Open Close
General Information
Symbol
Dmel\Snr1R3
Species
D. melanogaster
Name
FlyBase ID
FBal0051957
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

Imprecise excision of P element results in an in-frame stop codon at amino acid 131.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

In-frame translation termination codon at amino acid 131.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

adult thorax | dorsal & chaeta | somatic clone

mechanosensory chaeta & adult abdomen | somatic clone

mechanosensory chaeta | supernumerary & adult abdomen | somatic clone

socket & adult abdomen | somatic clone

Detailed Description
Statement
Reference

Snr1R3 mutant MARCM somatic clone in the third instar larval wing disc display increased levels of apoptosis and are much smaller compared to control clones.

Snr1R3/Snr1E1 flies have an extra vein phenotype in the wings, with extra vein material posterior to wing vein L5 and extending distally from the posterior crossvein.

The frequency and size of homozygous clones is reduced relative to control clones, indicating that Snr1 is important for cell viability. Homozygous clones in the abdomen result in duplicated, fused or malformed (stunted, twisted or bent) mechanosensory bristles. Within the clones, patches of tissue that lack bristles and/or bristle sockets are seen. Cuticle defects are also seen, including fusion of adjacent segments within clones, loss of pigmentation and cuticle disruptions. Homozygous clones on the dorsal thorax show only minor shortening of bristles within the clone. Homozygous clones in the eye disc result in only slightly reduced eye sizes, with no significant morphological defects. Few homozygous clones are recovered in the head region. Homozygous clones in the leg occur at a similar frequency to control clones and no not result in any obvious mutant phenotype. Females containing homozygous germline clones are infertile and do not produce any eggs. Expression of Snr1cdel.3.Scer\UAS under the control of Scer\GAL4e22c in a Snr1R3/+ background results in lethality at 29oC, and significant cuticle disruption, including incomplete fusion of the abdominal tergites along the dorsal midline. More than 70% of females expressing Snr1cdel.3.Scer\UAS under the control of Scer\GAL4Act5C.PI in a Snr1R3 background are sterile. Scer\GAL4Act5C.PI/Snr1cdel.3.Scer\UAS;Snr1R3 adults show a rapid decrease in viability following eclosion, with the effect being more pronounced among males.

Heterozygotes are phenotypically normal.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

HDAC104556, Snr1R3/Snr1[+] has visible | dominant phenotype, suppressible | partially by brm2

Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

Snr1R3 is a suppressor | partially of visible | dominant phenotype of AntpNs

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

Snr1R3 has adult abdomen | somatic clone phenotype, enhanceable by brm[+]/brm2

NOT Enhanced by
Statement
Reference

Snr1R3/Snr1E1 has wing vein | ectopic phenotype, non-enhanceable by ash14

Snr1R3/Snr1E1 has wing phenotype, non-enhanceable by ash14

Snr1R3/Snr1E1 has wing vein | ectopic phenotype, non-enhanceable by trxE2

Suppressed by
Statement
Reference

Snr1R3/Snr1E1 has wing vein | ectopic phenotype, suppressible by dpps1/dpps1

HDAC3B, Snr1R3/Snr1[+] has wing vein | ectopic phenotype, suppressible | partially by brm2

HDAC3B, Snr1R3/Snr1[+] has wing phenotype, suppressible | partially by brm2

HDAC104556, Snr1R3/Snr1[+] has wing vein | ectopic phenotype, suppressible | partially by brm2

HDAC104556, Snr1R3/Snr1[+] has wing phenotype, suppressible | partially by brm2

NOT suppressed by
Statement
Reference

Snr1R3/Snr1E1 has wing vein | ectopic phenotype, non-suppressible by ash14

Snr1R3/Snr1E1 has wing phenotype, non-suppressible by ash14

Snr1R3/Snr1E1 has wing vein | ectopic phenotype, non-suppressible by trxE2

Enhancer of
Statement
Reference

Snr1R3/Snr1[+] is an enhancer of eye phenotype of Scer\GAL4ey.PH, brmK804R.UAS.Tag:HA

Snr1R3/Snr1E1 is an enhancer of wing vein phenotype of dpps1

Snr1R3/Snr1E1 is an enhancer of wing vein phenotype of Dl9P

Snr1R3/Snr1[+] is an enhancer of wing vein | ectopic phenotype of net1

Snr1R3/Snr1[+] is an enhancer of wing vein | ectopic phenotype of HDAC3B

Snr1R3/Snr1[+] is an enhancer of wing phenotype of HDAC3B

Snr1R3 is an enhancer of phenotype of trxE2

Suppressor of
Statement
Reference

Snr1R3/Snr1[+] is a suppressor of wing vein phenotype of Scer\GAL469B, brmK804R.UAS.Tag:HA

Snr1R3/Snr1E1 is a suppressor of wing vein L5 phenotype of rhove-1

Snr1R3 is a suppressor | partially of antenna phenotype of AntpNs

Snr1R3 is a suppressor | partially of leg | ectopic phenotype of AntpNs

Snr1R3 is a suppressor of eye phenotype of CycEJP

Other
Additional Comments
Genetic Interactions
Statement
Reference

The loss of wing veins seen in animals expressing brmK804R.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL469B is suppressed by Snr1R3. The Dl9P thick vein phenotype is enhanced by Snr1E1/Snr1R3. dpps1/dpps1 Snr1E1/Snr1R3 animals show suppression of the Snr1 extra wing vein phenotype and enhancement of the dpp loss of vein phenotype in L5. Snr1E1/Snr1R3 suppresses the loss of wing vein L5 seen in rhove-1 homozygotes and rhove-1 suppresses the Snr1E1/Snr1R3 extra wing vein phenotype.

Rpd304556/Snr1R3 double heterozygotes have wing vein defects; 32% have normal wings, 38% have an ectopic vein emanating from the posterior crossvein and 30% have ectopic veins emanating from the posterior crossvein and posterior to the L5 longitudinal vein. The ectopic wing vein phenotype seen in Rpd304556/Snr1R3 double heterozygotes at 29oC is partially suppressed by brm2/+.

Homozygous Snr1R3 clones induced in a brm2/+ background are less frequently observed and are smaller in size compared to both brm+ and control clones induced at similar stages, suggesting an additive effect between brm and Snr1. The presence of brm2/+ enhances the Snr1R3 clone phenotype in the abdomen. The AntpNs/+ antenna to leg transformation is suppressed about 50% by Snr1R3.

Loss of one copy of Snr1 does not suppress adult Pc- mutant phenotypes. Snr1R3/brm2 transheterozygous adults display prothoracic defects, including loss of the humerus.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (11)