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General Information
Symbol
Dmel\E(spl)mδ-HLHUAS.cdCa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of de Celis
FlyBase ID
FBal0052338
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-mδ, UAS-E(spl)mδ
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Expression of E(spl)mδ-HLH is governed by UAS regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of E(spl)mδ-HLHScer\UAS.cdCa in the somatic musculature, under the control of Scer\GAL4Mef2.PU causes a significant failure in SNa branching.

Expression of E(spl)mδ-HLHScer\UAS.cdCa in neurons, under the control of Scer\GAL4elav-C155, does not affect SNa branching.

Embryos expressing E(spl)mδ-HLHScer\UAS.cdCa in the somatic musculature, under the control of Scer\GAL4Mef2.PU show higher rates of muscle pattern failure, demonstrating a disordered muscle phenotype in 58% of hemisegments.

No extra neuroblasts are seen when E(spl)mδ-HLHScer\UAS.cdCa is expressed under the control of Scer\GAL4wor.PA or Scer\GAL4elav.PU.

In 14% of ommatidia expressing Scer\GAL4hs.2sev driven HLHmδScer\UAS.cdCa, some of the R1/6 precursors develop as R7-like cells.

Flies expressing HLHmδScer\UAS.cdCa under the control of Scer\GAL4dpp.blk1 have missing scutellar bristles.

Expression of HLHmδScer\UAS.cdCa under the control of Scer\GAL4pnr-MD237 inhibits the formation of both macro- and micro-chaetae, resulting in a bald stripe in the centre of the adult thorax.

When HLHmδScer\UAS.cdCa is driven by Scer\GAL4sca-109-68 R8 photoreceptor cells are sometimes missing. Adult eyes are small and rough.

Expression of HLHmδScer\UAS.cdCa under the control of Scer\GAL4ey.PB has no effect on either eye or antenna disc development.

When HLHmδScer\UAS.cdCa is driven by Scer\GAL4sca-537.4 bristle los is observed on the notum.

Scutellar bristles are completely suppressed in flies with HLHmδScer\UAS.cdCa driven by Scer\GAL4ptc-559.1. Scutellar bristles are completely suppressed in flies with HLHmδScer\UAS.cdCa driven by Scer\GAL4455.2.

Flies expressing HLHmδScer\UAS.cdCa under the control of Scer\GAL432B show loss of wing veins. Loss of notum microchaetae and wing margin bristles is seen. Flies expressing HLHmδScer\UAS.cdCa under the control of Scer\GAL4ap-md544 show loss of notum microchaetae and macrochaetae, except for a few central microchaetae and at the very anterior edge of the notum. Flies expressing HLHmδScer\UAS.cdCa under the control of Scer\GAL4455.2 show severe loss of scutellar bristles. Flies expressing HLHmδScer\UAS.cdCa under the control of Scer\GAL4h-1J3 show loss of notum macrochaetae.

Flies expressing two copies of HLHmδScer\UAS.cdCa under the control of two copies of Scer\GAL4h-H10 have much smaller eyes than normal which contain a few facets. Eye imaginal discs contain few ommatidia. These animals survive to pharate adulthood, occasionally producing adult escapers. Flies expressing one copy of HLHmβScer\UAS.cdCa under the control of one copy of Scer\GAL4h-H10 have a mild rough eye phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Enhancer of
Statement
Reference

Scer\GAL432B/E(spl)mδ-HLHUAS.cdCa is an enhancer of visible | recessive | heat sensitive phenotype of Nl1N-ts1

Suppressor of
Statement
Reference

Scer\GAL432B/E(spl)mδ-HLHUAS.cdCa is a suppressor of visible | recessive | heat sensitive phenotype of Nl1N-ts1

Phenotype Manifest In
NOT suppressed by
Enhancer of
Statement
Reference

Scer\GAL432B/E(spl)mδ-HLHUAS.cdCa is an enhancer of wing | heat sensitive phenotype of Nl1N-ts1

Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of HLHmδScer\UAS.cdCa partially suppresses the ectopic chaetae phenotype caused by expression of scScer\UAS.cPa under the control of Scer\GAL4pnr-MD237.

HLHmδScer\UAS.cdCa expressed under the control of Scer\GAL432B restores the distal wing margin and adjacent wing blade tissue that is missing in Df(1)N-54l9 heterozygotes. Expression of HLHmδScer\UAS.cdCa under the control of Scer\GAL432B enhances the scalloped wing phenotype seen in hemizygous Nl1N-ts1 flies shifted to the non-permissive temperature at the early third larval instar stage (72-84 hours after egg laying). Expression of HLHmδScer\UAS.cdCa under the control of Scer\GAL432B suppresses the nicked wing phenotype seen in hemizygous Nl1N-ts1 flies shifted to the non-permissive temperature at the mid third larval instar stage (96-108 hours after egg laying).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

The relative ability of UAS constructs of the E(spl) complex to induce wing vein deletion when expressed under the control of Scer\GAL432B is (ranked according to severity of phenotype): HLHmβScer\UAS.cdCa = HLHmγScer\UAS.cLa > E(spl)Scer\UAS.cNa = HLHm7Scer\UAS.cdCa > HLHmδScer\UAS.cdCa. The relative ability of UAS constructs of the E(spl) complex to induce loss of notum microchaetae when expressed under the control of Scer\GAL432B is (ranked according to severity of phenotype): E(spl)Scer\UAS.cNa > HLHm7Scer\UAS.cdCa >> HLHmγScer\UAS.cLa = HLHmβScer\UAS.cdCa = HLHm3Scer\UAS.cLa > HLHmδScer\UAS.cdCa. The relative ability of UAS constructs of the E(spl) complex to induce loss of wing margin bristles when expressed under the control of Scer\GAL432B is (ranked according to severity of phenotype): HLHm7Scer\UAS.cdCa > E(spl)Scer\UAS.cNa > HLHmγScer\UAS.cLa > HLHmδScer\UAS.cdCa > HLHmβScer\UAS.cdCa. The relative ability of UAS constructs of the E(spl) complex to induce loss of notum macrochaetae when expressed under the control of Scer\GAL4h-1J3 is (ranked according to severity of phenotype): E(spl)Scer\UAS.cNa > HLHm7Scer\UAS.cdCa > HLHmβScer\UAS.cdCa > HLHmδScer\UAS.cdCa > HLHmγScer\UAS.cLa = HLHm3Scer\UAS.cLa.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
E(spl)mδ-HLHScer\UAS.cdCa
E(spl)mδ-HLHUAS.cdCa
HLHmδScer\UAS.cdCa
HLHmδUAS.cdCa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of de Celis
Secondary FlyBase IDs
    References (19)