FlyBase Allele Report: Dmel\spi[SCP1]

General Information

Symbol

Dmel\spi^SCP1

Species

D. melanogaster

Name

FlyBase ID

FBal0056119

Feature type

allele

Associated gene

Dmel\spi

Associated Insertion(s)

P{ry11}spi^SCP1

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Tio et al., 1994)

Mutagen

P-element activity

(Tio et al., 1994)

Progenitor genotype

Associated Insertion(s)

P{ry11}spi^SCP1

Cytology

Description

P{ry11} insertion within 5' flanking sequences.

(Tio et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:19,575,578..19,583,783

(Brown and Freeman, 2003, Tio et al., 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal

(Tio et al., 1994)

viable

(Tio et al., 1994)

visible

(Freeman, 1996, Tio et al., 1994)

visible | recessive

(Casci et al., 1999, Howes et al., 1998)

Phenotype Manifest In

eye

(Casci et al., 1999, Howes et al., 1998, Freeman, 1996)

eye photoreceptor cell

(Yamada et al., 2003)

photoreceptor

(Brown and Freeman, 2003)

retina & basal lamina

(Tio et al., 1994)

rhabdomere

(Tio et al., 1994)

Detailed Description

Statement

Reference

Mutant adults show a siginifican under-recruitment of photoreceptors in the eye. Misrotation of ommatidia is not seen.

(Brown and Freeman, 2003)

Homozygous ommatidia show a reduction in the number of photoreceptor neurons.

(Yamada et al., 2003)

Homozygotes have a rough eye phenotype.

(Casci et al., 1999, Howes et al., 1998)

95% homozygotes are viable. Homozygotes exhibit a rough eye phenotype, ommatidia have variable and reduced numbers of rhabdomeres and defects in the retinal basement membrane (cells with rhabdomeres appear below the retina). Hemizygotes exhibit enhanced rough eye phenotype and reduced viability.

(Tio et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

spi^SCP1 has visible | recessive phenotype, suppressible by sty[+]/sty^S73

(Casci et al., 1999)

spi^SCP1 has visible | recessive phenotype, suppressible by sty[+]/sty^S88

(Casci et al., 1999)

Enhancer of

Statement

Reference

spi^SCP1/spi[+] is an enhancer of abnormal cell polarity phenotype of S⁰⁵⁶⁷¹

(Brown and Freeman, 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

spi^SCP1 has eye photoreceptor cell phenotype, enhanceable by edl^JV/Df(2R)edl-L19

(Yamada et al., 2003)

Suppressed by

Statement

Reference

spi^SCP1 has eye phenotype, suppressible by sty[+]/sty^S73

(Casci et al., 1999)

spi^SCP1 has eye phenotype, suppressible by sty[+]/sty^S88

(Casci et al., 1999)

spi^SCP1 has eye phenotype, suppressible by Scer\GAL4^hs.2sev/aos::spi^AS.UAS

(Howes et al., 1998)

Enhancer of

Statement

Reference

spi^SCP1/spi[+] is an enhancer of ommatidium phenotype of S⁰⁵⁶⁷¹

(Brown and Freeman, 2003)

spi^SCP1/spi[+] is an enhancer of photoreceptor phenotype of S⁰⁵⁶⁷¹

(Brown and Freeman, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The loss of photoreceptor neurons seen in spi^SCP1/spi^SCP1 animals is enhanced by edl^JV/Df(2R)edl-L19.

(Yamada et al., 2003)

Null alleles of ru interact dominantly with spi^SCP1 and spi^SCP2.

(Wasserman et al., 2000)

The spi^SCP1 rough eye phenotype is dominantly suppressed by sty^S73 or sty^S88.

(Casci et al., 1999)

The rough eye phenotype is partially rescued by argos::spi^AS.Scer\UAS expressed under the control of Scer\GAL4^hs.2sev.

(Howes et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

spi^SCP1 is rescued by spi^s.sev

(Freeman, 1996)

Comments

spi^s.sev can rescue the eye specific mutation.

(Freeman, 1996)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

spi^SCP1

spi^scp1

(Brown and Freeman, 2003, Wasserman et al., 2000, Casci et al., 1999, Howes et al., 1998)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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