Allele Dmel\spi^unspecified

General Information
Symbol	Dmel\spi^unspecified	Species	D. melanogaster
Name		FlyBase ID	FBal0059934
Feature type	allele	Associated gene	Dmel\spi

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Tearle and Nusslein-Volhard, 1987)
Phenotype Manifest In
	abdominal 1 lateral pentascolopidial chordotonal organ lch5 (Okabe and Okano, 1997) abdominal 1 ventral monoscolopidial chordotonal organ vch1 (Okabe and Okano, 1997) abdominal 2 lateral pentascolopidial chordotonal organ lch5 (Okabe and Okano, 1997) abdominal 2 ventral monoscolopidial chordotonal organ vch1 (Okabe and Okano, 1997) abdominal 3 lateral pentascolopidial chordotonal organ lch5 (Okabe and Okano, 1997) abdominal 3 ventral monoscolopidial chordotonal organ vch1 (Okabe and Okano, 1997) abdominal 4 lateral pentascolopidial chordotonal organ lch5 (Okabe and Okano, 1997) abdominal 4 ventral monoscolopidial chordotonal organ vch1 (Okabe and Okano, 1997) abdominal 5 lateral pentascolopidial chordotonal organ lch5 (Okabe and Okano, 1997) abdominal 5 ventral monoscolopidial chordotonal organ vch1 (Okabe and Okano, 1997) abdominal 6 lateral pentascolopidial chordotonal organ lch5 (Okabe and Okano, 1997) abdominal 6 ventral monoscolopidial chordotonal organ vch1 (Okabe and Okano, 1997) abdominal 7 lateral pentascolopidial chordotonal organ lch5 (Okabe and Okano, 1997) abdominal 7 ventral monoscolopidial chordotonal organ vch1 (Okabe and Okano, 1997) anal pad (Tearle and Nusslein-Volhard, 1987) cephalopharyngeal skeleton (Tearle and Nusslein-Volhard, 1987) commissure (Hummel et al., 1999) denticle belt (Tearle and Nusslein-Volhard, 1987) embryonic ventral nervous system (Tearle and Nusslein-Volhard, 1987) Keilin's organ (Tearle and Nusslein-Volhard, 1987) larval sense organ & antennal segment (Tearle and Nusslein-Volhard, 1987) larval sense organ & maxillary segment (Tearle and Nusslein-Volhard, 1987) longitudinal connective (Hummel et al., 1999) midline glial cell (Hummel et al., 1999) motor neuron (Hummel et al., 1999) presumptive embryonic/larval central nervous system (Hummel et al., 1999) presumptive embryonic/larval peripheral nervous system (Hummel et al., 1999) sensory neuron (Hummel et al., 1999)
Detailed Description
	Statement Reference Homozygous clones in the eye disc lead to normal R8 cell spacing. (Baonza et al., 2001) Mutant embryos show a clear fusion of commissures and frequent disruption of longitudinal connectives. Midline glial cells are either reduce in number or fail to properly migrate in between anterior and posterior commissures. General embryonic morphology is relatively normal, though the PNS shows a slight reduction in sensory neurons and defects in the trajectories of motoneurons. (Hummel et al., 1999) Homozygous embryos show a loss of 3 chordotonal organs per abdominal hemisegment (VChA and two in LCh5). (Okabe and Okano, 1997) spi^unspecified mutant embryos have narrow denticle bands and the ventral arms of the head skeleton are fused. Anal pads, Keilin's organs, maxillary sense organs and antennal sense organs are reduced. The transverse commissure of the ventral nervous system are reduced. Semilethal in the germline. (Tearle and Nusslein-Volhard, 1987)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement Reference spi^unspecified is an enhancer of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, nej^{ΔBHQ.Scer\UAS} (Anderson et al., 2005)
Suppressor of
Statement Reference spi^unspecified, spi[+], Scer\GAL4^Bx-MS1096 is a suppressor \| partially of wing phenotype of Pstu\aarA^Scer\UAS.cGa (Gallio et al., 2002) spi^unspecified, spi[+], Scer\GAL4^Bx-MS1096 is a suppressor \| partially of wing vein \| ectopic phenotype of Pstu\aarA^Scer\UAS.cGa (Gallio et al., 2002)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	spi^s3547 (Dworkin and Gibson, 2006)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	spi^unspecified unspecified (Okabe and Okano, 1997)
Name Synonym
Secondary FlyBase IDs

References ( 9 )
Research paper	Dworkin and Gibson, 2006, Genetics 173(3): 1417--1431 Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. [FBrf0193945] Anderson et al., 2005, Genetics 171(4): 1655--1672 A genetic screen identifies putative targets and binding partners of CREB-binding protein in the developing Drosophila eye. [FBrf0190701] Wilson et al., 2005, Development 132(3): 491--501 FGF signalling and the mechanism of mesoderm spreading in Drosophila embryos. [FBrf0183935] Carmena et al., 2002, Dev. Biol. 244(2): 226--242 Reciprocal regulatory interactions between the notch and ras signaling pathways in the Drosophila embryonic mesoderm. [FBrf0146966] Gallio et al., 2002, Proc. Natl. Acad. Sci. U.S.A. 99(19): 12208--12213 A conserved mechanism for extracellular signaling in eukaryotes and prokaryotes. [FBrf0152308] Baonza et al., 2001, Curr. Biol. 11(6): 396--404 A primary role for the epidermal growth factor receptor in ommatidial spacing in the Drosophila eye. [FBrf0135707] Hummel et al., 1999, Dev. Biol. 209(2): 381--398 Commissure formation in the embryonic CNS of Drosophila. [FBrf0108204] Okabe and Okano, 1997, Development 124(5): 1045--1053 Two-step induction of chordotonal organ precursors in Drosophila embryogenesis. [FBrf0092648]
Stock list	Tearle and Nusslein-Volhard, 1987, D. I. S. 66: 209--269 Tubingen mutants and stock list. [FBrf0045941]

Allele Dmel\spiunspecified

Allele Dmel\spi^unspecified