W273term | Diap1-PA; W273term | Diap1-PB; W273term | Diap1-PC; W273term | Diap1-PD; W273term | Diap1-PE; W273term | Diap1-PF
G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.
The addition of WGMR.PG to th5 heterozygotes leads to an enhancement of cell killing. The subsequent addition of ArkCD4/ArkCD4 suppresses that enhancement. The developmental arrest phenotype is also suppressed, embryos developing through stage 10. In about 5% of cases although no cell death is seen, arrest at stage 7 is still seen.
The Hsp60DdsRNA.Sym.Scer\UAS-mediated suppression of the eye degeneration phenotype caused by Hsap\MJDtr.Q78.Scer\UAS.T:Ivir\HA1 overexpression via Scer\GAL4GMR.PU is not much affected by heterozygosity for th5.
The enhancement of the eye degeneration resulting from the overexpression of Zzzz\CAG127Q.Scer\UAS.T:Ivir\HA1 via Scer\GAL4GMR.PU in a th5/+ background is not suppressed when Hsp60DdsRNA.Sym.Scer\UAS is co-expressed.