Allele Dmel\RasGAP1^EP45

General Information
Symbol	Dmel\RasGAP1^EP45	Species	D. melanogaster
Name		FlyBase ID	FBal0058737
Feature type	allele	Associated gene	Dmel\RasGAP1

Allele class	wild-type allele
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	wild-type allele (Rorth, 1996)
Mutagen	P-element activity (Rorth, 1996)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion of a P{EP} element approximately 20bp upstream of the Gap1 transcription start site. (Rorth, 1996)
Caused by insertion	P{EP}RasGAP1^EP45 (Rorth, 1996, Botella et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class
	visible, with Scer\GAL4^hs.2sev (Rorth, 1996)
Phenotype Manifest In
	eye, with Scer\GAL4^hs.2sev (Rorth, 1996)
Detailed Description
	Statement Reference Flies have rough eyes when Gap1^EP45 expression is driven by Scer\GAL4^hs.2sev. (Rorth, 1996)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference RasGAP1^EP45, Scer\GAL4^hs.2sev has visible phenotype, enhanceable by Ras85D⁰⁵⁷⁰³ (Rorth, 1996)
Phenotype Manifest In
Enhanced by
Statement Reference RasGAP1^EP45, Scer\GAL4^hs.2sev has eye phenotype, enhanceable by Ras85D⁰⁵⁷⁰³ (Rorth, 1996)
Additional Comments
Genetic Interactions
Statement Reference The rough eye phenotype caused when Gap1^EP45 expression is driven by Scer\GAL4^hs.2sev is strongly enhanced if the flies are also homozygous for Ras85D⁰⁵⁷⁰³. (Rorth, 1996)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	EP45 (Rorth, 1996) Gap1^EP45 (Walker et al., 2006) RasGAP1^EP45
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Walker et al., 2006, Genes Dev. 20(23): 3311--3323 Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons. [FBrf0193208] Botella et al., 2003, Mol. Biol. Cell 14(1): 241--250 Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap. [FBrf0155942] Rorth, 1996, Proc. Natl. Acad. Sci. U.S.A. 93(22): 12418--12422 A modular misexpression screen in Drosophila detecting tissue-specific phenotypes. [FBrf0090768]

Allele Dmel\RasGAP1EP45

Allele Dmel\RasGAP1^EP45