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General Information
Symbol
Dmel\scribsmi97B
Species
D. melanogaster
Name
FlyBase ID
FBal0050518
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
smi97B
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{lArB} insertion in the promoter region, 1084bp upstream of the transcription start site.

P{lArB} insertion 1084bp upstream of the scrib open reading frame.

P{lArB} insertion 159bp upstream of the transcription initiation site.

Insertion components
P{lArB}scribsmi97B
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous adults show impaired olfactory ability; the avoidance response to benzaldehyde is reduced compared to wild-type controls. This reduction in avoidance response is sexually dimorphic; homozygous males are hyposmic while homozygous females are anosmic (even at high odorant concentrations). The avoidance response of heterozygous adults to benzaldehyde is indistinguishable from wild type. Homozygous larvae show defects in response to isoamylacetate and benzaldehyde compared to controls. Larval motility in the absence of odour cue is not significantly different between homozygous and wild-type larvae. scribsmi97B/Df(3R)Tl-X adults show reduced avoidance responses to benzaldehyde compared to Df(3R)Tl-X/+ controls and females show significantly more smell impairment than males. scribsmi97B/scrib1 and scribsmi97B/scrib673 adults show a significantly lower avoidance response to benzaldehyde compared to controls. scribsmi97B/scribS042405b adult females show a significantly lower avoidance response to benzaldehyde compared to control females, while the response of scribsmi97B/scribS042405b adult males is not significantly different from that of control males. The avoidance response to benzaldehyde of scribj7B3/scribsmi97B adults is not significantly different from that of controls.

Olfaction defective as measured in a dipstick assay using 1% benzaldehyde.

Avoidance score to benzaldehyde overlaps the avoidance score to water. Shows general hyposmia: avoidance score to 2-n-propylpyrazine and 2-isobutylthiazole is also reduced.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

scribsmi97B has phenotype, enhanceable by smi51A1

Suppressed by
Statement
Reference

scribsmi97B has phenotype, suppressible by Pinosmi21F

Enhancer of
Statement
Reference

scribsmi97B is an enhancer of phenotype of smi51A1

Suppressor of
Statement
Reference

scribsmi97B is a suppressor of phenotype of Pinosmi21F

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Precise excision of the P{lArB} element reverts the olfactory deficit seen in scribsmi97B mutants.

External Crossreferences and Linkouts ( 8 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)