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General Information
Symbol
Dpse\l(2)gl+t12.2
Species
D. pseudoobscura pseudoobscura
Name
FlyBase ID
FBal0053678
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
P[l(2)gl]
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Construct: Included within a 12.2kb genomic BamHI-EcoRI fragment.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Four copies of P{D.ps6/5} leads to an arrest in early embryogenesis.

The timing of salivary gland histolysis (and of cellular vacuolisation which precedes the histolysis) is accelerated compared to wild type in D.melanogaster animals carrying four copies of Dpse\l(2)gl+t12.2. The duration of larval, prepupal and pupal development is normal in these animals.

Two hours after pupariation, the chromosomes of the salivary glands of D.melanogaster animals carrying four copies of Dpse\l(2)gl+t12.2 show none of the major puffs seen in wild-type prepupae of the same age. However, a puff is consistently seen in the 52A region, which usually occurs in very late prepupae.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

Dpse\l(2)gl+t12.2 is a suppressor of lethal | heat sensitive phenotype of l(2)glts3/Df(2L)net62

Dpse\l(2)gl+t12.2 is a suppressor of lethal | heat sensitive phenotype of l(2)glts2/Df(2L)net62

Dpse\l(2)gl+t12.2 is a suppressor of lethal | heat sensitive phenotype of Df(2L)net62/l(2)glts1

Other
Phenotype Manifest In
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

Dpse\l(2)gl+t12.2 is a suppressor of phenotype of l(2)gl334

Dpse\l(2)gl+t12.2 is a suppressor of phenotype of l(2)gl4

Dpse\l(2)gl+t12.2 is a suppressor | partially of phenotype of l(2)gl275

Other
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Expression of two copies of Dpse\l(2)gl+t12.2 raises the penetrance of the zip1/zip2 failed dorsal closure phenotype to 100%. Ubiquitous overexpression of zipFL.Scer\UAS.T:Avic\GFP, under the control of the Scer\GAL4sqh.PW, rescues dorsal closure in more than 84% of zip1/zip2; Dpse\l(2)gl+t12.2/Dpse\l(2)gl+t12.2 embryos. 61% of these rescued flies survive to hatch as larvae, 41% survive to pupal stages and 2.8% eclose as adults. Expression of zipFL.Scer\UAS.T:Avic\GFP in the epidermis and a few amnioserosa cells, driven by Scer\GAL4e22c, rescues the zip1/zip2; Dpse\l(2)gl+t12.2/Dpse\l(2)gl+t12.2 dorsal closure phenotype in 88% of embryos. Rescued flies survive to larval stages in 60% of cases and to pupal stages in 21% of cases, although no flies eclose. Expression of zipFL.Scer\UAS.T:Avic\GFP in the amnioserosa, driven by Scer\GAL4c381, rescues the dorsal closure phenotype of Dpse\l(2)gl+t12.2/Dpse\l(2)gl+t12.2 mutants in 82% of embryos. However, none of the rescued embryos survive to larval stages. Similarly, when zipFL.Scer\UAS.T:Avic\GFP expression is driven in the leading edge by Scer\GAL4LE, dorsal closure is rescued in 87% of embryos, but only 1% of flies survive to larval stages. zipFL.Scer\UAS.T:Avic\GFP expression in epidermal stripes, driven by Scer\GAL4en-e16E, rescues dorsal closure in only half of embryos and does not rescue lethality.

Completely rescues the lethality of l(2)glts1, l(2)glts2 and l(2)glts3.

Completely rescues the mutant phenotype of l(2)gl4 and l(2)gl334.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Assayed in D.melanogaster for ability to rescue l(2)gl mutant phenotypes.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Dpse\l(2)gl+t12.2
Name Synonyms
Secondary FlyBase IDs
    References (5)