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General Information
Symbol
Dmel\Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
Species
D. melanogaster
Name
FlyBase ID
FBal0058397
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Dp110CAAX, PI3KCAAX, UAS-Dp110-CAAX, dp110CAAX, Dp110-CAAX, UAS-Pi3KCAAX, UAS-Pi3K92ECAAX, UAS-Dp110CAAX
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of wild-type Pi3K92E that is targeted to the membrane due to the presence of a C-terminal Tag:PM(hKRAS) sequence. The open reading frame is tagged at the N-terminal end with Tag:MYC.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Clonal expression of Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS) under the control of Scer\GAL4Act5C.PP in the larval fat body induces extremely large cells and extremely large nuclei, as compared to neighboring control cells.

Under control nutrition conditions, the expression of Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS) under the combined control of Scer\GAL4C587 and Gal80[ts] does not lead to any significant changes in the number of escort cells in the germarium, as compared to controls.

Expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4insc-Mz1407 is capable of driving central brain neuroblast reactivation in the absence of dietary amino acids.

Expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4hh.PU results in increased size of the posterior compartment in in third instar larval wing discs.

Clones expressing Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4Act5C.PU in the third larval instar wing disc and fat body are larger than control clones.

Cells expressing Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4en.PU show a significant increase in zippering speed during dorsal closure compared to neighbouring control cells. The number of filopodia at the leading edge is significantly increased in the mutant cells.

Third instar larvae expressing Scer\GAL4Gli-rL82>Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX develop very thick and irregular nerves with ectopically attached plasmatocytes.

Scer\GAL4elav.PLu-mediated expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX has no significant effect on axon guidance in the visual system.

Expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX in motor neurons under the control of Scer\GAL4D42 increases neuromuscular junction synapse number by approximately 2.5 times.

Expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX in motor neurons under the control of Scer\GAL4D42 increases motor axon diameter by approximately 75%.

Central nervous system neuroblasts of fed larvae expressing Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4nab show an increase in EdU incorporation compared to controls.

Central nervous system neuroblasts of larvae expressing Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4nab and raised on a diet lacking amino acids for 24 hours show an increase in EdU incorporation compared to controls.

Expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4Ilp2.PR results in an increase in the mass of third instar larvae compared to controls.

Central nervous system neuroblasts of fed second instar larvae expressing Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4repo.PU show an increase in EdU incorporation compared to controls.

Expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX driven by Scer\GAL4GMR.PU leads to a significant increase in eye size compared to controls.

Overexpression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX in fat body cell clones under the control of Scer\GAL4αTub84B.PP leads to a fat body cell overgrowth phenotype.

Expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4repo.PU produces viable animals with relatively normal brains compared to controls.

Expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4GMR.PF results in an eye overgrowth phenotype.

Flies expressing Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4hs.PB have an increased average body weight compared to control flies.

Expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4amn-c651 reduces pupal body size. This genotype also causes an increase in the prothoracic gland cell size, with no effect on cell number.

Cells in sector C of the wing expressing Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4dpp.blk1 are 14.9% larger than control cells. The average area of the mutant sector is increased by 22.8% compared to controls and the average number of cells in the mutant sector is increased by 18.3%. In addition to the autonomous increase in the area of the sector expressing Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4dpp.blk1 (sector C), a non-autonomous reduction of the area of all other wing sectors is seen; the average reduction of the other sectors is 29.8% and the maximal reduction is 41% in region D of the wing. Expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4ap-md544 results in a bigger notum than normal which has more chaetae than wild type. In the acrostical region there are on average 79.6% less microchaetae than in controls and there is a reduction in the number of cells between microchaetae (2.66 in mutant tissue compared to 5.34 in wild type).

Animals expressing Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4Adh.PF feed poorly, often having no food in their gut, and frequently wander away from their food.

The border cells in the ovaries of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX; Scer\GAL4slbo.2.6 animals form normal numbers and sizes of cellular extensions, and migrate normally.

Expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4slbo.2.6 has no effect on border cell migration.

Expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4en-e16E results in considerable overgrowth of the posterior compartment of the wing disc.

When expression is driven by Scer\GAL4dpp.blk1 the area between wing veins LIII and LIV is significantly increased due to a increase in both cell number and cell size.

Scer\GAL4dpp.blk1 mediated expression caused expansion of the wing margin due to an increase in overall number of cells and their size. Scer\GAL4GMR.PF mediated expression causes enlarged and bulging roughened eyes with fused ommatidia and misplaced or duplicated bristles.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
NOT Enhanced by
Suppressed by
Statement
Reference
NOT suppressed by
Suppressor of
NOT Suppressor of
Other
Statement
Reference
Phenotype Manifest In
Enhanced by
NOT Enhanced by
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference

Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), Scer\GAL4GMR.PU has eye phenotype, non-suppressible by dj-1βΔ93/dj-1beta[+]

Suppressor of
NOT Suppressor of
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Co-expressing btl::Egfrλ.UAS and Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS) under the control of Scer\GAL4repo induces glial neoplasia (glioblastoma) in the third instar larval brain, with severe increases in glial cell number and severely expanding the glial network (i.e. increased membrane volume in the brain and increased glial membrane volume/glial cell number ratio), as compared to controls; glial cells wrap clusters of neurons in individual "nests"; GRASP experiments indicate a significant increase of glia-neuron membrane interaction; the glial protrusions have markers of cytonemes (i.e. LifeAct-GFP, GMA-GFP, GPI=YFP, GFP-MLC). The third instar larval neuromuscular junction shows significantly fewer synapses, as compared to controls.

Co-expressing btl::Egfrλ.UAS and Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS) during adulthood under the combined control of Scer\GAL4repo and Gal80[ts] leads to a significantly shorter lifespan; the neuromuscular junction has significantly fewer synapses, as compared to controls.

Clonal expression of Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS) under the control of Scer\GAL4Act5C.PP in the larval fat body induces extremely large cells with extremely large nuclei, both of which are suppressed by clonal co-expression of Tl10b.UAS.cUa.

The ability of Scer\GAL4insc-Mz1407-driven expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX to induce central brain neuroblast reactivation in the absence of dietary amino acids is prevented by co-expression of ChroKK105370.

There is no increase in the frequency of clone splitting in the Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX-expressing 'loser' cells when cell competition is induced through generation of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX-expressing clones in super-competitive MycαTub84B.PBb-expressing tissues compared with wild type clones in MycαTub84B.PBb-expressing tissue.

Expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX partially suppresses the niche (posterior signalling center) cell loss and increased differentiation of prohemocytes into plasmatocytes and crystal cells seen in the lymph gland when Arf79FGD12522 is expressed under the control of Scer\GAL4kn-col85-GAL4.

Co-expression of Arf79FScer\UAS.cKa and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4kn-col85-GAL4 results in an enlarged niche (posterior signalling center) in the lymph gland primary lobe. Increased differentiation of prohemocytes into plasmatocytes and crystal cells is seen.

Overexpression of constitutively active Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX in the salivary glands, under the control of Scer\GAL4ppl.PP, fully suppresses the small cell size phenotype found upon knockdown of CdsA through expression of CdsANIG.7962R. The ectopic lipid accumulation phenotype of CdsANIG.7962R mutants is partially rescued by overexpression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX.

The reduction in the distance between wing veins 3 and 4 that is seen in animals expressing PrpkdsRNA.Scer\UAS.462 under the control of Scer\GAL4salm.EPv is not suppressed if they are also co-expressing Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX.

Clones expressing PrpkdsRNA.Scer\UAS.462 and also co-expressing Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4Act5C.PU in the third larval instar wing disc and fat body are small and apoptotic, showing the same phenotype as clones expressing PrpkdsRNA.Scer\UAS.462 alone under the control of Scer\GAL4Act5C.PU.

Co-expression of btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4repo.PU induces glial overgrowth in third instar larval brains.

Expression of RIOK2GD7407 suppresses the glial overgrowth seen when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU. There are few excess glia and remaining glial cells show abnormal development. The resulting brains are smaller in size than controls, due to a reduction in both glial and neuronal cells.

Expression of RIOK2NIG.11859R suppresses the glial overgrowth seen when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU. There are few excess glia and remaining glial cells show abnormal development.

Expression of RIOK2KK101850 suppresses the glial overgrowth seen when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU. There are few excess glia and remaining glial cells show abnormal development.

Expression of RIOK1GD8541 suppresses the increase in brain size and glial overgrowth seen when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU. There are few excess glia and remaining glial cells show abnormal development. The resulting brains are smaller in size than controls, due to a reduction in both glial and neuronal cells.

Expression of RIOK1KK100810 suppresses the increase in brain size and glial overgrowth seen when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU. There are few excess glia and remaining glial cells show abnormal development. The resulting brains are smaller in size than controls, due to a reduction in both glial and neuronal cells.

Expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX in the fat body under the control of Scer\GAL4c729 partially rescues the starvation resistance phenotype seen in itgr[ku] (Itp-r83Aka1091/Itp-r83Aug3) mutant flies. Expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX leads to reduced levels of stored TAGs and their mobilization upon starvation as compared to itgr[ku] alone. The increase in body weight is only partially rescued.

The increase in synapse number seen in larvae expressing Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX in motor neurons under the control of Scer\GAL4D42 is unaffected by a Fak56DCG1 background.

The axon diameter increase seen upon expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4D42 is unaffected by a Fak56DCG1 mutant background.

Co-expression of DJ-1αScer\UAS.cMa or dj-1βScer\UAS.cMa does not enhance or presence of dj-1βΔ93/+ does not suppress increases in eye size in flies with expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX driven by Scer\GAL4GMR.PU.

Expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4tub.PU does not suppress the defective growth seen in l(2)gl4 mutant clone cells.

The effect of Scer\GAL4αTub84B.PP>Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX overexpression on cell growth in fat body cell clones is suppressed by srlKG08646.

Co-expression of btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4repo.PU induces progressive accumulation of ~50 fold excess glia in third instar larvae. The excess glia emerge in early larval stages and accumulate over 5-7 days. They severely disrupt the normal cellular architecture of the larval brain, lose normal stellate glial morphologies and generate multilayered aggregations of abnormal glia throughout the brain. The brains of larvae expressing btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4repo.PU also display abnormal polyploid glia.

When brain fragments from larvae co-expressing btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4repo.PU are transplanted into young wild type adult flies, the mutant glia survive and proliferate into massive tumours that fill the host abdomen, often causing premature death. Tumours are composed of small glial cells with little cytoplasm. Tumours also contain trachea embedded throughout their mass. The leading edge of the tumor harbours individual cells invading nearby tissues, such as the ovary. However some tissues, such as the gut, do not contain metastases.

Expression of PtenScer\UAS.cUa strongly suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Expression of Ras85DN17.Scer\UAS moderately suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Expression of dapScer\UAS.cdNa completely suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU. The gross neural morphogenesis defects are also suppressed.

Expression of RbfScer\UAS.cDa suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU. The gross neural morphogenesis defects are also suppressed.

Expression of pntGD1513 completely suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

One copy of stg01235 partially suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Expression of stgScer\UAS.cNa enhances the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Expression of Akt1GD1361 strongly suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Expression of TorTED.Scer\UAS partially suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Sin1e03756/Df(2R)BSC11 almost completely suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Expression of foxoTM.Scer\UAS partially suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Expression of raptorGD5138 significantly suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Expression of S6kGD6646 significantly suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Expression of eIF-4EGD1432 significantly suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Expression of ThorGD12533 significantly suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Expression of Tsc1GD11836 enhances the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

One copy of dmP0 suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU. The late larval lethality is also partially suppressed.

Expression of MaxGD4743 strongly suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Cdk43/Cdk4k06503 completely suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Expression of RbfGD4484 enhances the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU. These animals display exacerbated glial neoplasia, with a substantial increase in small anaplastic-like glia throughout the CNS.

The eye overgrowth phenotype caused by expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4GMR.PF is not suppressed by Lnk4Q3/Lnk6S2.

The increased average body weight seen in flies expressing Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4hs.PB is not suppressed by Grp1k08110/Grp1SH0323.

Overgrowth in the eye due to Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX with Scer\GAL4GMR.PF is not suppressed by B4Scer\UAS.cSa, but is suppressed by PtenScer\UAS.cHa.

Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX; Scer\GAL4srp.Hemo suppresses the reduction in hemocytes seen at stage 12 in Pvr1 homozygous embryos, but fails to suppress the reduction in hemocyte numbers at stage 16 and only mildly suppresses the macrophage aggregation phenotype.

Xenogenetic Interactions
Statement
Reference

Expression of Hsap\EGFRΔ.Scer\UAS and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX under the control of Scer\GAL4repo.PU induces glial overgrowth in third instar larval brains.

Expression of RIOK1GD8541 suppresses the brain enlargement and glial overgrowth seen when Hsap\EGFRΔ.Scer\UAS and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Expression of RIOK2GD7407 suppresses the brain enlargement and glial overgrowth seen when Hsap\EGFRΔ.Scer\UAS and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Co-expression of Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX in motor neurons with Rat\CamKII-IAla.hs, both under the control of Scer\GAL4D42, suppresses the Rat\CamKII-IAla.hs-dependent decrease in synapse number. Synapse number is significantly increased in these double mutants and is indistinguishable from synapse number in larvae expressing Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX alone.

Complementation and Rescue Data
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Comments

Protein is targetted to the membrane.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (10)
Reported As
Symbol Synonym
Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX
Pi3K92EUAS.T:Myc,T:CAAX
Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
Name Synonyms
Secondary FlyBase IDs
    References (61)