Allele Dmel\P\T^UP2.a.hs

General Information
Symbol	Dmel\P\T^UP2.a.hs	Species	D. melanogaster
Name		FlyBase ID	FBal0058421
Feature type	allele	Associated gene	Dmel\P\T

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Simmons et al., 1996)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Fragment carrying the UP2 P-element (deletion of nucleotides 211 to 1965, compared to a full length P-element) cloned from the UK4 strain is fused to an Hsp70 promoter in antisense orientation. (Simmons et al., 1996)
Carried in construct	P{A-UP2} (Simmons et al., 1996)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference The presence of Δ2-3 somatic transposase to Muller5-B X chromosome carrying five target P-elements causes pupal lethality, without heat shock P{A-UP2} can repress some of the lethality but heat induced expression significantly enhances repression. Combination of P{S-UP2} and P{A-UP2} can repress pupal lethality, repression is induced or enhanced by heat shock. Combination of P{A-MP2} and P{A-UP2}, and P{A-BP2} and P{A-UP2} can repress pupal lethality when induced by heat shock about as effectively as the single construct. P{A-UP2} cannot repress sn^w mutability in the male germline or the somatic instability of sn^w (males have patches of weak sn, extreme sn and wild-type bristles) with or without heat shock. P{A-UP2} has no effect on the expression of the Ecol\lacZ gene of P{lacZ}sn^unspecified or P{lacZ}vas^unspecified. (Simmons et al., 1996)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	P\T^UP2.a.hs
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Simmons et al., 1996, Genetics 144(4): 1529--1544 Repression of hybrid dysgenesis in Drosophila melanogaster by heat-shock-inducible sense and antisense P-element constructs. [FBrf0091172]

Allele Dmel\P\TUP2.a.hs

Allele Dmel\P\T^UP2.a.hs