|Feature type||allele||Associated gene||Dmel\pb|
|Mutagen||in vitro construct - regulatory fusion|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Carried in construct|
|Phenotype Manifest In|
When pbScer\UAS.A is driven by Scer\GAL4sd-SG29.1 abnormal wing vein patterns and incisions in the wing margin are seen.
Expression of pbScer\UAS.A under the control of Scer\GAL4sca-537.4 results in a mutant phenotype in the embryonic tritocerebrum. The phenotype has a penetrance of more than 70-80%.
When pbScer\UAS.A is driven by Scer\GAL4dpp.blk1 a substantial eye loss phenotype as well as wing and leg defects are seen. When pbScer\UAS.A is driven by Scer\GAL4ey.PH a substantial or full eye loss phenotype is seen. When driven by Scer\GAL4GMR.PF no effect is seen.
Most imaginal discs expressing pbScer\UAS.A under the control of Scer\GAL4dpp.blk1 are misshapen; the discs have abnormal folding and do not lay flat like wild-type discs.
Expression of pbScer\UAS.A under the control of Scer\GAL4lab.PH does not result in morphological defects in the tritocerebrum or any other part of the embryonic brain.
Scer\GAL4dpp.blk1-mediated expression in the imaginal discs results in striking growth and patterning defects in the antenna, legs and wings. Upon eclosion flies are unable to pull themselves free of the pupal case. Labial-like structures are observed along the T1 legs, maxillary palp-like structures are formed along the lateral aspects of the legs in some locations. General leg patterning defects include a shortening and distortion of the leg along the PD axis, fusion of tarsal segments and large bulbous outgrowths of tissue along the lateral surfaces. Wings do not exhibit homeotic transformation but are smaller in size than wild type, are missing both longitudinal and cross veins, have ectopic socketed bristles growing from the wing blade surface and display a crumpled appearance. Ectopic expression does not increase apoptosis in the wing, leg, haltere or eye discs. Scer\GAL469B- or Scer\GAL471B-mediated expression causes embryonic or early larval lethality. Scer\GAL430A-mediated expression causes minor non-homeotic disruptions of the legs that include fusion of tarsal segments.
|Phenotype Manifest In|
pbScer\UAS.A/Scer\GAL4dpp.blk1 is a suppressor of eye | ectopic phenotype of Scer\GAL4dpp.blk1, eyScer\UAS.cHa
pbScer\UAS.A/Scer\GAL4lz-gal4 is a suppressor of eye phenotype of Scer\GAL4lz-gal4, sensScer\UAS.cNa
Co-expression of pb[Scer\UAS.A] strongly suppresses the disorganised eye phenotype caused by expression of sens[Scer\UAS.cNa] under the control of Scer\GAL4[lz-gal4].
When pbScer\UAS.A is overexpressed along with ciScer\UAS.cAa, both under the control of Scer\GAL4pb.PJ, the ciScer\UAS.cAa phenotype is suppressed and labial palps appear almost the same as wild type.
|Complementation & Rescue Data|
|Stocks ( 1 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 9 )|