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General Information
Symbol
Dmel\DlUAS.cHa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Haenlin
FlyBase ID
FBal0059140
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Dl, UAS-Dl.H, UASDl, UAS-Delta
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of Dl.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of DlScer\UAS.cHa in the third instar eye discs (under the control of Scer\GAL4elav-C155) results in a loss in the specification of R1, R6 and R7 and an over-specification of non-neuronal cone and pigment cell types.

Expression of DlScer\UAS.cHa under the control of Scer\GAL4neur-P72 results in extra polar follicle cells.

Expression of DlScer\UAS.cHa under the control of Scer\GAL4upd-E132 results in loss of the stalk between egg chambers and fusion of neighbouring chambers.

Expression of DlScer\UAS.cHa in a Ubxlac1-GAL4 background (the transgene expression is driven by the P{GawB} in the insertion that generates the Ubxlac1-GAL4 allele) enhances the haltere phenotype of Ubxlac1-GAL4 flies, leading to a large number of wing-type bristle and trichomes on the haltere.

Expression of DlScer\UAS.cHa, under the control of Scer\GAL4ey.PH, causes adult flies to have larger eyes than wild type.

Expression of DlScer\UAS.cHa under the control of Scer\GAL4bi-omb-Gal4 does not affect eye size.

The number and length of filopodia formed by sensory organ precursors in wing disc cells at the time puparium formation is dramatically increased in DlScer\UAS.cHa; Scer\GAL4neur-P72 flies compared to wild-type.

Expression of DlScer\UAS.cHa under the control of Scer\GAL4ptc-559.1 results in a small wing with an ectopic margin along the anterior/posterior boundary on both surfaces of the wing.

Flies expressing DlScer\UAS.cHa under the control of Scer\GAL4hs.2sev develop many symmetrical ommatidial clusters showing the R4/R4 phenotype. The development of outer photoreceptors R1 to R6 is also affected.

Transformation of the trichogen to a tormogen fate is seen in notal macrochaetae of flies expressing DlScer\UAS.cHa under the control of Scer\GAL4l(3)31-1-31-1, including the anterior dorsocentral and posterior supraalar bristles.

Scer\GAL4ptc-559.1-mediated expression in wild type at 18oC causes pharate adult lethality, mutants exhibit severe defects in the wings and legs which often do not evert and are occasionally duplicated. In less severe cases wings have extra tissue on the ventral and dorsal sides, with a new margin on both sides which runs perpendicular to and crosses the endogenous margin. Wings do not exhibit margin nicks. Ectopic wings develop in the head.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressed by
NOT suppressed by
Enhancer of
Suppressor of
NOT Suppressor of
Other
Additional Comments
Genetic Interactions
Statement
Reference

Expression of DlScer\UAS.cHa under the control of Scer\GAL4h-H10 significantly suppresses the multiple photoreceptor-R8 phenotype in rno3; Rbf15aΔ somatic clones in the eye.

The following heterozygous mutations suppress the large eye phenotype of Scer\GAL4ey.PH > DlScer\UAS.cHa flies: eyg685, Df(1)N-54l9, upd154 and hop25. Heterozygosity for either domeG0218, domeG0282 or Stat92Ej6C8 fails to suppress this phenotype.

Co-expression of tshScer\UAS.cGa and DlScer\UAS.cHa under the control of Scer\GAL4bi-omb-Gal4 results in eye enlargements on both dorsal and ventral margins in both the eye disc and the adult eye. Ventrally and dorsally located clones in the eye co-expressing tshScer\UAS.cGa and DlScer\UAS.cHa under the control of Scer\GAL4Act5C.PI result in overgrowth.

The ectopic margin caused by expression of DlScer\UAS.cHa under the control of Scer\GAL4ptc-559.1 is suppressed by coexpression of NECN.Scer\UAS, except for a small patch on the dorsal side, and the wing is almost wild type in shape. The wing phenotype caused by expression of DlScer\UAS.cHa under the control of Scer\GAL4ptc-559.1 is not suppressed by coexpression of NECNΔ10-12.Scer\UAS or NECNΔ17-19;24-26.Scer\UAS.

The loss of wing disc tissue seen in SerRX106/SerCS94 animals is rescued by DlScer\UAS.cHa expressed under the control of Scer\GAL4dpp.blk1.

The loss of wing seen in apUGO35 homozygotes is partially rescued by DlScer\UAS.cHa expressed under the control of Scer\GAL4dpp.blk1.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to rescue
Comments

Scer\GAL4arm.T:Hsim\VP16 mediated expression fails to rescue DlRevF10 embryos.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
DlScer\UAS.cHa
DlUAS.cHa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Haenlin
Secondary FlyBase IDs
    References (30)