FB2025_01 , released February 20, 2025
Allele: Dmel\sggM1-1
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General Information
Symbol
Dmel\sggM1-1
Species
D. melanogaster
Name
FlyBase ID
FBal0059940
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
zw3M1-1
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
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    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Follicle cell clones for sggM1-1 continue mitotic division after the mitotic-to-endocycle transition and are twice the size of their respective twin spots. These cells continue to express mitotic markers after the stage where their expression has ceased in wild-type cells.

    sggM1-1 somatic stem cell (SSC) clones in the ovary are lost more rapidly than wild-type clones. In germaria carrying both wild-type and sggM1-1 mutant SSC clones, mutant follicle cells appear more in number than wild-type ones, indicating that sggM1-1 SSCs and/or follicle cells are over-proliferative. In germaria where most or all the follicle cells are mutant for sggM1-1, germline cysts do not undergo normal morphological changes from ball-like structures in region 2a to lens-shape cysts in region 2b, remaining in ball-like structures in region 2b. Mutant follicle cells do not integrate properly into egg chambers and accumulate instead as a disorganised mass between egg chambers. The mutant follicle cells have abnormal morphology, but neighbouring wild-type cells are normal in morphology.

    Homozygous embryos derived from homozygous female germline clones show loss of nuclei from the surface of the embryo during syncytial development.

    Embryos deficient for maternal and zygotic sgg show puckering of dorsal epidermis with loss of dorsal hair identity and a naked scar at the dorsal midline.

    Homozygous clones in the leg disc produce ventral type bristles. Clones in the dorsal part of the leg disc show ectopic growth and cause bifurcations and triplications of the leg in adult flies. Clones in the tibia and tarsi can form complete secondary axes and triplications. Ventral clones in the leg disc that fall within the wg expression domain have no effect on patterning. Clones in the eye field of the eye disc show ectopic growth and produce cuticle and large sensory bristles characteristic of cells at the dorsal margin of the eye. sggM1-1 dsh75 double mutant clones behave like sggM1-1 single mutant clones.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Suppressor of
    Statement
    Reference

    sggM1-1/sgg[+] is a suppressor of visible phenotype of Hsap\MAPTGMR.Ex.PJ

    Phenotype Manifest In
    Suppressor of
    Statement
    Reference

    sggM1-1/sgg[+] is a suppressor of eye phenotype of Hsap\MAPTGMR.Ex.PJ

    sggM1-1 is a suppressor of phenotype of arm2

    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference

    One copy of sggM1-1 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPTGMR.Ex.PJ.

    The bristle loss phenotype found upon overexpression of Hsap\MAPTScer\UAS.cWa under the control of Scer\GAL4Eq1 is significantly abated in a sggM1-1 heterozygous background.

    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (2)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    References (11)