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General Information
Symbol
Dmel\NUAS.cBb
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct b of Baylies
FlyBase ID
FBal0052152
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of N.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies expressing NScer\UAS.cBb under the control of Scer\GAL4bs-1348 show a wing phenotype similar to Dp(1;2)51b flies.

Scer\GAL4sd-SG29.1-mediated expression does not change the general shape of the wing but leads to a mixture of neurogenic and antineurogenic effects: thickened veins and loss of bristles at the wing margin. Scer\GAL4Bx-MS1096-mediated expression leads to deletions of the anterior region of the wing and thickened veins. Scer\GAL4ptc-559.1-mediated expression produces small overgrowths at the distal part of the wing.

When expression is driven by Scer\GAL4Ubx.PdC in clones in the wing, outpocketings of the wing occur which include both Nint.G.Scer\UAS-expressing and neighboring wild type cells. Ectopic wing margin bristles appear in both mutant and wild type cells. The cells are smaller and have altered polarity. The effects are similar to but milder than those seen for Nint.G.Scer\UAS.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Coexpression of SerScer\UAS.cSa and NScer\UAS.cBb under the control of Scer\GAL4sd-SG29.1 generates very large wings with a clearly defined margin with an antineurogenic phenotype. Coexpression under the control of Scer\GAL4Bx-MS1096 results in normally shaped wings in which the dorsal surface has overgrown the ventral one. Coexpression under the control of Scer\GAL4ptc-559.1 causes ectopic ventral double margin is transformed into a single thick one and the ventral margin and associated overgrowth are extended into the dorsal surface of the wing.

Scer\GAL4h-1J3 induced coexpression of wgl-12.Scer\UAS and SerScer\UAS.cSa fails to cause ectopic wings, expression of P{UAS-N.Bb} with both wgl-12.Scer\UAS and SerScer\UAS.cSa causes ectopic wing development.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
NScer\UAS.cBb
NUAS.cBb
Name Synonyms
Saccharomyces cerevisiae UAS construct b of Baylies
Secondary FlyBase IDs
    References (9)