FlyBase Allele Report: Dmel\fra[3]

General Information

Symbol

Dmel\fra³

Species

D. melanogaster

Name

FlyBase ID

FBal0057434

Feature type

allele

Associated gene

Dmel\fra

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Kolodziej et al., 1996)

Mutagen

ethyl methanesulfonate

(Kolodziej et al., 1996)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G?A.

(Kolodziej et al., 1996)

Amino acid replacement: W1028term.

(Kolodziej et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:12,560,784..12,560,784 [+]

Nucleotide change:

G12560784A

Reported nucleotide change:

G?A

Amino acid change:

W1028term | fra-PA; W877term | fra-PB; W1019term | fra-PC

Reported amino acid change:

W1028term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation. (exact site of mutation unspecified).

(Kolodziej et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell adhesion | embryonic stage

(Raza and Jacobs, 2016)

abnormal cell migration | dominant | embryonic stage

(Raza and Jacobs, 2016)

abnormal cell migration | third instar larval stage (with fra⁴)

(Halachmi et al., 2016)

abnormal neuroanatomy

(O'Donnell and Bashaw, 2013)

abnormal neuroanatomy (with Df(2R)BSC3)

(O'Donnell and Bashaw, 2013)

abnormal neuroanatomy (with Df(2R)vg135)

(O'Donnell and Bashaw, 2013)

abnormal neuroanatomy (with fra⁴)

(Evans et al., 2015, O'Donnell and Bashaw, 2013, Mauss et al., 2009, Andrews et al., 2008, Ratnaparkhi et al., 2002, Keleman and Dickson, 2001)

abnormal neuroanatomy (with fra⁶)

(O'Donnell and Bashaw, 2013, O'Donnell and Bashaw, 2013)

abnormal neuroanatomy | embryonic stage

(Chaudhari et al., 2024)

abnormal neuroanatomy | embryonic stage (with fra⁴)

(Zang et al., 2022, Morikawa et al., 2011, Dorsten et al., 2010, von Hilchen et al., 2010, Garbe et al., 2007)

abnormal neuroanatomy | embryonic stage (with fra⁶)

(Zang et al., 2022)

abnormal neuroanatomy | somatic clone

(Brierley et al., 2009)

abnormal neuroanatomy | third instar larval stage (with fra⁴)

(Halachmi et al., 2016, Morikawa et al., 2011)

increased cell number | somatic clone

(de Torres-Jurado et al., 2022)

Phenotype Manifest In

abdominal 1 ventral monoscolopidial chordotonal organ vch1 | third instar larval stage (with fra⁴)

(Halachmi et al., 2016)

abdominal lch1 neuron | third instar larval stage (with fra⁴)

(Halachmi et al., 2016)

abdominal ventral monoscolopidial chordotonal organ vch2 | third instar larval stage (with fra⁴)

(Halachmi et al., 2016)

adult optic lobe | somatic clone

(Timofeev et al., 2012)

adult optic lobe | somatic clone, with Scer\GAL80^ey.3.5

(Timofeev et al., 2012)

axon | embryonic stage (with fra⁴)

(Zang et al., 2022)

axon | embryonic stage (with fra⁶)

(Zang et al., 2022)

Bolwig nerve (with fra⁴)

(Andrews et al., 2008)

commissure & embryo & axon

(Kolodziej et al., 1996)

commissure | embryonic stage

(Chaudhari et al., 2024)

commissure | embryonic stage (with fra⁴)

(Zang et al., 2022)

commissure | embryonic stage (with fra⁶)

(Zang et al., 2022)

connective | embryonic stage

(Chaudhari et al., 2024)

connective | embryonic stage (with fra⁶)

(Zang et al., 2022)

dendrite (with fra⁴)

(Mauss et al., 2009)

dendrite | somatic clone

(Brierley et al., 2009)

dMP2 neuron (with fra⁴)

(Hiramoto et al., 2000)

dMP2 neuron (with fra⁴), with Scer\GAL4⁶⁰⁵, fra^{ΔC.UAS.Tag:MYC}

(Hiramoto et al., 2000)

embryonic heart cardioblast

(Raza and Jacobs, 2016)

embryonic longitudinal glial cell (with fra⁴)

(von Hilchen et al., 2010)

fascicle | embryonic stage (with fra⁴)

(Ratnaparkhi et al., 2002)

filopodium | embryonic stage

(Raza and Jacobs, 2016)

heart primordium

(Raza and Jacobs, 2016)

intermediate neuronal progenitor | increased number | somatic clone

(de Torres-Jurado et al., 2022)

lamellipodium | embryonic stage

(Raza and Jacobs, 2016)

larval anterior commissure (with fra⁴)

(Andrews et al., 2008, Keleman and Dickson, 2001)

larval EW neuron

(O'Donnell and Bashaw, 2013)

larval EW neuron (with Df(2R)BSC3)

(O'Donnell and Bashaw, 2013)

larval EW neuron (with Df(2R)vg135)

(O'Donnell and Bashaw, 2013)

larval EW neuron (with fra⁴)

(Evans et al., 2015, O'Donnell and Bashaw, 2013, Garbe et al., 2007)

larval EW neuron (with fra⁶)

(O'Donnell and Bashaw, 2013, O'Donnell and Bashaw, 2013)

larval EW neuron | embryonic stage

(Chaudhari et al., 2024)

larval EW neuron | embryonic stage (with fra⁴)

(Zang et al., 2022)

larval EW neuron | embryonic stage (with fra⁶)

(Zang et al., 2022)

larval intersegmental nerve

(Winberg et al., 1998)

larval longitudinal connective

(O'Donnell and Bashaw, 2013)

larval longitudinal connective (with Df(2R)vg135)

(O'Donnell and Bashaw, 2013)

larval longitudinal connective (with fra⁴)

(O'Donnell and Bashaw, 2013, Keleman and Dickson, 2001)

larval longitudinal connective (with fra⁶)

(O'Donnell and Bashaw, 2013)

larval longitudinal connective | embryonic stage

(Kolodziej et al., 1996)

larval multidendritic class IV neuron | third instar larval stage (with fra⁴)

(Morikawa et al., 2011)

larval posterior commissure

(O'Donnell and Bashaw, 2013)

larval posterior commissure (with Df(2R)vg135)

(O'Donnell and Bashaw, 2013)

larval posterior commissure (with fra⁴)

(O'Donnell and Bashaw, 2013, Andrews et al., 2008, Keleman and Dickson, 2001)

larval posterior commissure (with fra⁶)

(O'Donnell and Bashaw, 2013)

larval ventral nerve cord commissure (with fra⁴)

(Dorsten et al., 2010)

larval ventral nerve cord commissure | embryonic stage (with fra⁴)

(Morikawa et al., 2011)

larval ventral nerve cord commissure | third instar larval stage (with fra⁴)

(Morikawa et al., 2011)

larval VL3/4 motor neuron

(Winberg et al., 1998)

motor neuron (with fra⁴)

(Mauss et al., 2009)

motor neuron | somatic clone

(Brierley et al., 2009)

neuroblast | increased number | somatic clone

(de Torres-Jurado et al., 2022)

neuropil | somatic clone

(Brierley et al., 2009)

photoreceptor cell R8 stalk | somatic clone

(Timofeev et al., 2012)

photoreceptor cell R8 stalk | somatic clone, with Scer\GAL80^ey.3.5

(Timofeev et al., 2012)

presumptive embryonic salivary gland (with fra⁴)

(Kolesnikov and Beckendorf, 2005)

symmetrical commissure (with Df(2R)BSC3)

(O'Donnell and Bashaw, 2013)

symmetrical commissure (with fra⁴)

(Evans et al., 2015)

symmetrical commissure (with fra⁶)

(O'Donnell and Bashaw, 2013)

symmetrical commissure | embryonic stage (with fra⁴)

(Ratnaparkhi et al., 2002)

Detailed Description

Statement

Reference

In 33 out of 72 abdominal segments examined in fra³/fra⁴ third instar larvae, the LCh1 cap cell migrates ventrally instead of dorsally; in 14 of 33 segments the cap cell travels along the ventral midline (along the VChA and VChB organs) and morphology of cap cells is largely normal, while in the remaining 19 segments the LCh1 cap cell often migrates towards the LCh5 LA cell and then turns ventrally after contact with the LA cell and cap cell morphology is abnormal. Similar phenotypes are seen with the migrating VChB cap cell, where in 18 out of 72 mutant segments it does not reach or attach to the LA cell.

(Halachmi et al., 2016)

fra³ homozygous embryonic heart cardioblasts show significant decreases in migration velocity, as well as in filopodial and lamellopodial extensions and activities, as compared to controls; these are associated with gaps in the leading edge (and lost adhesions with ipsilateral partners), cell clumping, improper linear alignment of the cardioblasts, and embryonic heart lumen formation defects, as compared to controls. fra³ heterozygous cardioblasts also show a significant decrease in migration velocity and filopodial activity, but not in lamellopodial activity, as compared to controls.

(Raza and Jacobs, 2016)

fra³/fra⁴ embryos show thinning of commissures in the central nervous system, with the EW axons failing to cross the midline in 30% of abdominal segments.

(Evans et al., 2015)

fra³/fra⁶ stage 15 embryos exhibit defects in EW midline axon crossing.

fra³/Df(2R)BSC3 mutants exhibit EW axon midline crossing defects in over 30% of segments.

(O'Donnell and Bashaw, 2013)

fra³ mutants exhibit defects in axon guidance. Posterior commissures are thin or absent and occasional breaks in longitudinal connectives occur.

fra³/Df(2R)vg135 embryos exhibit defects in midline crossing in eg-positive axons (EW neurons).

fra³/fra⁴ mutants exhibit defects in Fas2-positive axons, including occasional breaks in longitudinal pathways, although the fascicles always remain ipsilateral.

EW axons in fra³/fra⁶ hypomorphic mutants fail to cross in ~20% of segments.

(O'Donnell and Bashaw, 2013)

Approximately 88.7% of the R8 axons in fra³ mutant eye clones exhibit strong projection defects: 56.2% stall at the medulla neuropil border, while 32.5% terminate prematurely at the more distal layers M1 and M2. In contrast, ganglion-specific targeting of R1-R6 axons to the lamina and layer-specific targeting of R7 axons to the M6 layer appear unaffected.

In Scer\GAL80^ey.3.5 fra³ eye mosaics, a small proportion of fra mutant R8 axons at 24 hours (12%) and 42 hours (6.2%) proceed prematurely into the neuropil located between R8 and R7 growth cones. At 55 hours, the majority of mutant R8 axons stall at the medulla neuropil border (91%).

(Timofeev et al., 2012)

fra³/fra⁴ mutants exhibit virtually complete loss of C4da neuron commissural fascicles. Furthermore the terminal processes of C4da axons in fra³/fra⁴ mutants appear to lose the asymmetric orientation towards the midline.

(Morikawa et al., 2011)

fra³/fra⁴ embryos display display commissure loss. One of the predominant defects in fra³/fra⁴ mutants is thinning and missing posterior commissures, with nearly a quarter of segments showing this defect.

Fas2-positive fascicles tend to fuse together or form small gaps in fra³/fra⁴ embryos.

(Dorsten et al., 2010)

Some hemisegments in fra³/fra⁴ embryos have ectopic glial cell clusters in the dorsal periphery. These ectopic clusters correspond to misplaced interface glia.

(von Hilchen et al., 2010)

Single cell robo¹ leg motoneuron clones induced 48 hr after hatching have the following phenotypes: the posterior dendritic branch fails to approach and cross the midline; there is an increase in dendritic arborization in the lateral regions of the neuropil; the mean centre of mass is shifted away from the midline compared to controls; the mean 33rd percentile of arborization is shifted away from the midline.

Single cell robo¹ leg motoneuron clones induced 96 hr after hatching do not show a major change in position of their dendrites.

(Brierley et al., 2009)

In fra³/fra⁴ mutant embryos, dendritic targeting to the midline is abolished in MN-VO4-6 and MN-VO4/5 projecting-neurons.

In fra³/fra⁴ mutant embryos, 63% of MN-LL1 dendritic arbors lack the normally pronounced intermediate dendritic arborisation, while targeting of MN-DA3 dendrites is not significantly affected. MN-LL1 has a clearly reduced innervation of the intermediate neuropile in 63-64% of cases.

(Mauss et al., 2009)

26% of fra³/fra⁴ embryos show defects in axon guidance in the Bolwig's nerve.

fra³/fra⁴ embryos show defects in the commissures of the central nervous system; 2% of anterior commissures are absent, 4% of anterior commissures are thin, 3% of posterior commissures are absent and 8% of posterior commissures are thin. 8% of segments fail to separate the anterior and posterior commissures correctly.

(Andrews et al., 2008)

EW axons frequently fail to cross the midline in fra³/fra⁴ mutant embryos. The trajectories of the EG axons are unaffected in these mutants.

(Garbe et al., 2007)

fra³/fra⁴ transheterozygote embryos show salivary gland guidance defects. Most mutants have salivary glands that lie parallel to the CNS midline as in wild type. However, in 4% of mutants, the glands curve laterally away from the midline and in 2% of mutants, the glands curve medially toward the midline.

(Kolesnikov and Beckendorf, 2005)

fra³/fra⁴ embryos exhibit breaks in Con-positive commissural axons and longitudinal tracts.

(Ratnaparkhi et al., 2002)

dMP2 axons make pathfinding errors in fra³/fra⁴ mutant embryos, often extending laterally, turning anteriorly or stalling. Expression of fra^{ΔC.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4⁶⁰⁵ in fra³/fra⁴ embryos results in abnormal spreading of the dMP2 growth cone over the region of induced ectopic NetB accumulation.

(Hiramoto et al., 2000)

The RP3 axon extends dorsally past and just adjacent to muscles 7 and 6 and then reached back to innervate them. RP3 neuron may extend into its normal muscle domain but fail to innervate muscles 7 and 6. The ISNb fails to innervate muscles 7 and 6.

(Winberg et al., 1998)

Commissural axons are absent or reduced in number and gaps appear in the longitudinal axon tracts. In fra³/fra⁴ embryos 12% of anterior commissures and 43% of posterior commissures in abdominal segments A1-A7 are thin or absent. Commissures that appear to have normal thickness are often less well organised than normal. Occasional breaks are also observed in the longitudinal tracts. A subset of motor axons exit the ventral CNS in the intersegmental nerve and extend dorsally, in fra³/fra⁴ embryos the axons often extend a colateral branch into an adjacent segment or make inappropriate contacts with dorsal muscles when they reach the dorsal muscle region.

(Kolodziej et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

fra⁶/fra³ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

fra⁶/fra³ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Df(3R)BSC794

(Zang et al., 2022)

fra³/fra⁴ has abnormal neuroanatomy phenotype, enhanceable by robo2^X123/robo2^x135

(Evans et al., 2015)

fra⁶/fra³ has abnormal neuroanatomy phenotype, enhanceable by Abl¹/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, enhanceable by Abl²/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, enhanceable by Abl⁴/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, enhanceable by Scer\GAL4^eg-Mz360/Src64B^YF.UAS

(O'Donnell and Bashaw, 2013)

fra³ has abnormal neuroanatomy phenotype, enhanceable by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Scer\GAL4^insc-Mz1407/Abl::Hsap\ABL1::Hsap\BCR^P210.UAS

(Dorsten et al., 2010)

fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Scer\GAL4^insc-Mz1407/Abl^UAS.cHa

(Dorsten et al., 2010)

fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Scer\GAL4^insc-Mz1407/Abl^KN.UAS

(Dorsten et al., 2010)

NOT Enhanced by

Statement

Reference

fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, non-enhanceable by Tace¹⁹

(Zang et al., 2022)

Df(3R)BSC794, fra⁶/fra³ has abnormal neuroanatomy | embryonic stage phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

Scer\GAL4^eg-Mz360, Tace^{10xUAS.Tag:HA}, fra⁶/fra³ has abnormal neuroanatomy | embryonic stage phenotype, non-enhanceable by Df(3R)BSC794

(Zang et al., 2022)

fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

Df(2R)BSC3/fra³ has abnormal neuroanatomy phenotype, non-enhanceable by Abl¹/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Abl²/Abl^{K417N.UAS.GFP}/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Abl⁴/Abl^{K417N.UAS.GFP}/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, non-enhanceable by unc-5[+]/unc-5²

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, non-enhanceable by drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, non-enhanceable by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

Suppressed by

Statement

Reference

fra³ has abnormal neuroanatomy | embryonic stage phenotype, suppressible by Scer\GAL4^eg.PU/Hsap\DCC^{ΔWIRS.10xUAS.Tag:MYC}

(Chaudhari et al., 2024)

fra³ has abnormal neuroanatomy | embryonic stage phenotype, suppressible by Scer\GAL4^eg.PU/Hsap\DCC^{10xUAS.Tag:MYC}

(Chaudhari et al., 2024)

fra³ has abnormal neuroanatomy | embryonic stage phenotype, suppressible by Scer\GAL4^eg.PU/Hsap\DCC^{R1343H.10xUAS.Tag:MYC}

(Chaudhari et al., 2024)

fra³ has increased cell number | somatic clone phenotype, suppressible by robo1¹/robo1¹

(de Torres-Jurado et al., 2022)

fra³ has abnormal cell migration | dominant | embryonic stage phenotype, suppressible by robo1¹/robo1[+]

(Raza and Jacobs, 2016)

fra⁶/fra³ has abnormal neuroanatomy phenotype, suppressible by Src64B[+]/Src64B^ko

(O'Donnell and Bashaw, 2013)

Df(2R)vg135/fra³ has abnormal neuroanatomy phenotype, suppressible by Scer\GAL4^eg-Mz360/Rnor\Dcc^UAS.Tag:MYC

(O'Donnell and Bashaw, 2013)

Df(2R)vg135/fra³ has abnormal neuroanatomy phenotype, suppressible by Scer\GAL4^eg-Mz360/Rnor\Dcc^{Y1418F.UAS.Tag:MYC}

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ has abnormal neuroanatomy phenotype, suppressible by fra::unc-5^fra.CD.UAS/Scer\GAL4^elav.PLu

(Keleman and Dickson, 2001)

NOT suppressed by

Statement

Reference

fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by Tace¹⁹

(Zang et al., 2022)

Df(3R)BSC794, fra⁶/fra³ has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

Scer\GAL4^eg-Mz360, Tace^{10xUAS.Tag:HA}, fra⁶/fra³ has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by Df(3R)BSC794

(Zang et al., 2022)

fra³ has abnormal cell migration | dominant | embryonic stage phenotype, non-suppressible by Scer\GAL4^Mef2.247/robo1^UAS.cKa

(Raza and Jacobs, 2016)

Df(2R)BSC3/fra³ has abnormal neuroanatomy phenotype, non-suppressible by Abl¹/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, non-suppressible by unc-5[+]/unc-5²

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, non-suppressible by drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has abnormal neuroanatomy phenotype, non-suppressible by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ has abnormal neuroanatomy phenotype, non-suppressible by Scer\GAL4^eg-Mz360/Rnor\Dcc^UAS.Tag:MYC

(O'Donnell and Bashaw, 2013)

fra³ has abnormal neuroanatomy phenotype, non-suppressible by Scer\GAL4^elav.PLu/Rnor\Dcc^UAS.Tag:MYC

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by fra::robo1^{UAS.FΔC.Tag:MYC}/Scer\GAL4^elav.PLu

(Garbe et al., 2007)

fra³/fra⁴ has abnormal neuroanatomy phenotype, non-suppressible by Scer\GAL4^elav-C155/Gαq^Q203L.UAS

(Ratnaparkhi et al., 2002)

Enhancer of

Statement

Reference

fra³ is an enhancer of abnormal neuroanatomy | embryonic stage phenotype of Tace¹⁹

(Zang et al., 2022)

fra³, Df(1)NP5, fra[+], + is an enhancer of abnormal neuroanatomy phenotype of Trim9⁴⁶

(Song et al., 2011)

NOT Enhancer of

Statement

Reference

fra³/fra[+] is a non-enhancer of abnormal cell migration | embryonic stage phenotype of Dscam1⁰⁵⁵¹⁸/Dscam1¹

(Raza and Jacobs, 2016)

fra³/fra[+] is a non-enhancer of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³, fra⁴, fra^UAS.cKa, Scer\GAL4^insc-Mz1407 is a non-enhancer of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra^ΔP1.UAS, fra³, fra⁴, Scer\GAL4^insc-Mz1407 is a non-enhancer of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³, fra⁴, fra^ΔP2.UAS, Scer\GAL4^insc-Mz1407 is a non-enhancer of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

Suppressor of

Statement

Reference

fra³/fra³ is a suppressor of increased cell number | somatic clone phenotype of robo1¹

(de Torres-Jurado et al., 2022)

fra³/fra[+] is a suppressor of abnormal cell migration | dominant | embryonic stage phenotype of robo1¹

(Raza and Jacobs, 2016)

fra³/fra⁴ is a suppressor of abnormal neuroanatomy | somatic clone | third instar larval stage phenotype of Scer\GAL4^ppk.PG, Trim9^UAS.Tag:HA

(Morikawa et al., 2011)

fra^ΔP3.UAS, fra³, fra⁴, Scer\GAL4^insc-Mz1407 is a suppressor | partially of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³/fra⁴ is a suppressor of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³ is a suppressor of abnormal neuroanatomy | embryonic stage phenotype of Gαq^Q203L.UAS, Scer\GAL4^15J2

(Hiramoto and Hiromi, 2006)

fra³ is a suppressor of abnormal neuroanatomy | embryonic stage phenotype of robo1¹

(Hiramoto and Hiromi, 2006)

fra³/fra[+] is a suppressor of abnormal neuroanatomy phenotype of Ggal\MLCK^ct.UAS, Scer\GAL4^ftz.ng

(Kim et al., 2002)

fra³/fra⁴ is a suppressor of abnormal neuroanatomy phenotype of Gαq^Q203L.UAS, Scer\GAL4^elav-C155

(Ratnaparkhi et al., 2002)

fra³/fra⁴ is a suppressor | partially of abnormal neuroanatomy phenotype of Scer\GAL4^ap-md544, unc-5^{UAS.Tag:HA,Tag:SS(wg)}

(Keleman and Dickson, 2001)

NOT Suppressor of

Statement

Reference

fra³/fra[+] is a non-suppressor of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³, fra⁴, fra^UAS.cKa, Scer\GAL4^insc-Mz1407 is a non-suppressor of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra^ΔP1.UAS, fra³, fra⁴, Scer\GAL4^insc-Mz1407 is a non-suppressor of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³, fra⁴, fra^ΔP2.UAS, Scer\GAL4^insc-Mz1407 is a non-suppressor of abnormal neuroanatomy | embryonic stage phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³/fra⁴ is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^elav.PLu, unc-5^{UAS.Tag:HA,Tag:SS(wg)}

(Keleman and Dickson, 2001)

Scer\GAL4^ap-md544, fra³, fra⁴, fra^UAS.cKa is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^ap-md544, unc-5^{UAS.Tag:HA,Tag:SS(wg)}

(Keleman and Dickson, 2001)

Other

Statement

Reference

Cyfip^85.1, fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype

(Chaudhari et al., 2024)

Cyfip^85.1, fra³/fra⁴ has lethal - all die during embryonic stage phenotype

(Chaudhari et al., 2024)

Df(3R)BSC794/Tace¹⁹, fra³ has abnormal neuroanatomy | embryonic stage phenotype

(Zang et al., 2022)

Abl^UAS.cHa, Scer\GAL4^insc-Mz1407, fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype

(Dorsten et al., 2010)

Abl^KN.UAS, Scer\GAL4^insc-Mz1407, fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407, fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype

(Dorsten et al., 2010)

Abl^UAS.cHa, Scer\GAL4^insc-Mz1407, fra³/fra[+] has abnormal neuroanatomy | embryonic stage phenotype

(Dorsten et al., 2010)

Df(2R)en-SFX31, fra³ has abnormal neuroanatomy phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, fra³ has lethal | adult stage phenotype

(Joly et al., 2007)

Phenotype Manifest In

Enhanced by

Statement

Reference

fra⁶/fra³ has axon | embryonic stage phenotype, enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

fra⁶/fra³ has larval EW neuron | embryonic stage phenotype, enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

fra⁶/fra³ has axon | embryonic stage phenotype, enhanceable by Df(3R)BSC794

(Zang et al., 2022)

fra⁶/fra³ has larval EW neuron | embryonic stage phenotype, enhanceable by Df(3R)BSC794

(Zang et al., 2022)

fra⁶/fra³ has commissure | embryonic stage phenotype, enhanceable by Df(3R)BSC794

(Zang et al., 2022)

fra³ has embryonic heart cardioblast phenotype, enhanceable by robo1¹/robo1[+]

(Raza and Jacobs, 2016)

fra³ has filopodium | embryonic stage phenotype, enhanceable by robo1¹/robo1[+]

(Raza and Jacobs, 2016)

fra³ has lamellipodium | embryonic stage phenotype, enhanceable by robo1¹/robo1[+]

(Raza and Jacobs, 2016)

fra³ has embryonic heart cardioblast phenotype, enhanceable by Dscam1[+]/Dscam1¹

(Raza and Jacobs, 2016)

fra³ has filopodium | embryonic stage phenotype, enhanceable by Dscam1[+]/Dscam1¹

(Raza and Jacobs, 2016)

fra³/fra⁴ has symmetrical commissure phenotype, enhanceable by robo2^X123/robo2^x135

(Evans et al., 2015)

fra³/fra⁴ has larval EW neuron phenotype, enhanceable by robo2^X123/robo2^x135

(Evans et al., 2015)

fra⁶/fra³ has larval EW neuron phenotype, enhanceable by Abl¹/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has symmetrical commissure phenotype, enhanceable by Abl¹/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, enhanceable by Abl²/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has symmetrical commissure phenotype, enhanceable by Abl²/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, enhanceable by Abl⁴/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has symmetrical commissure phenotype, enhanceable by Abl⁴/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, enhanceable by Scer\GAL4^eg-Mz360/Abl⁴/Abl^{K417N.UAS.GFP}/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has symmetrical commissure phenotype, enhanceable by Scer\GAL4^eg-Mz360/Abl⁴/Abl^{K417N.UAS.GFP}/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, enhanceable by Scer\GAL4^eg-Mz360/Src64B^YF.UAS

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval posterior commissure phenotype, enhanceable by Scer\GAL4^eg-Mz360/Src64B^YF.UAS

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval longitudinal connective phenotype, enhanceable by Scer\GAL4^eg-Mz360/Src64B^YF.UAS

(O'Donnell and Bashaw, 2013)

fra³ has larval EW neuron phenotype, enhanceable by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

fra³ has larval posterior commissure phenotype, enhanceable by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

fra³ has larval longitudinal connective phenotype, enhanceable by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ has larval ventral nerve cord commissure phenotype, enhanceable by Scer\GAL4^insc-Mz1407/Abl::Hsap\ABL1::Hsap\BCR^P210.UAS

(Dorsten et al., 2010)

fra³/fra⁴ has larval ventral nerve cord commissure phenotype, enhanceable by Scer\GAL4^insc-Mz1407/Abl^UAS.cHa

(Dorsten et al., 2010)

fra³/fra⁴ has larval ventral nerve cord commissure phenotype, enhanceable by Scer\GAL4^insc-Mz1407/Abl^KN.UAS

(Dorsten et al., 2010)

fra³/fra⁴ has presumptive embryonic salivary gland phenotype, enhanceable by mew^M6

(Kolesnikov and Beckendorf, 2005)

NOT Enhanced by

Statement

Reference

fra³/fra⁴ has axon | embryonic stage phenotype, non-enhanceable by Tace¹⁹

(Zang et al., 2022)

fra³/fra⁴ has larval EW neuron | embryonic stage phenotype, non-enhanceable by Tace¹⁹

(Zang et al., 2022)

Df(3R)BSC794, fra⁶/fra³ has axon | embryonic stage phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

Df(3R)BSC794, fra⁶/fra³ has larval EW neuron | embryonic stage phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

Scer\GAL4^eg-Mz360, Tace^{10xUAS.Tag:HA}, fra⁶/fra³ has larval EW neuron | embryonic stage phenotype, non-enhanceable by Df(3R)BSC794

(Zang et al., 2022)

Scer\GAL4^eg-Mz360, Tace^{10xUAS.Tag:HA}, fra⁶/fra³ has axon | embryonic stage phenotype, non-enhanceable by Df(3R)BSC794

(Zang et al., 2022)

fra³/fra⁴ has axon | embryonic stage phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

fra³/fra⁴ has larval EW neuron | embryonic stage phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

Df(2R)BSC3/fra³ has larval EW neuron phenotype, non-enhanceable by Abl¹/Abl[+]

(O'Donnell and Bashaw, 2013)

Df(2R)BSC3/fra³ has symmetrical commissure phenotype, non-enhanceable by Abl¹/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Abl²/Abl^{K417N.UAS.GFP}/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has symmetrical commissure phenotype, non-enhanceable by Scer\GAL4^eg-Mz360/Abl²/Abl^{K417N.UAS.GFP}/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, non-enhanceable by unc-5[+]/unc-5²

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval posterior commissure phenotype, non-enhanceable by unc-5[+]/unc-5²

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval longitudinal connective phenotype, non-enhanceable by unc-5[+]/unc-5²

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, non-enhanceable by drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval posterior commissure phenotype, non-enhanceable by drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval longitudinal connective phenotype, non-enhanceable by drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, non-enhanceable by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval posterior commissure phenotype, non-enhanceable by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval longitudinal connective phenotype, non-enhanceable by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

Suppressed by

Statement

Reference

fra³ has larval EW neuron | embryonic stage phenotype, suppressible by Scer\GAL4^eg.PU/Hsap\DCC^{10xUAS.Tag:MYC}

(Chaudhari et al., 2024)

fra³ has larval EW neuron | embryonic stage phenotype, suppressible by Scer\GAL4^eg.PU/Hsap\DCC^{R1343H.10xUAS.Tag:MYC}

(Chaudhari et al., 2024)

fra³ has commissure | embryonic stage phenotype, suppressible by Scer\GAL4^eg.PU/Hsap\DCC^{ΔWIRS.10xUAS.Tag:MYC}

(Chaudhari et al., 2024)

fra³ has commissure | embryonic stage phenotype, suppressible by Scer\GAL4^eg.PU/Hsap\DCC^{10xUAS.Tag:MYC}

(Chaudhari et al., 2024)

fra³ has commissure | embryonic stage phenotype, suppressible by Scer\GAL4^eg.PU/Hsap\DCC^{R1343H.10xUAS.Tag:MYC}

(Chaudhari et al., 2024)

fra³ has larval EW neuron | embryonic stage phenotype, suppressible by Scer\GAL4^eg.PU/Hsap\DCC^{ΔWIRS.10xUAS.Tag:MYC}

(Chaudhari et al., 2024)

fra³ has neuroblast | increased number | somatic clone phenotype, suppressible by robo1¹/robo1¹

(de Torres-Jurado et al., 2022)

fra³ has embryonic heart cardioblast phenotype, suppressible by Scer\GAL4^Mef2.247/robo1^UAS.cKa

(Raza and Jacobs, 2016)

fra³ has lamellipodium | embryonic stage phenotype, suppressible by Scer\GAL4^Mef2.247/robo1^UAS.cKa

(Raza and Jacobs, 2016)

fra³ has filopodium | embryonic stage phenotype, suppressible by Scer\GAL4^Mef2.247/robo1^UAS.cKa

(Raza and Jacobs, 2016)

fra³ has heart primordium phenotype, suppressible by Scer\GAL4^Mef2.247/robo1^UAS.cKa

(Raza and Jacobs, 2016)

fra³ has embryonic heart cardioblast phenotype, suppressible by robo1¹/robo1[+]

(Raza and Jacobs, 2016)

fra⁶/fra³ has larval EW neuron phenotype, suppressible by Src64B[+]/Src64B^ko

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval posterior commissure phenotype, suppressible by Src64B[+]/Src64B^ko

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval longitudinal connective phenotype, suppressible by Src64B[+]/Src64B^ko

(O'Donnell and Bashaw, 2013)

Df(2R)vg135/fra³ has larval EW neuron phenotype, suppressible by Scer\GAL4^eg-Mz360/Rnor\Dcc^UAS.Tag:MYC

(O'Donnell and Bashaw, 2013)

Df(2R)vg135/fra³ has larval posterior commissure phenotype, suppressible by Scer\GAL4^eg-Mz360/Rnor\Dcc^UAS.Tag:MYC

(O'Donnell and Bashaw, 2013)

Df(2R)vg135/fra³ has larval longitudinal connective phenotype, suppressible by Scer\GAL4^eg-Mz360/Rnor\Dcc^UAS.Tag:MYC

(O'Donnell and Bashaw, 2013)

Df(2R)vg135/fra³ has larval EW neuron phenotype, suppressible by Scer\GAL4^eg-Mz360/Rnor\Dcc^{Y1418F.UAS.Tag:MYC}

(O'Donnell and Bashaw, 2013)

Df(2R)vg135/fra³ has larval posterior commissure phenotype, suppressible by Scer\GAL4^eg-Mz360/Rnor\Dcc^{Y1418F.UAS.Tag:MYC}

(O'Donnell and Bashaw, 2013)

Df(2R)vg135/fra³ has larval longitudinal connective phenotype, suppressible by Scer\GAL4^eg-Mz360/Rnor\Dcc^{Y1418F.UAS.Tag:MYC}

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ has larval EW neuron phenotype, suppressible by Scer\GAL4^eg-Mz360/Rnor\Dcc^UAS.Tag:MYC

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ has larval posterior commissure phenotype, suppressible by Scer\GAL4^eg-Mz360/Rnor\Dcc^UAS.Tag:MYC

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ has larval longitudinal connective phenotype, suppressible by Scer\GAL4^eg-Mz360/Rnor\Dcc^UAS.Tag:MYC

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ has larval anterior commissure phenotype, suppressible by fra::unc-5^fra.CD.UAS/Scer\GAL4^elav.PLu

(Keleman and Dickson, 2001)

fra³/fra⁴ has larval longitudinal connective phenotype, suppressible by fra::unc-5^fra.CD.UAS/Scer\GAL4^elav.PLu

(Keleman and Dickson, 2001)

fra³/fra⁴ has larval posterior commissure phenotype, suppressible by fra::unc-5^fra.CD.UAS/Scer\GAL4^elav.PLu

(Keleman and Dickson, 2001)

NOT suppressed by

Statement

Reference

fra³/fra⁴ has axon | embryonic stage phenotype, non-suppressible by Tace¹⁹

(Zang et al., 2022)

fra³/fra⁴ has larval EW neuron | embryonic stage phenotype, non-suppressible by Tace¹⁹

(Zang et al., 2022)

Df(3R)BSC794, fra⁶/fra³ has axon | embryonic stage phenotype, non-suppressible by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

Df(3R)BSC794, fra⁶/fra³ has larval EW neuron | embryonic stage phenotype, non-suppressible by Scer\GAL4^eg-Mz360/Tace^{10xUAS.Tag:HA}

(Zang et al., 2022)

Scer\GAL4^eg-Mz360, Tace^{10xUAS.Tag:HA}, fra⁶/fra³ has larval EW neuron | embryonic stage phenotype, non-suppressible by Df(3R)BSC794

(Zang et al., 2022)

Scer\GAL4^eg-Mz360, Tace^{10xUAS.Tag:HA}, fra⁶/fra³ has axon | embryonic stage phenotype, non-suppressible by Df(3R)BSC794

(Zang et al., 2022)

Df(2R)BSC3/fra³ has larval EW neuron phenotype, non-suppressible by Abl¹/Abl[+]

(O'Donnell and Bashaw, 2013)

Df(2R)BSC3/fra³ has symmetrical commissure phenotype, non-suppressible by Abl¹/Abl[+]

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, non-suppressible by unc-5[+]/unc-5²

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval posterior commissure phenotype, non-suppressible by unc-5[+]/unc-5²

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval longitudinal connective phenotype, non-suppressible by unc-5[+]/unc-5²

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, non-suppressible by drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval posterior commissure phenotype, non-suppressible by drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval longitudinal connective phenotype, non-suppressible by drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval EW neuron phenotype, non-suppressible by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval posterior commissure phenotype, non-suppressible by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

fra⁶/fra³ has larval longitudinal connective phenotype, non-suppressible by drl[+]/drl^R343

(O'Donnell and Bashaw, 2013)

fra³ has larval EW neuron phenotype, non-suppressible by Scer\GAL4^elav.PLu/Rnor\Dcc^UAS.Tag:MYC

(O'Donnell and Bashaw, 2013)

fra³ has larval posterior commissure phenotype, non-suppressible by Scer\GAL4^elav.PLu/Rnor\Dcc^UAS.Tag:MYC

(O'Donnell and Bashaw, 2013)

fra³ has larval longitudinal connective phenotype, non-suppressible by Scer\GAL4^elav.PLu/Rnor\Dcc^UAS.Tag:MYC

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ has symmetrical commissure | embryonic stage phenotype, non-suppressible by Scer\GAL4^elav-C155/Gαq^Q203L.UAS

(Ratnaparkhi et al., 2002)

fra³/fra⁴ has fascicle | embryonic stage phenotype, non-suppressible by Scer\GAL4^elav-C155/Gαq^Q203L.UAS

(Ratnaparkhi et al., 2002)

Enhancer of

Statement

Reference

fra³ is an enhancer of axon | embryonic stage phenotype of Tace¹⁹

(Zang et al., 2022)

fra³ is an enhancer of larval EW neuron | embryonic stage phenotype of Tace¹⁹

(Zang et al., 2022)

fra³/fra[+] is an enhancer of embryonic heart cardioblast | embryonic stage phenotype of robo1¹

(Raza and Jacobs, 2016)

fra³/fra[+] is an enhancer of filopodium | embryonic stage phenotype of robo1¹

(Raza and Jacobs, 2016)

fra³/fra[+] is an enhancer of lamellipodium | embryonic stage phenotype of robo1¹

(Raza and Jacobs, 2016)

fra³/fra[+] is an enhancer of embryonic heart cardioblast | embryonic stage phenotype of Dscam1¹

(Raza and Jacobs, 2016)

fra³/fra[+] is an enhancer of filopodium | embryonic stage phenotype of Dscam1¹

(Raza and Jacobs, 2016)

fra³/fra[+] is an enhancer of filopodium | embryonic stage phenotype of Dscam1⁰⁵⁵¹⁸/Dscam1¹

(Raza and Jacobs, 2016)

fra³/fra[+] is an enhancer of lamellipodium | embryonic stage phenotype of Dscam1⁰⁵⁵¹⁸/Dscam1¹

(Raza and Jacobs, 2016)

fra³/fra[+] is an enhancer of embryonic heart cardioblast phenotype of Dscam1⁰⁵⁵¹⁸/Dscam1¹

(Raza and Jacobs, 2016)

fra³, Df(1)NP5, fra[+], + is an enhancer of dopaminergic neuron phenotype of Trim9⁴⁶

(Song et al., 2011)

robo[+], fra³, robo1¹, fra[+] is an enhancer of commissure phenotype of Trim9⁴⁶

(Song et al., 2011)

fra³/fra⁴ is an enhancer of symmetrical commissure | embryonic stage phenotype of Gαq^Q203L.UAS, Scer\GAL4^elav-C155

(Ratnaparkhi et al., 2002)

fra³/fra⁴ is an enhancer of fascicle | embryonic stage phenotype of Gαq^Q203L.UAS, Scer\GAL4^elav-C155

(Ratnaparkhi et al., 2002)

NOT Enhancer of

Statement

Reference

fra³/fra[+] is a non-enhancer of larval ventral nerve cord commissure phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³, fra⁴, fra^UAS.cKa, Scer\GAL4^insc-Mz1407 is a non-enhancer of larval ventral nerve cord commissure phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra^ΔP1.UAS, fra³, fra⁴, Scer\GAL4^insc-Mz1407 is a non-enhancer of larval ventral nerve cord commissure phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³, fra⁴, fra^ΔP2.UAS, Scer\GAL4^insc-Mz1407 is a non-enhancer of larval ventral nerve cord commissure phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

Suppressor of

Statement

Reference

fra³/fra³ is a suppressor of neuroblast | increased number | somatic clone phenotype of robo1¹

(de Torres-Jurado et al., 2022)

fra³/fra[+] is a suppressor of embryonic heart cardioblast | embryonic stage phenotype of robo1¹

(Raza and Jacobs, 2016)

fra³/fra⁴ is a suppressor of abdominal anterior ventral multidendritic neuron vdaa phenotype of Scer\GAL4^ppk.PG, Trim9^UAS.Tag:HA

(Morikawa et al., 2011)

fra^ΔP3.UAS, fra³, fra⁴, Scer\GAL4^insc-Mz1407 is a suppressor | partially of commissure | ectopic phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³/fra⁴ is a suppressor of commissure | ectopic phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³ is a suppressor of dMP2 neuron phenotype of Gαq^Q203L.UAS, Scer\GAL4^15J2

(Hiramoto and Hiromi, 2006)

fra³ is a suppressor of dMP2 neuron phenotype of robo1¹

(Hiramoto and Hiromi, 2006)

fra³/fra⁴ is a suppressor of presumptive embryonic salivary gland phenotype of sli²

(Kolesnikov and Beckendorf, 2005)

fra³/fra[+] is a suppressor of larval longitudinal connective phenotype of Ggal\MLCK^ct.UAS, Scer\GAL4^ftz.ng

(Kim et al., 2002)

fra³/fra⁴ is a suppressor | partially of larval ventral nerve cord phenotype of Scer\GAL4^ap-md544, unc-5^{UAS.Tag:HA,Tag:SS(wg)}

(Keleman and Dickson, 2001)

fra³ is a suppressor of larval transverse nerve phenotype of NetA^UAS.cHa, Scer\GAL4^how-24B

(Winberg et al., 1998)

fra³ is a suppressor of larval transverse nerve phenotype of NetB^UAS.cHa, Scer\GAL4^how-24B

(Winberg et al., 1998)

NOT Suppressor of

Statement

Reference

fra³, fra⁴, fra^UAS.cKa, Scer\GAL4^insc-Mz1407 is a non-suppressor of commissure | ectopic phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra^ΔP1.UAS, fra³, fra⁴, Scer\GAL4^insc-Mz1407 is a non-suppressor of commissure | ectopic phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³, fra⁴, fra^ΔP2.UAS, Scer\GAL4^insc-Mz1407 is a non-suppressor of commissure | ectopic phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³/fra[+] is a non-suppressor of larval ventral nerve cord commissure phenotype of Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

fra³/fra⁴ is a non-suppressor of larval anterior commissure phenotype of Scer\GAL4^elav.PLu, unc-5^{UAS.Tag:HA,Tag:SS(wg)}

(Keleman and Dickson, 2001)

fra³/fra⁴ is a non-suppressor of larval posterior commissure phenotype of Scer\GAL4^elav.PLu, unc-5^{UAS.Tag:HA,Tag:SS(wg)}

(Keleman and Dickson, 2001)

fra³, fra⁴, fra^UAS.cKa is a non-suppressor of larval ventral nerve cord phenotype of Scer\GAL4^ap-md544, unc-5^{UAS.Tag:HA,Tag:SS(wg)}

(Keleman and Dickson, 2001)

Other

Statement

Reference

Df(3R)BSC794/Tace¹⁹, fra³ has axon | embryonic stage phenotype

(Zang et al., 2022)

Df(3R)BSC794/Tace¹⁹, fra³ has larval EW neuron | embryonic stage phenotype

(Zang et al., 2022)

Dscam1[+]/Dscam1¹, fra³ has embryonic heart cardioblast phenotype

(Raza and Jacobs, 2016)

Dscam1[+]/Dscam1¹, fra³ has lamellipodium | embryonic stage phenotype

(Raza and Jacobs, 2016)

Abl^UAS.cHa, Scer\GAL4^insc-Mz1407, fra³/fra⁴ has tract | ectopic | embryonic stage phenotype

(Dorsten et al., 2010)

Abl^KN.UAS, Scer\GAL4^insc-Mz1407, fra³/fra⁴ has tract | ectopic | embryonic stage phenotype

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407, fra³/fra⁴ has tract | ectopic | embryonic stage phenotype

(Dorsten et al., 2010)

Abl^UAS.cHa, Scer\GAL4^insc-Mz1407, fra³/fra[+] has larval ventral nerve cord commissure phenotype

(Dorsten et al., 2010)

Df(2R)en-SFX31, fra³ has larval ventral nerve cord phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, fra³ has larval anterior commissure phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, fra³ has larval posterior commissure phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, fra³ has lateral tract phenotype

(Joly et al., 2007)

fra³/fra⁴, mew^M6 has presumptive embryonic salivary gland phenotype

(Kolesnikov and Beckendorf, 2005)

NetB^UAS.cHa, Scer\GAL4⁶⁰⁵, fra³/fra⁴ has dMP2 neuron phenotype

(Hiramoto et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The decreased filopodial and lamellopodial activities, but not the slow migration, displayed by fra³ homozygous embryonic heart cardioblasts are partially suppressed by the expression of robo1^Scer\UAS.cKa under the control of Scer\GAL4^Mef2.247; the associated embryonic heart lumen formation defects observed in fra³ homozygotes are also partially suppressed by the expression of robo1^Scer\UAS.cKa.

fra³, robo1¹ double heterozygotes show a more severe decrease in filopodial activity compared to either single heterozygote conditions and a more severe decrease in lamellopodial activity compared to robo1¹ heterozygotes, but do not show significant changes in migration velocity compared to wild-type controls. Dscam1¹, fra³ double heterozygotes show a severe decrease in lamellopodial activity compared to wild-type controls and a more severe decrease in filopodial activity compared to either single heterozygote conditions, but do not show significant changes in migration velocity compared to wild-type controls.

The decreased filopodial and lamellopodial activities, but not the decreased migration velocity, observed in Dscam1¹/Dscam1⁰⁵⁵¹⁸ transheterozygous embryonic heart cardioblasts are enhanced by fra³ heterozygosity.

(Raza and Jacobs, 2016)

robo2^X123/robo2^x135 strongly enhances the midline crossing defects seen in fra³/fra⁴ embryos: approximately 70% of EW neurons fail to cross the midline in the double mutant embryos.

(Evans et al., 2015)

An Abl¹/+ heterozygous background enhances the EW axon midline crossing defects seen in fra³/fra⁶ stage 15 embryos.

An Abl²/+ heterozygous background enhances the EW axon midline crossing defects seen in fra³/fra⁶ stage 15 embryos. However, the addition of Abl^{K417N.Scer\UAS} or Abl^{K417N.Scer\UAS.T:Avic\GFP} (under the control of Scer\GAL4^eg-Mz360) to these embryos reduces the percentage of segments affected with EW midline crossing defects.

An Abl⁴/+ heterozygous background enhances the EW axon midline crossing defects seen in fra³/fra⁶ stage 15 embryos. However, the addition of Abl^{K417N.Scer\UAS} or Abl^{K417N.Scer\UAS.T:Avic\GFP} (under the control of Scer\GAL4^eg-Mz360) to these embryos significantly reduces the percentage of segments affected with EW midline crossing defects.

An Abl¹/+ heterozygous background fails to significantly affect the level of EW axon midline crossing defects seen in fra³/Df(2R)BSC3 stage 15 embryos.

(O'Donnell and Bashaw, 2013)

A Src64B^ko heterozygous background suppresses the EW axon midline crossing defects found in fra³/fra⁶ hypomorphic mutants.

Co-expression of Src64B^YF.Scer\UAS under the control of Scer\GAL4^eg-Mz360 enhances the EW axon midline crossing defects found in fra³/fra⁶ hypomorphic mutants.

An unc-5² heterozygous background does not affect the level EW axon midline crossing defects found in fra³/fra⁶ hypomorphic mutants.

A drl^R343 homo or heterozygous background does not affect the level EW axon midline crossing defects found in fra³/fra⁶ hypomorphic mutants.

A drl^R343 heterozygous background enhances the percentage of fra³ mutant embryonic segments containing EW axon crossing defects.

(O'Donnell and Bashaw, 2013)

Expression of Trim9^Scer\UAS.cSa under the control of Scer\GAL4^ppk.1.9 fails to suppress the fra³ mutant phenotype.

The Trim9⁴⁶ axon midline crossing phenotype is significantly enhanced in a Df(1)NP5 and fra³ heterozygous background.

(Song et al., 2011)

Over-expression of Abl^Scer\UAS.cHa using Scer\GAL4^insc-Mz1407 enhances the degree of thinning and missing posterior commissures in fra³/fra⁴ embryos, and many anterior commissures disappear. Large bundles of axons are observed ectopically exiting the central nervous system (CNS), often extending beyond the CNS/PNS boundary.

A rare commissure may be malformed in heterozygous fra³ embryos expressing Scer\GAL4^insc-Mz1407>Abl^Scer\UAS.cHa.

Pan-neural expression of Abl^KN.Scer\UAS under the control of Scer\GAL4^insc-Mz1407 in fra³ heterozygotes has no embryonic commissural phenotype.

Pan-neural expression of Abl^KN.Scer\UAS under the control of Scer\GAL4^insc-Mz1407 in fra³/fra⁴ embryos significantly increases the frequency of thin and missing posterior commissure defects.

Commissure formation is restored in fra³/fra⁴ mutants expressing both fra^{ΔP1.Scer\UAS} and Abl^Scer\UAS.cHa under the control of Scer\GAL4^insc-Mz1407.

Commissure formation is restored in fra³/fra⁴ mutants expressing both fra^{ΔP2.Scer\UAS} and Abl^Scer\UAS.cHa under the control of Scer\GAL4^insc-Mz1407.

Commissure formation is restored in fra³/fra⁴ mutants expressing both fra^{ΔP3.Scer\UAS} and Abl^Scer\UAS.cHa under the control of Scer\GAL4^insc-Mz1407.

Nearly a third of hemi-segments in fra³/fra⁴ embryos expressing Scer\GAL4^insc-Mz1407>Abl^Scer\UAS.cHa exhibit defects characterised by Fas2-positive axons ectopically exiting the central nervous system (CNS).

Less than 10% of fra³/fra⁴ embryos expressing Scer\GAL4^insc-Mz1407>Abl^KN.Scer\UAS exhibit defects characterised by Fas2-positive axons ectopically exiting the central nervous system (CNS).

(Dorsten et al., 2010)

fra³/fra⁴ Dscam3^c02826 embryos show defects in the commissures of the central nervous system; 2% of anterior commissures are absent, 3% of anterior commissures are thin, 1% of posterior commissures are absent and 9% of posterior commissures are thin. 48% of segments fail to separate the anterior and posterior commissures correctly.

(Andrews et al., 2008)

Expression of fra::robo^{Scer\UAS.FΔC.T:Hsap\MYC}under the control of Scer\GAL4^elav.PLu fails to rescue the fra³/fra⁴ axon guidance phenotypes.

(Garbe et al., 2007)

Approximately 58% of fra³/Df(2R)en-SFX31 double mutants exhibit defects in axonal pathfinding. Stage 15 embryos display dramatic defects in ventral nerve cord architecture, with the posterior commissures missing or fused with the anterior commissures, and longitudinal tracts thinner. Nearly all the segments are affected in these embryos.

Approximately 42.1% of fra³/Df(2R)en-SFX31 double mutants are adult lethal.

(Joly et al., 2007)

fra³ strongly suppresses the dMP2 axon misprojection phenotype seen in homozygous robo¹ embryos, reducing the penetrance of the contralateral misprojection along the anterior commissure of the next segment from 99% to 24%. Expression of fra^{ΔC.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^insc-Mz1407, but not under the control of Scer\GAL4^15J2, restores the aberrant midline-crossing phenotype in these animals.

The pCC and vMP2 midline-crossing phenotypes seen in homozygous robo¹ embryos are partially and strongly suppressed by fra³ respectively. Expression of fra^{ΔC.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4⁶⁰⁵ restores the aberrant midline-crossing phenotype in these animals.

(Hiramoto and Hiromi, 2006)

In mew^M6/Y; fra³/fra⁴ double mutant embryos, the misguided salivary gland phenotype is modified, compared to that of each single mutant. Like fra³/fra⁴ mutants, the majority (75%) of misguided glands curve laterally, but levels of penetrance are high, similar to mew^M6/Y single mutants. In sli²; fra³/fra⁴ double mutants, the penetrance of the salivary gland guidance defects is by 40% compared to sli² single mutants.

(Kolesnikov and Beckendorf, 2005)

A reduction in midline crossing is observed upon removal of two copies of the fra gene in Scer\GAL4^elav-C155/Gα49B^{Q203L.Scer\UAS};fra³/fra⁴, from 48.10% of abdominal segments exhibiting midline crossover in Scer\GAL4^elav-C155/Gα49B^{Q203L.Scer\UAS} embryos to 5.3% in Scer\GAL4^elav-C155/Gα49B^{Q203L.Scer\UAS};fra³/fra⁴ mutant embryos. Embryos of the genotype Scer\GAL4^elav-C155/Gα49B^{Q203L.Scer\UAS} and fra³/fra⁴ exhibit breaks in Con-positive commissural axons and longitudinal tracts, similar to Scer\GAL4^elav-C155/Gα49B^{Q203L.Scer\UAS}; fra³/fra⁴ embryos, indicating that Gα49B does not have an effect on the fra mutant phenotype.

(Ratnaparkhi et al., 2002)

Expression of NetB^Scer\UAS.cHa under the control of Scer\GAL4⁶⁰⁵ in fra³/fra⁴ embryos results in abnormal spreading of the dMP2 growth cone over the region of ectopic NetB expression.

(Hiramoto et al., 2000)

Scer\GAL4^how-24B-mediated expression of NetA^Scer\UAS.cHa or NetB^Scer\UAS.cHa allows the axons of the transverse nerve to ectopically innervate muscles 7 and 6, loss of fra function suppresses this phenotype.

(Winberg et al., 1998)

Xenogenetic Interactions

Statement

Reference

Expression of Rnor\Dcc^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^eg-Mz360 rescues the EW commissural axon defects seen in fra³/Df(2R)vg135 embryos.

Expression of Rnor\Dcc^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^eg-Mz360 rescues the midline crossing defects found in EW neurons in fra³/fra⁴ mutants.

Expression of Rnor\Dcc^{Y1418F.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^eg-Mz360 rescues the midline crossing defects found in EW neurons in fra³/fra⁴ mutants.

Expression of Rnor\Dcc^{Y1418F.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^eg-Mz360 rescues the EW commissural axon defects seen in fra³/Df(2R)vg135 embryos.

Pan-neuronal expression of Rnor\Dcc^{Scer\UAS.T:Hsap\MYC} (under the control of Scer\GAL4^elav.PLu) does not rescue the motor guidance defects or longitudinal connective defects found in fra³ mutants and only mildly rescues the commissural guidance phenotype.

(O'Donnell and Bashaw, 2013)

Over-expression of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} using Scer\GAL4^insc-Mz1407 enhances the degree of thinning and missing posterior commissures in fra³/fra⁴ embryos, and many anterior commissures disappear. Large bundles of axons are observed ectopically exiting the central nervous system (CNS), often extending beyond the CNS/PNS boundary. The anterior commissures, which are virtually unaffected in fra³/fra⁴ embryos, are thin or missing in 41% of segments.

Fuzzy commissures remain evident in heterozygous fra³ embryos expressing Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} under the control of Scer\GAL4^insc-Mz1407.

Re-expression of fra^Scer\UAS.cKa in fra³/fra⁴ mutants reverts the phenotype back to that seen when Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} is expressed alone under the control of Scer\GAL4^insc-Mz1407 : fuzzy commissures.

Re-expression of fra^Scer\UAS.cKa in fra³/fra⁴ mutants reverts the phenotype back to that seen when Abl^Scer\UAS.cHa is expressed alone under the control of Scer\GAL4^insc-Mz1407 : normal anterior and posterior commissure formation.

In fra³/fra⁴ mutants expressing Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}, expression of fra^{ΔP1.Scer\UAS} is able tor revert the commissure loss seen in fra³/fra⁴ mutants. These mutants display fuzzy commissures.

In fra³/fra⁴ mutants expressing Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}, expression of fra^{ΔP2.Scer\UAS} is able tor revert the commissure loss seen in fra³/fra⁴ mutants. These mutants display fuzzy commissures.

In fra³/fra⁴ mutants expressing Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}, expression of fra^{ΔP3.Scer\UAS} restores commissure formation in fra³/fra⁴ mutants. The frequency of fuzzy commissures is also significantly reduced.

fra³/fra⁴ significantly reduces the frequency of ectopic axonal midline-crossovers resulting from the expression of Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}.

fra³/fra⁴ fails to reduce the frequency of ectopic axonal midline-crossovers resulting from the expression of Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} when fra^Scer\UAS.cKa is co-expressed.

fra³/fra⁴ significantly reduces the frequency of ectopic axonal midline-crossovers resulting from the expression of Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} when fra^{ΔP3.Scer\UAS} is co-expressed.

Nearly a third of hemi-segments in fra³/fra⁴ embryos expressing Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} exhibit defects characterised by Fas2-positive axons ectopically exiting the central nervous system (CNS).

(Dorsten et al., 2010)

The midline crossover phenotype caused expression of Ggal\MLCK^ct.Scer\UAS under the control of Scer\GAL4^ftz.ng is completely suppressed by fra³/+.

(Kim et al., 2002)

Complementation and Rescue Data

Rescued by

fra³ is rescued by fra^{UAS.cOa.Tag:MYC}/Scer\GAL4^eg.PU

(Chaudhari et al., 2024)

fra³ is rescued by Scer\GAL4^Mef2.247/fra^UAS.cKa

(Raza and Jacobs, 2016)

fra³/fra⁴ is rescued by fra^{UAS.cOa.Tag:MYC}/Scer\GAL4^elav.PLu

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ is rescued by fra^{9YF.UAS.Tag:MYC}/Scer\GAL4^elav.PLu

(O'Donnell and Bashaw, 2013)

fra³ is rescued by fra^{UAS.cOa.Tag:MYC}/Scer\GAL4^elav.PLu

(O'Donnell and Bashaw, 2013)

fra³ is rescued by fra^{9YF.UAS.Tag:MYC}/Scer\GAL4^elav.PLu

(O'Donnell and Bashaw, 2013)

fra³/fra⁴ is rescued by Scer\GAL4^gcm.PU/fra^UAS.cKa

(von Hilchen et al., 2010)

fra³/fra⁴ is rescued by fra^UAS.cKa/Scer\GAL4^eve.CQ2

(Mauss et al., 2009)

fra³/fra⁴ is rescued by Scer\GAL4^eg-Mz360/fra^UAS.Tag:MYC

(Garbe et al., 2007)

fra³/fra⁴ is rescued by fra^UAS.Tag:MYC/Scer\GAL4^elav.PLu

(Garbe et al., 2007)

fra³/fra⁴ is rescued by Scer\GAL4^eg-Mz360/fra^UAS.Tag:HA

(Garbe et al., 2007)

fra³/fra⁴ is rescued by fra^{ΔP1.UAS.Tag:MYC}/Scer\GAL4^eg-Mz360

(Garbe et al., 2007)

fra³/fra⁴ is rescued by Scer\GAL4^eg-Mz360/fra^{ΔP2.UAS.Tag:MYC}

(Garbe et al., 2007)

fra³/fra⁴ is rescued by Scer\GAL4^eg-Mz360/fra^{ΔP1ΔP2.UAS.Tag:MYC}

(Garbe et al., 2007)

fra³/fra⁴ is rescued by fra^UAS.cKa/Scer\GAL4^elav.PLu

(Keleman and Dickson, 2001)

fra³/fra⁴ is rescued by Scer\GAL4⁶⁰⁵/fra^UAS.cKa

(Hiramoto et al., 2000)

Partially rescued by

fra³ is partially rescued by Scer\GAL4^eg.PU/fra^{ΔWIRS.10xUAS.Tag:MYC}

(Chaudhari et al., 2024)

fra³/fra⁴ is partially rescued by Scer\GAL4^ppk.PG/fra^UAS.cKa

(Morikawa et al., 2011)

fra³/fra⁴ is partially rescued by Scer\GAL4^MZ1580/fra^UAS.cKa

(von Hilchen et al., 2010)

fra³/fra⁴ is partially rescued by Scer\GAL4^insc-Mz1407/fra^UAS.cKa

(Kolodziej et al., 1996)

Not rescued by

fra³ is not rescued by Scer\GAL4^eg.PU/fra^{ΔWIRS.5xUAS.Tag:MYC}

(Chaudhari et al., 2024)

fra³/fra⁴ is not rescued by Scer\GAL4^repo/fra^UAS.cKa

(von Hilchen et al., 2010)

fra³/fra⁴ is not rescued by Scer\GAL4^pros.PMG/fra^UAS.cKa

(von Hilchen et al., 2010)

fra³/fra⁴ is not rescued by Scer\GAL4^elav.PU/fra^UAS.cKa

(von Hilchen et al., 2010)

fra³/fra⁴ is not rescued by Scer\GAL4^Mz605/fra^UAS.cKa

(von Hilchen et al., 2010)

fra³/fra⁴ is not rescued by Scer\GAL4^eg-Mz360/fra^{ΔP3.UAS.Tag:MYC}

(Garbe et al., 2007)

fra³/fra⁴ is not rescued by Scer\GAL4^eg-Mz360/fra^{ΔP3.5.UAS.Tag:MYC}

(Garbe et al., 2007)

fra³/fra⁴ is not rescued by Scer\GAL4^eg-Mz360/fra^{UAS.Tag:Myr(Src64B),Tag:MYC}

(Garbe et al., 2007)

fra³/fra⁴ is not rescued by fra^{ΔC.UAS.Tag:HA}/Scer\GAL4^elav.PLu

(Garbe et al., 2007)

fra³/fra⁴ is not rescued by Scer\GAL4^15J2/fra^UAS.cKa

(Hiramoto et al., 2000)

fra³/fra⁴ is not rescued by Scer\GAL4^how-24B/fra^UAS.cKa

(Kolodziej et al., 1996)

Comments

The fra³ homozygous embryonic heart cardioblast defects (i.e. migration velocity and in filopodial and lamellopodial extensions and activities) and embryonic heart lumen formation defects are rescued by the expression of fra^Scer\UAS.cKa under the control of Scer\GAL4^Mef2.247.

(Raza and Jacobs, 2016)

Expression of fra^{Scer\UAS.cOa.T:Hsap\MYC} under the control of Scer\GAL4^eg-Mz360 rescues the EW commissural axon defects seen in fra³/Df(2R)vg135 embryos.

Expression of fra^{Scer\UAS.cOa.T:Hsap\MYC} in all neurons, through expression under the control of Scer\GAL4^elav.PLu, rescues EW midline crossing defects in fra³/fra⁴ mutants.

Pan-neuronal expression of fra^{Scer\UAS.cOa.T:Hsap\MYC} (under the control of Scer\GAL4^elav.PLu) rescues both the commissural and longitudinal axon defects found in fra³ mutants.

Pan-neuronal expression of fra^{9YF.Scer\UAS.T:Hsap\MYC} (under the control of Scer\GAL4^elav.PLu) rescues both the commissural and longitudinal axon defects found in fra³ mutants.

Expression of fra^{Scer\UAS.cOa.T:Hsap\MYC} in all neurons, through expression under the control of Scer\GAL4^elav.PLu, fully rescues fra³ commissural axon defects.

Expression of fra^{9YF.Scer\UAS.T:Hsap\MYC} in all neurons, through expression under the control of Scer\GAL4^elav.PLu, fully rescues fra³ commissural axon defects.

Expression of fra^{9YF.Scer\UAS.T:Hsap\MYC} in all neurons, through expression under the control of Scer\GAL4^elav.PLu, rescues EW midline crossing defects in fra³/fra⁴ mutants.

(O'Donnell and Bashaw, 2013)

Expression of fra^Scer\UAS.cKa in C4da neurons under the control of Scer\GAL4^ppk.PG partially rescues the axonal defects seen in fra³/fra⁴ mutants.

(Morikawa et al., 2011)

Expression of fra^Scer\UAS.cKa under the control of Scer\GAL4^gcm.PU rescues the defects in interface glial cell migration seen in fra³/fra⁴ embryos.

Expression of fra^Scer\UAS.cKa under the control of Scer\GAL4^MZ1580 weakly rescues the defects in interface glial cell migration seen in fra³/fra⁴ embryos.

The defects in interface glial cell migration seen in fra³/fra⁴ embryos are not rescued by expression of fra^Scer\UAS.cKa under the control of any one of Scer\GAL4^repo, Scer\GAL4^pros.PMG, Scer\GAL4^elav.PU or Scer\GAL4^Mz605.

(von Hilchen et al., 2010)

Expression of fra^Scer\UAS.cKa under the control of Scer\GAL4^eve.CQ2 rescues dendritic targeting to the midline in fra³/fra⁴ mutant MN-VO4-6 and MN-VO4/5 neurons.

Expression of fra^Scer\UAS.cKa under the control of Scer\GAL4^eve.CQ2 selectively in MN-LL1 neurons in fra³/fra⁴ mutant embryos efficiently rescues dendritic targeting to the intermediate neuropile. Moreover, this manipulation leads to a greater proportion of dendritic branches innervating the intermediate neuropile.

(Mauss et al., 2009)

Expression of fra^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^eg-Mz360 cell-autonomously rescues the EW guidance defects of fra³/fra⁴ embryos.

Expression of fra^{Scer\UAS.T:Ivir\HA} under the control of Scer\GAL4^eg-Mz360 cell-autonomously rescues the EW guidance defects of fra³/fra⁴ embryos.

(Garbe et al., 2007)

Expression of fra^Scer\UAS.cKa under the control of Scer\GAL4^15J2 does not rescue the dMP2 axonal phenotype of fra³/fra⁴ embryos. Expression of fra^Scer\UAS.cKa under the control of Scer\GAL4⁶⁰⁵ does rescue the dMP2 axonal phenotype of fra³/fra⁴ embryos.

(Hiramoto et al., 2000)

Scer\GAL4¹⁴⁰⁷ induced expression of fra^Scer\UAS.cKa in fra³/fra⁴ embryos rescues the commissure phenotype, commissures form normally in abdominal segments A1-A7. ISN motor axons also innervate their targets at near wild type levels. Scer\GAL4^how-24B induced expression of fra^Scer\UAS.cKa in fra³/fra⁴ embryos fails to rescue the ISN motor axon defects.

(Kolodziej et al., 1996)

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Mutant

Wild-type

Stocks (1)

Bloomington

8813

w^*; P{FRT(w^hs)}G13 fra³/CyO, P{lacZ.w⁺}276

Notes on Origin

Discoverer

Comments

Complements: unch^k15501.

(Prokopenko et al., 2000)

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Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Name Synonyms

Secondary FlyBase IDs

References (43)

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