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General Information
Symbol
Dmel\ifm8.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0051512
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-╬▒PS2m8
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

The m8 form of if (lacking exon 8) is expressed under the control of UASt regulatory sequences.

UASt regulatory sequences drive expression of cDNA sequences encoding the if 'm8' splice variant.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Adult wings of ifm8.Scer\UAS-expressing flies (under the control of Scer\GAL4684) exhibit a significant number of cells that fail to delaminate.

Animals expressing ifm8.Scer\UAS under the control of Scer\GAL4337Y usually have wing blisters at 25o.

Scer\GAL4684 induced expression of ifm8.Scer\UAS is temperature sensitive, the penetrance and expressivity of the blister phenotype increases with temperature. Temperature shift experiments reveal the critical period for the generation of wing blisters by overexpression of integrin is at about the time the dorsal and ventral wing epithelia first become apposed. By the time re-apposition is occurring in the pupal period the wing is relatively insensitive to overexpression.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

Scer\GAL4c684, ifm8.UAS has visible phenotype, suppressible by msk[+]/msk5

Scer\GAL4c684, ifm8.UAS has visible phenotype, suppressible by Raf1

Scer\GAL4c684, ifm8.UAS has visible phenotype, suppressible by msk1/msk[+]

Scer\GAL4c684, ifm8.UAS has visible phenotype, suppressible by Dsor1r2

Scer\GAL4c684, ifm8.UAS has visible phenotype, suppressible by cswEsev1A-eOP/csw[+]

Scer\GAL4c684, ifm8.UAS has visible phenotype, suppressible by msk[+]/msk2

Scer\GAL4c684, ifm8.UAS has visible phenotype, suppressible by msk4/msk[+]

Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference

Scer\GAL4c684, ifm8.UAS has wing phenotype, suppressible by msk[+]/msk5

Scer\GAL4c684, ifm8.UAS has wing phenotype, suppressible by Raf1

Scer\GAL4c684, ifm8.UAS has wing phenotype, suppressible by msk1/msk[+]

Scer\GAL4c684, ifm8.UAS has wing phenotype, suppressible by Dsor1r2

Scer\GAL4c684, ifm8.UAS has wing phenotype, suppressible by cswEsev1A-eOP/csw[+]

Scer\GAL4c684, ifm8.UAS has wing phenotype, suppressible by msk[+]/msk2

Scer\GAL4c684, ifm8.UAS has wing phenotype, suppressible by msk4/msk[+]

Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The wing blistering caused by expression of ifm8.Scer\UAS under the control of Scer\GAL4337Y is suppressed by msk1/+, msk2/+, msk4/+, msk5/+ or cswEsev1A-eOP/+.

mew498 clones in the eye disrupt photoreceptor organisation. Scer\GAL4hs.PB-mediated expression of ifm8.Scer\UAS allows some rescue of the phenotype.

Partially rescues the first instar lethality of mewM6 homozygotes when expressed using Scer\GAL448Y, although the animals do not survive past the second larval instar stage.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The lethality caused by ifk27e can be rescued by Scer\GAL4how-24B mediated expression of one copy of a copy of both P{UAS-if.C} and P{UAS-if.m8} or two copies of P{UAS-if.m8}. Expression of one copy of P{UAS-if.m8} fails to rescue lethality, embryos die during development and fail to emerge from the egg cases. These embryos exhibit a muscle phenotype.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
ifm8.Scer\UAS
ifm8.UAS
Name Synonyms
Secondary FlyBase IDs
    References (6)