FlyBase Allele Report: Dmel\spi[SC2]

General Information

Symbol

Dmel\spi^SC2

Species

D. melanogaster

Name

FlyBase ID

FBal0056121

Feature type

allele

Associated gene

Dmel\spi

Associated Insertion(s)

Carried in Construct

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Tio et al., 1994)

Mutagen

ethyl methanesulfonate

(Tio et al., 1994)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

lethal | recessive

(Tio et al., 1994)

Phenotype Manifest In

ommatidium | somatic clone

(Tio and Moses, 1997)

photoreceptor cell R2

(Tio et al., 1994)

photoreceptor cell R2 | somatic clone

(Tio and Moses, 1997)

photoreceptor cell R3

(Tio et al., 1994)

photoreceptor cell R4

(Tio et al., 1994)

photoreceptor cell R5

(Tio et al., 1994)

photoreceptor cell R5 | somatic clone

(Tio and Moses, 1997)

photoreceptor cell R8

(Tio et al., 1994)

Detailed Description

Statement

Reference

spi^SC2 Minute clones in the eye disc do not affect the formation of rosettes and arcs of cells in the morphogenetic furrow.

(Brown et al., 2006)

Large homozygous clones crossing the dorsal/ventral boundary are recovered in the wing and they show no phenotype.

(Nagaraj et al., 1999)

In mutant eye clones the initial single neuron stage ommatidia appear normal, as do their spacing. However no further progression occurs, and the clusters appear to be arrested at the one neuron stage. The wave of DNA synthesis immediately following the furrow is unaffected in spi mutant clones. The early development of the preclusters is normal up until the 5-cell stage. Development proceeds normally anterior to and in the furrow (up to the specification and early differentiation of the founding R8 photoreceptor cells) but the specification of R2 and R5, and all subsequent steps, fail. Homozygous spi mutant clones are apparently equal in size to their homozygous wild-type twin-spots.

(Tio and Moses, 1997)

Retinal clones induced during first larval instar show defects in the formation of photoreceptor cells R8, R2, R5, R3 and R4.

(Tio et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

spi^SC2 is an enhancer of phenotype of Egfr^E1

(Tio et al., 1994)

NOT Enhancer of

Statement

Reference

spi^SC2 is a non-enhancer | somatic clone of photoreceptor cell R8 | increased number phenotype of ed^4.12

(Rawlins et al., 2003)

NOT Suppressor of

Statement

Reference

spi^SC2 is a non-suppressor | somatic clone of photoreceptor cell R8 | increased number phenotype of ed^4.12

(Rawlins et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The ed^4.12 R8 cell twinning phenotype is not affected in spi^SC2 homozygous clones in a ed^4.12 background.

(Rawlins et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

spi^SC2

(Brown et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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