FB2025_01 , released February 20, 2025
Allele: Dmel\ptcUAS.cCa
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General Information
Symbol
Dmel\ptcUAS.cCa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Chen
FlyBase ID
FBal0056272
Feature type
allele
Associated gene
Dmel\ptc
Associated Insertion(s)
Carried in Construct
P{UAS(-FRT)ptc.C}
Also Known As
UAS-ptc
Key Links
Transgenic product class
wild_type
(Chen and Struhl, 1996)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Chen and Struhl, 1996)
Mutagen
FLPase
(Chen and Struhl, 1996)
Progenitor genotype
ptcFRT.UAS
(Chen and Struhl, 1996)
Carried in construct
P{UAS(-FRT)ptc.C}
Cytology
Description

FRT cassette has been excised, juxtaposing UAS regulatory sequences with ptc coding sequences.

(Chen and Struhl, 1996)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
ptc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Clones in the wing disc expressing ptcScer\UAS.cCa under the control of Scer\GAL4Act5C.PP are significantly smaller than control clones, covering only 65% of the area covered by control clones. Cell proliferation rates in the clone are decreased, but individual cell size and cell cycle phasing are unaffected.

      (Duman-Scheel et al., 2002)

      Scer\GAL4Bx-MS1096 induced wing clones that do not abut the A/P boundary develop normally. Clones that abut the boundary from either the anterior or posterior side cause mild patterning defects in the adult.

      (Chen and Struhl, 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Cdk4Scer\UAS.cMa and CycDScer\UAS.cDa suppresses the inhibition of growth seen in clones in the wing discs expressing ptcScer\UAS.cCa under the control of Scer\GAL4Act5C.PP. Expression of ptcScer\UAS.cCa under the control of Scer\GAL4Act5C.PP does not significantly reduce the size of clones induced in the wing disc in a Cdk43 mutant background.

      (Duman-Scheel et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ptcScer\UAS.cCa
      ptcUAS.cCa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Chen
      (Chen and Struhl, 1996)
      Secondary FlyBase IDs
        References (5)