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General Information
Symbol
Dmel\lncRNA:roX1MB710
Species
D. melanogaster
Name
FlyBase ID
FBal0056222
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
roX1mb710
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion in the roX1 gene about 1.4kb from the 5' end.
Insertion of P{lArB} element into roX1.
Insertion components
P{lArB}lncRNA:roX1MB710
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Normal male development is seen in roX1MB710 animals.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Only 5% of roX1MB710 Df(1)52 hemizygous males with P{w+4Δ4.3} survive to adulthood, but these animals are abundant and healthy at late third instar.
Xenogenetic Interactions
Statement
Reference
The presence of roX1::Dpse\roX1Δ39pseudo.Hsp83 rescues roX1MB710 Df(1)52 male viability.
Complementation and Rescue Data
Comments
The presence of roX1Scer\UAS.cKa (without a Scer\GAL4 driver) fails to rescue the viability found in roX1MB710 Df(1)52 double mutant males. When the polytene chromosomes of these dying males are examined, the X chromosome exhibits collapsed morphology and very low levels of bound MSL proteins. However, the autosomal region around the transgene insertion site (within 1-2Mbp) is heavily coated with MSL complex in all nuclei. The presence of roX1Δ39 rescues roX1MB710 Df(1)52 male viability. The presence of roX1ΔReg1.Hsp83 partially rescues roX1MB710 Df(1)52 male viability to 47% of wild-type levels. The presence of roX1ΔSL1.Hsp83 fails to rescue roX1MB710 Df(1)52 male viability to wild-type levels. The presence of roX1ΔIRB.Hsp83 partially rescues roX1MB710 Df(1)52 male viability to 62% of wild-type levels. The presence of roX1ΔIRB.Hsp83 partially rescues roX1MB710 Df(1)52 male viability to 10% of wild-type levels. The presence of roX1ΔAB.Hsp83 partially rescues roX1MB710 Df(1)52 male viability to 12% of wild-type levels. The presence of roX1ΔRB1.Hsp83 partially rescues roX1MB710 Df(1)52 male viability to 38% of wild-type levels. The presence of roX1ΔRB2.Hsp83 partially rescues roX1MB710 Df(1)52 male viability to 60% of wild-type levels. The presence of roX1ΔRB3.Hsp83 partially rescues roX1MB710 Df(1)52 male viability to 47% of wild-type levels. The presence of roX1ΔRB123.Hsp83 fails to rescue roX1MB710 Df(1)52 male viability to wild-type levels. The presence of roX1ΔRB1-3.Hsp83 fails to rescue roX1MB710 Df(1)52 male viability to wild-type levels.
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments
MB710 P{lArB} element resides in a transcribed region that affects yin and roX1 expression.
External Crossreferences and Linkouts ( 1 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
Synonyms and Secondary IDs (7)
Reported As
Name Synonyms
Secondary FlyBase IDs
  • FBal0046868
References (13)