Allele Dmel\spi^SC2

General Information
Symbol	Dmel\spi^SC2	Species	D. melanogaster
Name		FlyBase ID	FBal0056121
Feature type	allele	Associated gene	Dmel\spi

Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Tio et al., 1994)
Mutagen	ethyl methanesulfonate (Tio et al., 1994)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Tio et al., 1994)
Phenotype Manifest In
	ommatidium \| somatic clone (Tio and Moses, 1997) photoreceptor cell R2 (Tio et al., 1994) photoreceptor cell R2 \| somatic clone (Tio and Moses, 1997) photoreceptor cell R3 (Tio et al., 1994) photoreceptor cell R4 (Tio et al., 1994) photoreceptor cell R5 (Tio et al., 1994) photoreceptor cell R5 \| somatic clone (Tio and Moses, 1997) photoreceptor cell R8 (Tio et al., 1994)
Detailed Description
	Statement Reference spi^SC2 Minute clones in the eye disc do not affect the formation of rosettes and arcs of cells in the morphogenetic furrow. (Brown et al., 2006) Large homozygous clones crossing the dorsal/ventral boundary are recovered in the wing and they show no phenotype. (Nagaraj et al., 1999) In mutant eye clones the initial single neuron stage ommatidia appear normal, as do their spacing. However no further progression occurs, and the clusters appear to be arrested at the one neuron stage. The wave of DNA synthesis immediately following the furrow is unaffected in spi mutant clones. The early development of the preclusters is normal up until the 5-cell stage. Development proceeds normally anterior to and in the furrow (up to the specification and early differentiation of the founding R8 photoreceptor cells) but the specification of R2 and R5, and all subsequent steps, fail. Homozygous spi mutant clones are apparently equal in size to their homozygous wild-type twin-spots. (Tio and Moses, 1997) Retinal clones induced during first larval instar show defects in the formation of photoreceptor cells R8, R2, R5, R3 and R4. (Tio et al., 1994)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement Reference spi^SC2 is an enhancer of phenotype of Egfr^E1 (Tio et al., 1994)
NOT Enhancer of
Statement Reference spi^SC2 is a non-enhancer \| somatic clone of photoreceptor cell R8 \| supernumerary phenotype of ed^4.12 (Rawlins et al., 2003)
NOT Suppressor of
Statement Reference spi^SC2 is a non-suppressor \| somatic clone of photoreceptor cell R8 \| supernumerary phenotype of ed^4.12 (Rawlins et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference The ed^4.12 R8 cell twinning phenotype is not affected in spi^SC2 homozygous clones in a ed^4.12 background. (Rawlins et al., 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	spi^SC2 (Brown et al., 2006)
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Brown et al., 2006, Dev. Biol. 300(2): 710--721 Epithelial cell adhesion in the developing Drosophila retina is regulated by Atonal and the EGF receptor pathway. [FBrf0192868] Rawlins et al., 2003, Development 130(16): 3715--3724 Echinoid limits R8 photoreceptor specification by inhibiting inappropriate EGF receptor signalling within R8 equivalence groups. [FBrf0160869] Nagaraj et al., 1999, Development 126(5): 975--985 Role of the EGF receptor pathway in growth and patterning of the Drosophila wing through the regulation of vestigial. [FBrf0107900] Tio and Moses, 1997, Development 124(2): 343--351 The Drosophila TGF homolog Spitz acts in photoreceptor recruitment in the developing retina. [FBrf0092704] Tio et al., 1994, Mech. Dev. 48(1): 13--23 spitz, a Drosophila homolog of transforming growth factor-, is required in the founding photoreceptor cells of the compound eye facets. [FBrf0079521]

Allele Dmel\spiSC2

Allele Dmel\spi^SC2