Expression of two copies of Dpse\l(2)gl+t12.2 raises the penetrance of the zip1/zip2 failed dorsal closure phenotype to 100%. Ubiquitous overexpression of zipFL.Scer\UAS.T:Avic\GFP, under the control of the Scer\GAL4sqh.PW, rescues dorsal closure in more than 84% of zip1/zip2; Dpse\l(2)gl+t12.2/Dpse\l(2)gl+t12.2 embryos. 61% of these rescued flies survive to hatch as larvae, 41% survive to pupal stages and 2.8% eclose as adults. Expression of zipFL.Scer\UAS.T:Avic\GFP in the epidermis and a few amnioserosa cells, driven by Scer\GAL4e22c, rescues the zip1/zip2; Dpse\l(2)gl+t12.2/Dpse\l(2)gl+t12.2 dorsal closure phenotype in 88% of embryos. Rescued flies survive to larval stages in 60% of cases and to pupal stages in 21% of cases, although no flies eclose. Expression of zipFL.Scer\UAS.T:Avic\GFP in the amnioserosa, driven by Scer\GAL4c381, rescues the dorsal closure phenotype of Dpse\l(2)gl+t12.2/Dpse\l(2)gl+t12.2 mutants in 82% of embryos. However, none of the rescued embryos survive to larval stages. Similarly, when zipFL.Scer\UAS.T:Avic\GFP expression is driven in the leading edge by Scer\GAL4LE, dorsal closure is rescued in 87% of embryos, but only 1% of flies survive to larval stages. zipFL.Scer\UAS.T:Avic\GFP expression in epidermal stripes, driven by Scer\GAL4en-e16E, rescues dorsal closure in only half of embryos and does not rescue lethality.