Allele Dmel\tkv^{Q199D.Scer\UAS.T:Ivir\HA1}

General Information
Symbol	Dmel\tkv^{Q199D.Scer\UAS.T:Ivir\HA1}	Species	D. melanogaster
Name		FlyBase ID	FBal0051066
Feature type	allele	Associated gene	Dmel\tkv

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Hoodless et al., 1996, Newfeld et al., 1997, Haerry et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	tkv^Q199D (Hoodless et al., 1996)
Nature of the lesion	Statement Reference A constitutively active form of tkv is expressed under the control of Scer\UAS regulatory sequences. (Newfeld et al., 1997) Construct: Expression of a XhoI-XbaI fragment containing a HA-tagged version of tkv^Q199D is driven by Scer\UAS Scer\GAL4 binding sites. (Hoodless et al., 1996)
Carried in construct	P{UAS-tkv^Q199D} (Baines, 2004, Chen et al., 2002, Evans et al., 2009, McCabe et al., 2004, Yu et al., 2000, McEwen et al., 2000, Dobens et al., 2000, Aldaz et al., 2005, Ribeiro et al., 2004, Newfeld et al., 1997, Haerry et al., 1998, Hou et al., 1997, Hoodless et al., 1996, Aldaz et al., 2003, Dudu, 2006, Dudu et al., 2006, Collins et al., 2006, Takaesu et al., 2006, Wang et al., 2007, Le and Wharton, 2012, Johnson et al., 2007, Terriente et al., 2008, Haussmann et al., 2008, Haerry, 2010, Merino et al., 2009, O'Connor-Giles et al., 2008, Zheng et al., 2011, Ball et al., 2010, Takaesu et al., 2012, Sun et al., 2012)
Tagged with	T:Ivir\HA1 (Haerry et al., 1998, Dobens et al., 2000, Yu et al., 2000, McEwen et al., 2000, Chen et al., 2002, Aldaz et al., 2003, McCabe et al., 2004, Ribeiro et al., 2004, Aldaz et al., 2005, Hoodless et al., 1996, Hou et al., 1997, Newfeld et al., 1997)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective \| larval stage, with Scer\GAL4^elav-C155 (O'Connor-Giles et al., 2008) neuroanatomy defective \| somatic clone \| third instar larval stage, with Scer\GAL4^elav.PH (Haussmann et al., 2008) neurophysiology defective, with Scer\GAL4^B19 (Baines, 2004) neurophysiology defective \| larval stage, with Scer\GAL4^BG380 (Sun et al., 2012) visible, with Scer\GAL4^A9 (Haerry et al., 1998, Yu et al., 2000, Takaesu et al., 2006, Haerry, 2010) visible, with Scer\GAL4^unspecified (Hoodless et al., 1996) visible \| recessive (Evans et al., 2009)
Phenotype Manifest In
	adherens junction & embryonic dorsal trunk, with Scer\GAL4^btl.B123 (Ribeiro et al., 2004) adherens junction & embryonic dorsal trunk, with Scer\GAL4^btl.PS (Ribeiro et al., 2004) dorsal triple row, with Scer\GAL4^A9 (Haerry et al., 1998) dorsal trunk primordium, with Scer\GAL4^btl.PS (Ribeiro et al., 2004) embryonic/larval neuromuscular junction \| somatic clone, with Scer\GAL4^elav.PH (Haussmann et al., 2008) medial triple row, with Scer\GAL4^A9 (Haerry et al., 1998) neuromuscular junction, with Scer\GAL4^Mhc.PW (Dudu et al., 2006) NMJ bouton \| larval stage \| supernumerary, with Scer\GAL4^elav-C155 (O'Connor-Giles et al., 2008) NMJ bouton \| somatic clone, with Scer\GAL4^elav.PH (Haussmann et al., 2008) ventral triple row, with Scer\GAL4^A9 (Haerry et al., 1998) wing, with Scer\GAL4^A9 (Haerry et al., 1998, Yu et al., 2000, Takaesu et al., 2006, Haerry, 2010) wing, with Scer\GAL4^T80 (Takaesu et al., 2012) wing, with Scer\GAL4^unspecified (Hoodless et al., 1996) wing cell (Evans et al., 2009) wing cell, with Scer\GAL4^A9 (Haerry et al., 1998) wing vein (Evans et al., 2009) wing vein, with Scer\GAL4^A9 (Haerry, 2010) wing vein \| ectopic, with Scer\GAL4^A9 (Takaesu et al., 2006)
Detailed Description
	Statement Reference The amplitude of miniature excitatory junctional currents (mEJCs) is normal at the neuromuscular junction (NMJ) in larvae expressing tkv[Q199D.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[BG380], but the evoked EJC shows an increase in amplitude compared to wild type, resulting in an increase in quantal content at the mutant NMJ. (Sun et al., 2012) Expression of tkv[Q199D.Scer\UAS.T:Ivir\HA1] in the wing discs under the control of Scer\GAL4[T80] leads to ectopic wing vein formation. (Takaesu et al., 2012) Expression of tkv[Q199D.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[A9] results in small wings that are highly pigmented with excess vein tissue. (Haerry, 2010) Expression of tkv[Q199D.Scer\UAS.T:Ivir\HA1] in the wing with Scer\GAL4[ptc-559.1] induces patterning abnormalities including extensive ectopic vein, fusion of longitudinal veins, and loss of intervein regions. (Evans et al., 2009) Expression of tkv[Q199D.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[BG380] does not significantly alter the number of boutons per muscle surface area at the neuromuscular junction of third instar larvae. (Merino et al., 2009) Expression of tkv[Q199D.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[elav.PH] in clones induced by FLP/FRT mediated recombination (to activate the Scer\GAL4[elav.PH] driver) results in an increase in the number of type 1b boutons at muscle 13 compared to wild type. (Haussmann et al., 2008) Expression of tkv[Q199D.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[elav.PU] does not affect synaptic growth at the larval neuromuscular junction (the average number of satellite boutons is not significantly different from wild type). Expression of two copies of tkv[Q199D.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[elav-C155] results in an increase in both the total number of boutons and the number of satellite boutons at the larval neuromuscular junction. (O'Connor-Giles et al., 2008) Expression of tkv^{Q199D.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Mhc.PW results in the ratio of import/export rates being higher than in control muscles (7.4 compared to 3.6). This difference in the import/export ratio explains the net accumulation of nuclear Mad in tkv^{Q199D.Scer\UAS.T:Ivir\HA1} muscles above the levels of control in steady state. The effective import rate does not increase, but decreases slightly upon constitutive signalling (1.6 times smaller in tkv^{Q199D.Scer\UAS.T:Ivir\HA1} than in controls), while it is the effective export rate that significantly decreases (3.4 times smaller in tkv^{Q199D.Scer\UAS.T:Ivir\HA1}). Constitutive signalling caused by expression of tkv^{Q199D.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Mhc.PW leads to an increase by an order of magnitude (67%) of the immobile pool of Mad in the nucleus. (Dudu et al., 2006) 100% of wings are overgrown and have numerous ectopic veins in flies expressing tkv^{Q199D.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^A9. (Takaesu et al., 2006) Expression of tkv^{Q199D.Scer\UAS.T:Ivir\HA1} in presynaptic cholinergic neurons, driven by Scer\GAL4^B19, is sufficient to produce a large and significant increase in synaptic current amplitude in aCC/RP2 neurons compared to controls. tkv^{Q199D.Scer\UAS.T:Ivir\HA1} expression in postsynaptic neurons, driven by Scer\GAL4^eve.RN2, has no effect on synaptic current amplitude. (Baines, 2004) Expression of tkv^{Q199D.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PLu or Scer\GAL4^OK6 in a wild-type background does not result in a significant increase in the number of neuromuscular junction synaptic boutons. (McCabe et al., 2004) Expression of tkv^{Q199D.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^btl.PS in the tracheal system results in the formation of fine dorsal trunks containing stretches of autocellular adherens junctions. Expression of tkv^{Q199D.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^btl.B123 in single cells or groups of cells in the dorsal trunk results in the formation of ectopic autocellular adherens junctions, although at a low frequency. (Ribeiro et al., 2004) Expression of tkv^{Q199D.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^A9 causes a wing phenotype. (Yu et al., 2000) Flies expressing tkv^{Q199D.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^A9 have small wings which are blistered due to lack of adhesion of the dorsal and ventral compartments. Intervein cells express vein-specific hairs and the marginal triple row bristles are transformed into the oversized double row bristles normally seen at more distal positions along the wing margin. The wings are darkly pigmented. (Haerry et al., 1998)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Scer\GAL4^A9, tkv^{Q199D.Scer\UAS.T:Ivir\HA1} has visible phenotype, suppressible by Snoo^Scer\UAS.cTa/Scer\GAL4^A9 (Takaesu et al., 2006) Scer\GAL4^BG380, sax^{A.Scer\UAS.cBa}, tkv^{Q199D.Scer\UAS.T:Ivir\HA1} has neurophysiology defective \| third instar larval stage phenotype, suppressible by trio^6A/trio^S137203 (Ball et al., 2010) Scer\GAL4^elav-C155, tkv^{Q199D.Scer\UAS.T:Ivir\HA1} has neuroanatomy defective \| larval stage phenotype, suppressible by Dap160^Scer\UAS.cKa, Scer\GAL4^elav-C155 (O'Connor-Giles et al., 2008) Scer\GAL4^elav-C155, tkv^{Q199D.Scer\UAS.T:Ivir\HA1} has neuroanatomy defective \| larval stage phenotype, suppressible by Scer\GAL4^elav-C155/nwk^Scer\UAS.cCa (O'Connor-Giles et al., 2008)
Enhancer of
Statement Reference Scer\GAL4^elav.PU/tkv^{Q199D.Scer\UAS.T:Ivir\HA1} is an enhancer of neuroanatomy defective \| larval stage phenotype of nwk² (O'Connor-Giles et al., 2008) Scer\GAL4^elav-C155/tkv^{Q199D.Scer\UAS.T:Ivir\HA1} is an enhancer of neuroanatomy defective \| larval stage phenotype of Scer\GAL4^elav-C155, Snx16^{3A.Scer\UAS.T:Avic\GFP} (Rodal et al., 2011) tkv^{Q199D.Scer\UAS.T:Ivir\HA1}/Scer\GAL4^elav.PLu is an enhancer of neuroanatomy defective phenotype of hiw^EMS (McCabe et al., 2004)
Suppressor of
Statement Reference Scer\GAL4^BG380/tkv^{Q199D.Scer\UAS.T:Ivir\HA1} is a suppressor of neuroanatomy defective \| third instar larval stage phenotype of nmo^unspecified (Merino et al., 2009)
Other
Statement Reference kek5^{Scer\UAS.T:Avic\GFP}, tkv^{Q199D.Scer\UAS.T:Ivir\HA1} has visible \| recessive phenotype (Evans et al., 2009) Scer\GAL4^BG380, sax^{A.Scer\UAS.cBa}, tkv^{Q199D.Scer\UAS.T:Ivir\HA1} has neurophysiology defective \| third instar larval stage phenotype (Ball et al., 2010)
Phenotype Manifest In
Enhanced by
Statement Reference tkv^{Q199D.Scer\UAS.T:Ivir\HA1} has wing cell phenotype, enhanceable by kek5^{Scer\UAS.T:Avic\GFP} (Evans et al., 2009) tkv^{Q199D.Scer\UAS.T:Ivir\HA1} has wing vein phenotype, enhanceable by kek5^{Scer\UAS.T:Avic\GFP} (Evans et al., 2009)
NOT Enhanced by
Statement Reference Scer\GAL4^A9, tkv^{Q199D.Scer\UAS.T:Ivir\HA1} has wing phenotype, non-enhanceable by Scer\GAL4^A9/sog^{supersog1.Scer\UAS} (Yu et al., 2000)
Suppressed by
Statement Reference Scer\GAL4^A9, tkv^{Q199D.Scer\UAS.T:Ivir\HA1} has wing phenotype, suppressible by Snoo^Scer\UAS.cTa/Scer\GAL4^A9 (Takaesu et al., 2006) Scer\GAL4^A9, tkv^{Q199D.Scer\UAS.T:Ivir\HA1} has wing vein \| ectopic phenotype, suppressible by Snoo^Scer\UAS.cTa/Scer\GAL4^A9 (Takaesu et al., 2006) Scer\GAL4^elav-C155, tkv^{Q199D.Scer\UAS.T:Ivir\HA1} has NMJ bouton \| supernumerary \| larval stage phenotype, suppressible by Dap160^Scer\UAS.cKa, Scer\GAL4^elav-C155 (O'Connor-Giles et al., 2008) Scer\GAL4^elav-C155, tkv^{Q199D.Scer\UAS.T:Ivir\HA1} has NMJ bouton \| supernumerary \| larval stage phenotype, suppressible by Scer\GAL4^elav-C155/nwk^Scer\UAS.cCa (O'Connor-Giles et al., 2008) Scer\GAL4^T80, tkv^{Q199D.Scer\UAS.T:Ivir\HA1} has wing phenotype, suppressible by Scer\GAL4^T80, tkv^{Q199D.Scer\UAS.T:Ivir\HA1} (Takaesu et al., 2012, Takaesu et al., 2012)
NOT suppressed by
Statement Reference Scer\GAL4^A9, tkv^{Q199D.Scer\UAS.T:Ivir\HA1} has wing phenotype, non-suppressible by Scer\GAL4^A9/sog^{supersog1.Scer\UAS} (Yu et al., 2000)
Enhancer of
Statement Reference Scer\GAL4^elav.PU/tkv^{Q199D.Scer\UAS.T:Ivir\HA1} is an enhancer of NMJ bouton \| supernumerary \| larval stage phenotype of nwk² (O'Connor-Giles et al., 2008) Scer\GAL4^elav-C155/tkv^{Q199D.Scer\UAS.T:Ivir\HA1} is an enhancer of NMJ bouton \| supernumerary \| larval stage phenotype of Scer\GAL4^elav-C155, Snx16^{3A.Scer\UAS.T:Avic\GFP} (Rodal et al., 2011) tkv^{Q199D.Scer\UAS.T:Ivir\HA1}/Scer\GAL4^elav.PLu is an enhancer of bouton \| supernumerary phenotype of hiw^EMS (McCabe et al., 2004) tkv^{Q199D.Scer\UAS.T:Ivir\HA1}/Scer\GAL4^elav.PLu is an enhancer of neuromuscular junction phenotype of hiw^EMS (McCabe et al., 2004)
Suppressor of
Statement Reference Scer\GAL4^BG380/tkv^{Q199D.Scer\UAS.T:Ivir\HA1} is a suppressor of NMJ bouton \| third instar larval stage phenotype of nmo^unspecified (Merino et al., 2009) Scer\GAL4^LE/tkv^{Q199D.Scer\UAS.T:Ivir\HA1} is a suppressor of embryonic epidermis \| dorsal phenotype of arm³ (McEwen et al., 2000) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/tkv^{Q199D.Scer\UAS.T:Ivir\HA1} is a suppressor of male germline stem cell \| third instar larval stage phenotype of magu^e00439/magu^f02256 (Zheng et al., 2011) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/tkv^{Q199D.Scer\UAS.T:Ivir\HA1} is a suppressor of testis phenotype of magu^e00439/magu^f02256 (Zheng et al., 2011) Scer\GAL4^{nos.UTR.T:Hsim\VP16}/tkv^{Q199D.Scer\UAS.T:Ivir\HA1} is a suppressor of wing vein phenotype of magu^e00439/magu^f02256 (Zheng et al., 2011) Scer\GAL4^pnr-MD237/tkv^{Q199D.Scer\UAS.T:Ivir\HA1} is a suppressor of embryonic dorsal epidermis phenotype of Jra^76-19 (Hou et al., 1997) Scer\GAL4^T80, tkv^{Q199D.Scer\UAS.T:Ivir\HA1} is a suppressor of wing phenotype of Scer\GAL4^T80, tkv^{Q199D.Scer\UAS.T:Ivir\HA1} (Takaesu et al., 2012, Takaesu et al., 2012) tkv^{Q199D.Scer\UAS.T:Ivir\HA1}/Scer\GAL4^hs.PB is a suppressor of embryonic dorsal epidermis \| germline clone \| rescuable maternal effect phenotype of Cka⁰⁵⁸³⁶ (Chen et al., 2002)
NOT Suppressor of
Statement Reference tkv^{Q199D.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^T80 is a non-suppressor of wing phenotype of fuss^Scer\UAS.cTa, Scer\GAL4^T80 (Takaesu et al., 2012)
Additional Comments
Genetic Interactions
Statement Reference Co-expression of CORL[Scer\UAS.cTa] in the wing disc under the control of Scer\GAL4[T80] suppresses ectopic wing vein formation from CORL[Scer\UAS.cTa] expression. These wings exhibit a few ectopic veins and truncations of L2, L4 and L5 wing veins. (Takaesu et al., 2012) Co-expression of tkv[Q199D.Scer\UAS.T:Ivir\HA1] dramatically enhances the increase in satellite bouton number at the neuromuscular junction which is seen in larvae expressing Snx16[3A.Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[elav-C155]. (Rodal et al., 2011) Expression of tkv[Q199D.Scer\UAS.T:Ivir\HA1] using the germ cell driver Scer\GAL4[nos.UTR.T:Hsim\VP16] raises the fraction of testes with germline stem cells from 63% to 100% in a magu[e00439]/magu[f02256] background. The median germline stem cell number also doubles compared to that observed in mutants. (Zheng et al., 2011) Co-expression of sax[A.Scer\UAS.cBa] and tkv[Q199D.Scer\UAS.T:Ivir\HA1] in motor neurons under the control of Scer\GAL4[BG380] produces increased mean evoked excitatory junctional potentials (EJPs) and quantal content compared to controls. The size of miniature excitatory junctional potentials (mEJPs) does not differ from controls. trio[S137203]/trio[6A] suppresses the increase in evoked excitatory junctional potential (EJPs) and quantal content seen when sax[A.Scer\UAS.cBa] and tkv[Q199D.Scer\UAS.T:Ivir\HA1] are expressed in motor neurons under the control of Scer\GAL4[BG380]. (Ball et al., 2010) The wing patterning phenotypes resulting from the expression of tkv[Q199D.Scer\UAS.T:Ivir\HA1] with Scer\GAL4[ptc-559.1] are enhanced by the co-expression of kek5[Scer\UAS.T:Avic\GFP], and there is an additional decrease in wing size. (Evans et al., 2009) Expression of tkv[Q199D.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[BG380] significantly suppresses the reduction in the number of boutons per muscle surface area which is seen at the neuromuscular junction in nmo[unspecified] third instar larvae. (Merino et al., 2009) Expression of tkv[Q199D.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[elav.PH] in ewg[2] motorneurons (these motorneurons have been obtained by using FLP/FRT mediated recombination to inactivate the ewg[elav.PH] rescuing transgene and simultaneously activate the Scer\GAL4[elav.PH] driver in a ewg[2] background) results in intermediate numbers of boutons at the larval neuromuscular junction compared to wild-type and ewg[2] motorneurons. (Haussmann et al., 2008) Expression of tkv[Q199D.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[elav.PU] enhances the increase in the average number of satellite boutons at the neuromuscular junction that is seen in nwk[2] larvae. Co-expression of nwk[Scer\UAS.cCa] suppresses the increase in the total number of boutons and in the number of satellite boutons at the neuromuscular junction that is seen in larvae expressing two copies of tkv[Q199D.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[elav-C155]. Expression of one copy of tkv[Q199D.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[elav-C155] in a Dap160[Δ1]/+ background results in an increase in both the total number of boutons and the number of satellite boutons at the larval neuromuscular junction compared to wild type. Co-expression of Dap160[Scer\UAS.cKa] suppresses the increase in the total number of boutons and in the number of satellite boutons at the neuromuscular junction that is seen in larvae expressing two copies of tkv[Q199D.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[elav-C155]. (O'Connor-Giles et al., 2008) The wing phenotypes caused by expression of tkv^{Q199D.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^A9 are suppressed by co-expression of Snoo^Scer\UAS.cTa; the wing in the co-expressing flies appears similar to the phenotype seen in flies expressing Snoo^Scer\UAS.cTa alone under the control of Scer\GAL4^A9. (Takaesu et al., 2006) Expression of tkv^{Q199D.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PLu in a hiw^EMS background results in a 30% increase in the number of boutons per muscle surface area at the neuromuscular junction compared to hiw^EMS single mutants. (McCabe et al., 2004) The dorsal open phenotype seen in homozygous Cka⁰⁵⁸³⁶ embryos derived from females carrying homozygous Cka⁰⁵⁸³⁶ germ-line clones is substantially rescued by expression of tkv^{Q199D.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^hs.PB using heat shock. (Chen et al., 2002) Scer\GAL4^pnr-MD237-mediated expression in Jra^76-19 embryos rescues the dorsal open phenotype. (Hou et al., 1997) Similar dominant wing phenotypes are observed in flies expressing dpp^Scer\UAS.cHa and tkv^{Q199D.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^unspecified that are not observed in flies expressing tkv^Scer\UAS.cHa under the control of Scer\GAL4^unspecified. (Hoodless et al., 1996)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Constitutively active. (Hoodless et al., 1996)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	tkv^{Q199D.Scer\UAS.T:Ivir\HA1} tkv^{Q199D.UAS.T:HA1} tkv^Q199D (Rodal et al., 2011) TKV-A (Dobens et al., 2000) TKVA (Haerry et al., 1998)
Name Synonym
Secondary FlyBase IDs

References ( 31 )

Generate a list of	All references relating to this allele ( 31 )

List References by type	Research paper ( 30 ) Supplementary material ( 1 )
Recent research papers ( 5 )
	Le and Wharton, 2012, Dev. Dyn. 241(1): 200--214 Hyperactive BMP signaling induced by ALK2(R206H) requires type II receptor function in a Drosophila model for classic fibrodysplasia ossificans progressiva. [FBrf0217004] Sun et al., 2012, PLoS Genet. 8(2): e1002515 Neurophysiological Defects and Neuronal Gene Deregulation in Drosophila mir-124 Mutants. [FBrf0217508] Takaesu et al., 2012, Development 139(18): 3392--3401 Drosophila CORL is required for Smad2-mediated activation of Ecdysone Receptor expression in the mushroom body. [FBrf0219224] Rodal et al., 2011, J. Cell Biol. 193(1): 201--217 A presynaptic endosomal trafficking pathway controls synaptic growth signaling. [FBrf0213353] Zheng et al., 2011, Dev. Biol. 357(1): 202--210 magu is required for germline stem cell self-renewal through BMP signaling in the Drosophila testis. [FBrf0214645] Show all research papers ...

Allele Dmel\tkvQ199D.Scer\UAS.T:Ivir\HA1

Allele Dmel\tkv^{Q199D.Scer\UAS.T:Ivir\HA1}