Allele Dmel\th^GMR.PH

General Information
Symbol	Dmel\th^GMR.PH	Species	D. melanogaster
Name	glass multimer reporter construct of Hay	FlyBase ID	FBal0050600
Feature type	allele	Associated gene	Dmel\th

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Hay et al., 1995)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: th cDNA is expressed from the glass multimer reporter. (Hay et al., 1995)
Carried in construct	P{GMR-DIAP1} (Otsuki et al., 2004, Lohmann et al., 2002, Bach et al., 2003, Jackson et al., 2002, Tenev et al., 2002, Yu et al., 2002, Jassim et al., 2003, Khan et al., 2008, Shulman and Feany, 2003, Takatsu et al., 2000, Meier et al., 2000, Wan et al., 2000, Quinn et al., 2000, Hawkins et al., 2000, Ye and Fortini, 1999, Kanuka et al., 1999, Sawamoto et al., 1998, Hay et al., 1995, Hsu et al., 2004, Koto et al., 2009, Guo et al., 2003, Hirose et al., 2001)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	eye \| P-stage (Hay et al., 1995) pigment cell (Hay et al., 1995)
Detailed Description
	Statement Reference Expression of th^GMR.PH does not cause retinal degeneration. (Hsu et al., 2004) Flies expressing th^GMR.PH have normal eye morphology. (Yu et al., 2002) Normally occurring cell death (35-50hr postpupation) is blocked in eye development, giving rise to extra cells. Also blocks a second wave of normally occurring cell death that takes place between 60 and 70 hrs postpupation. (Hay et al., 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference th^GMR.PH is a suppressor of cell death defective phenotype of rpr^GMR.PH (Hay et al., 1995) th^GMR.PH is a suppressor of cell death defective phenotype of W^GMR.PG/W^GMR.PG (Hay et al., 1995) th^GMR.PH is a suppressor of eye color defective phenotype of Nc^GMR.PH (Hawkins et al., 2000) th^GMR.PH is a suppressor of increased cell death phenotype of Dref^Scer\UAS.cSa, Scer\GAL4^GMR.PS (Hirose et al., 2001) th^GMR.PH is a suppressor of increased cell death phenotype of Fmr1^sev.PW (Wan et al., 2000) th^GMR.PH is a suppressor of increased cell death phenotype of Jafrac2^AKP.Ub.GMR (Tenev et al., 2002) th^GMR.PH is a suppressor of visible \| heat sensitive phenotype of HtrA2^GMR.PK (Khan et al., 2008) th^GMR.PH is a suppressor of visible phenotype of BacA\p35^GMR.PH (Yu et al., 2002) th^GMR.PH is a suppressor of visible phenotype of Hsap\MAPT^{V337M.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Shulman and Feany, 2003) th^GMR.PH is a suppressor of visible phenotype of Nc^GMR.PH (Hawkins et al., 2000) th^GMR.PH is a suppressor of visible phenotype of Nc^{Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Quinn et al., 2000) th^GMR.PH is a suppressor of visible phenotype of Psn^+14.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Ye and Fortini, 1999) th^GMR.PH is a suppressor of visible phenotype of Rfx2^{202-480.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PS (Otsuki et al., 2004) th^GMR.PH is a suppressor of visible phenotype of Scer\GAL4^{GMR.T:Hsap\APP}, grim^Scer\UAS.cYa (Guo et al., 2003)
NOT Suppressor of
Statement Reference th^GMR.PH is a non-suppressor of increased cell death phenotype of norpA³⁶ (Hsu et al., 2004) th^GMR.PH is a non-suppressor of visible phenotype of os^GMR.PB (Bach et al., 2003)
Phenotype Manifest In
Suppressor of
Statement Reference th^GMR.PH is a suppressor \| partially of eye phenotype of Cele\ced-4^GMR.PK (Kanuka et al., 1999) th^GMR.PH is a suppressor \| partially of eye phenotype of Nc^ΔN.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Meier et al., 2000) th^GMR.PH is a suppressor \| partially of eye photoreceptor cell phenotype of Cele\ced-4^GMR.PK (Kanuka et al., 1999) th^GMR.PH is a suppressor \| partially of pigment cell phenotype of Cele\ced-4^GMR.PK (Kanuka et al., 1999) th^GMR.PH is a suppressor of cone cell phenotype of aos^GMR.PS (Sawamoto et al., 1998) th^GMR.PH is a suppressor of eye \| heat sensitive phenotype of HtrA2^GMR.PK (Khan et al., 2008) th^GMR.PH is a suppressor of eye phenotype of aos^GMR.PS (Sawamoto et al., 1998) th^GMR.PH is a suppressor of eye phenotype of Dfd^Scer\UAS.cLa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Lohmann et al., 2002) th^GMR.PH is a suppressor of eye phenotype of Dfd^{Scer\UAS.T:Hsim\VP16}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Lohmann et al., 2002) th^GMR.PH is a suppressor of eye phenotype of Dref^Scer\UAS.cSa, Scer\GAL4^GMR.PS (Hirose et al., 2001) th^GMR.PH is a suppressor of eye phenotype of Fmr1^sev.PW (Wan et al., 2000) th^GMR.PH is a suppressor of eye phenotype of Hsap\MAPT^{V337M.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Shulman and Feany, 2003) th^GMR.PH is a suppressor of eye phenotype of Jafrac2^AKP.Ub.GMR (Tenev et al., 2002) th^GMR.PH is a suppressor of eye phenotype of Nc^GMR.PH (Hawkins et al., 2000) th^GMR.PH is a suppressor of eye phenotype of Nc^pro.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Meier et al., 2000) th^GMR.PH is a suppressor of eye phenotype of Nc^{Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Quinn et al., 2000) th^GMR.PH is a suppressor of eye phenotype of Psn^+14.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Ye and Fortini, 1999) th^GMR.PH is a suppressor of eye phenotype of Rfx2^{202-480.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PS (Otsuki et al., 2004) th^GMR.PH is a suppressor of eye phenotype of rpr^AKP.Ub.GMR (Tenev et al., 2002) th^GMR.PH is a suppressor of eye phenotype of rpr^AVA.Ub.GMR (Tenev et al., 2002) th^GMR.PH is a suppressor of eye phenotype of rpr^GMR.PH (Lohmann et al., 2002) th^GMR.PH is a suppressor of eye phenotype of Scer\GAL4^{GMR.T:Hsap\APP}, grim^Scer\UAS.cYa (Guo et al., 2003) th^GMR.PH is a suppressor of eye phenotype of W^Ala3.GMR (Bergmann et al., 1998) th^GMR.PH is a suppressor of eye phenotype of W^Ala5.GMR (Bergmann et al., 1998) th^GMR.PH is a suppressor of eye phenotype of W^GMR.PG/W^GMR.PG (Bergmann et al., 1998) th^GMR.PH is a suppressor of ommatidium phenotype of BacA\p35^GMR.PH (Yu et al., 2002) th^GMR.PH is a suppressor of ommatidium phenotype of Fmr1^sev.PW (Wan et al., 2000) th^GMR.PH is a suppressor of ommatidium phenotype of Hsap\MAPT^{V337M.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Shulman and Feany, 2003) th^GMR.PH is a suppressor of ommatidium phenotype of Nc^pro.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Meier et al., 2000) th^GMR.PH is a suppressor of ommatidium phenotype of W^GMR.PG/W^GMR.PG (Bergmann et al., 1998) th^GMR.PH is a suppressor of photoreceptor cell phenotype of aos^GMR.PS (Sawamoto et al., 1998) th^GMR.PH is a suppressor of pigment cell phenotype of aos^GMR.PS (Sawamoto et al., 1998) th^GMR.PH is a suppressor of pigment cell phenotype of Nc^GMR.PH (Hawkins et al., 2000) th^GMR.PH is a suppressor of pigment cell phenotype of Nc^pro.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Meier et al., 2000)
NOT Suppressor of
Statement Reference th^GMR.PH is a non-suppressor of eye phenotype of os^GMR.PB (Bach et al., 2003) th^GMR.PH is a non-suppressor of ommatidium phenotype of Nc^ΔN.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Meier et al., 2000) th^GMR.PH is a non-suppressor of pigment cell phenotype of Nc^ΔN.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Meier et al., 2000) th^GMR.PH is a non-suppressor of retina phenotype of norpA³⁶ (Hsu et al., 2004)
Additional Comments
Genetic Interactions
Statement Reference Co-expression of th[GMR.PH] suppresses the eye ablation phenotype seen in animals in which HtrA2[GMR.PK] has been expressed under heat-stress conditions (30[o]C for 5 days). (Khan et al., 2008) Expression of th^GMR.PH does not alter the degeneration of norpA³⁶ rhabdomeres. (Hsu et al., 2004) The enlarged eye phenotype seen in flies carrying one copy of os^GMR.PB is not modified by th^GMR.PH. (Bach et al., 2003) The small eye phenotype caused by expression of grim[Scer\UAS.cYa] under the control of Scer\GAL4[GMR.T:Hsap\APP] is completely suppressed by co-expression of th[GMR.PH]. (Guo et al., 2003) The addition of th^GMR.PH suppresses the eye phenotype in Hsap\MAPT^GMR.Ex.PJ animals. (Jackson et al., 2002) When th^GMR.PH is added to Dfd^Scer\UAS.cLa, Scer\GAL4^GMR.PF animals the eye phenotype is almost completely suppressed. When th^GMR.PH is added to Dfd^{Scer\UAS.T:Hsim\VP16}, Scer\GAL4^GMR.PF animals the eye phenotype is suppressed. When th^GMR.PH is added to rpr^GMR.PH animals the eye phenotype is almost completely suppressed. (Lohmann et al., 2002) The rough eye phenotype of BacA\p35^GMR.PH animals is suppressed by th^GMR.PH. Flies expressing Nc^C318S.GMR and th^GMR.PH have normal eye morphology. Flies expressing Nc^GMR.PH and th^GMR.PH have normal eye morphology. (Yu et al., 2002) The rough eye phenotype seen upon expression of Dref[Scer\UAS.cSa] in the developing eye under the control of Scer\GAL4[GMR.PS] is suppressed by co-expression of th[GMR.PH]. (Hirose et al., 2001) The small eye and pigment loss phenotypes of flies expressing high levels of Nc^GMR.PH is suppressed by co-expression of th^GMR.PH. (Hawkins et al., 2000) The addition of th^GMR.PH to Nc^pro.Scer\UAS,Scer\GAL4^GMR.PF completely rescues the phenotypes seen in these flies. The addition of th^GMR.PH to Nc^ΔN.Scer\UAS,Scer\GAL4^GMR.PF fails to rescue the phenotypes seen in these flies. (Meier et al., 2000) Largely suppresses the rough eye phenotype caused by expression of two copies of Psn^+14.Scer\UAS under the control of Scer\GAL4^GMR.PF. (Ye and Fortini, 1999) Suppresses the rough eye phenotype of argos^GMR.PS: normal number of cone cells and primary pigment cells are restored in most ommatidia. (Sawamoto et al., 1998)
Xenogenetic Interactions
Statement Reference The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is suppressed by co-expression of th^GMR.PH. (Shulman and Feany, 2003)
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	5782 w^*; P{GMR-DIAP1}1/CyO
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	th^GMR.PH
Name Synonym	glass multimer reporter construct of Hay (Hay et al., 1995)
Secondary FlyBase IDs

References ( 23 )

Generate a list of	All references relating to this allele ( 23 )

List References by type	Research paper ( 23 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...

Allele Dmel\thGMR.PH

Allele Dmel\th^GMR.PH