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General Information
Symbol
Dmel\simUAS.cXa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Xiao
FlyBase ID
FBal0059939
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-sim, p[UAS-sim]
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a full-length sim cDNA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of simScer\UAS.cXa under the control of Scer\GAL4sim.P3.7 results in the loss of the preoral commissures and reduced postoral commissures in the embryonic brain. The circumesophageal longitudinal connectives are thinner than normal.

Expression of simScer\UAS.cXa under the control of Scer\GAL4ey.PH results in a headless phenotype. Three classes of phenotype are seen; class I pharate adults lack all head structures derived from the eye-antennal discs, class II consists of eyeless flies which lack most head structures and both antennae and class III consists of eyeless animals with large parts of the head missing but one or both antennae present.

Eye morphology is essentially normal in flies expressing simScer\UAS.cXa under the control of Scer\GAL4GMR.PF.

Scer\GAL4prd.RG1 mediated expression in wild type embryos causes a pair-rule larval cuticle phenotype. Segmentation defect may result in part from the inability of ectopic midline cells to generate cuticle structures and/or excessive cell death in regions expressing ectopic sim.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Flies expressing both DScer\UAS.cMa and simScer\UAS.cXa under the control of Scer\GAL4GMR.PF show a stronger disorganisation of ommatidia and mechanosensory bristles in the eye than seen in flies expressing either DScer\UAS.cMa or simScer\UAS.cXa alone under the control of Scer\GAL4GMR.PF. There is also a dramatic loss of eye pigmentation in flies expressing both DScer\UAS.cMa and simScer\UAS.cXa under the control of Scer\GAL4GMR.PF.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
simScer\UAS.cXa
simUAS.cXa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Xiao
Secondary FlyBase IDs
    References (11)