FlyBase Allele Report: Dmel\y[+mDint2]

5.2kb y gene fragment containing 2.8kb of 5' flanking and 0.13kb of 3' flanking DNA and lacking the intron that is the location of the tissue-specific bristle and tarsal claw enhancers.

(Roseman et al., 1995)

5.2kb SalI y gene intronless fragment containing 2.9kb of 5' flanking and 0.3kb of 3' flanking DNA.

(Patton et al., 1992)

Allele components

Product class / Tool use(s)

Regulatory region(s)

Encoded product / tool

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color

(Ring and Garza, 2003.6.10, Roseman et al., 2001)

visible

(Roseman et al., 2001)

Phenotype Manifest In

adult cuticle

(Roseman et al., 2001)

arista

(Ring and Garza, 2003.6.10)

macrochaeta

(Ring and Garza, 2003.6.10)

unguis

(Ring and Garza, 2003.6.10)

Detailed Description

Statement

Reference

y^- flies transformed with PBac{3HPy⁺} lack y⁺ pigmentation in bristles (all types), tarsal claw and arista.

(Ring and Garza, 2003.6.10)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, enhanceable by Pc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)^V/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, enhanceable by esc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)^V/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, enhanceable by Pc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, enhanceable by Scm^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)^V/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, enhanceable by Scm^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, enhanceable by esc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

NOT Enhanced by

Statement

Reference

su(Hw)^V/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, non-enhanceable by esc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, non-enhanceable by Scm^{ZnF-ΔSPM.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)^V/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, non-enhanceable by Scm^{ZnF-ΔSPM.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has abnormal body color phenotype, non-enhanceable by esc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, enhanceable by Pc^{ZnF.hs.Tag:FLAG}, su(Hw)⁷/su(Hw)^E8

(Roseman et al., 2001)

su(Hw)^V/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, enhanceable by esc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)^V/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, enhanceable by Pc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, enhanceable by Scm^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)^V/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, enhanceable by Scm^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, enhanceable by esc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

NOT Enhanced by

Statement

Reference

su(Hw)^V/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, non-enhanceable by esc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, non-enhanceable by Scm^{ZnF-ΔSPM.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)^V/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, non-enhanceable by Scm^{ZnF-ΔSPM.hs.Tag:FLAG}

(Roseman et al., 2001)

su(Hw)⁷/su(Hw)^E8, y^+mDint2 has adult cuticle phenotype, non-enhanceable by esc^{ZnF.hs.Tag:FLAG}

(Roseman et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of y^+mDint2 is reduced (in a background of reduced su(Hw)⁺) by the expression of tethered Pc, Scm or esc. In the case of Pc^{hs.T:su(Hw)-ZnF,T:Zzzz\FLAG}, the effect is seen without the use of heat shock. For Scm^{hs.T:su(Hw)-ZnF,T:Zzzz\FLAG} and esc^{hs.T:su(Hw)-ZnF,T:Zzzz\FLAG} heat shock must be applied daily. Expression in the body cuticle is less sensitive to repression than in the wing cuticle.