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General Information
Symbol
Dmel\dos1.46
Species
D. melanogaster
Name
FlyBase ID
FBal0051665
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    dos1.46/dos2.42 mutant flies give rise to 33% of the expected number of pupae.

    dos1.46 mutant clones rarely contain photoreceptors and are composed of very few cells.

    Heterozygotes exhibit no eye abnormalities. Mitotic clones in the eye are identical to lack of csw function, cells can proliferate but do not differentiate as photoreceptors.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Suppressed by
    NOT Enhancer of
    Statement
    Reference

    dos1.46 is a non-enhancer of visible phenotype of Pp2B-14Dact.GMR

    NOT Suppressor of
    Statement
    Reference

    dos1.46 is a non-suppressor of visible phenotype of Pp2B-14Dact.GMR

    dos1.46 is a non-suppressor of visible phenotype of CanBGMR.PS, Pp2B-14Dact.GMR

    Phenotype Manifest In
    Suppressed by
    Enhancer of
    Statement
    Reference

    dos1.46 is an enhancer of eye phenotype of cswCS.hs.2sev

    dos1.46 is an enhancer of ommatidium phenotype of cswCS.hs.2sev

    dos1.46 is an enhancer of phenotype of cswCS.hs.2sev

    NOT Enhancer of
    Statement
    Reference

    dos1.46 is a non-enhancer of eye phenotype of Pp2B-14Dact.GMR

    dos1.46 is a non-enhancer of eye phenotype of CanBGMR.PS, Pp2B-14Dact.GMR

    dos1.46 is a non-enhancer of eye phenotype of Ras85DV12

    dos1.46 is a non-enhancer of eye phenotype of Raf::tor13D.hs.sev

    Suppressor of
    Statement
    Reference

    dos1.46 is a suppressor of phenotype of csw::Src64Bhs.2sev

    dos1.46 is a suppressor of phenotype of sevS11.Tag:MYC

    NOT Suppressor of
    Statement
    Reference

    dos1.46 is a non-suppressor of eye phenotype of Pp2B-14Dact.GMR

    dos1.46 is a non-suppressor of eye phenotype of CanBGMR.PS, Pp2B-14Dact.GMR

    dos1.46 is a non-suppressor of eye phenotype of Ras85DV12

    dos1.46 is a non-suppressor of eye phenotype of Raf::tor13D.hs.sev

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The rough eye phenotype seen in cswCS.hs.2sev flies is enhanced by the addition of dos1.46. The addition of doshs.2sev.cHa or dosYY.hs.2sev to cswCS.hs.2sev/dos1.46 flies strongly suppresses this phenotype. The addition of dosY854F.hs.2sev, dosY801F.hs.2sev.cHa, or dosY810F.Y854F.hs.2sev leads to markedly enhanced eye roughness.

    Xenogenetic Interactions
    Statement
    Reference

    Expression of Zzzz\cagAScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4hs.PB suppresses the lethality seen in dos1.46/dos2.42 mutants. 89% of the expected number of pupae are seen, compared to only 33% in homozygous dos1.46 mutants.

    Expression of Zzzz\cagAScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF increases dos1.46 mutant clone size in the eye. The clones are much larger and contain increased numbers of photoreceptors.

    Complementation and Rescue Data
    Partially rescued by
    Comments

    Expression of dosScer\UAS.cRa under the control of Scer\GAL4GMR.PF increases dos1.46 mutant clone size in the eye. The clones are much larger and contain increased numbers of photoreceptors.

    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (5)