Open Close
General Information
Symbol
Mmus\NumbUAS.Tag:MYC
Species
M. musculus
Name
Saccharomyces cerevisiae UAS construct a of Zhong
FlyBase ID
FBal0052165
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a 3.3kb Mmus\Numb cDNA. Xenopus β-globin 5' UTR sequences sequence encoding a Tag:MYC epitope are added at the N-terminal end of the cDNA sequence. The encoded protein is predicted to have an additional 44 amino acid residues, MEEKLISEEDLEDGTRVKLRNLSKVTQLVKGTAKIQSQVVKVN, at the N-terminal end.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Mmus\NumbScer\UAS.cZa in the SOP lineage, under the control of Scer\GAL4sca-537.4 causes balding of the notum due to transformation of IIA daughter into a second IIB and subsequent transformation of IIIb's sheath daughter into another neuron, resulting in mutant external sensory organs with as many as four neurons.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Scer\GAL4h-1J3 induced expression rescues the neuronal phenotype of numb1 embryos and rescues the two dorsal most es organs in abdominal hemisegments to wild type.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Mmus\NumbScer\UAS.cZa
Mmus\NumbUAS.Tag:MYC
Mmus\numbUAS.cZa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Zhong
Secondary FlyBase IDs
    References (2)