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General Information
Symbol
Dmel\egh9pp4
Species
D. melanogaster
Name
FlyBase ID
FBal0057543
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

A 15bp deletion of the sequence encoding amino acids 113-117.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

15bp deletion removing the sequence encoding amino acids 113-117.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In egh9pp4 third instar visual systems, R-cell axonal projections are defective and the lamina plexus is discontinuous and of variable thickness.

Females with germline clones lay eggs with fused dorsal appendages and the embryos have an expanded nervous system. Only a few eggs are laid because early oogenesis is blocked due to the development of egg chambers containing multiple oocyte-nurse cell complexes. Germ cell divisions in the egg chambers are not regulated. Follicle cells display an unusual behaviour; organised as an epithelial sheet within the germarium that encapsulates germ cells. Follicle cells also migrate between germ cells, not around them, perhaps splitting them in two. Follicle cells at the posterior of egg chamber become mesenchymal-like indicating they have not adopted a border cell fate. Stalk cells are determined correctly but are usually disorganised compared to wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement
Reference

egh9pp4 has neuroanatomy defective phenotype, non-enhanceable by brnl.6P6

Suppressed by
NOT suppressed by
Statement
Reference
Other
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

egh9pp4 has photoreceptor cell R4 & axon phenotype, non-enhanceable by brnl.6P6

egh9pp4 has photoreceptor cell R5 & axon phenotype, non-enhanceable by brnl.6P6

egh9pp4 has photoreceptor cell R6 & axon phenotype, non-enhanceable by brnl.6P6

egh9pp4 has photoreceptor cell R1 & axon phenotype, non-enhanceable by brnl.6P6

egh9pp4 has photoreceptor cell R2 & axon phenotype, non-enhanceable by brnl.6P6

egh9pp4 has photoreceptor cell R3 & axon phenotype, non-enhanceable by brnl.6P6

Suppressed by
Statement
Reference

egh9pp4 has photoreceptor cell R1 & axon phenotype, suppressible by Hsap\B4GALT6UAS.cWa/Scer\GAL4arm.PS

egh9pp4 has photoreceptor cell R2 & axon phenotype, suppressible by Hsap\B4GALT6UAS.cWa/Scer\GAL4arm.PS

egh9pp4 has photoreceptor cell R3 & axon phenotype, suppressible by Hsap\B4GALT6UAS.cWa/Scer\GAL4arm.PS

egh9pp4 has photoreceptor cell R4 & axon phenotype, suppressible by Hsap\B4GALT6UAS.cWa/Scer\GAL4arm.PS

egh9pp4 has photoreceptor cell R5 & axon phenotype, suppressible by Hsap\B4GALT6UAS.cWa/Scer\GAL4arm.PS

egh9pp4 has photoreceptor cell R6 & axon phenotype, suppressible by Hsap\B4GALT6UAS.cWa/Scer\GAL4arm.PS

NOT suppressed by
Statement
Reference

brnl.6P6, egh9pp4 has photoreceptor cell R3 & axon phenotype, non-suppressible by Hsap\B4GALT6UAS.cWa/Scer\GAL4arm.PS

brnl.6P6, egh9pp4 has photoreceptor cell R4 & axon phenotype, non-suppressible by Hsap\B4GALT6UAS.cWa/Scer\GAL4arm.PS

brnl.6P6, egh9pp4 has photoreceptor cell R5 & axon phenotype, non-suppressible by Hsap\B4GALT6UAS.cWa/Scer\GAL4arm.PS

brnl.6P6, egh9pp4 has photoreceptor cell R6 & axon phenotype, non-suppressible by Hsap\B4GALT6UAS.cWa/Scer\GAL4arm.PS

brnl.6P6, egh9pp4 has photoreceptor cell R1 & axon phenotype, non-suppressible by Hsap\B4GALT6UAS.cWa/Scer\GAL4arm.PS

brnl.6P6, egh9pp4 has photoreceptor cell R2 & axon phenotype, non-suppressible by Hsap\B4GALT6UAS.cWa/Scer\GAL4arm.PS

NOT Enhancer of
Statement
Reference

egh9pp4 is a non-enhancer of photoreceptor cell R2 & axon phenotype of brnl.6P6

egh9pp4 is a non-enhancer of photoreceptor cell R3 & axon phenotype of brnl.6P6

egh9pp4 is a non-enhancer of photoreceptor cell R4 & axon phenotype of brnl.6P6

egh9pp4 is a non-enhancer of photoreceptor cell R5 & axon phenotype of brnl.6P6

egh9pp4 is a non-enhancer of photoreceptor cell R6 & axon phenotype of brnl.6P6

egh9pp4 is a non-enhancer of photoreceptor cell R1 & axon phenotype of brnl.6P6

Additional Comments
Genetic Interactions
Statement
Reference

The R-cell axonal projection phenotype of brnl.6P6 and egh9pp4 mutants is not enhanced when flies carry both mutations simultaneously.

Xenogenetic Interactions
Statement
Reference

Expression of Hsap\β4Gal-T6Scer\UAS.cWa, under the control of Scer\GAL4arm.PS, in egh9pp4 mutants rescues the R-cell axonal projection phenotype. However, Scer\GAL4arm.PS > Hsap\β4Gal-T6Scer\UAS.cWa expression does not rescue the R-cell axonal projection phenotype in brnl.6P6 egh9pp4 double mutants.

Complementation and Rescue Data
Comments

Lethality and fertility phenotypes are rescued by egh+t7 and eghhs.PG.

Lethality is rescued by egh+t7, rescued adults are fertile.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)