Allele Scer\GAL4^sim.PS

General Information
Symbol	Scer\GAL4^sim.PS	Species	S. cerevisiae
Name	single-minded promoter construct of Scholz	FlyBase ID	FBal0058755
Feature type	allele	Associated gene	Scer\GAL4

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Golembo et al., 1996, Scholz et al., 1997, Scholz et al., 1997)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference 3.5kb EcoRV sim promoter fragment drives expression of Scer\GAL4. (Scholz et al., 1997, Scholz et al., 1997) Construct: sim promoter fragment drives expression of Scer\GAL4. (Golembo et al., 1996)
Carried in construct	P{GAL4-sim.S} (Wood et al., 2006, Franch-Marro et al., 2005, Shandala et al., 2003, Bergmann et al., 2002, Yoshikawa et al., 2003, Menne et al., 1997, Giesen et al., 2003, Merianda et al., 2005, Dorfman et al., 2002, Fradkin et al., 2004, Gallio et al., 2004, McGovern et al., 2003, Zhu et al., 2008, Steigemann et al., 2004, Desbordes and Sanson, 2003, Hummel et al., 2000, Hummel et al., 2000, Olofsson and Page, 2005, Onel et al., 2004, Miguel-Aliaga and Thor, 2004, Wojtowicz et al., 2004, Schimmelpfeng et al., 2001, Sanchez Soriano and Russell, 1998, Page, 2003, Vorbruggen and Jackle, 1997, Scholz et al., 1997, Luer et al., 1997, Becker et al., 1997, Scholz et al., 1997, Golembo et al., 1996, Bossing and Brand, 2006, Boyle et al., 2006, Huelsmeier et al., 2007, Schimmelpfeng et al., 2006, Wu et al., 2011, Wu et al., 2011, von Hilchen et al., 2010, Al-Anzi and Wyman, 2009, Ding et al., 2011, Araújo and Casanova, 2011, Gemmill et al., 2002, Bossing et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class
	decreased cell death, with NT1^{Cterm.Scer\UAS} (Zhu et al., 2008) decreased cell death, with NT1^{Cysknot.Scer\UAS} (Zhu et al., 2008) increased cell death, with hh^Scer\UAS.cIa (Bossing and Brand, 2006) increased cell death \| embryonic stage 17, with Df(3L)ED4342, NT1^{dsRNA.pwCK.Scer\UAS} (Zhu et al., 2008) increased cell death \| embryonic stage 17, with NT1⁴¹, NT1^{dsRNA.CK.Scer\UAS} (Zhu et al., 2008) increased cell death \| embryonic stage 17, with NT1⁴¹, NT1^{dsRNA.pro.Scer\UAS} (Zhu et al., 2008) increased cell death \| embryonic stage 17, with NT1⁴¹, NT1^{dsRNA.pwCK.Scer\UAS} (Zhu et al., 2008) increased cell death \| embryonic stage 17, with NT1⁴¹/NT1^{dsRNA.CK.Scer\UAS} (Zhu et al., 2008) increased cell death \| embryonic stage 17, with NT1⁴¹/NT1^{dsRNA.pro.Scer\UAS} (Zhu et al., 2008) neuroanatomy defective, with en^Scer\UAS.cYa (Bossing and Brand, 2006) neuroanatomy defective, with Ephrin^Scer\UAS.cBa (Bossing and Brand, 2002) neuroanatomy defective, with Ephrin^{Scer\UAS.T:Hsap\MYC} (Boyle et al., 2006) neuroanatomy defective, with tutl^{AT02763.Scer\UAS} (Al-Anzi and Wyman, 2009) neuroanatomy defective, with tutl^{GH15753.Scer\UAS} (Al-Anzi and Wyman, 2009) neuroanatomy defective, with Wnt5^Scer\UAS.cFa (Ding et al., 2011) neuroanatomy defective \| embryonic stage, with plexB^{EcTM.Scer\UAS.T:Hsap\MYC} (Wu et al., 2011, Wu et al., 2011)
Phenotype Manifest In
	aCC neuron, with spi^s.Scer\UAS (Menne et al., 1997) anterior commissure, with en^Scer\UAS.cYa (Bossing and Brand, 2006) anterior commissure, with Wnt5^EY03178 (Yoshikawa et al., 2003) anterior commissure, with Wnt5^Scer\UAS.cFa (Fradkin et al., 2004, Ding et al., 2011) axon, with futsch^EP1419 (Hummel et al., 2000) commissure, with aop^ACT.Scer\UAS (Scholz et al., 1997, Scholz et al., 1997) commissure, with Egfr^DN.Scer\UAS (Scholz et al., 1997, Scholz et al., 1997) commissure, with Ephrin^Scer\UAS.cBa (Bossing and Brand, 2002) commissure, with Ephrin^{Scer\UAS.T:Hsap\MYC} (Boyle et al., 2006) commissure, with Ephrin^{ΔIC.Scer\UAS.T:Hsap\MYC} (Boyle et al., 2006) commissure, with Jra^Asp.Scer\UAS (Scholz et al., 1997, Scholz et al., 1997) commissure, with tutl^{AT02763.Scer\UAS} (Al-Anzi and Wyman, 2009) commissure, with tutl^{GH15753.Scer\UAS} (Al-Anzi and Wyman, 2009) denticle, with wg^Scer\UAS.cLa (Desbordes and Sanson, 2003) dorsal neurohemal organ, with spi^s.Scer\UAS (Luer et al., 1997) embryonic/first instar larval cuticle, with wg^Scer\UAS.cLa (Desbordes and Sanson, 2003) embryonic/larval ganglionic branch, with bnl^Scer\UAS.cSa (Araújo and Casanova, 2011) embryonic/larval neuron, with Ephrin^Scer\UAS.cBa (Bossing and Brand, 2002) embryonic/larval somatic muscle \| ventral, with sr^b.Scer\UAS (Vorbruggen and Jackle, 1997) embryonic central brain, with rho^{Scer\UAS.cdCa} (Page, 2003) embryonic hemocyte, with Pvf2^d02444 (Wood et al., 2006) embryonic somatic muscle, with kuz^DN.Scer\UAS (Schimmelpfeng et al., 2001) embryonic somatic muscle \| lateral, with Df(3R)DG4, sr^Scer\UAS.cBa (Becker et al., 1997) ganglionic branch 1 \| embryonic stage, with rho^Scer\UAS.cBa (Gallio et al., 2004) intermediate longitudinal fascicle, with plexB^{EcTM.Scer\UAS.T:Hsap\MYC} (Wu et al., 2011, Wu et al., 2011) intersegmental nerve branch ISNd of A1-7, with tutl^{AT02763.Scer\UAS} (Al-Anzi and Wyman, 2009) intersegmental nerve branch ISNd of A1-7, with tutl^{GH15753.Scer\UAS} (Al-Anzi and Wyman, 2009) longitudinal connective, with aop^ACT.Scer\UAS (Scholz et al., 1997, Scholz et al., 1997) longitudinal connective, with kuz^DN.Scer\UAS (Schimmelpfeng et al., 2001) longitudinal connective, with tutl^{AT02763.Scer\UAS} (Al-Anzi and Wyman, 2009) longitudinal connective, with tutl^{GH15753.Scer\UAS} (Al-Anzi and Wyman, 2009) medial longitudinal fascicle, with Cnx99A^EP3522 (McGovern et al., 2003) midline glial cell, with en^Scer\UAS.cYa (Bossing and Brand, 2006) midline glial cell, with pnt^P1.Scer\UAS (Scholz et al., 1997, Scholz et al., 1997) midline glial cell \| ectopic, with BacA\p35^Scer\UAS.cHa (Giesen et al., 2003) midline neuronal primordium, with en^Scer\UAS.cYa (Bossing and Brand, 2006) midline primordium, with αTub67C^{Scer\UAS.P\T.T:Avic\GFP} (Bossing et al., 2012) midline primordium, with βTub56D^{Scer\UAS.P\T.T:Avic\GFP} (Bossing et al., 2012) MP1 neuron, with en^Scer\UAS.cYa (Bossing and Brand, 2006) MP1 tract, with plexB^{EcTM.Scer\UAS.T:Hsap\MYC} (Wu et al., 2011) pCC neuron, with spi^s.Scer\UAS (Menne et al., 1997) posterior commissure, with Dscam^Scer\UAS.cWa, Scer\GAL4^eg-Mz360 (Wojtowicz et al., 2004) posterior commissure, with en^Scer\UAS.cYa (Bossing and Brand, 2006) presumptive embryonic/larval central nervous system, with Ephrin^{Scer\UAS.T:Hsap\MYC} (Boyle et al., 2006) presumptive embryonic/larval central nervous system, with kuz^DN.Scer\UAS (Schimmelpfeng et al., 2001) trachea, with bnl^Scer\UAS.cSa (Dorfman et al., 2002) transverse nerve, with tutl^{AT02763.Scer\UAS} (Al-Anzi and Wyman, 2009) transverse nerve, with tutl^{GH15753.Scer\UAS} (Al-Anzi and Wyman, 2009) UMI interneuron & axon, with en^Scer\UAS.cYa (Bossing and Brand, 2006) ventral midline, with hh^Scer\UAS.cIa (Bossing and Brand, 2006) ventral nerve cord, with Cnx99A^EP3522 (McGovern et al., 2003) ventral nerve cord \| embryonic stage, with Pvr^DN.Scer\UAS (Olofsson and Page, 2005) ventral nerve cord commissure, with CG11966^GS-A304 (McGovern et al., 2003) ventral nerve cord commissure, with Cnx99A^EP3522 (McGovern et al., 2003) ventral nerve cord commissure, with Rac1^V12.Scer\UAS (Hummel et al., 2000) ventral nerve cord commissure, with shi^{K44A.Scer\UAS} (Onel et al., 2004) VUM neuron, with Hem^Scer\UAS.cHa (Hummel et al., 2000) VUM neuron, with Rac1^V12.Scer\UAS (Hummel et al., 2000) VUM neuron & axon, with en^Scer\UAS.cYa (Bossing and Brand, 2006)
Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement Reference Scer\GAL4^sim.PS, Wnt5^Scer\UAS.cFa has neuroanatomy defective phenotype, non-enhanceable by uzip^D43 (Ding et al., 2011)
NOT suppressed by
Statement Reference Scer\GAL4^sim.PS, Wnt5^Scer\UAS.cFa has neuroanatomy defective phenotype, non-suppressible by uzip^D43 (Ding et al., 2011)
NOT Suppressor of
Statement Reference sli^Scer\UAS.cKa, Scer\GAL4^sim.PS, Scer\GAL4^Scer\UAS.cHa is a non-suppressor of neuroanatomy defective phenotype of ptc^unspecified (Merianda et al., 2005) sli^Scer\UAS.cKa/Scer\GAL4^sim.PS is a non-suppressor of neuroanatomy defective phenotype of ptc^unspecified (Merianda et al., 2005)
Phenotype Manifest In
Enhanced by
Statement Reference Scer\GAL4^sim.PS, bnl^Scer\UAS.cSa has trachea phenotype, enhanceable by sr^Scer\UAS.cBa (Dorfman et al., 2002)
NOT Enhanced by
Statement Reference Scer\GAL4^sim.PS, Wnt5^Scer\UAS.cFa has anterior commissure phenotype, non-enhanceable by uzip^D43 (Ding et al., 2011)
Suppressed by
Statement Reference Ephrin^Scer\UAS.cBa, Scer\GAL4^sim.PS has commissure phenotype, suppressible by Eph^dsRNA.cBa (Bossing and Brand, 2002) Ephrin^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^sim.PS has commissure phenotype, suppressible by Eph^x652 (Boyle et al., 2006) Scer\GAL4^sim.PS, Wnt5^EY03178 has anterior commissure phenotype, suppressible by drl^Red2 (Yoshikawa et al., 2003) Scer\GAL4^sim.PS, Wnt5^Scer\UAS.cFa has anterior commissure phenotype, suppressible by por^PB16 (Fradkin et al., 2004)
NOT suppressed by
Statement Reference Scer\GAL4^sim.PS, wg^Scer\UAS.cLa has denticle phenotype, non-suppressible by dlp^dsRNA.3'/Scer\GAL4^sim.PS (Desbordes and Sanson, 2003, Desbordes and Sanson, 2003) Scer\GAL4^sim.PS, wg^Scer\UAS.cLa has denticle phenotype, non-suppressible by dlp^dsRNA.3'/Scer\GAL4^sim.PS/dally^dsRNA.3' (Desbordes and Sanson, 2003, Desbordes and Sanson, 2003) Scer\GAL4^sim.PS, Wnt5^Scer\UAS.cFa has anterior commissure phenotype, non-suppressible by uzip^D43 (Ding et al., 2011)
Enhancer of
Statement Reference Scer\GAL4^sim.PS/BacA\p35^Scer\UAS.cHa is an enhancer of midline glial cell \| ectopic phenotype of dib^unspecified (Giesen et al., 2003)
Suppressor of
Statement Reference Mmus\Sox2^Scer\UAS.cSa/Scer\GAL4^sim.PS is a suppressor of longitudinal connective phenotype of D^r72/Df(3L)fz-GS1a (Sanchez Soriano and Russell, 1998) Mmus\Sox2^Scer\UAS.cSa/Scer\GAL4^sim.PS is a suppressor of ventral nerve cord commissure phenotype of D^r72/Df(3L)fz-GS1a (Sanchez Soriano and Russell, 1998) Rac1^V12.Scer\UAS/Scer\GAL4^sim.PS is a suppressor \| partially of longitudinal connective phenotype of Hem^J4-48 (Hummel et al., 2000) Rac1^V12.Scer\UAS/Scer\GAL4^sim.PS is a suppressor \| partially of ventral nerve cord commissure phenotype of Hem^J4-48 (Hummel et al., 2000) rho^Scer\UAS.cBa/Scer\GAL4^sim.PS is a suppressor \| partially of embryonic/larval ganglionic branch phenotype of ru^unspecified (Gallio et al., 2004) Scer\GAL4^sim.PS/NetB^Scer\UAS.cHa is a suppressor \| partially of ventral nerve cord commissure \| embryonic stage phenotype of siz^U112 (Onel et al., 2004)
NOT Suppressor of
Statement Reference dlp^dsRNA.3', Scer\GAL4^sim.PS, dally^dsRNA.3' is a non-suppressor of denticle phenotype of Scer\GAL4^sim.PS, wg^Scer\UAS.cLa (Desbordes and Sanson, 2003, Desbordes and Sanson, 2003) dlp^dsRNA.3'/Scer\GAL4^sim.PS is a non-suppressor of denticle phenotype of Scer\GAL4^sim.PS, wg^Scer\UAS.cLa (Desbordes and Sanson, 2003, Desbordes and Sanson, 2003)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Scer\GAL4^sim.PS/tutl^{HL01565.Scer\UAS} rescues Df(2L)ed-dp/tutl^ex383 (Al-Anzi and Wyman, 2009) Scer\GAL4^sim.PS/tutl^{HL01565.Scer\UAS} rescues tutl^ex383 (Al-Anzi and Wyman, 2009) siz^P1.Scer\UAS/Scer\GAL4^sim.PS rescues siz^U112 (Onel et al., 2004) siz^P2.Scer\UAS/Scer\GAL4^sim.PS rescues siz^U112 (Onel et al., 2004) tutl^{AT02763.Scer\UAS}/Scer\GAL4^sim.PS rescues Df(2L)ed-dp/tutl^ex383 (Al-Anzi and Wyman, 2009) tutl^{AT02763.Scer\UAS}/Scer\GAL4^sim.PS rescues tutl^ex383 (Al-Anzi and Wyman, 2009) tutl^{GH08133.Scer\UAS}/Scer\GAL4^sim.PS rescues Df(2L)ed-dp/tutl^ex383 (Al-Anzi and Wyman, 2009) tutl^{GH08133.Scer\UAS}/Scer\GAL4^sim.PS rescues tutl^ex383 (Al-Anzi and Wyman, 2009) tutl^{GH15753.Scer\UAS}/Scer\GAL4^sim.PS rescues Df(2L)ed-dp/tutl^ex383 (Al-Anzi and Wyman, 2009) tutl^{GH15753.Scer\UAS}/Scer\GAL4^sim.PS rescues tutl^ex383 (Al-Anzi and Wyman, 2009) tutl^{LD28224.Scer\UAS}/Scer\GAL4^sim.PS rescues Df(2L)ed-dp/tutl^ex383 (Al-Anzi and Wyman, 2009) tutl^{LD28224.Scer\UAS}/Scer\GAL4^sim.PS rescues tutl^ex383 (Al-Anzi and Wyman, 2009)
Partially rescues	D^{ΔC75.Scer\UAS}/Scer\GAL4^sim.PS partially rescues D^r72/Df(3L)fz-GS1a (Sanchez Soriano and Russell, 1998) Hem^Scer\UAS.cHa/Scer\GAL4^sim.PS partially rescues Hem^J4-48 (Hummel et al., 2000) Scer\GAL4^sim.PS/D^Scer\UAS.cSa partially rescues D^r72/Df(3L)fz-GS1a (Sanchez Soriano and Russell, 1998) seq^Scer\UAS.cBa/Scer\GAL4^sim.PS partially rescues seq^C022 (Araújo and Casanova, 2011) seq^Scer\UAS.cBa/Scer\GAL4^sim.PS partially rescues seq^C022/seq^Z1241 (Araújo and Casanova, 2011) seq^Scer\UAS.cBa/Scer\GAL4^sim.PS partially rescues seq^Z1241 (Araújo and Casanova, 2011) sim^Scer\UAS.cMa/Scer\GAL4^sim.PS partially rescues sim² (Menne et al., 1997)
Fails to rescue	Scer\GAL4^sim.PS/β-Spec^Scer\UAS.cHa fails to rescue β-Spec^unspecified/β-Spec^unspecified (Huelsmeier et al., 2007) Sdc^Scer\UAS.cSa/Scer\GAL4^sim.PS fails to rescue Sdc^unspecified (Steigemann et al., 2004) Wnt5^Scer\UAS.cFa/Scer\GAL4^sim.PS fails to rescue Wnt5⁴⁰⁰ (Fradkin et al., 2004)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	GAL4^sim.PS Scer\GAL4^sim.PS
Name Synonym	single-minded promoter construct of Scholz (Golembo et al., 1996)
Secondary FlyBase IDs

References ( 43 )

Generate a list of	All references relating to this allele ( 43 )

List References by type	Research paper ( 41 ) Supplementary material ( 1 ) Erratum ( 1 )
Recent research papers ( 4 )
	Bossing et al., 2012, Dev. Cell 23(2): 433--440 Disruption of Microtubule Integrity Initiates Mitosis during CNS Repair. [FBrf0219196] Araújo and Casanova, 2011, J. Cell Sci. 124(14): 2335--2340 Sequoia establishes tip-cell number in Drosophila trachea by regulating FGF levels. [FBrf0214024] Ding et al., 2011, Dev. Dyn. 240(1): 122--134 Glial cell adhesive molecule unzipped mediates axon guidance in Drosophila. [FBrf0212620] Wu et al., 2011, Neuron 70(2): 281--298 A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS. [FBrf0213571] Show all research papers ...

Allele Scer\GAL4sim.PS

Allele Scer\GAL4^sim.PS