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General Information
Symbol
Dmel\unc25
Species
D. melanogaster
Name
FlyBase ID
FBal0050681
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Single-base change creating a stop codon within the open reading frame.

Amino acid replacement: ??term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies are uncoordinated showing frequent leg crossing and wings held up or out. Walking and righting ability is impaired. Spontaneous or induced (by light or mechanical stimuli) activity is vigorous. Mechanoreceptor potentials are invariably absent in thoracic macrochaete bristles. The sound evoked response (measured via the antennal nerve) is eliminated. ERGs are normal.

Larval behavioural phenotype: homozygous larvae have very low sensitivity to touch. Homozygous larval motility is visibly reduced. Adults can neither stand nor walk so die by adhesion. Nervous system morphology is indistinguishable from wild type. Gyandromorph mosaics were used for the bristle scratch test to test the mutant mechanosensory bristle function, the tegular and abdominal bristles fail to elicit the scratch response.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
unc25
Name Synonyms
Secondary FlyBase IDs
    References (4)