Allele Dmel\fra^Scer\UAS.cKa

General Information
Symbol	Dmel\fra^Scer\UAS.cKa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Kolodziej	FlyBase ID	FBal0057431
Feature type	allele	Associated gene	Dmel\fra

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Kolodziej et al., 1996)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: EcoRI-XbaI DNA fragment containing nucleotides 1-5038 from the shorter isoform of fra cDNA is cloned into pUAST. (Kolodziej et al., 1996)
Carried in construct	P{UAS-fra} (Kolesnikov and Beckendorf, 2005, Bhat, 2005, Keleman and Dickson, 2001, Hu, 2005, Kim et al., 2002, Hiramoto et al., 2000, Kolodziej et al., 1996, Dorsten et al., 2007, von Hilchen et al., 2010, Morikawa et al., 2011, Simionato et al., 2007, Joly et al., 2007, Mauss et al., 2009, Song et al., 2011, Timofeev et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective, with Scer\GAL4^eve.CQ2 (Mauss et al., 2009)
Phenotype Manifest In
	motor neuron, with Scer\GAL4^eve.CQ2 (Mauss et al., 2009) presumptive embryonic salivary gland, with Scer\GAL4^prd.RG1 (Kolesnikov and Beckendorf, 2005)
Detailed Description
	Statement Reference Expression of fra[Scer\UAS.cKa] in all R cells (using Scer\GAL4[GMR.long] as a driver) does not result in the redirection of R7 axons to the M3 layer, with many R8 axons remaining in the temporary layer. (Timofeev et al., 2012) Expression of fra[Scer\UAS.cKa] in a wild-type background n MN-LL1 neurons under the control of Scer\GAL4[eve.CQ2] leads to a greater proportion of dendritic branches innervating the intermediate neuropile. MN-DA3 expression of fra[Scer\UAS.cKa] leads to ectopic innervation of the intermediate neuropile in 50% of cases, converting the dendritic arbor to a MN-LL1-like morphology. Overexpression in MN-LL1 or MN-DA3 does not lead to ectopic midline targeting of dendrites. (Mauss et al., 2009) Ventral nerve cord axon bundles of stage 16 embryos overexpressing fra[Scer\UAS.cKa] via Scer\GAL4[ftz.ng] do not display any incorrect midline crossing. (Dorsten et al., 2007) Expression of fra^Scer\UAS.cKa under the control of Scer\GAL4^elav.PLu does not result in any axon guidance defects in embryos. (Bhat, 2005) Expression of fra^Scer\UAS.cKa in the salivary gland, driven by Scer\GAL4^prd.RG1, causes 75% of glands to aberrantly curve medially. (Kolesnikov and Beckendorf, 2005) Embryos expressing fra^Scer\UAS.cKa under the control of Scer\GAL4^ftz.ng develop normally. (Kim et al., 2002) Scer\GAL4¹⁴⁰⁷ induced expression fails to cause defects in the CNS or PNS projections, viable adult flies are recovered. (Kolodziej et al., 1996)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng, fra^Scer\UAS.cKa has neuroanatomy defective \| embryonic stage 16 phenotype, enhanceable by Abl⁴ (Dorsten et al., 2007) Rho1^V14.Scer\UAS, Scer\GAL4^ftz.ng, fra^Scer\UAS.cKa has neuroanatomy defective \| embryonic stage 16 phenotype, enhanceable by Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng (Dorsten et al., 2007)
Suppressed by
Statement Reference Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng, fra^Scer\UAS.cKa has neuroanatomy defective \| embryonic stage 16 phenotype, suppressible by Abl⁴/Abl[+] (Dorsten et al., 2007) Rho1^V14.Scer\UAS, Scer\GAL4^ftz.ng, fra^Scer\UAS.cKa has neuroanatomy defective \| embryonic stage 16 phenotype, suppressible by sqh^{T20A.S21A.Scer\UAS}, Scer\GAL4^ftz.ng (Dorsten et al., 2007)
Enhancer of
Statement Reference fra^Scer\UAS.cKa, Scer\GAL4^ftz.ng is an enhancer of neuroanatomy defective \| embryonic stage 16 phenotype of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}, Scer\GAL4^ftz.ng (Dorsten et al., 2007) fra^Scer\UAS.cKa, Scer\GAL4^ftz.ng is an enhancer of neuroanatomy defective \| embryonic stage 16 phenotype of Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng (Dorsten et al., 2007) fra^Scer\UAS.cKa, Scer\GAL4^ftz.ng is an enhancer of neuroanatomy defective \| embryonic stage 16 phenotype of Rac1^V12.Scer\UAS, Scer\GAL4^ftz.ng (Dorsten et al., 2007) fra^Scer\UAS.cKa, Scer\GAL4^ftz.ng is an enhancer of neuroanatomy defective \| embryonic stage 16 phenotype of Rho1^V14.Scer\UAS, Scer\GAL4^ftz.ng (Dorsten et al., 2007) fra^Scer\UAS.cKa, Scer\GAL4^ftz.ng is an enhancer of neuroanatomy defective phenotype of Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng (Kim et al., 2002)
NOT Enhancer of
Statement Reference fra^Scer\UAS.cKa/Scer\GAL4^elav.PLu is a non-enhancer of neuroanatomy defective phenotype of sli^E-158 (Bhat, 2005)
Suppressor of
Statement Reference fra^Scer\UAS.cKa/Scer\GAL4^ppk.1.9 is a suppressor of neuroanatomy defective phenotype of Trim9⁴⁶ (Song et al., 2011) Scer\GAL4^prd.RG1/fra^Scer\UAS.cKa is a suppressor of lethal \| adult stage phenotype of Df(2R)en-SFX31, fra¹ (Joly et al., 2007) Scer\GAL4^prd.RG1/fra^Scer\UAS.cKa is a suppressor of neuroanatomy defective phenotype of Df(2R)en-SFX31, fra¹ (Joly et al., 2007)
NOT Suppressor of
Statement Reference fra^Scer\UAS.cKa/Scer\GAL4^elav.PLu is a non-suppressor of lethal \| adult stage phenotype of Df(2R)en-SFX31, fra¹ (Joly et al., 2007) fra^Scer\UAS.cKa/Scer\GAL4^elav.PLu is a non-suppressor of neuroanatomy defective phenotype of Df(2R)en-SFX31, fra¹ (Joly et al., 2007) Scer\GAL4^ap-md544, fra³, fra⁴, fra^Scer\UAS.cKa is a non-suppressor of neuroanatomy defective phenotype of Scer\GAL4^ap-md544, unc-5^{Scer\UAS.T:Ivir\HA1,T:SS-wg} (Keleman and Dickson, 2001) Scer\GAL4^eg-Mz360/fra^Scer\UAS.cKa is a non-suppressor of neuroanatomy defective phenotype of elav⁵ (Simionato et al., 2007)
Other
Statement Reference Abl⁴/Abl[+], Scer\GAL4^ftz.ng, fra^Scer\UAS.cKa has neuroanatomy defective \| embryonic stage 16 phenotype (Dorsten et al., 2007)
Phenotype Manifest In
Enhanced by
Statement Reference Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng, fra^Scer\UAS.cKa has midline crossing tract \| embryonic stage 16 phenotype, enhanceable by Abl⁴ (Dorsten et al., 2007) Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng, fra^Scer\UAS.cKa has ventral nerve cord commissure \| embryonic stage 16 phenotype, enhanceable by Abl⁴ (Dorsten et al., 2007) Rho1^V14.Scer\UAS, Scer\GAL4^ftz.ng, fra^Scer\UAS.cKa has midline crossing tract \| embryonic stage 16 phenotype, enhanceable by Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng (Dorsten et al., 2007) Rho1^V14.Scer\UAS, Scer\GAL4^ftz.ng, fra^Scer\UAS.cKa has ventral nerve cord commissure \| embryonic stage 16 phenotype, enhanceable by Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng (Dorsten et al., 2007)
Suppressed by
Statement Reference Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng, fra^Scer\UAS.cKa has midline crossing tract \| embryonic stage 16 phenotype, suppressible by Abl⁴/Abl[+] (Dorsten et al., 2007) Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng, fra^Scer\UAS.cKa has ventral nerve cord commissure \| embryonic stage 16 phenotype, suppressible by Abl⁴/Abl[+] (Dorsten et al., 2007) Rho1^V14.Scer\UAS, Scer\GAL4^ftz.ng, fra^Scer\UAS.cKa has midline crossing tract \| embryonic stage 16 phenotype, suppressible by sqh^{T20A.S21A.Scer\UAS}, Scer\GAL4^ftz.ng (Dorsten et al., 2007) Rho1^V14.Scer\UAS, Scer\GAL4^ftz.ng, fra^Scer\UAS.cKa has ventral nerve cord commissure \| embryonic stage 16 phenotype, suppressible by sqh^{T20A.S21A.Scer\UAS}, Scer\GAL4^ftz.ng (Dorsten et al., 2007)
Enhancer of
Statement Reference fra^Scer\UAS.cKa, Scer\GAL4^ftz.ng is an enhancer of longitudinal connective phenotype of Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng (Kim et al., 2002) fra^Scer\UAS.cKa, Scer\GAL4^ftz.ng is an enhancer of midline crossing tract \| embryonic stage 16 phenotype of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}, Scer\GAL4^ftz.ng (Dorsten et al., 2007) fra^Scer\UAS.cKa, Scer\GAL4^ftz.ng is an enhancer of midline crossing tract \| embryonic stage 16 phenotype of Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng (Dorsten et al., 2007) fra^Scer\UAS.cKa, Scer\GAL4^ftz.ng is an enhancer of midline crossing tract \| embryonic stage 16 phenotype of Rac1^V12.Scer\UAS, Scer\GAL4^ftz.ng (Dorsten et al., 2007) fra^Scer\UAS.cKa, Scer\GAL4^ftz.ng is an enhancer of midline crossing tract \| embryonic stage 16 phenotype of Rho1^V14.Scer\UAS, Scer\GAL4^ftz.ng (Dorsten et al., 2007) fra^Scer\UAS.cKa, Scer\GAL4^ftz.ng is an enhancer of ventral nerve cord commissure \| embryonic stage 16 phenotype of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}, Scer\GAL4^ftz.ng (Dorsten et al., 2007) fra^Scer\UAS.cKa, Scer\GAL4^ftz.ng is an enhancer of ventral nerve cord commissure \| embryonic stage 16 phenotype of Ggal\MLCK^ct.Scer\UAS, Scer\GAL4^ftz.ng (Dorsten et al., 2007) fra^Scer\UAS.cKa, Scer\GAL4^ftz.ng is an enhancer of ventral nerve cord commissure \| embryonic stage 16 phenotype of Rac1^V12.Scer\UAS, Scer\GAL4^ftz.ng (Dorsten et al., 2007) fra^Scer\UAS.cKa, Scer\GAL4^ftz.ng is an enhancer of ventral nerve cord commissure \| embryonic stage 16 phenotype of Rho1^V14.Scer\UAS, Scer\GAL4^ftz.ng (Dorsten et al., 2007)
NOT Enhancer of
Statement Reference fra^Scer\UAS.cKa/Scer\GAL4^elav.PLu is a non-enhancer of longitudinal connective phenotype of sli^E-158 (Bhat, 2005)
Suppressor of
Statement Reference fra^Scer\UAS.cKa/Scer\GAL4^ppk.1.9 is a suppressor of dopaminergic neuron phenotype of Trim9⁴⁶ (Song et al., 2011) fra^Scer\UAS.cKa/Scer\GAL4^ppk.1.9 is a suppressor of midline crossing tract phenotype of Trim9⁴⁶ (Song et al., 2011) Scer\GAL4^prd.RG1/fra^Scer\UAS.cKa is a suppressor of anterior commissure phenotype of Df(2R)en-SFX31, fra¹ (Joly et al., 2007) Scer\GAL4^prd.RG1/fra^Scer\UAS.cKa is a suppressor of lateral tract phenotype of Df(2R)en-SFX31, fra¹ (Joly et al., 2007) Scer\GAL4^prd.RG1/fra^Scer\UAS.cKa is a suppressor of posterior commissure phenotype of Df(2R)en-SFX31, fra¹ (Joly et al., 2007) Scer\GAL4^prd.RG1/fra^Scer\UAS.cKa is a suppressor of ventral nerve cord phenotype of Df(2R)en-SFX31, fra¹ (Joly et al., 2007)
NOT Suppressor of
Statement Reference fra³, fra⁴, fra^Scer\UAS.cKa is a non-suppressor of ventral nerve cord phenotype of Scer\GAL4^ap-md544, unc-5^{Scer\UAS.T:Ivir\HA1,T:SS-wg} (Keleman and Dickson, 2001) fra^Scer\UAS.cKa/Scer\GAL4^elav.PLu is a non-suppressor of anterior commissure phenotype of Df(2R)en-SFX31, fra¹ (Joly et al., 2007) fra^Scer\UAS.cKa/Scer\GAL4^elav.PLu is a non-suppressor of lateral tract phenotype of Df(2R)en-SFX31, fra¹ (Joly et al., 2007) fra^Scer\UAS.cKa/Scer\GAL4^elav.PLu is a non-suppressor of posterior commissure phenotype of Df(2R)en-SFX31, fra¹ (Joly et al., 2007) fra^Scer\UAS.cKa/Scer\GAL4^elav.PLu is a non-suppressor of ventral nerve cord phenotype of Df(2R)en-SFX31, fra¹ (Joly et al., 2007) Scer\GAL4^eg-Mz360/fra^Scer\UAS.cKa is a non-suppressor of commissure phenotype of elav⁵ (Simionato et al., 2007)
Other
Statement Reference Abl⁴/Abl[+], Scer\GAL4^ftz.ng, fra^Scer\UAS.cKa has midline crossing tract \| embryonic stage 16 phenotype (Dorsten et al., 2007) Abl⁴/Abl[+], Scer\GAL4^ftz.ng, fra^Scer\UAS.cKa has ventral nerve cord commissure \| embryonic stage 16 phenotype (Dorsten et al., 2007)
Additional Comments
Genetic Interactions
Statement Reference Overexpression of fra[Scer\UAS.cKa] under the control of Scer\GAL4[ppk.1.9] significantly suppresses the Trim9[46] midline crossing defects. (Song et al., 2011) Co-expression of fra[Scer\UAS.cKa] with Rac1[V12.Scer\UAS] under the control of Scer\GAL4[ftz.ng] results in a strong synergistic increase in the frequency of incorrect axon projections across the midline, compared with Rac1[V12.Scer\UAS]-overexpression alone. The frequency of crossovers across the midline in embryos expressing Rho1[V14.Scer\UAS] driven by Scer\GAL4[ftz.ng] is significantly increased by co-expression of fra[Scer\UAS.cKa]. Co-expression of sqh[T20A.S21A.Scer\UAS] under the control of Scer\GAL4[ftz.ng] suppresses the midline crossing phenotype in embryos expressing both Rho1[V14.Scer\UAS] and fra[Scer\UAS.cKa]. Ventral nerve cord axon bundles of stage 16 embryos overexpressing fra[Scer\UAS.cKa] via Scer\GAL4[ftz.ng] in a heterozygous Abl[4] genetic background display few incorrect midline crossings. (Dorsten et al., 2007) Expression of fra[Scer\UAS.cKa] in the early stages of axon pathfinding under the control of Scer\GAL4[prd.RG1] rescues axonal defects in even segments of fra[1]/Df(2R)en-SFX31 transheterozygous embryos. Approximately 60% of the segments display normal commissures, in contrast to fra[1]/Df(2R)en-SFX31 embryos, in which nearly all the segments are affected. A partial rescue of odd segments is also seen. In contrast, overexpression of fra[Scer\UAS.cKa] in later stages of development, under the control of Scer\GAL4[elav.PLu] does not rescue the the defects in ventral nerve cord architecture seen in fra[1]/Df(2R)en-SFX31 mutants. Overexpression of fra[Scer\UAS.cKa] under the control of Scer\GAL4[prd.RG1] does not suppress the abnormal pathfinding phenotype observed in Df(2R)en-SFX31 mutants. Expression of fra[Scer\UAS.cKa] in the early stages of axon pathfinding under the control of Scer\GAL4[prd.RG1] rescues axonal defects in even segments of fra[1]/Df(2R)en-SFX31 transheterozygous embryos. Approximately 60% of the segments display normal commissures, in contrast to fra[1]/Df(2R)en-SFX31 embryos, in which nearly all the segments are affected. A partial rescue of odd segments is also seen. In contrast, overexpression of fra[Scer\UAS.cKa] in later stages of development, under the control of Scer\GAL4[elav.PLu] does not rescue the the defects in ventral nerve cord architecture seen in fra[1]/Df(2R)en-SFX31 mutants. (Joly et al., 2007) Expression of fra[Scer\UAS.cKa] in elav[5] mutant EW and EG neurons (under the control of Scer\GAL4[eg-Mz360]) does not modify the proportion of contralateral projection defects in elav[5] mutant embryos. For example, EW axons fail to cross the midline in 755 of the neuromeres in such embryos. (Simionato et al., 2007) Expression of fra^Scer\UAS.cKa under the control of Scer\GAL4^elav.PLu does not enhance the sli^E-158 longitudinal tract phenotype. (Bhat, 2005)
Xenogenetic Interactions
Statement Reference Co-expression of fra[Scer\UAS.cKa] with Ggal\MLCK[ct.Scer\UAS] under the control of Scer\GAL4[ftz.ng] increases the frequency of axonal midline crossing abnormalities. Heterozygous Abl[4] almost completely suppresses the axonal midline crossing phenotype of embryos co-expressing Ggal\MLCK[ct.Scer\UAS] with fra[Scer\UAS.cKa] under the control of Scer\GAL4[ftz.ng]. Homozygous Abl[4] enhances the axonal midline crossing phenotype of embryos co-expressing Ggal\MLCK[ct.Scer\UAS] with fra[Scer\UAS.cKa] under the control of Scer\GAL4[ftz.ng]. The frequency of neuronal crossover projections induced by Scer\GAL4[ftz.ng]-driven expression of Abl::Hsap\ABL1::Hsap\BCR[P210.Scer\UAS] is significantly increased by co-expression of fra[Scer\UAS.cKa]. (Dorsten et al., 2007) The midline crossover phenotype caused expression of Ggal\MLCK^ct.Scer\UAS under the control of Scer\GAL4^ftz.ng is enhanced by coexpression of fra^Scer\UAS.cKa. (Kim et al., 2002)
Complementation & Rescue Data
Rescues	fra^Scer\UAS.cKa/Scer\GAL4^elav.PLu rescues fra³/fra⁴ (Keleman and Dickson, 2001) fra^Scer\UAS.cKa/Scer\GAL4^eve.CQ2 rescues fra³/fra⁴ (Mauss et al., 2009) Scer\GAL4⁶⁰⁵/fra^Scer\UAS.cKa rescues fra³/fra⁴ (Hiramoto et al., 2000) Scer\GAL4^gcm.PU/fra^Scer\UAS.cKa rescues fra³/fra⁴ (von Hilchen et al., 2010)
Partially rescues	fra^Scer\UAS.cKa/Scer\GAL4¹⁴⁰⁷ partially rescues fra³/fra⁴ (Kolodziej et al., 1996) Scer\GAL4^MZ1580/fra^Scer\UAS.cKa partially rescues fra³/fra⁴ (von Hilchen et al., 2010) Scer\GAL4^ppk.PG/fra^Scer\UAS.cKa partially rescues fra³/fra⁴ (Morikawa et al., 2011)
Fails to rescue	Scer\GAL4^15J2/fra^Scer\UAS.cKa fails to rescue fra³/fra⁴ (Hiramoto et al., 2000) Scer\GAL4^elav.PU/fra^Scer\UAS.cKa fails to rescue fra³/fra⁴ (von Hilchen et al., 2010) Scer\GAL4^how-24B, Scer\GAL4^how-24B, fra^Scer\UAS.cKa fails to rescue fra³/fra⁴ (Kolodziej et al., 1996) Scer\GAL4^Mz605/fra^Scer\UAS.cKa fails to rescue fra³/fra⁴ (von Hilchen et al., 2010) Scer\GAL4^pros.PMG/fra^Scer\UAS.cKa fails to rescue fra³/fra⁴ (von Hilchen et al., 2010) Scer\GAL4^repo/fra^Scer\UAS.cKa fails to rescue fra³/fra⁴ (von Hilchen et al., 2010)
Comments	Expression of fra[Scer\UAS.cKa] in C4da neurons under the control of Scer\GAL4[ppk.PG] partially rescues the axonal defects seen in fra[3]/fra[4] mutants. (Morikawa et al., 2011) Expression of fra[Scer\UAS.cKa] under the control of Scer\GAL4[gcm.PU] rescues the defects in interface glial cell migration seen in fra[3]/fra[4] embryos. Expression of fra[Scer\UAS.cKa] under the control of Scer\GAL4[MZ1580] weakly rescues the defects in interface glial cell migration seen in fra[3]/fra[4] embryos. The defects in interface glial cell migration seen in fra[3]/fra[4] embryos are not rescued by expression of fra[Scer\UAS.cKa] under the control of any one of Scer\GAL4[repo], Scer\GAL4[pros.PMG], Scer\GAL4[elav.PU] or Scer\GAL4[Mz605]. (von Hilchen et al., 2010) Expression of fra[Scer\UAS.cKa] under the control of Scer\GAL4[eve.CQ2] rescues dendritic targeting to the midline in fra[3]/fra[4] mutant MN-VO4-6 and MN-VO4/5 neurons. Expression of fra[Scer\UAS.cKa] under the control of Scer\GAL4[eve.CQ2] selectively in MN-LL1 neurons in fra[3]/fra[4] mutant embryos efficiently rescues dendritic targeting to the intermediate neuropile. Moreover, this manipulation leads to a greater proportion of dendritic branches innervating the intermediate neuropile. (Mauss et al., 2009) Expression of fra^Scer\UAS.cKa under the control of Scer\GAL4^15J2 does not rescue the dMP2 axonal phenotype of fra³/fra⁴ embryos. Expression of fra^Scer\UAS.cKa under the control of Scer\GAL4⁶⁰⁵ does rescue the dMP2 axonal phenotype of fra³/fra⁴ embryos. (Hiramoto et al., 2000) Scer\GAL4¹⁴⁰⁷ induced expression in fra³/fra⁴ embryos rescues the commissure phenotype, commissures form normally in abdominal segments A1-A7. ISN motor axons also innervate their targets at near wild type levels. Scer\GAL4^how-24B induced expression in fra³/fra⁴ embryos fails to rescue the ISN motor axon defects. (Kolodziej et al., 1996)
Stocks ( 1 )
Bloomington	8814 y¹ w^*; P{UAS-fra}3
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	fra^Scer\UAS.cKa fra^UAS.cKa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Kolodziej (Kolodziej et al., 1996)
Secondary FlyBase IDs

References ( 15 )
Research paper	Timofeev et al., 2012, Neuron 75(1): 80--93 Localized netrins act as positional cues to control layer-specific targeting of photoreceptor axons in Drosophila. [FBrf0218874] Morikawa et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(48): 19389--19394 Different levels of the Tripartite motif protein, Anomalies in sensory axon patterning (Asap), regulate distinct axonal projections of Drosophila sensory neurons. [FBrf0216734] Song et al., 2011, J. Genet. Genomics 38(1): 1--11 TRIM-9 functions in the UNC-6/UNC-40 pathway to regulate ventral guidance. [FBrf0213082] von Hilchen et al., 2010, Development 137(8): 1251--1262 Netrins guide migration of distinct glial cells in the Drosophila embryo. [FBrf0210391] Mauss et al., 2009, PLoS Biol. 7(9): e1000200 Midline signalling systems direct the formation of a neural map by dendritic targeting in the Drosophila motor system. [FBrf0208790] Dorsten et al., 2007, Dev. Biol. 308(1): 120--132 Frazzled regulation of myosin II activity in the Drosophila embryonic CNS. [FBrf0200818] Joly et al., 2007, Dev. Biol. 301(2): 542--554 Engrailed controls the organization of the ventral nerve cord through frazzled regulation. [FBrf0194180] Simionato et al., 2007, Dev. Biol. 301(1): 166--177 The Drosophila RNA-binding protein ELAV is required for commissural axon midline crossing via control of commissureless mRNA expression in neurons. [FBrf0193348] Bhat, 2005, Genetics 170(1): 149--159 Slit-roundabout signaling neutralizes Netrin-Frazzled-mediated attractant cue to specify the lateral positioning of longitudinal axon pathways. [FBrf0187630] Kolesnikov and Beckendorf, 2005, Dev. Biol. 284(1): 102--111 NETRIN and SLIT guide salivary gland migration. [FBrf0187388] Kim et al., 2002, Dev. Biol. 249(2): 367--381 Constitutively active myosin light chain kinase alters axon guidance decisions in Drosophila embryos. [FBrf0151882] Keleman and Dickson, 2001, Neuron 32(4): 605--617 Short- and long-range repulsion by the Drosophila Unc5 Netrin receptor. [FBrf0141688] Kolodziej et al., 1996, Cell 87(2): 197--204 frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. [FBrf0090650]
Supplementary material	Hu, 2005, Proc. Natl. Acad. Sci. USA 102(12): [title not yet available] [FBrf0191477]
Letter	Hiramoto et al., 2000, Nature 406(6798): 886--889 The Drosophila Netrin receptor Frazzled guides axons by controlling Netrin distribution. [FBrf0129858]

Allele Dmel\fraScer\UAS.cKa

Allele Dmel\fra^Scer\UAS.cKa