Allele Dmel\edl^k06602

General Information
Symbol	Dmel\edl^k06602	Species	D. melanogaster
Name		FlyBase ID	FBal0057093
Feature type	allele	Associated gene	Dmel\edl
Also Known As	l(2)k06602, mae^k06602, l(2)k06602^k06602

Map ( GBrowse )	Untitled Document
Allele class	loss of function allele
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Baker et al., 2001)
Mutagen	P-element activity (Beaton, 1997.3.4, Roch et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 2R:14,561,159..14,561,159 (Beaton, 1997.3.4, BDGP Project Members, 1994-1999, Bianchi-Frias et al., 2004, Vivekanand et al., 2004, Baker et al., 2001, Roch et al., 1998, Spradling et al., 1999)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion of P{lacW} into the 5'UTR of the edl transcription unit 800bp upstream of the edl initiation codon. (Baker et al., 2001)
Caused by insertion	P{lacW}edl^k06602 (Beaton, 1997.3.4, BDGP Project Members, 1994-1999, Bianchi-Frias et al., 2004, Vivekanand et al., 2004, Baker et al., 2001, Roch et al., 1998, Spradling et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Roch et al., 1998, Spradling et al., 1999, Baker et al., 2001, Beaton, 1997.3.4) neuroanatomy defective (Tootle et al., 2003)
Phenotype Manifest In
	denticle belt & embryonic abdominal segment 1 (Baker et al., 2001) denticle belt & embryonic abdominal segment 2 (Baker et al., 2001) denticle belt & embryonic abdominal segment 3 (Baker et al., 2001) denticle belt & embryonic abdominal segment 4 (Baker et al., 2001) embryonic ventral epidermis & embryonic abdominal segment 1 (Baker et al., 2001) embryonic ventral epidermis & embryonic abdominal segment 2 (Baker et al., 2001) embryonic ventral epidermis & embryonic abdominal segment 3 (Baker et al., 2001) embryonic ventral epidermis & embryonic abdominal segment 4 (Baker et al., 2001) presumptive embryonic/larval central nervous system (Tootle et al., 2003)
Detailed Description
	Statement Reference Neuronal differentiation in the central nervous system is inhibited in homozygous embryos. (Tootle et al., 2003) Denticle belts are narrowed along the midline, in abdominal segments 1 to 4. This is reminiscent of phenotypes shown by rho and pnt mutant embryos. (Baker et al., 2001) Lethality occurs during third instar larval or pupal stages. Mutants do not show any visible disc abnormalities. (Roch et al., 1998)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference edl[+]/edl^k06602 is an enhancer of visible phenotype of aop^ACT.sev (Vivekanand et al., 2004)
Suppressor of
Statement Reference edl[+]/edl^k06602 is a suppressor \| partially of visible phenotype of Ras85D^V12.sev (Tootle et al., 2003)
Other
Statement Reference edl[+]/edl^k06602, h²⁶ has lethal \| partially phenotype (Bianchi-Frias et al., 2004) edl[+]/edl^k06602, hⁱ²² has lethal \| partially phenotype (Bianchi-Frias et al., 2004) edl^k06602, h[+]/h²⁶ has lethal \| partially phenotype (Bianchi-Frias et al., 2004) edl^k06602, h²⁶ has lethal \| partially phenotype (Bianchi-Frias et al., 2004, Bianchi-Frias et al., 2004) edl^k06602, hⁱ²²/h[+] has lethal \| partially phenotype (Bianchi-Frias et al., 2004) edl^k06602, hⁱ²² has lethal \| partially phenotype (Bianchi-Frias et al., 2004, Bianchi-Frias et al., 2004)
Phenotype Manifest In
Enhancer of
Statement Reference edl[+]/edl^k06602 is an enhancer of eye phenotype of aop^ACT.sev (Vivekanand et al., 2004)
Suppressor of
Statement Reference edl[+]/edl^k06602 is a suppressor \| partially of eye phenotype of Ras85D^V12.sev (Tootle et al., 2003) edl[+]/edl^k06602 is a suppressor \| partially of ommatidium phenotype of Ras85D^V12.sev (Tootle et al., 2003) edl[+]/edl^k06602 is a suppressor \| partially of photoreceptor cell R7 \| supernumerary phenotype of Ras85D^V12.sev (Tootle et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference The rough eye phenotype caused by aop^ACT.sev is enhanced if the flies also carry edl^k06602/+. (Vivekanand et al., 2004)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	edl^k12907 (BDGP Project Members, 1994-1999)
Comments
Stocks ( 2 )
Bloomington	10633 y¹ w^67c23; P{lacW}edl^k06602/CyO
Kyoto	102488 y¹ w^67c23 ; P{lacW}edl^k06602 / CyO
Notes on Origin
Discoverer

Comments
	Complements: l(2)08717⁰⁸⁷¹⁷. (BDGP Project Members, 1994-1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	66/2 (Roch et al., 1998) edl^k06602 l(2)k06602 (Vivekanand et al., 2004, Tootle et al., 2003, Spradling et al., 1999) l(2)k06602^k06602 (Beaton, 1997.3.4, BDGP Project Members, 1994-1999, ) mae^k06602 (Bianchi-Frias et al., 2004, Baker et al., 2001, )
Name Synonym
Secondary FlyBase IDs

References ( 9 )
Research paper	Bianchi-Frias et al., 2004, PLoS Biol. 2(7): e178 Hairy transcriptional repression targets and cofactor recruitment in Drosophila. [FBrf0179136] Vivekanand et al., 2004, Mech. Dev. 121(12): 1469--1479 MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN. [FBrf0180485] Tootle et al., 2003, Development 130(5): 845--857 CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE. [FBrf0157239] Baker et al., 2001, Nature 411(6835): 330--334 Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila. [FBrf0135901] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Roch et al., 1998, Mol. Gen. Genet. 257(2): 103--112 Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: clonal analysis and morphology of imaginal discs. [FBrf0100624]
Personal communication to FlyBase	Beaton, 1999.12.12, Alleles of the lines in the P-element paper. Alleles of the lines in the P-element paper. [FBrf0125032] Beaton, 1997.3.4, Update: Deficiencies. Update: Deficiencies. [FBrf0092781] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]

Allele Dmel\edlk06602

Allele Dmel\edl^k06602