FlyBase Allele Report: Dmel\grim[GMR.PC]

General Information

Symbol

Dmel\grim^GMR.PC

Species

D. melanogaster

Name

glass multimer reporter construct of Chen

FlyBase ID

FBal0051534

Feature type

allele

Associated gene

Dmel\grim

Associated Insertion(s)

Carried in Construct

P{GMR-grim}

Also Known As

GMR-grim, P[GMR-grim], pGMR-grim

Key Links

Transgenic product class

cDNA

(Chen et al., 1996)

wild_type

(Chen et al., 1996)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Chen et al., 1996)

wild_type

(Chen et al., 1996)

Mutagen

in vitro construct

(Chen et al., 1998, Chen et al., 1996)

Progenitor genotype

Carried in construct

P{GMR-grim}

Cytology

Description

GMR regulatory sequences drive expression of an EcoRI fragment of grim cDNA.

(Chen et al., 1996)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

grim

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

grim^GMR.PC induces a small eye.

(Nagel et al., 2021)

Flies carrying one copy of grim^GMR.PC show depigmentation, mild roughness and slight reduction in the size of adult eyes; in flies carrying two copies of the transgene, only a sliver of an eye remains and is largely depigmented.

(Sinenko, 2017)

Adult flies expressing grim^GMR.PC show retinal degeneration phenotype.

(Neves et al., 2016)

One copy of grim^GMR.PC has no effect on the eye in an otherwise wild-type background. Flies carrying two copies of grim^GMR.PC show a reduction in eye size.

(Yang et al., 2014)

grim^GMR.PC eyes are small owing to cell death of a large percentage of the developing cells of the eye.

Increased cell death is seen in grim^GMR.PC third instar eye discs.

(Wu et al., 2010)

W^GMR.PG eyes are ablated.

(Galindo et al., 2009)

Flies expressing grim^GMR.PC have a rough eye phenotype.

(Krieser et al., 2007)

Flies carrying grim^GMR.PC show almost complete ablation of the eye.

(Pfleger et al., 2007)

Adults expressing grim^GMR.PC show a reduction in eye size compared to wild type.

(Kondo et al., 2006)

Expression of the grim^GMR.PC transgene in postmitotic cells of the eye disc leads to small, rough eyes.

(Nairz et al., 2006)

Flies carrying grim^GMR.PC have rough and reduced eyes.

(Gottfried et al., 2004)

Flies expressing grim^GMR.PC have small, rough eyes.

(Rusconi et al., 2004)

grim^GMR.PC flies have small, rough eyes. In third instar eye discs of these animals, abnormally high levels of cell death occur posterior to the morphogenetic furrow.

(Harvey et al., 2003)

grim^GMR.PC results in a dosage dependent eye degeneration phenotype.

(Higashiyama et al., 2002)

grim^GMR.PC has little or no effect on eye suize in heterozygotes.

(Srinivasula et al., 2002)

grim^GMR.PC has little or no effect on eye size in heterozygotes.

(Srinivasula et al., 2002)

Eye is small and roughened.

(Lisi et al., 2000)

grim^GMR.PC flies have a mild but easily detectable eye phenotype.

(Song et al., 2000)

Two copies of grim^GMR.PC in an otherwise wild-type background completely eliminate the ommatidia.

(Rodriguez et al., 1999)

Causes a dose-dependent mild eye ablation phenotype.

(Bergmann et al., 1998)

Induces cell death. This phenotype is not modified by modulating the Ras/MAPK pathway, or by reducing W gene dosage.

(Kurada and White, 1998)

Single copy of P{GMR-grim} causes disordering of ommatidia and mechanosensory bristles. Two copies causes a complete elimination of ommatidia with only a few bristles remaining.

(Chen et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

grim^GMR.PC has visible phenotype, enhanceable by DUBAI^KG07439/DUBAI^KG07439

(Yang et al., 2014)

grim^GMR.PC has visible phenotype, enhanceable by PSR[+]/JMJD6^FM1

(Krieser et al., 2007)

grim^GMR.PC has visible phenotype, enhanceable by JMJD6^FM1/JMJD6^FM1

(Krieser et al., 2007)

grim^GMR.PC has abnormal cell death phenotype, enhanceable by Df(3L)brm11

(Lisi et al., 2000)

grim^GMR.PC has abnormal cell death phenotype, enhanceable by Diap1^109.07

(Lisi et al., 2000)

grim^GMR.PC has abnormal cell death phenotype, enhanceable by Diap1⁵

(Lisi et al., 2000)

grim^GMR.PC has abnormal cell death phenotype, enhanceable by Diap1⁴

(Lisi et al., 2000)

grim^GMR.PC has abnormal cell death phenotype, enhanceable by Diap1^6B

(Lisi et al., 2000)

grim^GMR.PC has abnormal cell death phenotype, enhanceable by Diap1⁷

(Lisi et al., 2000)

grim^GMR.PC has abnormal cell death phenotype, enhanceable by Diap1^81.03

(Lisi et al., 2000)

grim^GMR.PC has abnormal cell death phenotype, enhanceable by Diap1⁹

(Lisi et al., 2000)

NOT Enhanced by

Statement

Reference

grim^GMR.PC has abnormal cell death phenotype, non-enhanceable by Ras85D^V12.sev

(Bergmann et al., 1998)

grim^GMR.PC has abnormal cell death phenotype, non-enhanceable by Ras85D^N17.sev

(Bergmann et al., 1998)

Suppressed by

Statement

Reference

grim^GMR.PC has visible | adult stage phenotype, suppressible by Scer\GAL4^ptc-559.1/Mnr^EP555

(Nagel et al., 2021)

grim^GMR.PC has decreased size | adult stage phenotype, suppressible by Scer\GAL4^ptc-559.1/Mnr^EP555

(Nagel et al., 2021)

grim^GMR.PC has visible | adult stage phenotype, suppressible by Usp15-31^KK101035/Scer\GAL4^GMR.PFa

(Sinenko, 2017)

grim^GMR.PC has abnormal eye color phenotype, suppressible by Usp15-31^KK101035/Scer\GAL4^GMR.PFa

(Sinenko, 2017)

grim^GMR.PC has abnormal size | adult stage phenotype, suppressible by Usp15-31^KK101035/Scer\GAL4^GMR.PFa

(Sinenko, 2017)

grim^GMR.PC has visible | adult stage phenotype, suppressible by Dark^KK104215/Scer\GAL4^GMR.PFa

(Sinenko, 2017)

grim^GMR.PC has abnormal eye color phenotype, suppressible by Dark^KK104215/Scer\GAL4^GMR.PFa

(Sinenko, 2017)

grim^GMR.PC has abnormal size | adult stage phenotype, suppressible by Dark^KK104215/Scer\GAL4^GMR.PFa

(Sinenko, 2017)

grim^GMR.PC has visible | adult stage phenotype, suppressible by Usp15-31^KG04149/Usp15-31[+]

(Sinenko, 2017)

grim^GMR.PC has abnormal eye color phenotype, suppressible by Usp15-31^KG04149/Usp15-31[+]

(Sinenko, 2017)

grim^GMR.PC has abnormal size | adult stage phenotype, suppressible by Usp15-31^KG04149/Usp15-31[+]

(Sinenko, 2017)

grim^GMR.PC has visible | adult stage phenotype, suppressible by Usp15-31^KG04149/Usp15-31^KG04149

(Sinenko, 2017)

grim^GMR.PC has abnormal eye color phenotype, suppressible by Usp15-31^KG04149/Usp15-31^KG04149

(Sinenko, 2017)

grim^GMR.PC has abnormal size | adult stage phenotype, suppressible by Usp15-31^KG04149/Usp15-31^KG04149

(Sinenko, 2017)

grim^GMR.PC has increased cell death phenotype, suppressible by Buffy^H37

(Wu et al., 2010)

grim^GMR.PC has visible phenotype, suppressible by Scer\GAL4^GMR.PF/JMJD6^UAS.cKa

(Krieser et al., 2007)

grim^GMR.PC has visible phenotype, suppressible by Uba1^B2/Uba1^B2

(Pfleger et al., 2007)

grim^GMR.PC has abnormal size | adult stage phenotype, suppressible by mir-278^{KN448.mirvana-1.UAS}/Scer\GAL4^GMR.PF

(Nairz et al., 2006)

grim^GMR.PC has abnormal size | adult stage phenotype, suppressible by mir-278^KN447.UAS/Scer\GAL4^GMR.PF

(Nairz et al., 2006)

grim^GMR.PC has visible phenotype, suppressible by Hr4^EP1232/Scer\GAL4^GMR.PF

(Müller et al., 2005)

grim^GMR.PC has visible phenotype, suppressible by mir-278^EP2316/Scer\GAL4^GMR.PF

(Müller et al., 2005)

grim^GMR.PC has visible phenotype, suppressible by Scer\GAL4^GMR.PF/Imp^EP1433

(Müller et al., 2005)

grim^GMR.PC has visible phenotype, suppressible by pnut[+]/pnut^XP

(Gottfried et al., 2004)

grim^GMR.PC has visible phenotype, suppressible by pnut[+]/pnut¹

(Gottfried et al., 2004)

grim^GMR.PC has visible phenotype, suppressible by klu[+]/klu^unspecified

(Rusconi et al., 2004)

grim^GMR.PC has increased cell death | larval stage phenotype, suppressible by hpo^MGH1

(Harvey et al., 2003)

Diap1⁵/th[+], grim^GMR.PC has increased cell death phenotype, suppressible by Dark^CD4

(Rodriguez et al., 2002)

grim^GMR.PC has abnormal cell death phenotype, suppressible by Diap1^SL

(Lisi et al., 2000)

grim^GMR.PC has abnormal cell death phenotype, suppressible by Diap1^UAS.cLa/Scer\GAL4^GMR.PF

(Lisi et al., 2000)

grim^GMR.PC has abnormal cell death phenotype, suppressible by Diap1^V85M.UAS/Scer\GAL4^GMR.PF

(Lisi et al., 2000)

grim^GMR.PC has visible phenotype, suppressible by Dark^CD4

(Rodriguez et al., 1999)

grim^GMR.PC has abnormal cell death phenotype, suppressible by Df(1)su(s)R194

(Chen et al., 1998)

NOT suppressed by

Statement

Reference

grim^GMR.PC has increased cell death phenotype, non-suppressible by Debcl^E26

(Wu et al., 2010)

grim^GMR.PC has abnormal size | adult stage phenotype, non-suppressible by mir-278^mirvana-1/Scer\GAL4^GMR.PF

(Nairz et al., 2006)

grim^GMR.PC has abnormal size | adult stage phenotype, non-suppressible by mir-278^mirvana-1/Df(2R)Exel7137

(Nairz et al., 2006)

grim^GMR.PC has visible phenotype, non-suppressible by TER94[+]/TER94^26-8

(Higashiyama et al., 2002)

grim^GMR.PC has abnormal cell death phenotype, non-suppressible by Ras85D^N17.sev

(Bergmann et al., 1998)

grim^GMR.PC has abnormal cell death phenotype, non-suppressible by Ras85D^V12.sev

(Bergmann et al., 1998)

Enhancer of

Statement

Reference

grim^GMR.PC is an enhancer of increased cell death phenotype of Scer\GAL4^GMR.PF, skl^UAS.cSa

(Srinivasula et al., 2002)

grim^GMR.PC is an enhancer of visible phenotype of Dcp-1^fl.GMR

(Song et al., 2000)

Other

Statement

Reference

DUBAI^GD14040, Scer\GAL4^GMR.PFa, grim^GMR.PC has visible phenotype

(Yang et al., 2014)

CG8830[+]/DUBAI^KG07439, grim^GMR.PC has visible phenotype

(Yang et al., 2014)

Diap1⁵/th[+], grim^GMR.PC has increased cell death phenotype

(Rodriguez et al., 2002)

Diap1⁵, grim^GMR.PC has increased cell death phenotype

(Rodriguez et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

grim^GMR.PC has eye phenotype, enhanceable by DUBAI^KG07439/DUBAI^KG07439

(Yang et al., 2014)

grim^GMR.PC has eye phenotype, enhanceable by PSR[+]/JMJD6^FM1

(Krieser et al., 2007)

grim^GMR.PC has eye phenotype, enhanceable by JMJD6^FM1/JMJD6^FM1

(Krieser et al., 2007)

grim^GMR.PC has eye phenotype, enhanceable by Diap1^109.07

(Lisi et al., 2000)

grim^GMR.PC has eye phenotype, enhanceable by Diap1⁵

(Lisi et al., 2000)

grim^GMR.PC has eye phenotype, enhanceable by Diap1⁴

(Lisi et al., 2000)

grim^GMR.PC has eye phenotype, enhanceable by Diap1^6B

(Lisi et al., 2000)

grim^GMR.PC has eye phenotype, enhanceable by Diap1⁷

(Lisi et al., 2000)

grim^GMR.PC has eye phenotype, enhanceable by Diap1^81.03

(Lisi et al., 2000)

grim^GMR.PC has eye phenotype, enhanceable by Diap1⁹

(Lisi et al., 2000)

NOT Enhanced by

Statement

Reference

grim^GMR.PC has eye phenotype, non-enhanceable by Debcl⁵⁹

(Galindo et al., 2009)

grim^GMR.PC has ommatidium phenotype, non-enhanceable by mir-278^mirvana-1/mir-278^mirvana-1

(Nairz et al., 2006)

grim^GMR.PC has interommatidial bristle phenotype, non-enhanceable by mir-278^mirvana-1/mir-278^mirvana-1

(Nairz et al., 2006)

grim^GMR.PC has ommatidium phenotype, non-enhanceable by mir-278^mirvana-1/Df(2R)Exel7137

(Nairz et al., 2006)

grim^GMR.PC has interommatidial bristle phenotype, non-enhanceable by mir-278^mirvana-1/Df(2R)Exel7137

(Nairz et al., 2006)

grim^GMR.PC has eye phenotype, non-enhanceable by Ras85D^V12.sev

(Bergmann et al., 1998)

grim^GMR.PC has eye phenotype, non-enhanceable by Ras85D^N17.sev

(Bergmann et al., 1998)

Suppressed by

Statement

Reference

grim^GMR.PC has eye phenotype, suppressible by Mnr^EP555/Scer\GAL4^GMR.PU

(Nagel et al., 2021)

grim^GMR.PC has eye phenotype, suppressible by Usp15-31^KK101035/Scer\GAL4^GMR.PFa

(Sinenko, 2017)

grim^GMR.PC has eye phenotype, suppressible by Dark^KK104215/Scer\GAL4^GMR.PFa

(Sinenko, 2017)

grim^GMR.PC has eye phenotype, suppressible by Usp15-31^KG04149/Usp15-31[+]

(Sinenko, 2017)

grim^GMR.PC has eye phenotype, suppressible by Usp15-31^KG04149/Usp15-31^KG04149

(Sinenko, 2017)

grim^GMR.PC has eye phenotype, suppressible by Buffy^H37

(Wu et al., 2010)

grim^GMR.PC has eye disc | third instar larval stage phenotype, suppressible by Buffy^H37

(Wu et al., 2010)

grim^GMR.PC has eye phenotype, suppressible by Scer\GAL4^GMR.PF/JMJD6^UAS.cKa

(Krieser et al., 2007)

grim^GMR.PC has eye phenotype, suppressible by Uba1^B2/Uba1^B2

(Pfleger et al., 2007)

grim^GMR.PC has ommatidium phenotype, suppressible by mir-278^{KN448.mirvana-1.UAS}/Scer\GAL4^GMR.PF

(Nairz et al., 2006)

grim^GMR.PC has interommatidial bristle phenotype, suppressible by mir-278^{KN448.mirvana-1.UAS}/Scer\GAL4^GMR.PF

(Nairz et al., 2006)

grim^GMR.PC has ommatidium phenotype, suppressible by mir-278^KN447.UAS/Scer\GAL4^GMR.PF

(Nairz et al., 2006)

grim^GMR.PC has interommatidial bristle phenotype, suppressible by mir-278^KN447.UAS/Scer\GAL4^GMR.PF

(Nairz et al., 2006)

grim^GMR.PC has eye phenotype, suppressible by Hr4^EP1232/Scer\GAL4^GMR.PF

(Müller et al., 2005)

grim^GMR.PC has eye phenotype, suppressible by mir-278^EP2316/Scer\GAL4^GMR.PF

(Müller et al., 2005)

grim^GMR.PC has eye phenotype, suppressible by Scer\GAL4^GMR.PF/Imp^EP1433

(Müller et al., 2005)

grim^GMR.PC has eye phenotype, suppressible by pnut[+]/pnut¹

(Gottfried et al., 2004)

grim^GMR.PC has eye phenotype, suppressible by pnut[+]/pnut^XP

(Gottfried et al., 2004)

grim^GMR.PC has ommatidium phenotype, suppressible by klu[+]/klu^unspecified

(Rusconi et al., 2004)

grim^GMR.PC has eye phenotype, suppressible by hpo^MGH1

(Harvey et al., 2003)

grim^GMR.PC has ommatidium phenotype, suppressible by hpo^MGH1

(Harvey et al., 2003)

grim^GMR.PC has eye phenotype, suppressible by Buffy^{ΔN.UAS.Tag:FLAG}/Scer\GAL4^GMR.PF

(Quinn et al., 2003)

grim^GMR.PC has eye phenotype, suppressible by Buffy^UAS.cQa/Scer\GAL4^GMR.PF

(Quinn et al., 2003)

grim^GMR.PC has eye phenotype, suppressible by Diap1^SL

(Lisi et al., 2000)

grim^GMR.PC has eye phenotype, suppressible by Diap1^UAS.cLa/Scer\GAL4^GMR.PF

(Lisi et al., 2000)

grim^GMR.PC has eye phenotype, suppressible by Diap1^V85M.UAS/Scer\GAL4^GMR.PF

(Lisi et al., 2000)

grim^GMR.PC has ommatidium phenotype, suppressible by Dark^CD4

(Rodriguez et al., 1999)

grim^GMR.PC has eye phenotype, suppressible by Dark^CD4

(Rodriguez et al., 1999)

grim^GMR.PC has eye phenotype, suppressible by Df(1)su(s)R194

(Chen et al., 1998)

NOT suppressed by

Statement

Reference

grim^GMR.PC has eye phenotype, non-suppressible by spoon^KG02745

(Das et al., 2023)

grim^GMR.PC has ommatidium phenotype, non-suppressible by spoon^KG02745

(Das et al., 2023)

grim^GMR.PC has eye phenotype, non-suppressible by Debcl^E26

(Wu et al., 2010)

grim^GMR.PC has eye phenotype, non-suppressible by Debcl⁵⁹

(Galindo et al., 2009)

grim^GMR.PC has eye phenotype, non-suppressible by TER94[+]/TER94^26-8

(Higashiyama et al., 2002)

grim^GMR.PC has eye phenotype, non-suppressible by Dark^k11502

(Zhou et al., 1999)

grim^GMR.PC has eye phenotype, non-suppressible by Ras85D^N17.sev

(Bergmann et al., 1998)

grim^GMR.PC has eye phenotype, non-suppressible by Ras85D^V12.sev

(Bergmann et al., 1998)

Enhancer of

Statement

Reference

grim^GMR.PC is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, skl^UAS.cSa

(Srinivasula et al., 2002)

grim^GMR.PC is an enhancer of eye phenotype of Dcp-1^fl.GMR

(Song et al., 2000)

NOT Enhancer of

Statement

Reference

grim^GMR.PC is a non-enhancer of phenotype of Drice^fl.GMR

(Song et al., 2000)

Other

Statement

Reference

DUBAI^GD14040, Scer\GAL4^GMR.PFa, grim^GMR.PC has eye phenotype

(Yang et al., 2014)

CG8830[+]/DUBAI^KG07439, grim^GMR.PC has eye phenotype

(Yang et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The eye phenotype (partial depigmentation, rough surface, slight size reduction) characteristic for adult flies carrying one copy of grim^GMR.PC is significantly improved by expression of Usp15-31^KK101035 and even more strongly by that of Dark^KK104215 driven by Scer\GAL4^GMR.PFa. Similarly, the even stronger eye phenotype observed in flies carrying two copies of grim^GMR.PC is partially suppressed by combination with Usp15-31^KG04149 in either homozygous or heterozygous state.

(Sinenko, 2017)

Expression of Manf^Scer\UAS.cPa under the control of Scer\GAL4^Hml.Δ reduces the severity of the retinal degeneration phenotype characteristic for adult flies expressing grim^GMR.PC.

(Neves et al., 2016)

Co-expression of grim^GMR.PC and DUBAI^GD14040 (expressed under the control of Scer\GAL4^GMR.PFa) results in a significant loss of pigment cells in the eye.

grim^GMR.PC DUBAI^KG07439/+ flies show loss of pigment cells in the eye.

Flies carrying one copy of grim^GMR.PC and expressing one of either Ubpy^KK100733 or Usp12-46^KK108313 under the control of Scer\GAL4^GMR.PFa do not show a mutant eye phenotype.

Flies carrying one copy of grim^GMR.PC and also heterozygous for CG5789^KG07791 do not show a mutant eye phenotype.

The eye phenotype caused by two copies of grim^GMR.PC is enhanced by DUBAI^KG07439/DUBAI^KG07439.

(Yang et al., 2014)

Ras85D^R68Q very mildly suppresses grim^GMR.PC-induced cell death although this is suspected to be due to suppression of endogenous W activity and not grim or rpr activity.

(Gafuik and Steller, 2011)

The cell death seen in grim^GMR.PC eyes is abrogated in a Buffy^H37 but not in a debcl^E26 background.

(Wu et al., 2010)

Co-expression of PSR^Scer\UAS.cKa under the control of Scer\GAL4^GMR.PF suppresses the rough eye phenotype seen in flies expressing grim^GMR.PC.

The rough eye phenotype caused by grim^GMR.PC is enhanced by one copy of PSR^FM1 and is further enhanced by two copies of PSR^FM1.

(Krieser et al., 2007)

The loss of eye tissue that is caused by grim^GMR.PC is partially suppressed if the eye is also homozygous for Uba1^B2.

(Pfleger et al., 2007)

The small, rough eye phenotype of grim^GMR.PC flies is partially suppressed by the expression of mir-278^{KN448.mirvana-1.Scer\UAS} under the control of Scer\GAL4^GMR.PF and strongly suppressed by mir-278^{KN447.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

The eye phenotype of flies expressing grim^GMR.PC is not enhanced by a mir-278^mirvana-1 or a mir-278^mirvana-1/Df(2R)Exel7137 background.

(Nairz et al., 2006)

The severity of the grim^GMR.PC eye phenotype is suppressed by "dronc[d5]" animals (Df(3L)Nc^Z in which CG6685 function, but not Nc function, is rescued by P{CG6685^+tDa}).

(Daish et al., 2004)

The reduced eye phenotype caused by expression of grim^GMR.PC is significantly suppressed by pnut¹/+ or pnut^XP/+.

(Gottfried et al., 2004)

The eye phenotype caused by grim^GMR.PC is mildly but consistently suppressed by klu^unspecified/+.

(Rusconi et al., 2004)

The small, rough eye phenotype of grim^GMR.PC flies is suppressed when somatic clones of hpo^MGH1 homozygous cells are generated throughout the eye discs using Scer\FLP1^ey.PN with P{neoFRT}42D. In the eye discs from these animals, the abnormal levels of cell death posterior to the morphogenetic furrow seen in grim^GMR.PC eye discs are suppressed in the hpo^MGH1 mutant tissue.

(Harvey et al., 2003)

The addition of th⁵ to grim^GMR.PC heterozygotes leads to an enhancement of retinal apoptosis. The subsequent addition of Ark^CD4/Ark^CD4 suppresses that enhancement.

(Rodriguez et al., 2002)

The addition of grim^GMR.PC to Dcp-1^fl.GMR flies show a strong enhancement of the eye phenotype seen in Dcp-1^fl.GMR flies. The addition of grim^GMR.PC to Ice^fl.GMR flies did not show a very effective enhancement of the eye phenotype seen in Ice^fl.GMR flies.

(Song et al., 2000)

The grim^GMR.PC ommatidia phenotype is suppressed if the flies are also homozygous for Ark^CD4; the eyes retain a substantial amount of retinal tissue with many surviving ommatidia.

(Rodriguez et al., 1999)

Ark^k11502 has little effect on the eye phenotype caused by grim^GMR.PC.

(Zhou et al., 1999)

The grim^GMR.PC eye ablation phenotype is not particularly affected by either Ras85D^V12.sev and Ras85D^N17.sev.

(Bergmann et al., 1998)

Cell-killing in the eye induced by grim^GMR.PC is suppressed by Df(1)su(s)R194.

(Chen et al., 1998)

Simultaneous expression of P{GMR-grim} and P{GMRP35} restores wild type size and organisation of the eye.

(Chen et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

9923

w^*; P{GMR-grim}4

9922

y¹ w^*; P{GMR-grim}1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

grim^GMR.PC

Name Synonyms

glass multimer reporter construct of Chen

(Chen et al., 1996)

Secondary FlyBase IDs

References (38)

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