FlyBase Allele Report: Dmel\fra[4]

In 33 out of 72 abdominal segments examined in fra³/fra⁴ third instar larvae, the LCh1 cap cell migrates ventrally instead of dorsally; in 14 of 33 segments the cap cell travels along the ventral midline (along the VChA and VChB organs) and morphology of cap cells is largely normal, while in the remaining 19 segments the LCh1 cap cell often migrates towards the LCh5 LA cell and then turns ventrally after contact with the LA cell and cap cell morphology is abnormal. Similar phenotypes are seen with the migrating VChB cap cell, where in 18 out of 72 mutant segments it does not reach or attach to the LA cell.

(Halachmi et al., 2016)

fra³/fra⁴ embryos show thinning of commissures in the central nervous system, with the EW axons failing to cross the midline in 30% of abdominal segments.

(Evans et al., 2015)

Levels of apoptosis are not increased in the thoracic and abdominal segments of the fra⁴ mutant ventral nerve cord.

(Newquist et al., 2013)

fra³/fra⁴ mutants exhibit defects in Fas2-positive axons, including occasional breaks in longitudinal pathways, although the fascicles always remain ipsilateral.

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ mutants exhibit virtually complete loss of commissural fascicles of C4da neurons. Furthermore the terminal processes of C4da axons in fra³/fra⁴ mutants appear to lose the asymmetric orientation towards the midline.

(Morikawa et al., 2011)

fra³/fra⁴ embryos display display commissure loss. One of the predominant defects in fra³/fra⁴ mutants is thinning and missing posterior commissures, with nearly a quarter of segments showing this defect.

Fas2-positive fascicles tend to fuse together or form small gaps in fra³/fra⁴ embryos.

Defects characterised by Fas2-positive axons ectopically exiting the central nervous system (CNS) are not observed in fra³/fra⁴ mutant embryos.

(Dorsten et al., 2010)

Some hemisegments in fra³/fra⁴ embryos have ectopic glial cell clusters in the dorsal periphery.

(von Hilchen et al., 2010)

In fra³/fra⁴ mutant embryos, dendritic targeting to the midline is abolished in MN-VO4-6 and MN-VO4/5 projecting neurons.

In fra³/fra⁴ mutant embryos, 63% of MN-LL1 dendritic arbors lack the normally pronounced intermediate dendritic arborisation, while targeting of MN-DA3 dendrites is not significantly affected. MN-LL1 has a clearly reduced innervation of the intermediate neuropile in 63-64% of cases.

(Mauss et al., 2009)

fra⁴/fra⁶ mutant embryos have normal commissure formation and a mild EW axon crossing defect.

(Yang et al., 2009)

26% of fra³/fra⁴ embryos show defects in axon guidance in the Bolwig's nerve.

fra³/fra⁴ embryos show defects in the commissures of the central nervous system; 2% of anterior commissures are absent, 4% of anterior commissures are thin, 3% of posterior commissures are absent and 8% of posterior commissures are thin. 8% of segments fail to separate the anterior and posterior commissures correctly.

(Andrews et al., 2008)

Heterozygous fra⁴ stage 16 embryos do not display abnormal midline crossing axon tract projections.

(Dorsten et al., 2007)

EW axons frequently fail to cross the midline in fra³/fra⁴ mutant embryos. The trajectories of the EG axons are unaffected in these mutants.

(Garbe et al., 2007)

13% of segments have thin/missing commissures and 8% of segment have commissures with pathfinding errors in fra⁴/Df(2R)vg135 embryos. Breaks in the longitudinal connectives are seen in 10% of these embryos 23% of segments have thin/missing commissures and 13% of segment have commissures with pathfinding errors in fra⁴/fra⁴ embryos.

(Forsthoefel et al., 2005)

fra³/fra⁴ transheterozygote embryos show salivary gland guidance defects. Most mutants have salivary glands that lie parallel to the CNS midline as in wild type. However, in 4% of mutants, the glands curve laterally away from the midline and in 2% of mutants, the glands curve medially toward the midline.

(Kolesnikov and Beckendorf, 2005)

fra³/fra⁴ embryos exhibit breaks in Con-positive commissural axons and longitudinal tracts.

(Ratnaparkhi et al., 2002)

dMP2 axons make pathfinding errors in fra³/fra⁴ mutant embryos, often extending laterally, turning anteriorly or stalling. Expression of fra^{ΔC.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4⁶⁰⁵ in fra³/fra⁴ embryos results in abnormal spreading of the dMP2 growth cone over the region of induced ectopic NetB accumulation.

(Hiramoto et al., 2000)

fra⁴ mutant clones in the eye show no discernable projection defects. fra⁴ mutant clones in the developing lamina are innervated abnormally. Wild type retinal fibers are incapable of innervating lamina target regions that lack fra function. Retinal fibers consistently avoid fra mutant patches and reroute to fra⁺ areas. Rerouting can occur in both the a-p and d-v axis. Incoming retinal fibers respect clonal boundaries.

(Gong et al., 1999)

The RP3 axon extends dorsally past and just adjacent to muscles 7 and 6 and then reached back to innervate them. RP3 neuron may extend into its normal muscle domain but fail to innervate muscles 7 and 6. The ISNb fails to innervate muscles 7 and 6. Scer\GAL4^how-24B-mediated expression of NetA^Scer\UAS.cHa or NetB^Scer\UAS.cHa allows the axons of the transverse nerve to ectopically innervate muscles 7 and 6, loss of fra function suppresses this phenotype.

(Winberg et al., 1998)

In fra³/fra⁴ embryos 12% of anterior commissures and 43% of posterior commissures in abdominal segments A1-A7 are thin or absent. Commissures that appear to have normal thickness are often less well organised than normal. Occasional breaks are also observed in the longitudinal tracts. A subset of motor axons exit the ventral CNS in the intersegmental nerve and extend dorsally, in fra³/fra⁴ embryos the axons often extend a colateral branch into an adjacent segment or make inappropriate contacts with dorsal muscles when they reach the dorsal muscle region.

(Kolodziej et al., 1996)

External Data

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Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

fra⁶/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Cyfip^85.1/Cyfip^85.1

(Chaudhari et al., 2024)

fra⁶/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Tace¹⁹

(Zang et al., 2022)

fra⁶/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

fra³/fra⁴ has abnormal neuroanatomy phenotype, enhanceable by robo2^X123/robo2^x135

(Evans et al., 2015)

fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Scer\GAL4^insc-Mz1407/Abl^UAS.cHa

(Dorsten et al., 2010)

fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Scer\GAL4^insc-Mz1407/Abl^KN.UAS

(Dorsten et al., 2010)

fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Scer\GAL4^insc-Mz1407/Abl::Hsap\ABL1::Hsap\BCR^P210.UAS

(Dorsten et al., 2010)

fra⁶/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by comm[+]/comm^Δe39

(Yang et al., 2009)

Df(2R)vg135/fra⁴ has abnormal neuroanatomy phenotype, enhanceable by Df(3L)Fpa1/+

(Forsthoefel et al., 2005)

Df(2R)vg135/fra⁴ has abnormal neuroanatomy phenotype, enhanceable by trio[+]/trio^IMP159.4

(Forsthoefel et al., 2005)

Df(2R)vg135/fra⁴ has abnormal neuroanatomy phenotype, enhanceable by trio^M89/trio^IMP159.4

(Forsthoefel et al., 2005)

Df(2R)vg135/fra⁴ has abnormal neuroanatomy phenotype, enhanceable by trio[+]/trio^M89

(Forsthoefel et al., 2005)

fra⁴ has abnormal neuroanatomy phenotype, enhanceable by Abl¹/Abl[+]

(Forsthoefel et al., 2005)

fra⁴ has abnormal neuroanatomy phenotype, enhanceable by Abl⁴/Abl¹

(Forsthoefel et al., 2005)

fra⁴ has abnormal neuroanatomy phenotype, enhanceable by Df(3L)Fpa1/+

(Forsthoefel et al., 2005)

fra⁴ has abnormal neuroanatomy phenotype, enhanceable by trio[+]/trio^IMP159.4

(Forsthoefel et al., 2005)

fra⁴ has abnormal neuroanatomy phenotype, enhanceable by trio^M89/trio^IMP159.4

(Forsthoefel et al., 2005)

fra⁴ has abnormal neuroanatomy phenotype, enhanceable by trio[+]/trio^M89

(Forsthoefel et al., 2005)

Df(2R)vg135/fra⁴ has abnormal neuroanatomy phenotype, enhanceable by Abl¹/Abl[+]

(Forsthoefel et al., 2005)

fra⁴ has abnormal neuroanatomy phenotype, enhanceable by trio^M89/trio^S036810

(Forsthoefel et al., 2005)

fra⁴ has abnormal neuroanatomy phenotype, enhanceable by trio[+]/trio^S036810

(Forsthoefel et al., 2005)

fra⁴ has abnormal neuroanatomy phenotype, enhanceable by Abl⁴/Abl[+]

(Forsthoefel et al., 2005)

Df(2R)vg135/fra⁴ has abnormal neuroanatomy phenotype, enhanceable by Abl⁴/Abl[+]

(Forsthoefel et al., 2005)

Df(2R)vg135/fra⁴ has abnormal neuroanatomy phenotype, enhanceable by Abl⁴/Abl¹

(Forsthoefel et al., 2005)

NOT Enhanced by

Statement

Reference

fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, non-enhanceable by Tace¹⁹

(Zang et al., 2022)

fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

Dscam1⁰⁵⁵¹⁸, fra⁴ has abnormal neuroanatomy phenotype, non-enhanceable by Dscam3^c02826/Dscam3^c02826

(Andrews et al., 2008)

Suppressed by

Statement

Reference

Dscam1⁰⁵⁵¹⁸, fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, suppressible by Scer\GAL4^scrt-11-6/Dscam1^{7.27.25.1.UAS.cZa}

(Hernández et al., 2023)

Dscam1⁰⁵⁵¹⁸, fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, suppressible by Scer\GAL4^scrt-11-6/Dscam1^{UAS.1.30.30.2}

(Hernández et al., 2023)

Df(2R)vg135/fra⁴ has abnormal neuroanatomy phenotype, suppressible | partially by ena[+]/ena^GC10

(Forsthoefel et al., 2005)

fra³/fra⁴ has abnormal neuroanatomy phenotype, suppressible by fra::unc-5^fra.CD.UAS/Scer\GAL4^elav.PLu

(Keleman and Dickson, 2001)

NOT suppressed by

Statement

Reference

fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by Tace¹⁹

(Zang et al., 2022)

fra³/fra⁴ has abnormal neuroanatomy phenotype, non-suppressible by Scer\GAL4^eg-Mz360/Rnor\Dcc^UAS.Tag:MYC

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by fra::robo1^{UAS.FΔC.Tag:MYC}/Scer\GAL4^elav.PLu

(Garbe et al., 2007)

fra³/fra⁴ has abnormal neuroanatomy phenotype, non-suppressible by Scer\GAL4^elav-C155/Gαq^Q203L.UAS

(Ratnaparkhi et al., 2002)

Enhancer of

Statement

Reference

fra⁴/fra[+] is an enhancer of abnormal neuroanatomy | recessive phenotype of N^l1N-ts1

(Kuzina et al., 2011)

NOT Enhancer of

Statement

Reference

fra³, fra⁴, fra^UAS.cKa, Scer\GAL4^insc-Mz1407 is a non-enhancer of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra^ΔP1.UAS, fra³, fra⁴, Scer\GAL4^insc-Mz1407 is a non-enhancer of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³, fra⁴, fra^ΔP2.UAS, Scer\GAL4^insc-Mz1407 is a non-enhancer of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra⁴/fra[+] is a non-enhancer of abnormal neuroanatomy phenotype of trio^M89/trio^IMP159.4

(Forsthoefel et al., 2005)

fra⁴/fra[+] is a non-enhancer of abnormal neuroanatomy phenotype of Df(3L)Fpa1/trio^IMP159.4

(Forsthoefel et al., 2005)

Suppressor of

Statement

Reference

fra³/fra⁴ is a suppressor of abnormal neuroanatomy | somatic clone | third instar larval stage phenotype of Scer\GAL4^ppk.PG, Trim9^UAS.Tag:HA

(Morikawa et al., 2011)

fra^ΔP3.UAS, fra³, fra⁴, Scer\GAL4^insc-Mz1407 is a suppressor | partially of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³/fra⁴ is a suppressor of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra⁴/fra[+] is a suppressor of visible phenotype of Dys^RNAi.NH2.UAS, Scer\GAL4^Act.PU

(Kucherenko et al., 2008)

fra⁴/fra[+] is a suppressor of visible phenotype of Dys^RNAi.C.UAS, Scer\GAL4^Tub.PU

(Kucherenko et al., 2008)

fra⁴/fra[+] is a suppressor | partially of abnormal neuroanatomy | embryonic stage 16 phenotype of Rac1^V12.UAS, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

fra⁴/fra[+] is a suppressor | partially of abnormal neuroanatomy | embryonic stage 16 phenotype of Cdc42^V12.UAS, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

fra⁴/fra[+] is a suppressor | partially of abnormal neuroanatomy phenotype of Ggal\MLCK^ct.UAS, Scer\GAL4^ftz.ng

(Kim et al., 2002)

fra³/fra⁴ is a suppressor of abnormal neuroanatomy phenotype of Gαq^Q203L.UAS, Scer\GAL4^elav-C155

(Ratnaparkhi et al., 2002)

fra³/fra⁴ is a suppressor | partially of abnormal neuroanatomy phenotype of Scer\GAL4^ap-md544, unc-5^{UAS.Tag:HA,Tag:SS(wg)}

(Keleman and Dickson, 2001)

NOT Suppressor of

Statement

Reference

fra³, fra⁴, fra^UAS.cKa, Scer\GAL4^insc-Mz1407 is a non-suppressor of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra^ΔP1.UAS, fra³, fra⁴, Scer\GAL4^insc-Mz1407 is a non-suppressor of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³, fra⁴, fra^ΔP2.UAS, Scer\GAL4^insc-Mz1407 is a non-suppressor of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³/fra⁴ is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^elav.PLu, unc-5^{UAS.Tag:HA,Tag:SS(wg)}

(Keleman and Dickson, 2001)

Scer\GAL4^ap-md544, fra³, fra⁴, fra^UAS.cKa is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^ap-md544, unc-5^{UAS.Tag:HA,Tag:SS(wg)}

(Keleman and Dickson, 2001)

Other

Statement

Reference

Cyfip^85.1, fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype

(Chaudhari et al., 2024)

Cyfip^85.1, fra³/fra⁴ has lethal - all die during embryonic stage phenotype

(Chaudhari et al., 2024)

Dscam1⁰⁵⁵¹⁸, fra⁴ has abnormal neuroanatomy | embryonic stage phenotype

(Hernández et al., 2023)

Abl^UAS.cHa, Scer\GAL4^insc-Mz1407, fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype

(Dorsten et al., 2010)

Abl^KN.UAS, Scer\GAL4^insc-Mz1407, fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407, fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype

(Dorsten et al., 2010)

Df(1)NP5/+, fra⁴ has abnormal neuroanatomy | dominant phenotype

(Andrews et al., 2008)

Dscam1⁰⁵⁵¹⁸/Dscam[+], fra⁴ has abnormal neuroanatomy | dominant phenotype

(Andrews et al., 2008)

Dys^E6, fra⁴/fra[+] has visible phenotype

(Kucherenko et al., 2008)

Df(2R)en-SFX31, fra⁴ has abnormal neuroanatomy phenotype

(Joly et al., 2007)

Phenotype Manifest In

Enhanced by

Statement

Reference

fra⁶/fra⁴ has larval EW neuron | embryonic stage phenotype, enhanceable by Cyfip^85.1/Cyfip^85.1

(Chaudhari et al., 2024)

fra⁶/fra⁴ has commissure | embryonic stage phenotype, enhanceable by Cyfip^85.1/Cyfip^85.1

(Chaudhari et al., 2024)

fra⁶/fra⁴ has connective | embryonic stage phenotype, enhanceable by Cyfip^85.1/Cyfip^85.1

(Chaudhari et al., 2024)

fra⁶/fra⁴ has axon | embryonic stage phenotype, enhanceable by Tace¹⁹

(Zang et al., 2022)

fra⁶/fra⁴ has larval EW neuron | embryonic stage phenotype, enhanceable by Tace¹⁹

(Zang et al., 2022)

fra⁶/fra⁴ has commissure | embryonic stage phenotype, enhanceable by Tace¹⁹

(Zang et al., 2022)

fra⁶/fra⁴ has axon | embryonic stage phenotype, enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

fra⁶/fra⁴ has larval EW neuron | embryonic stage phenotype, enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

fra³/fra⁴ has symmetrical commissure phenotype, enhanceable by robo2^X123/robo2^x135

(Evans et al., 2015)

fra³/fra⁴ has larval EW neuron phenotype, enhanceable by robo2^X123/robo2^x135

(Evans et al., 2015)

fra³/fra⁴ has larval ventral nerve cord commissure phenotype, enhanceable by Scer\GAL4^insc-Mz1407/Abl^UAS.cHa

(Dorsten et al., 2010)

fra³/fra⁴ has larval ventral nerve cord commissure phenotype, enhanceable by Scer\GAL4^insc-Mz1407/Abl^KN.UAS

(Dorsten et al., 2010)

fra³/fra⁴ has larval ventral nerve cord commissure phenotype, enhanceable by Scer\GAL4^insc-Mz1407/Abl::Hsap\ABL1::Hsap\BCR^P210.UAS

(Dorsten et al., 2010)

fra⁶/fra⁴ has larval EW neuron phenotype, enhanceable by comm[+]/comm^Δe39

(Yang et al., 2009)

Df(2R)vg135/fra⁴ has symmetrical commissure phenotype, enhanceable by Df(3L)Fpa1/+

(Forsthoefel et al., 2005)

Df(2R)vg135/fra⁴ has symmetrical commissure phenotype, enhanceable by trio[+]/trio^IMP159.4

(Forsthoefel et al., 2005)

Df(2R)vg135/fra⁴ has symmetrical commissure phenotype, enhanceable by trio^M89/trio^IMP159.4

(Forsthoefel et al., 2005)

Df(2R)vg135/fra⁴ has symmetrical commissure phenotype, enhanceable by trio[+]/trio^M89

(Forsthoefel et al., 2005)

fra⁴ has symmetrical commissure phenotype, enhanceable by Abl¹/Abl[+]

(Forsthoefel et al., 2005)

fra⁴ has symmetrical commissure phenotype, enhanceable by Abl⁴/Abl¹

(Forsthoefel et al., 2005)

fra⁴ has symmetrical commissure phenotype, enhanceable by Df(3L)Fpa1/+

(Forsthoefel et al., 2005)

fra⁴ has symmetrical commissure phenotype, enhanceable by trio[+]/trio^IMP159.4

(Forsthoefel et al., 2005)

fra⁴ has symmetrical commissure phenotype, enhanceable by trio^M89/trio^IMP159.4

(Forsthoefel et al., 2005)

fra⁴ has symmetrical commissure phenotype, enhanceable by trio[+]/trio^M89

(Forsthoefel et al., 2005)

fra⁴ has symmetrical commissure phenotype, enhanceable by trio^M89/trio^S036810

(Forsthoefel et al., 2005)

fra⁴ has symmetrical commissure phenotype, enhanceable by trio[+]/trio^S036810

(Forsthoefel et al., 2005)

fra⁴ has symmetrical commissure phenotype, enhanceable by Abl⁴/Abl[+]

(Forsthoefel et al., 2005)

Df(2R)vg135/fra⁴ has symmetrical commissure phenotype, enhanceable by Abl¹/Abl[+]

(Forsthoefel et al., 2005)

Df(2R)vg135/fra⁴ has symmetrical commissure phenotype, enhanceable by Abl⁴/Abl[+]

(Forsthoefel et al., 2005)

Df(2R)vg135/fra⁴ has symmetrical commissure phenotype, enhanceable by Abl⁴/Abl¹

(Forsthoefel et al., 2005)

fra³/fra⁴ has presumptive embryonic salivary gland phenotype, enhanceable by mew^M6

(Kolesnikov and Beckendorf, 2005)

NOT Enhanced by

Statement

Reference

fra³/fra⁴ has axon | embryonic stage phenotype, non-enhanceable by Tace¹⁹

(Zang et al., 2022)

fra³/fra⁴ has larval EW neuron | embryonic stage phenotype, non-enhanceable by Tace¹⁹

(Zang et al., 2022)

fra³/fra⁴ has axon | embryonic stage phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

fra³/fra⁴ has larval EW neuron | embryonic stage phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

Dscam1⁰⁵⁵¹⁸, fra⁴ has Bolwig nerve phenotype, non-enhanceable by Dscam3^c02826/Dscam3^c02826

(Andrews et al., 2008)

Df(2R)vg135/fra⁴ has larval longitudinal connective phenotype, non-enhanceable by trio^M89/trio^IMP159.4

(Forsthoefel et al., 2005)

Df(2R)vg135/fra⁴ has larval longitudinal connective phenotype, non-enhanceable by Abl⁴/Abl¹

(Forsthoefel et al., 2005)

Suppressed by

Statement

Reference

Dscam1⁰⁵⁵¹⁸, fra⁴ has commissure | embryonic stage phenotype, suppressible by Scer\GAL4^scrt-11-6/Dscam1^{7.27.25.1.UAS.cZa}

(Hernández et al., 2023)

Dscam1⁰⁵⁵¹⁸, fra⁴ has commissure | embryonic stage phenotype, suppressible by Scer\GAL4^scrt-11-6/Dscam1^{UAS.1.30.30.2}

(Hernández et al., 2023)

fra³/fra⁴ has larval EW neuron phenotype, suppressible by Scer\GAL4^eg-Mz360/Rnor\Dcc^UAS.Tag:MYC

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ has larval posterior commissure phenotype, suppressible by Scer\GAL4^eg-Mz360/Rnor\Dcc^UAS.Tag:MYC

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ has larval longitudinal connective phenotype, suppressible by Scer\GAL4^eg-Mz360/Rnor\Dcc^UAS.Tag:MYC

(O'Donnell and Bashaw, 2013)

Df(2R)vg135/fra⁴ has symmetrical commissure phenotype, suppressible | partially by ena[+]/ena^GC10

(Forsthoefel et al., 2005)

fra³/fra⁴ has larval anterior commissure phenotype, suppressible by fra::unc-5^fra.CD.UAS/Scer\GAL4^elav.PLu

(Keleman and Dickson, 2001)

fra³/fra⁴ has larval longitudinal connective phenotype, suppressible by fra::unc-5^fra.CD.UAS/Scer\GAL4^elav.PLu

(Keleman and Dickson, 2001)

fra³/fra⁴ has larval posterior commissure phenotype, suppressible by fra::unc-5^fra.CD.UAS/Scer\GAL4^elav.PLu

(Keleman and Dickson, 2001)

NOT suppressed by

Statement

Reference

fra³/fra⁴ has axon | embryonic stage phenotype, non-suppressible by Tace¹⁹

(Zang et al., 2022)

fra³/fra⁴ has larval EW neuron | embryonic stage phenotype, non-suppressible by Tace¹⁹

(Zang et al., 2022)

fra³/fra⁴ has symmetrical commissure | embryonic stage phenotype, non-suppressible by Scer\GAL4^elav-C155/Gαq^Q203L.UAS

(Ratnaparkhi et al., 2002)

fra³/fra⁴ has fascicle | embryonic stage phenotype, non-suppressible by Scer\GAL4^elav-C155/Gαq^Q203L.UAS

(Ratnaparkhi et al., 2002)

Enhancer of

Statement

Reference

fra⁴/fra[+] is an enhancer of pioneer neuron phenotype of N^l1N-ts1

(Kuzina et al., 2011)

fra³/fra⁴ is an enhancer of symmetrical commissure | embryonic stage phenotype of Gαq^Q203L.UAS, Scer\GAL4^elav-C155

(Ratnaparkhi et al., 2002)

fra³/fra⁴ is an enhancer of fascicle | embryonic stage phenotype of Gαq^Q203L.UAS, Scer\GAL4^elav-C155

(Ratnaparkhi et al., 2002)

NOT Enhancer of

Statement

Reference

fra³, fra⁴, fra^UAS.cKa, Scer\GAL4^insc-Mz1407 is a non-enhancer of larval ventral nerve cord commissure phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra^ΔP1.UAS, fra³, fra⁴, Scer\GAL4^insc-Mz1407 is a non-enhancer of larval ventral nerve cord commissure phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³, fra⁴, fra^ΔP2.UAS, Scer\GAL4^insc-Mz1407 is a non-enhancer of larval ventral nerve cord commissure phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra⁴/fra[+] is a non-enhancer of symmetrical commissure phenotype of trio^M89/trio^IMP159.4

(Forsthoefel et al., 2005)

fra⁴/fra[+] is a non-enhancer of symmetrical commissure phenotype of Df(3L)Fpa1/trio^IMP159.4

(Forsthoefel et al., 2005)

Suppressor of

Statement

Reference

fra³/fra⁴ is a suppressor of abdominal anterior ventral multidendritic neuron vdaa phenotype of Scer\GAL4^ppk.PG, Trim9^UAS.Tag:HA

(Morikawa et al., 2011)

fra^ΔP3.UAS, fra³, fra⁴, Scer\GAL4^insc-Mz1407 is a suppressor | partially of commissure | ectopic phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³/fra⁴ is a suppressor of commissure | ectopic phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra⁴/fra[+] is a suppressor of posterior crossvein phenotype of Dys^RNAi.NH2.UAS, Scer\GAL4^Act.PU

(Kucherenko et al., 2008)

fra⁴/fra[+] is a suppressor of posterior crossvein phenotype of Dys^RNAi.C.UAS, Scer\GAL4^Tub.PU

(Kucherenko et al., 2008)

fra⁴/fra[+] is a suppressor | partially of commissure | embryonic stage 16 phenotype of Rac1^V12.UAS, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

fra⁴/fra[+] is a suppressor | partially of larval ventral nerve cord commissure | embryonic stage 16 phenotype of Rac1^V12.UAS, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

fra⁴/fra[+] is a suppressor | partially of commissure | embryonic stage 16 phenotype of Cdc42^V12.UAS, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

fra⁴/fra[+] is a suppressor | partially of larval ventral nerve cord commissure | embryonic stage 16 phenotype of Cdc42^V12.UAS, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

fra³/fra⁴ is a suppressor of presumptive embryonic salivary gland phenotype of sli²

(Kolesnikov and Beckendorf, 2005)

fra⁴/fra[+] is a suppressor | partially of larval longitudinal connective phenotype of Ggal\MLCK^ct.UAS, Scer\GAL4^ftz.ng

(Kim et al., 2002)

fra³/fra⁴ is a suppressor | partially of larval ventral nerve cord phenotype of Scer\GAL4^ap-md544, unc-5^{UAS.Tag:HA,Tag:SS(wg)}

(Keleman and Dickson, 2001)

fra⁴ is a suppressor of larval transverse nerve phenotype of NetA^UAS.cHa, Scer\GAL4^how-24B

(Winberg et al., 1998)

fra⁴ is a suppressor of larval transverse nerve phenotype of NetB^UAS.cHa, Scer\GAL4^how-24B

(Winberg et al., 1998)

NOT Suppressor of

Statement

Reference

fra^ΔP1.UAS, fra³, fra⁴, Scer\GAL4^insc-Mz1407 is a non-suppressor of commissure | ectopic phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³, fra⁴, fra^ΔP2.UAS, Scer\GAL4^insc-Mz1407 is a non-suppressor of commissure | ectopic phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³, fra⁴, fra^UAS.cKa, Scer\GAL4^insc-Mz1407 is a non-suppressor of commissure | ectopic phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³/fra⁴ is a non-suppressor of larval anterior commissure phenotype of Scer\GAL4^elav.PLu, unc-5^{UAS.Tag:HA,Tag:SS(wg)}

(Keleman and Dickson, 2001)

fra³/fra⁴ is a non-suppressor of larval posterior commissure phenotype of Scer\GAL4^elav.PLu, unc-5^{UAS.Tag:HA,Tag:SS(wg)}

(Keleman and Dickson, 2001)

fra³, fra⁴, fra^UAS.cKa is a non-suppressor of larval ventral nerve cord phenotype of Scer\GAL4^ap-md544, unc-5^{UAS.Tag:HA,Tag:SS(wg)}

(Keleman and Dickson, 2001)

Other

Statement

Reference

Dscam1⁰⁵⁵¹⁸, fra⁴ has commissure | embryonic stage phenotype

(Hernández et al., 2023)

Dscam1⁰⁵⁵¹⁸, fra⁴ has embryonic/larval frontal nerve | embryonic stage | absent phenotype

(Hernández et al., 2023)

Dscam1⁰⁵⁵¹⁸, fra⁴ has frontal ganglion | embryonic stage phenotype

(Hernández et al., 2023)

Abl^UAS.cHa, Scer\GAL4^insc-Mz1407, fra³/fra⁴ has tract | ectopic | embryonic stage phenotype

(Dorsten et al., 2010)

Abl^KN.UAS, Scer\GAL4^insc-Mz1407, fra³/fra⁴ has tract | ectopic | embryonic stage phenotype

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407, fra³/fra⁴ has tract | ectopic | embryonic stage phenotype

(Dorsten et al., 2010)

Df(1)NP5/+, fra⁴ has Bolwig nerve phenotype

(Andrews et al., 2008)

Dscam1⁰⁵⁵¹⁸/Dscam[+], fra⁴ has Bolwig nerve phenotype

(Andrews et al., 2008)

Dys^E6, fra⁴/fra[+] has posterior crossvein phenotype

(Kucherenko et al., 2008)

Dys^RNAi.C.UAS, fra⁴/fra[+] has wing vein | ectopic phenotype

(Kucherenko et al., 2008)

Df(2R)en-SFX31, fra⁴ has larval ventral nerve cord phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, fra⁴ has larval anterior commissure phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, fra⁴ has larval posterior commissure phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, fra⁴ has lateral tract phenotype

(Joly et al., 2007)

fra³/fra⁴, mew^M6 has presumptive embryonic salivary gland phenotype

(Kolesnikov and Beckendorf, 2005)

NetB^UAS.cHa, Scer\GAL4⁶⁰⁵, fra³/fra⁴ has dMP2 neuron phenotype

(Hiramoto et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

robo2^X123/robo2^x135 strongly enhances the midline crossing defects seen in fra³/fra⁴ embryos: approximately 70% of EW neurons fail to cross the midline in the double mutant embryos.

(Evans et al., 2015)

Dscam⁰⁵⁵¹⁸ fra⁴ double mutants show a significant increase in apoptosis in the thoracic and abdominal segments of the ventral nerve cord compared to controls.

(Newquist et al., 2013)

The N^l1N-ts1 pioneer axon phenotype is strongly enhanced by heterozygosity for fra⁴.

(Kuzina et al., 2011)

A fra⁴ mutant background suppresses the ectopic contralateral projections seen when Trim9^{Scer\UAS.T:Ivir\HA1} is expressed in v'ada neurons under the control of Scer\GAL4^ppk.PG.

(Morikawa et al., 2011)

Over-expression of Abl^Scer\UAS.cHa using Scer\GAL4^insc-Mz1407 enhances the degree of thinning and missing posterior commissures in fra³/fra⁴ embryos, and many anterior commissures disappear. Large bundles of axons are observed ectopically exiting the central nervous system (CNS), often extending beyond the CNS/PNS boundary.

Pan-neural expression of Abl^KN.Scer\UAS under the control of Scer\GAL4^insc-Mz1407 in fra³/fra⁴ embryos significantly increases the frequency of thin and missing posterior commissure defects.

Commissure formation is restored in fra³/fra⁴ mutants expressing both fra^{ΔP1.Scer\UAS} and Abl^Scer\UAS.cHa under the control of Scer\GAL4^insc-Mz1407.

Commissure formation is restored in fra³/fra⁴ mutants expressing both fra^{ΔP2.Scer\UAS} and Abl^Scer\UAS.cHa under the control of Scer\GAL4^insc-Mz1407.

Commissure formation is restored in fra³/fra⁴ mutants expressing both fra^{ΔP3.Scer\UAS} and Abl^Scer\UAS.cHa under the control of Scer\GAL4^insc-Mz1407.

Nearly a third of hemi-segments in fra³/fra⁴ embryos expressing Scer\GAL4^insc-Mz1407>Abl^Scer\UAS.cHa exhibit defects characterised by Fas2-positive axons ectopically exiting the central nervous system (CNS).

Less than 10% of fra³/fra⁴ embryos expressing Scer\GAL4^insc-Mz1407>Abl^KN.Scer\UAS exhibit defects characterised by Fas2-positive axons ectopically exiting the central nervous system (CNS).

(Dorsten et al., 2010)

The commissural defects seen in fra⁴/fra⁶ embryos are enhanced in a heterozygous comm^E39/+ genetic background as shown by missing and thin commissures in many segments, as well as an increased frequency of non-crossing defects in a subset of of commissural neurons.

(Yang et al., 2009)

67% of Dscam⁰⁵⁵¹⁸/Dscam⁰⁵⁵¹⁸ fra⁴/fra⁴ embryos show defects in axon guidance in the Bolwig's nerve.

The penetrance of the axon guidance defect phenotype that is seen in the Bolwig's nerve of Dscam⁰⁵⁵¹⁸/Dscam⁰⁵⁵¹⁸ fra⁴/fra⁴ double mutant embryos is not increased by addition of Dscam3^c02826/Dscam3^c02826.

30% of Df(1)NP5/+ ; fra⁴/+ embryos show defects in axon guidance in the Bolwig's nerve.

22.5% of Dscam⁰⁵⁵¹⁸/+ ; fra⁴/+ embryos show defects in axon guidance in the Bolwig's nerve.

Dscam⁰⁵⁵¹⁸ fra⁴ embryos show defects in the commissures of the central nervous system; 9% of anterior commissures are absent, 24% of anterior commissures are thin, 5% of posterior commissures are absent and 39% of posterior commissures are thin. 51% of segments fail to separate the anterior and posterior commissures correctly.

fra³/fra⁴ Dscam3^c02826 embryos show defects in the commissures of the central nervous system; 2% of anterior commissures are absent, 3% of anterior commissures are thin, 1% of posterior commissures are absent and 9% of posterior commissures are thin. 48% of segments fail to separate the anterior and posterior commissures correctly.

fra⁴ Abl⁴ embryos show defects in the commissures of the central nervous system; 14% of anterior commissures are absent, 24% of anterior commissures are thin, 16% of posterior commissures are absent and 24% of posterior commissures are thin. 19% of segments fail to separate the anterior and posterior commissures correctly.

Dscam⁰⁵⁵¹⁸ fra⁴ Dscam3^c02826 embryos show defects in the commissures of the central nervous system; 39% of anterior commissures are absent, 51% of anterior commissures are thin, 36% of posterior commissures are absent and 55% of posterior commissures are thin. 5% of segments fail to separate the anterior and posterior commissures correctly.

Dscam⁰⁵⁵¹⁸ fra⁴ Abl⁴ embryos show defects in the commissures of the central nervous system; 98% of anterior commissures are absent, 2% of anterior commissures are thin and 100% of posterior commissures are absent.

(Andrews et al., 2008)

One copy of fra⁴ weakly suppresses the detached posterior crossvein phenotype seen when Dys^{dsRNA.NH2.Scer\UAS} is expressed under the control of Scer\GAL4^Act.PU.

One copy of fra⁴ moderately suppresses the detached posterior crossvein phenotype seen when Dys^{dsRNA.C.Scer\UAS} is expressed under the control of Scer\GAL4^tub.PU but produces extra wing vein material.

One copy of fra⁴ weakly in a Dys^E6/+ background results in posterior crossvein defects.

(Kucherenko et al., 2008)

Heterozygous fra⁴ partially suppresses the incorrect midline crossing phenotype of ventral nerve cord axons in embryos overexpressing Cdc42^V12.Scer\UAS via Scer\GAL4^ftz.ng.

Heterozygous fra⁴ partially suppresses the incorrect midline crossing phenotype of ventral nerve cord axons in embryos overexpressing Rac1^V12.Scer\UAS via Scer\GAL4^ftz.ng.

(Dorsten et al., 2007)

Expression of fra::robo^{Scer\UAS.FΔC.T:Hsap\MYC}under the control of Scer\GAL4^elav.PLu fails to rescue the fra³/fra⁴ axon guidance phenotypes.

(Garbe et al., 2007)

Approximately 66% of fra⁴/Df(2R)en-SFX31 double mutants exhibit defects in axonal pathfinding. Stage 15 embryos display dramatic defects in ventral nerve cord architecture, with the posterior commissures missing or fused with the anterior commissures, and longitudinal tracts thinner. Nearly all the segments are affected in these embryos.

(Joly et al., 2007)

The frequency of the loss of commissure phenotype seen in Abl¹/Abl⁴ embryos is not enhanced by fra⁴/+, but the frequency of commissures with pathfinding errors is increased in the fra⁴/+; Abl¹/Abl⁴ embryos compared to Abl¹/Abl⁴.

(Forsthoefel et al., 2005)

In mew^M6/Y; fra³/fra⁴ double mutant embryos, the misguided salivary gland phenotype is modified, compared to that of each single mutant. Like fra³/fra⁴ mutants, the majority (75%) of misguided glands curve laterally, but levels of penetrance are high, similar to mew^M6/Y single mutants. In sli²; fra³/fra⁴ double mutants, the penetrance of the salivary gland guidance defects is by 40% compared to sli² single mutants.

(Kolesnikov and Beckendorf, 2005)

A reduction in midline crossing is observed upon removal of two copies of the fra gene in Scer\GAL4^elav-C155/Gα49B^{Q203L.Scer\UAS};fra³/fra⁴, from 48.10% of abdominal segments exhibiting midline crossover in Scer\GAL4^elav-C155/Gα49B^{Q203L.Scer\UAS} embryos to 5.3% in Scer\GAL4^elav-C155/Gα49B^{Q203L.Scer\UAS};fra³/fra⁴ mutant embryos. Embryos of the genotype Scer\GAL4^elav-C155/Gα49B^{Q203L.Scer\UAS} and fra³/fra⁴ exhibit breaks in Con-positive commissural axons and longitudinal tracts, similar to Scer\GAL4^elav-C155/Gα49B^{Q203L.Scer\UAS}; fra³/fra⁴ embryos, indicating that Gα49B does not have an effect on the fra mutant phenotype.

(Ratnaparkhi et al., 2002)

Expression of NetB^Scer\UAS.cHa under the control of Scer\GAL4⁶⁰⁵ in fra³/fra⁴ embryos results in abnormal spreading of the dMP2 growth cone over the region of ectopic NetB expression.

(Hiramoto et al., 2000)

Xenogenetic Interactions

Statement

Reference

Expression of Rnor\Dcc^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^eg-Mz360 rescues the midline crossing defects found in EW neurons in fra³/fra⁴ mutants.

Expression of Rnor\Dcc^{Y1418F.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^eg-Mz360 rescues the midline crossing defects found in EW neurons in fra³/fra⁴ mutants.

(O'Donnell and Bashaw, 2013)

Over-expression of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} using Scer\GAL4^insc-Mz1407 enhances the degree of thinning and missing posterior commissures in fra³/fra⁴ embryos, and many anterior commissures disappear. Large bundles of axons are observed ectopically exiting the central nervous system (CNS), often extending beyond the CNS/PNS boundary. The anterior commissures, which are virtually unaffected in fra³/fra⁴ embryos, are thin or missing in 41% of segments.

Re-expression of fra^Scer\UAS.cKa in fra³/fra⁴ mutants reverts the phenotype back to that seen when Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} is expressed alone under the control of Scer\GAL4^insc-Mz1407 : fuzzy commissures.

Re-expression of fra^Scer\UAS.cKa in fra³/fra⁴ mutants reverts the phenotype back to that seen when Abl^Scer\UAS.cHa is expressed alone under the control of Scer\GAL4^insc-Mz1407 : normal anterior and posterior commissure formation.

In fra³/fra⁴ mutants expressing Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}, expression of fra^{ΔP1.Scer\UAS} is able tor revert the commissure loss seen in fra³/fra⁴ mutants. These mutants display fuzzy commissures.

In fra³/fra⁴ mutants expressing Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}, expression of fra^{ΔP2.Scer\UAS} is able tor revert the commissure loss seen in fra³/fra⁴ mutants. These mutants display fuzzy commissures.

In fra³/fra⁴ mutants expressing Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}, expression of fra^{ΔP3.Scer\UAS} restores commissure formation in fra³/fra⁴ mutants. The frequency of fuzzy commissures is also significantly reduced.

fra³/fra⁴ significantly reduces the frequency of ectopic axonal midline-crossovers resulting from the expression of Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}.

fra³/fra⁴ fails to reduce the frequency of ectopic axonal midline-crossovers resulting from the expression of Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} when fra^Scer\UAS.cKa is co-expressed.

fra³/fra⁴ significantly reduces the frequency of ectopic axonal midline-crossovers resulting from the expression of Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} when fra^{ΔP3.Scer\UAS} is co-expressed.

Nearly a third of hemi-segments in fra³/fra⁴ embryos expressing Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} exhibit defects characterised by Fas2-positive axons ectopically exiting the central nervous system (CNS).

(Dorsten et al., 2010)

The midline crossover phenotype caused expression of Ggal\MLCK^ct.Scer\UAS under the control of Scer\GAL4^ftz.ng is partially suppressed by fra⁴/+.

(Kim et al., 2002)

Complementation and Rescue Data

Rescued by

fra³/fra⁴ is rescued by fra^{UAS.cOa.Tag:MYC}/Scer\GAL4^elav.PLu

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ is rescued by fra^{9YF.UAS.Tag:MYC}/Scer\GAL4^elav.PLu

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ is rescued by Scer\GAL4^gcm.PU/fra^UAS.cKa

(von Hilchen et al., 2010)

fra³/fra⁴ is rescued by fra^UAS.cKa/Scer\GAL4^eve.CQ2

(Mauss et al., 2009)

fra³/fra⁴ is rescued by Scer\GAL4^eg-Mz360/fra^UAS.Tag:MYC

(Garbe et al., 2007)

fra³/fra⁴ is rescued by fra^UAS.Tag:MYC/Scer\GAL4^elav.PLu

(Garbe et al., 2007)

fra³/fra⁴ is rescued by Scer\GAL4^eg-Mz360/fra^UAS.Tag:HA

(Garbe et al., 2007)

fra³/fra⁴ is rescued by fra^{ΔP1.UAS.Tag:MYC}/Scer\GAL4^eg-Mz360

(Garbe et al., 2007)

fra³/fra⁴ is rescued by Scer\GAL4^eg-Mz360/fra^{ΔP2.UAS.Tag:MYC}

(Garbe et al., 2007)

fra³/fra⁴ is rescued by Scer\GAL4^eg-Mz360/fra^{ΔP1ΔP2.UAS.Tag:MYC}

(Garbe et al., 2007)

fra³/fra⁴ is rescued by fra^UAS.cKa/Scer\GAL4^elav.PLu

(Keleman and Dickson, 2001)

fra³/fra⁴ is rescued by Scer\GAL4⁶⁰⁵/fra^UAS.cKa

(Hiramoto et al., 2000)

Partially rescued by

fra³/fra⁴ is partially rescued by Scer\GAL4^ppk.PG/fra^UAS.cKa

(Morikawa et al., 2011)

fra³/fra⁴ is partially rescued by Scer\GAL4^MZ1580/fra^UAS.cKa

(von Hilchen et al., 2010)

fra³/fra⁴ is partially rescued by Scer\GAL4^insc-Mz1407/fra^UAS.cKa

(Kolodziej et al., 1996)

Not rescued by

fra³/fra⁴ is not rescued by Scer\GAL4^repo/fra^UAS.cKa

(von Hilchen et al., 2010)

fra³/fra⁴ is not rescued by Scer\GAL4^pros.PMG/fra^UAS.cKa

(von Hilchen et al., 2010)

fra³/fra⁴ is not rescued by Scer\GAL4^elav.PU/fra^UAS.cKa

(von Hilchen et al., 2010)

fra³/fra⁴ is not rescued by Scer\GAL4^Mz605/fra^UAS.cKa

(von Hilchen et al., 2010)

fra³/fra⁴ is not rescued by Scer\GAL4^eg-Mz360/fra^{ΔP3.UAS.Tag:MYC}

(Garbe et al., 2007)

fra³/fra⁴ is not rescued by Scer\GAL4^eg-Mz360/fra^{ΔP3.5.UAS.Tag:MYC}

(Garbe et al., 2007)

fra³/fra⁴ is not rescued by Scer\GAL4^eg-Mz360/fra^{UAS.Tag:Myr(Src64B),Tag:MYC}

(Garbe et al., 2007)

fra³/fra⁴ is not rescued by fra^{ΔC.UAS.Tag:HA}/Scer\GAL4^elav.PLu

(Garbe et al., 2007)

fra³/fra⁴ is not rescued by Scer\GAL4^15J2/fra^UAS.cKa

(Hiramoto et al., 2000)

fra³/fra⁴ is not rescued by Scer\GAL4^how-24B/fra^UAS.cKa

(Kolodziej et al., 1996)

Comments

Expression of fra^{Scer\UAS.cOa.T:Hsap\MYC} in all neurons, through expression under the control of Scer\GAL4^elav.PLu, rescues EW midline crossing defects in fra³/fra⁴ mutants.

Expression of fra^{9YF.Scer\UAS.T:Hsap\MYC} in all neurons, through expression under the control of Scer\GAL4^elav.PLu, rescues EW midline crossing defects in fra³/fra⁴ mutants.

(O'Donnell and Bashaw, 2013)

Expression of fra^Scer\UAS.cKa in C4da neurons under the control of Scer\GAL4^ppk.PG partially rescues the axonal defects seen in fra³/fra⁴ mutants.

(Morikawa et al., 2011)

Expression of fra^Scer\UAS.cKa under the control of Scer\GAL4^gcm.PU rescues the defects in interface glial cell migration seen in fra³/fra⁴ embryos.

Expression of fra^Scer\UAS.cKa under the control of Scer\GAL4^MZ1580 weakly rescues the defects in interface glial cell migration seen in fra³/fra⁴ embryos.

The defects in interface glial cell migration seen in fra³/fra⁴ embryos are not rescued by expression of fra^Scer\UAS.cKa under the control of any one of Scer\GAL4^repo, Scer\GAL4^pros.PMG, Scer\GAL4^elav.PU or Scer\GAL4^Mz605.

(von Hilchen et al., 2010)

Expression of fra^Scer\UAS.cKa under the control of Scer\GAL4^eve.CQ2 rescues dendritic targeting to the midline in fra³/fra⁴ mutant MN-VO4-6 and MN-VO4/5 neurons.

Expression of fra^Scer\UAS.cKa under the control of Scer\GAL4^eve.CQ2 selectively in MN-LL1 neurons in fra³/fra⁴ mutant embryos efficiently rescues dendritic targeting to the intermediate neuropile. Moreover, this manipulation leads to a greater proportion of dendritic branches innervating the intermediate neuropile.

(Mauss et al., 2009)

Expression of fra^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^eg-Mz360 cell-autonomously rescues the EW guidance defects of fra³/fra⁴ embryos.

Expression of fra^{Scer\UAS.T:Ivir\HA} under the control of Scer\GAL4^eg-Mz360 cell-autonomously rescues the EW guidance defects of fra³/fra⁴ embryos.

(Garbe et al., 2007)

Expression of fra^Scer\UAS.cKa under the control of Scer\GAL4^15J2 does not rescue the dMP2 axonal phenotype of fra³/fra⁴ embryos. Expression of fra^Scer\UAS.cKa under the control of Scer\GAL4⁶⁰⁵ does rescue the dMP2 axonal phenotype of fra³/fra⁴ embryos.

(Hiramoto et al., 2000)

Scer\GAL4¹⁴⁰⁷ induced expression of fra^Scer\UAS.cKa in fra³/fra⁴ embryos rescues the commissure phenotype, commissures form normally in abdominal segments A1-A7. ISN motor axons also innervate their targets at near wild type levels.

(Kolodziej et al., 1996)

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Mutant

Wild-type

Stocks (1)

Bloomington

8743

w^*; P{FRT(w^hs)}G13 fra⁴/CyO, P{lacZ.w⁺}276

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

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Name Synonyms

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