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General Information
Symbol
Dmel\nmoadk1
Species
D. melanogaster
Name
FlyBase ID
FBal0057941
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Mutation resulting in alterations in the pattern of transcripts produced (truncated transcripts are produced in pupae).
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Mutant flies have a mild ectopic vein phenotype in the wing.
nmoadk1 germline clones result in embryonic lethality characterized by moderate head defects in 80% of clonal embryos. The embryos also display moderate and variable segmentation defects, including loss of denticle structures. They also show a reduction in embryonic cell death, particularly in the head region. Post death stage homozygous nmoadk1 pupal retinae have an increased density of secondary/tertiary pigment cells compared to wild-type. Unlike wild-type, the local density of these cells is variable: dependent on the specific aberrations in ommatidial shape and orientation in the region in question. In some regions the ommatidia are square-like and have approximately wild-type numbers of secondary/tertiary cells. In other regions of the same retina, ommatidia retain a hexagonal- like shape but have increased numbers of secondary/tertiary pigment cells.
Mutant flies have a shorter, broader wing than normal. Excess wing vein tissue originating from the posterior crossvein and extending distally between veins L4 and L5 is seen (this phenotype is fully penetrant). Additional vein material can also form parallel to vein L2 and posterior to vein L5. The wings are held away from the body at a 45o angle. Flies show a variable polarity defect in the wing. Homozygotes show a mild loss of bristles on the head and notum (having an average of 37.4 +/- 1.71 bristles compared to the wild-type number of 40) and occasionally have bent or duplicated bristles.
Semi-lethal, rare homozygous flies display rough, small eyes and several wing phenotypes. Wings are rounder and shorter and held out at an angle from the body, and also display ectopic cross vein material.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
nmoadk1 has visible phenotype, enhanceable by Dadj1E4
Suppressed by
Statement
Reference
Enhancer of
Statement
Reference
nmoadk2/nmoadk1 is an enhancer of visible | dominant phenotype of H1
nmoadk1/nmoadk1 is an enhancer of visible | dominant phenotype of H1
Phenotype Manifest In
Enhanced by
Statement
Reference
nmoadk1 has wing vein | ectopic phenotype, enhanceable by Dadj1E4
Suppressed by
Statement
Reference
Enhancer of
Statement
Reference
nmoadk2/nmoadk1 is an enhancer of head bristle phenotype of H1
nmoadk2/nmoadk1 is an enhancer of mesothoracic tergum & macrochaeta phenotype of H1
nmoadk1/nmoadk1 is an enhancer of head bristle phenotype of H1
nmoadk1/nmoadk1 is an enhancer of mesothoracic tergum & macrochaeta phenotype of H1
nmoadk1 is an enhancer of phenotype of Nnucl.sev
Additional Comments
Genetic Interactions
Statement
Reference
The severity of the ectopic wing vein phenotype seen in nmoadk1 flies is increased in Dadj1E4 ; nmoadk1 double mutants.
Heterozygosity for nmoadk1 partially rescues the small eye size of rprGMR.PH animals.
The loss of bristles on the head and notum seen in H1/+ flies is dramatically enhanced by nmoadk1/nmoadk1 or nmoadk1/nmoadk2. Expression of HLHmβScer\UAS.cdCa under the control of Scer\GAL432B completely suppresses the extra wing vein phenotype of nmoadk1/nmoadk2 flies.
Second site dominant enhancer of Nnucl.sev that increases the roughness of the eye, eye shape is smaller and flatter and eyes appear more glossy or shiny.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Expression of nmoc5-1.Scer\UAS under the control of Scer\GAL4bs-1348 rescues the extra wing vein phenotype seen in nmoadk1/nmoadk2 flies.
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (7)