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General Information
Symbol
Dmel\Sec61αk04917
Species
D. melanogaster
Name
FlyBase ID
FBal0057094
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion in the second intron.

Insertion components
P{lacW}Sec61αk04917
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
 

Transheterozygous combination of Sec61αk04917/Sec61αEP2567 suppresses neurodegenerative disease induced by Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1.

Phenotypic Data
Phenotypic Class
Phenotype Manifest In

autophagic vacuole & larval fat body | somatic clone | cell autonomous

lysosome & larval fat body | somatic clone | cell autonomous

Detailed Description
Statement
Reference

Sec61α1/Sec61αk04917 animals show 46 +/- 6% embryonic lethality, with the majority of the animals dying during the early first larval instar.

Homozygous animals show 58 +/- 8% embryonic lethality, with the remainder of the animals dying during the early first larval instar.

Sec61αk04917 clones in fat bodies from well-fed early third instar larvae accumulate lysosomes, as indicated by elevated LysoTracker staining, and show redistribution of the Atg8a product into autophagosomes.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

Sec61αk04917/Sec61alpha[+] is a suppressor of visible | heat sensitive phenotype of peb1

Phenotype Manifest In
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

Sec61αt4.4 rescues the lethality of Sec61αk04917 so that more than 70% of the rescued animals are viable as adults.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

Lethality is revertable on excision of the P{lacW}.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)