppressible | partially by Df(3L)AC1

(Quinn et al., 2000)

rpr^GMR.PW has eye phenotype, suppressible by cln^SF3-2

(Taguchi et al., 2000)

rpr^GMR.PW has eye phenotype, suppressible by Dark^k11502

(Kanuka et al., 1999)

rpr^GMR.PW has ommatidium phenotype, suppressible by Dark^CD4

(Rodriguez et al., 1999)

rpr^GMR.PW has eye phenotype, suppressible by Dark^CD4

(Rodriguez et al., 1999)

rpr^GMR.PW has eye phenotype, suppressible by Df(1)su(s)R194

(Chen et al., 1998)

rpr^GMR.PW has ommatidium phenotype, suppressible by Df(1)su(s)R194

(Chen et al., 1998)

rpr^GMR.PW has eye phenotype, suppressible by Ras85D^V12.sev

(Kurada and White, 1998)

rpr^GMR.PW has phenotype, suppressible by Df(3L)X14/+

(Kurada and White, 1998)

rpr^GMR.PW has eye phenotype, suppressible by Dsor1^Su1

(Kurada and White, 1998)

rpr^GMR.PW has eye phenotype, suppressible by rl^Sem

(Kurada and White, 1998)

NOT suppressed by

Statement

Reference

rpr^GMR.PW has eye phenotype, non-suppressible by Drice^Δ1/Drice[+]

(Wu et al., 2016)

rpr^GMR.PW has eye phenotype, non-suppressible by Drice[+]/Drice¹⁷

(Wu et al., 2016)

Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, rpr^GMR.PW, Diap1^{dsRNA.UAS.cLa}/Diap1^{dsRNA.Scer\UAS.cLa} has eye phenotype, non-suppressible by Hsrω^{a.Sym.Scer\UAS}/lncRNA:Hsrω^{dsRNA.Sym.UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

rpr^GMR.PW has eye phenotype, non-suppressible by Diap1^{D20A.αTub84B}

(Ditzel et al., 2008)

rpr^GMR.PW has eye phenotype, non-suppressible by Diap1^{N21M.21-438.αTub84B}

(Ditzel et al., 2008)

rpr^GMR.PW has eye phenotype, non-suppressible by Diap1^{C406Y.αTub84B}

(Ditzel et al., 2008)

rpr^GMR.PW has eye phenotype, non-suppressible by Dark^unspecified/Ark[+]

(Gottfried et al., 2004)

rpr^GMR.PW has eye phenotype, non-suppressible by TER94[+]/TER94^26-8

(Higashiyama et al., 2002)

rpr^GMR.PW has phenotype, non-suppressible by lwr^unspecified

(Ryoo et al., 2002)

rpr^GMR.PW has phenotype, non-suppressible by Ubc2^k13206

(Ryoo et al., 2002)

rpr^GMR.PW has eye phenotype, non-suppressible by Damm^{C156G.GMR.Tag:FLAG}

(Harvey et al., 2001)

rpr^GMR.PW has phenotype, non-suppressible by SM2-1^SM2-1

(Taguchi et al., 2000)

rpr^GMR.PW has phenotype, non-suppressible by SM3-3^SM3-3

(Taguchi et al., 2000)

rpr^GMR.PW has phenotype, non-suppressible by SM3-6^SM3-6

(Taguchi et al., 2000)

rpr^GMR.PW has phenotype, non-suppressible by SM3-8^SM3-8

(Taguchi et al., 2000)

rpr^GMR.PW has phenotype, non-suppressible by bul^SF3-1

(Taguchi et al., 2000)

rpr^GMR.PW has phenotype, non-suppressible by sty^SM3-5

(Taguchi et al., 2000)

rpr^GMR.PW has phenotype, non-suppressible by sty^SM3-9

(Taguchi et al., 2000)

rpr^GMR.PW has eye phenotype, non-suppressible by Dark^k11502

(Zhou et al., 1999)

rpr^GMR.PW has eye phenotype, non-suppressible by Ras85D^N17.sev

(Bergmann et al., 1998)

rpr^GMR.PW has eye phenotype, non-suppressible by Ras85D^V12.sev

(Bergmann et al., 1998)

Enhancer of

Statement

Reference

rpr^GMR.PW is an enhancer of eye phenotype of Dcp-1^fl.GMR

(Song et al., 2000)

rpr^GMR.PW is an enhancer of eye phenotype of Drice^fl.GMR

(Song et al., 2000)

rpr^GMR.PW is an enhancer of eye phenotype of Dcp-1^GMR.PS

(Zhou et al., 1999)

Other

Statement

Reference

Df(1)su(s)R194, Dredd^+tCa, rpr^GMR.PW has eye phenotype

(Chen et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Drice¹⁷/Drice^Δ1, Drice^Δ1/Drice^L1, Drice^Δ1/Drice^L2, Drice^Δ1/Drice^C1, Drice^Δ1/Drice^C2, Drice^Δ1/Drice^S1, Drice^Δ1/Drice^S2 (but not Drice^Δ1/+) significantly suppresses the eye ablation phenotype in rpr^GMR.PW flies.

Drice^C1/+ or Drice^C2/+ significantly enhance and Drice^L1/+, Drice^L2/+, Drice^S1/+ or Drice^S2/+ weakly suppress the eye ablation phenotype in rpr^GMR.PW flies; Drice¹⁷/+ does not suppress the phenotype. Drice^L1/+ significantly suppresses and Drice^C1/+ or Drice^C2/+ significantly enhance the increased cell death seen in rpr^GMR.PW larval eye discs.

(Wu et al., 2016)

Expression of CG3251^GD10916 under the control of Scer\GAL4^GMR.PF enhances the rpr^GMR.PW-induced cell death in the eye.

Expression of CG3251^KK106465 under the control of Scer\GAL4^GMR.PF enhances the rpr^GMR.PW-induced cell death in the eye.

(Louis et al., 2015)

A Cdk7^S164A.T170A mutant background significantly suppresses the partial eye ablation found upon expression of rpr^GMR.PW in the developing eye.

(Morishita et al., 2013)

Ras85D^R68Q very mildly suppresses rpr^GMR.PW-induced cell death although this is suspected to be due to suppression of endogenous W activity and not grim or rpr activity.

(Gafuik and Steller, 2011)

Scer\GAL4^GMR.PF-mediated expression of P{Sym-UAS-Hsrω} significantly rescues the rpr^GMR.PW eye phenotype.

Scer\GAL4^GMR.PF-mediated expression of Hsrω^EP3037 significantly enhances the rpr^GMR.PW eye phenotype.

Scer\GAL4^GMR.PF-mediated expression of P{Sym-UAS-Hsrω} eliminates the enhancing effect of Hsrω^EP3037 on rpr^GMR.PW eyes as well as reversing the level of degeneration seen in eyes expressing rpr^GMR.PW alone.

Expression of th^Scer\UAS.cHa using Scer\GAL4^GMR.PF rescues the rpr^GMR.PW small eye phenotype.

Co-expression of P{Sym-UAS-Hsrω} in the rpr^GMR.PW, th^Scer\UAS.cHa, Scer\GAL4^GMR.PF background improves eye morphology such that eyes are indistinguishable from wild type.

Expression of th^{dsRNA.Scer\UAS.cLa} using Scer\GAL4^GMR.PF enhances the rpr^GMR.PW small eye phenotype.

Co-expression of P{Sym-UAS-Hsrω} fails to suppress the eye damage in the rpr^GMR.PW, th^{dsRNA.Scer\UAS.cLa}, Scer\GAL4^GMR.PF background.

(Mallik and Lakhotia, 2009)

Expression of th^αTub84B.WT or th^{N.21-438.αTub84B} suppresses the small-eye phenotype observed in rpr^GMR.PW mutants.

Expression of th^{D20A.αTub84B} or th^{N21M.21-438.αTub84B} fails to suppress the small-eye phenotype observed in rpr^GMR.PW mutants.

Expression of th^{C406Y.αTub84B}, which lacks a functional RING domain, fails to inhibit the small-eye phenotype observed in rpr^GMR.PW mutants.

(Ditzel et al., 2008)

The rough eye phenotype caused by rpr^GMR.PW is enhanced by one copy of PSR^FM1 and is further enhanced by two copies of PSR^FM1.

(Krieser et al., 2007)

Expression of scramb1^Scer\UAS.cAa, scramb2^Scer\UAS.cAa, or both, under the control of Scer\GAL4^Act does not affect rpr^GMR.PW-induced photoreceptor apoptosis. The eye sizes are not significantly different in the three mutant backgrounds compared with control flies.

(Acharya et al., 2006)

Csk^IR.Scer\UAS; Scer\GAL4^GMR.PF partially suppresses the reduction in eye size due to rpr^GMR.PW.

(Vidal et al., 2006)

The eye ablation phenotype caused by rpr^GMR.PW is weakly suppressed by homozygosity for Ice¹⁷.

(Xu et al., 2006)

Reducing lz activity by transferring lz^ts1 rpr^GMR.PW flies to the non-permissive temperature of 33^oC partially suppresses the rpr^GMR.PW eye phenotype.

(Wildonger et al., 2005)

The severity of the rpr^GMR.PW eye phenotype is suppressed by "dronc[d5]" animals (Df(3L)Nc^Z in which CG6685 function, but not Nc function, is rescued by P{CG6685^+tDa}).

(Daish et al., 2004)

The reduced eye phenotype caused by expression of rpr^GMR.PW is significantly suppressed by pnut¹/+ or pnut^XP/+, but Ark^unspecified/+ has little effect.

(Gottfried et al., 2004)

The eye phenotype caused by rpr^GMR.PW is mildly but consistently suppressed by klu^unspecified/+.

(Rusconi et al., 2004)

The rpr^GMR.PW eye phenotypes are significantly suppressed by heterozygosity for Df(2L)sc19-8, Df(2L)ed-dp, Df(2L)dp-h25, Df(2L)M24F-B, Traf1^EP578, Df(3R)H-B79, bsk² or hep¹, but not Df(2L)tkv3 or Df(2L)ed1.

(Kuranaga et al., 2002)

The eye ablation phenotype of rpr^GMR.PW flies is partially suppressed by eff^D73/+.

(Ryoo et al., 2002)

The small eye phenotype of rpr^GMR.PW flies is significantly enhanced by th^21-4s or th^33-1s.

(Wilson et al., 2002)

The addition of skl^Scer\UAS.cWa (driven by Scer\GAL4^GMR.PF) to rpr^GMR.PW flies enhances the eye phenotype. Flies exhibit much more severe eye cell death, with greatly reduced size and pigmentation. The subsequent addition of BacA\p35^Scer\UAS.cHa represses these phenotypes.

(Wing et al., 2002)

The eye cell death phenotype caused by rpr^GMR.PW is suppressed by Df(2L)morgue¹⁹/+.

(Wing et al., 2002)

The rpr^GMR.PW severely ablated eye phenotype is not suppressed by Damm^{C156G.GMR.T:Zzzz\FLAG}.

(Harvey et al., 2001)

The addition of rpr^GMR.PW to Dcp-1^fl.GMR flies show a strong enhancement of the eye phenotype seen in Dcp-1^fl.GMR flies. The addition of rpr^GMR.PW to Ice^fl.GMR flies show a strong enhancement of the eye phenotype seen in Ice^fl.GMR flies.

(Song et al., 2000)

The eye phenotype caused by expression of rpr^GMR.PW is significantly suppressed by Ark^k11502.

(Kanuka et al., 1999)

The rpr^GMR.PW rough eye phenotype is strongly suppressed if the flies are also homozygous for Ark^CD4.

(Rodriguez et al., 1999)

Ark^k11502 has little effect on the eye phenotype caused by rpr^GMR.PW. A strong synergism in cell ablation is seen when Dcp-1^GMR.PS and rpr^GMR.PW are coexpressed in the eye. This phenotype is not modified by Ark^k11502.

(Zhou et al., 1999)

The grim^GMR.PC eye ablation phenotype is not particularly affected by either Ras85D^V12.sev and Ras85D^N17.sev.

(Bergmann et al., 1998)

The rpr^GMR.PW rough eye phenotype is suppressed if the flies are also heterozygous for Df(1)su(s)R194. The rough eye phenotype is restored in flies carrying rpr^GMR.PW, heterozygous for Df(1)su(s)R194 and also carrying Dredd^+tCa.

(Chen et al., 1998)

Loss of function alleles of Egfr and spi dominantly enhance the rpr^GMR.PW mutant phenotype. Reduction in W dosage also suppresses the rpr^GMR.PW mutant phenotype.

(Kurada and White, 1998)

Expression of BacA\p35 abrogates the effects of ectopic rpr; flies carrying both P{GMRP35} and P{GMR-rpr.W} (two copies) show the same slightly rough eye phenotype as flies carrying P{GMRP35} alone.

(White et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

rpr^GMR.PW

Name Synonyms

glass multimer reporter construct of White

(White et al., 1996)

Secondary FlyBase IDs

References (50)

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