Allele Dmel\tkv^TAJ3

General Information
Symbol	Dmel\tkv^TAJ3	Species	D. melanogaster
Name		FlyBase ID	FBal0051061
Feature type	allele	Associated gene	Dmel\tkv

Allele class
Mutagen	Delta2-3
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	Delta2-3 (Hoodless et al., 1996)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	tkv^{Q199D.Scer\UAS.T:Ivir\HA1} (Hoodless et al., 1996)
Nature of the lesion	Statement Reference
Caused by insertion	P{UAS-tkv}TAJ3 (Hoodless et al., 1996, Ricos et al., 1999, Zahedi et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	viable (Hoodless et al., 1996) visible (Hoodless et al., 1996, Zahedi et al., 2008)
Phenotype Manifest In
	wing (Hoodless et al., 1996) wing vein \| ectopic (Zahedi et al., 2008)
Detailed Description
	Statement Reference tkv[TAJ3] flies form ectopic wing vein material between veins L3 and L4. (Zahedi et al., 2008) Blistered and reduced wing phenotype. (Hoodless et al., 1996)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference tkv^TAJ3 has visible phenotype, suppressible by Ack^10b/Ack^10b (Zahedi et al., 2008)
Phenotype Manifest In
Suppressed by
Statement Reference tkv^TAJ3 has phenotype, suppressible by shn^unspecified/shn[+] (Hoodless et al., 1996) tkv^TAJ3 has wing phenotype, suppressible by Df(2L)C28 (Hoodless et al., 1996) tkv^TAJ3 has wing phenotype, suppressible by Mad[+]/Mad¹ (Hoodless et al., 1996) tkv^TAJ3 has wing phenotype, suppressible by Mad[+]/Mad⁶ (Hoodless et al., 1996) tkv^TAJ3 has wing phenotype, suppressible by Mad[+]/Mad^P-23D (Hoodless et al., 1996) tkv^TAJ3 has wing phenotype, suppressible by Mad¹²/Mad[+] (Hoodless et al., 1996) tkv^TAJ3 has wing vein \| ectopic phenotype, suppressible by Ack^10b/Ack^10b (Zahedi et al., 2008)
NOT suppressed by
Statement Reference tkv^TAJ3 has wing phenotype, non-suppressible by put^unspecified (Hoodless et al., 1996)
Suppressor of
Statement Reference tkv^TAJ3 is a suppressor \| partially of dorsal closure embryo phenotype of Rac1^N17.Scer\UAS, Scer\GAL4^hs.PB (Ricos et al., 1999)
NOT Suppressor of
Statement Reference tkv^TAJ3 is a non-suppressor of embryonic epidermis phenotype of Cdc42^N17.Scer\UAS, Scer\GAL4^hs.PB (Ricos et al., 1999)
Additional Comments
Genetic Interactions
Statement Reference The ectopic wing vein phenotype seen in tkv[TAJ3] flies is significantly suppressed by Ack[10b]/Ack[10b]. (Zahedi et al., 2008) tkv^TAJ3 partially rescues the dorsal closure defect caused by expression of Rac1^N17.Scer\UAS under the control of Scer\GAL4^hs.PB. tkv^TAJ3 has no effect on the phenotype caused by expression of Cdc42^N17.Scer\UAS under the control of Scer\GAL4^hs.PB. (Ricos et al., 1999) Wing phenotype is completely suppressed by Df(2L)C28, almost completely suppressed by Mad¹ or Mad⁶ and weakly suppressed by Mad¹² or Mad^P-23D. (Hoodless et al., 1996)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	tkv^TAJ3 unnamed (Hoodless et al., 1996)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Zahedi et al., 2008, Dev. Dyn. 237(10): 2936--2946 Leading edge-secreted Dpp cooperates with ACK-dependent signaling from the amnioserosa to regulate myosin levels during dorsal closure. [FBrf0205999] Ricos et al., 1999, J. Cell Sci. 112(8): 1225--1235 Dcdc42 acts in TGF-beta signaling during Drosophila morphogenesis: Distinct roles for the Drac1/JNK and Dcdc42/TGF-beta cascades in cytoskeletal regulation. [FBrf0108393] Hoodless et al., 1996, Cell 85(4): 489--500 MADR1, a MAD-related protein that functions in BMP2 signalling pathways. [FBrf0089932]

Allele Dmel\tkvTAJ3

Allele Dmel\tkv^TAJ3