Allele Dmel\tkv^unspecified

General Information
Symbol	Dmel\tkv^unspecified	Species	D. melanogaster
Name		FlyBase ID	FBal0055978
Feature type	allele	Associated gene	Dmel\tkv
Also Known As	unspecified

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Tearle and Nusslein-Volhard, 1987) neuroanatomy defective (McCabe et al., 2004)
Phenotype Manifest In
	embryonic epidermis (Tearle and Nusslein-Volhard, 1987) genital disc primordium (Chen et al., 2005) synapse (McCabe et al., 2004) t-bar (McCabe et al., 2004)
Detailed Description
	Statement Reference Stage 15 tkv^unspecified embryos have 30-34 genital disc precursor cells, while wild type embryos have only 22 at this stage. (Chen et al., 2005) The number of T bars per active zone and bouton surface area per active zone is increased compared to wild type in the boutons of muscle 6/7 in mutant third instar larvae. 10 +/- 2% detachment of the presynaptic membrane is seen. (McCabe et al., 2004) Homozygotes do not exhibit a wing vein phenotype. (Yu et al., 1996) tkv^unspecified mutant embryos lack dorsal hypoderm. Internal organs appear normal and are extruded though the open dorsal side of the embryo. The ventral hypoderm is contracted. (Tearle and Nusslein-Volhard, 1987)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement Reference tkv^unspecified has phenotype, suppressible by Egfr^t1/Egfr^f11 (Diaz-Benjumea and Garcia-Bellido, 1990)
Suppressor of
Statement Reference dpp^d-ho/tkv^unspecified is a suppressor of phenotype of CycE^JP (Horsfield et al., 1998) tkv^unspecified/tkv^unspecified is a suppressor of phenotype of Egfr^t1/Egfr^f11 (Diaz-Benjumea and Garcia-Bellido, 1990, Diaz-Benjumea and Garcia-Bellido, 1990)
NOT Suppressor of
Statement Reference tkv^unspecified/tkv[+] is a non-suppressor of wing vein \| ectopic phenotype of Egfr^E1 (Li and Li, 2003)
Other
Statement Reference sog^EP2, tkv^unspecified has wing vein L4 phenotype (Yu et al., 1996, Yu et al., 1996) sog^EP7, tkv^unspecified has wing vein L4 phenotype (Yu et al., 1996, Yu et al., 1996) sog^EP7, tkv^unspecified has wing vein L5 phenotype (Yu et al., 1996, Yu et al., 1996)
Additional Comments
Genetic Interactions
Statement Reference Introduction of sog^EP2 into tkv^unspecified flies causes truncation of wing vein L4 and introduction of sog^EP7 causes severe truncation of wing veins L4 and L5. (Yu et al., 1996) Egfr^t1/Egfr^f11 shows a negative interaction in combination with tkv^unspecified/tkv^unspecified. (Diaz-Benjumea and Garcia-Bellido, 1990)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	tkv^KG01923 (Dworkin and Gibson, 2006) tkv^P906 (Tanimoto et al., 2000)
Rescued by	tkv^unspecified is rescued by tkv^hs.PR (Ruberte et al., 1995)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	tkv^unspecified unspecified (Yu et al., 1996, Diaz-Benjumea and Garcia-Bellido, 1990)
Name Synonym
Secondary FlyBase IDs

References ( 12 )
Research paper	Anderson et al., 2006, Dev. Biol. 297(2): 536--549 Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila. [FBrf0193889] Dworkin and Gibson, 2006, Genetics 173(3): 1417--1431 Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. [FBrf0193945] Chen et al., 2005, Dev. Biol. 281(2): 270--285 Allocation and specification of the genital disc precursor cells in Drosophila. [FBrf0187379] McCabe et al., 2004, Neuron 41(6): 891--905 Highwire regulates presynaptic BMP signaling essential for synaptic growth. [FBrf0175022] Li and Li, 2003, Genetics 164(1): 247--258 Drosophila gain-of-function mutant RTK Torso triggers ectopic Dpp and STAT signaling. [FBrf0158996] Tanimoto et al., 2000, Mol. Cell 5(1): 59--71 Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs. [FBrf0125394] Fuss and Hoch, 1998, Mech. Dev. 79(1-2): 83--97 Drosophila endoderm development requires a novel homeobox gene which is a target of Wingless and Dpp signalling. [FBrf0108180] Horsfield et al., 1998, Development 125(24): 5069--5078 decapentaplegic is required for arrest in G1 phase during Drosophila eye development. [FBrf0105843] Yu et al., 1996, Development 122(12): 4033--4044 The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development. [FBrf0091302] Ruberte et al., 1995, Cell 80(6): 889--897 An absolute requirement for both the Type II and Type I receptors, punt and thick veins, for Dpp signaling in vivo. [FBrf0080361] Diaz-Benjumea and Garcia-Bellido, 1990, Proc. Biol. Sci. 242: 36--44 Behaviour of cells mutant for an EGF receptor homologue of Drosophila in genetic mosaics. [FBrf0052884]
Stock list	Tearle and Nusslein-Volhard, 1987, D. I. S. 66: 209--269 Tubingen mutants and stock list. [FBrf0045941]

Allele Dmel\tkvunspecified

Allele Dmel\tkv^unspecified