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General Information
Symbol
Dmel\Pclunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0052127
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Homozygous embryos show weak posterior transformation of abdominal segments, which is strongly enhanced in combination with other Pc like mutants. Heterozygous males sometimes have sex combs on the second or third legs.

    Abdominal segments in the embryo are transformed posteriorly. In the strongest alleles, the first abdominal segment resembles the second abdominal segment, and abdominal segments 2-7 are transformed to more posterior segments, while the head and thorax are normal. Weaker alleles affect only the more posterior segments. In Pclunspecified Scmunspecified double mutants, all denticle bands are similar to each other, and resemble A8 of wild-type embryos, although the thorax appears less transformed as the Keilin's organs are present. Head involution does not occur. A prominent abdominal denticle appears on the dorsal surface of the head and a few abdominal denticles are found behind the floor of the pharynx. Psc1 Asxunspecified Pclunspecified triple mutant embryos are characterised by a tandem array of posterior abdominal segments including up to four abdominal denticle bands in the head region. This phenotype is suppressed in embryos also lacking the bithorax complex region.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Enhanced by
    Statement
    Reference

    Pclunspecified has phenotype, enhanceable by E(Pc)1

    Suppressed by
    Statement
    Reference

    Pclunspecified has phenotype, suppressible by skd2

    Asx[-], Pclunspecified, Psc[-] has sex comb | ectopic phenotype, suppressible by esc+tEP4

    Asx[-], Pclunspecified, Psc[-] has sex comb | ectopic phenotype, suppressible by brm2

    NOT Enhancer of
    Statement
    Reference
    NOT Suppressor of
    Statement
    Reference
    Other
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The transformation seen in Pclunspecified heterozygotes is dominantly enhanced by Su(z)121, giving additional sex comb teeth on the second and third legs in male double heterozygous flies.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    Comments
    Comments

    Strongly affects the "co-suppression" seen in flies carrying increasing numbers of the P{Adhw.PR} transgene.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (10)