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General Information
Symbol
Dmel\dlg1UAS.cBa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Budnik
FlyBase ID
FBal0057607
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Dlg
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulatory sequences drive expression of a complete dlg1 cDNA (coding sequence for the A transcript).
UASt regulatory sequences drive expression of a dlg1A cDNA fragment that contains the complete coding region plus 143bp of 5' and 40bp of 3' untranslated sequence.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
The subsynaptic reticulum underlying larval neuromuscular junctions is expanded in dlg1Scer\UAS.cBa; Scer\GAL4BG487.
Scer\GAL4BG487 mediated expression in wild type causes overdevelopment of the subsynaptic reticulum (SSR) and results in a larger than normal immunoreactive area around type I boutons.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Additional Comments
Genetic Interactions
Statement
Reference
The expansion of the subsynaptic reticulum of larval neuromuscular junctions due to dlg1Scer\UAS.cBa; Scer\GAL4BG487 is partially suppressed by co-expression of Syx18Scer\UAS.cGa.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Expression of dlg1Scer\UAS.cBa, driven by either Scer\GAL4BG380 or Scer\GAL4BG487, rescues the neurological phenotype of dlg114/Df(1)N71 mutants, leading to wild-type vesicle and quantal size. The synaptic area is reduced to a wild-type size in type 1s boutons, while in type 1b boutons, the rescued synaptic area is actually smaller than wild-type controls.
Scer\GAL4BG487 or Scer\GAL4C57 mediated postsynaptic expression partially rescues SSR mutant phenotype, Scer\GAL4sca.PC or Scer\GAL4BG380 mediated presynaptic expression fully rescues.
Rescues lethality of dlg114, dlg112 and dlg17 when expressed from Scer\GAL432B.
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
dlg1Scer\UAS.cBa
dlg1UAS.cBa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Budnik
Secondary FlyBase IDs
    References (8)