Allele Dmel\fz^Scer\UAS.cAa

General Information
Symbol	Dmel\fz^Scer\UAS.cAa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Adler	FlyBase ID	FBal0060399
Feature type	allele	Associated gene	Dmel\fz

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Axelrod et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Carried in construct	P{UAS-fz.A} (Simons et al., 2009, Tree et al., 2002, Bastock et al., 2003, Lee and Adler, 2002, Ma et al., 2003, Weber et al., 2000, Gao et al., 2000, Rulifson et al., 2000, Lu et al., 1999, Usui et al., 1999, Adler et al., 1997, Axelrod et al., 1998, Ciapponi et al., 2001, Axelrod, 2001, Strutt, 2001, Strutt et al., 1997, Adler, 1997.3.14, Bhanot et al., 1999, Djiane et al., 2005, Chung et al., 2007, Jenny et al., 2005, Lim et al., 2005, Hermle et al., 2010, Buechling et al., 2010, Bastock and Strutt, 2007, Mottola et al., 2010, Lu et al., 2010, Franke et al., 2010, Weber et al., 2012, Hermle et al., 2013)
Cytology
Phenotypic Data
Phenotypic Class
	cell polarity defective, with Scer\GAL4^ptc-559.1 (Tree et al., 2002) planar polarity defective, with Scer\GAL4^Dll-md23 (Lee and Adler, 2002) planar polarity defective, with Scer\GAL4^dpp.blk1 (Axelrod, 2001, Lim et al., 2005, Ma et al., 2003) planar polarity defective, with Scer\GAL4^dpp.PS (Buechling et al., 2010) planar polarity defective, with Scer\GAL4^en-e16E (Hermle et al., 2010) planar polarity defective, with Scer\GAL4^hs.2sev (Strutt et al., 1997, Ciapponi et al., 2001, Weber et al., 2000, Chung et al., 2007, Simons et al., 2009, Hermle et al., 2010, Weber et al., 2012) planar polarity defective, with Scer\GAL4^hs.2sev, fz^{arm.T:Avic\GFP-EGFP} (Chung et al., 2007) planar polarity defective, with Scer\GAL4^sev.PM181 (Djiane et al., 2005) planar polarity defective \| cell autonomous, with Scer\GAL4^ptc-559.1 (Lu et al., 2010) visible, with Scer\GAL4^Dll-md23 (Adler et al., 1997) visible, with Scer\GAL4^dpp.blk1 (Jenny et al., 2005) visible, with Scer\GAL4^en-e16E (Franke et al., 2010) visible, with Scer\GAL4^ptc-559.1 (Usui et al., 1999, Adler et al., 1997)
Phenotype Manifest In
	border follicle cell, with Scer\GAL4^slbo.2.6 (Bastock and Strutt, 2007) denticle belt, with Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} (Axelrod et al., 1998) embryonic/first instar larval cuticle, with Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} (Axelrod et al., 1998) eye, with Scer\GAL4^hs.2sev (Simons et al., 2009) macrochaeta \| ectopic, with Scer\GAL4^ap-md52 (Lu et al., 1999) microchaeta, with Scer\GAL4^ap-md52 (Lu et al., 1999) ommatidium, with Scer\GAL4^hs.2sev (Strutt et al., 1997, Ciapponi et al., 2001, Weber et al., 2000, Chung et al., 2007, Hermle et al., 2010, Weber et al., 2012) ommatidium, with Scer\GAL4^hs.2sev, fz^{arm.T:Avic\GFP-EGFP} (Chung et al., 2007) ommatidium, with Scer\GAL4^sev.PM181 (Djiane et al., 2005) photoreceptor cell R3 \| ectopic, with Scer\GAL4^sev.PM181 (Djiane et al., 2005) photoreceptor cell R3 \| supernumerary, with Scer\GAL4^hs.2sev (Weber et al., 2000) photoreceptor cell R4, with Scer\GAL4^hs.2sev (Weber et al., 2000) photoreceptor cell R4, with Scer\GAL4^sev.PM181 (Djiane et al., 2005) sensory mother cell & spindle, with Scer\GAL4^ap-md52 (Lu et al., 1999) wing & microchaeta, with Scer\GAL4^ptc-559.1 (Adler et al., 1997) wing & microchaeta \| distal, with Scer\GAL4^Dll-md23 (Adler et al., 1997) wing \| anterior/posterior compartment boundary, with Scer\GAL4^ptc-559.1 (Adler et al., 1997) wing \| anterior compartment, with Scer\GAL4^ptc-559.1 (Adler et al., 1997) wing hair, with Scer\GAL4^Dll-md23 (Lee and Adler, 2002) wing hair, with Scer\GAL4^dpp.blk1 (Axelrod, 2001, Lim et al., 2005, Jenny et al., 2005) wing hair, with Scer\GAL4^dpp.PS (Buechling et al., 2010) wing hair, with Scer\GAL4^en-e16E (Hermle et al., 2010, Franke et al., 2010) wing hair, with Scer\GAL4^ptc-559.1 (Tree et al., 2002, Lu et al., 2010) wing hair & 1st posterior cell, with Scer\GAL4^ptc-559.1 (Usui et al., 1999) wing hair \| P-stage, with Scer\GAL4^dpp.blk1 (Ma et al., 2003)
Detailed Description
	Statement Reference Expression of fz[Scer\UAS.cAa] using Scer\GAL4[hs.2sev] results in ommatidial orientation defects in the eye. (Weber et al., 2012) Expression of fz[Scer\UAS.cAa] under the control of Scer\GAL4[dpp.PS] results in planar polarity defects in the wing. (Buechling et al., 2010) Expression of fz[Scer\UAS.cAa] under the control of Scer\GAL4[en-e16E] results in a very mild multiple wing hair phenotype. (Franke et al., 2010) Expression of fz[Scer\UAS.cAa] under the control of Scer\GAL4[en-e16E] results in wing hairs pointing from the posterior to the anterior compartment in the wing. Expression of fz[Scer\UAS.cAa] under the control of Scer\GAL4[hs.2sev] results in planar cell polarity defects in the eye, including a high number of symmetrical ommatidia containing two R3 cells. (Hermle et al., 2010) Expression of fz[Scer\UAS.cAa] under the control of Scer\GAL4[ptc-559.1] results in wing hairs pointing away from the midline within the expression domain. Outside of the expression domain wing hair polarity is normal. (Lu et al., 2010) Expression of fz[Scer\UAS.cAa] under the control of Scer\GAL4[hs.2sev] results in planar cell polarity defects in the eye. (Simons et al., 2009) Expression of fz[Scer\UAS.cAa] in the border cells under the control of Scer\GAL4[slbo.2.6] delays border cell migration. A reduction in the number of large actin-protrusions from the border cell cluster compared to wild-type clusters is observed. (Bastock and Strutt, 2007) Expression of fz^Scer\UAS.cAa under the control of Scer\GAL4^hs.2sev results in planar polarity defects in the eye; misrotated ommatidia and symmetrical nonchiral ommatidia are seen (only 44.9% of ommatidia are correctly rotated). The planar polarity defects seen in the eyes of animals expressing fz^Scer\UAS.cAa under the control of Scer\GAL4^hs.2sev are almost completely suppressed by fz³⁰ (76.0% of ommatidia are correctly rotated). Only 30.3% of ommatidia are correctly rotated in flies expressing fz^Scer\UAS.cAa under the control of Scer\GAL4^hs.2sev and also co-expressing fz^{arm.T:Avic\GFP-EGFP}. (Chung et al., 2007) The ommatidia of fz^Scer\UAS.cAa; Scer\GAL4^sev.PM181 adult eyes have random chirality and some are symmetrical, with two R3 photoreceptors in place of an R3/R4 pair. (Djiane et al., 2005) Expression of fz^Scer\UAS.cAa under the control of Scer\GAL4^dpp.blk1 in a stripe along the proximo-distal axis of the wing results in a reorientation of wing hairs, which now point laterally away from the expression domain. (Jenny et al., 2005) Expression of fz^Scer\UAS.cAa under the control of Scer\GAL4^dpp.blk1 results in reorientation of wing hairs away from the domain of fz expression. (Lim et al., 2005) fz^Scer\UAS.cAa; Scer\GAL4^dpp.blk1 flies have a zone extending anterior to the dpp expression domain in which wing hairs point away from the fz overexpressing cells. (Ma et al., 2003) When expression is driven by Scer\GAL4^Dll-md23, such that fz expression decreases away from the distal part of the wing, the wing hairs point proximally, instead of distally. (Lee and Adler, 2002) When fz^Scer\UAS.cAa is driven by Scer\GAL4^ptc-559.1 in a stripe along the proximal distal axis of the wing, a reorganized polarity results in those cells, that is perpendicular to the normal axis. The wing hairs in the region between wing vein L3 and L4, distal to the anterior crossvein point away from the midline of the wing, unlike wild-type wings, where the wing hairs point distally. (Tree et al., 2002) Expression of fz^Scer\UAS.cAa under the control of Scer\GAL4^dpp.blk1 in the wing results in reorientation of the hairs from high to low levels of fz expression. (Axelrod, 2001) When fz^Scer\UAS.cAa is driven by Scer\GAL4^hs.2sev, planar polarity defects are seen in the ommatidia. (Ciapponi et al., 2001) Expression of fz^Scer\UAS.cAa driven by Scer\GAL4^109(2)80 does not give rise to any detectable dendritic phenotypes. (Gao et al., 2000) When expression is driven by Scer\GAL4^hs.2sev, ommatidia are often mis-rotated and show chirality defects. Most of the symmetrical clusters are R3/R3 symmetrical. (Weber et al., 2000) fz^Scer\UAS.cAa driven by Scer\GAL4^ap-md52 disrupts the planar polarity of bristles in the notum, primarily affecting microchaetae. Induction of ectopic scutellar bristles are also seen about 80% of the time. In the pupal notum of flies expressing fz^Scer\UAS.cAa driven by Scer\GAL4^ap-md52, the spindle orientations of the Sensory organ precursors (SOP) become randomized. (Lu et al., 1999) When expressed in the wing under the control of Scer\GAL4^ptc-559.1, wing hairs are orientated away from the highest point of the fz gradient. (Usui et al., 1999) Embryos expressing fz^Scer\UAS.cAa under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} have a lawn of denticles phenotype. (Axelrod et al., 1998) Scer\GAL4^Dll-md23-mediated expression causes a region of reversed polarity near the distal end of the wing. Scer\GAL4^ptc-559.1-mediated expression causes a region of reverse polarity in anterior compartment cells along the anterior-posterior compartment border. (Adler et al., 1997) Causes a tissue polarity defect when expressed in a subset of photoreceptors in the developing eye using Scer\GAL4^hs.2sev; ommatidia frequently show abnormal rotation and chirality. (Strutt et al., 1997)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference fz^Scer\UAS.cAa has planar polarity defective phenotype, enhanceable by Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa (Weber et al., 2012, Weber et al., 2012) Scer\GAL4^dpp.blk1, fz^Scer\UAS.cAa has planar polarity defective phenotype, enhanceable \| somatic clone by ft^G-rv (Ma et al., 2003) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, enhanceable by tow^Scer\UAS.cCa/Scer\GAL4^hs.2sev (Chung et al., 2007) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, enhanceable by VhaM8.9^{Scer\UAS.T:Disc\RFP-mCherry}/Scer\GAL4^hs.2sev (Hermle et al., 2010)
Suppressed by
Statement Reference Scer\GAL4^dpp.blk1, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible by Wnt4^Scer\UAS.cGa/Scer\GAL4^dpp.blk1 (Lim et al., 2005) Scer\GAL4^dpp.PS, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible \| partially by VhaM8.9^5-HA-1890 (Buechling et al., 2010) Scer\GAL4^dpp.PS, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible \| partially by VhaM8.9^EY03616 (Buechling et al., 2010) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible \| partially by +/Df(2R)E73 (Weber et al., 2000) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible \| partially by In(3L)tow^fz/+ (Chung et al., 2007) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible \| partially by Jra^76-19/Jra[+] (Weber et al., 2000) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible \| partially by Jra^IA109/Jra[+] (Weber et al., 2000) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible \| partially by Nhe2^{dsRNA.Scer\UAS.WIZ}/Nhe2[+]/Nhe2¹, Scer\GAL4^hs.2sev (Simons et al., 2009) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible \| partially by tow[+]/tow⁷⁵⁴ (Chung et al., 2007) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible \| partially by VhaM8.9^EY03616/CG8444[+] (Hermle et al., 2010) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible \| partially by VhaM8.9^KK107676/Scer\GAL4^hs.2sev (Hermle et al., 2010) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible by bsk¹ (Strutt et al., 1997) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible by bsk² (Strutt et al., 1997) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible by dsh³ (Strutt et al., 1997) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible by kay^{C-Ala.Scer\UAS}/Scer\GAL4^hs.2sev (Ciapponi et al., 2001) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible by kay^{pan-Ala.Scer\UAS}/Scer\GAL4^hs.2sev (Ciapponi et al., 2001) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible by Rho1^k07236 (Strutt et al., 1997) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible by Rho1^k07903 (Strutt et al., 1997) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible by Scer\GAL4^hs.2sev/kay² (Ciapponi et al., 2001) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, suppressible by Scer\GAL4^hs.2sev/kay^{N-Ala.Scer\UAS} (Ciapponi et al., 2001)
NOT suppressed by
Statement Reference Scer\GAL4^dpp.PS, fz^Scer\UAS.cAa has planar polarity defective phenotype, non-suppressible by VhaM8.9^{EY03616-excΔ} (Buechling et al., 2010) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, non-suppressible by nmo^E33 (Strutt et al., 1997) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, non-suppressible by pk^pk-sple-13 (Strutt et al., 1997) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, non-suppressible by rl¹⁰ (Strutt et al., 1997) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, non-suppressible by Scer\GAL4^hs.2sev/kay^Scer\UAS.cEa (Ciapponi et al., 2001) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, non-suppressible by VhaM8.9^EY03616-ex (Hermle et al., 2010) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has planar polarity defective phenotype, non-suppressible by wg^l-17 (Strutt et al., 1997)
Enhancer of
Statement Reference Scer\GAL4^en-e16E/fz^Scer\UAS.cAa is an enhancer of visible phenotype of Scer\GAL4^en-e16E, zip^{Rod.Scer\UAS.T:Avic\GFP} (Franke et al., 2010) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa is an enhancer of planar polarity defective phenotype of fz^Scer\UAS.cAa (Weber et al., 2012, Weber et al., 2012)
Suppressor of
Statement Reference fz^Scer\UAS.cAa/Scer\GAL4^Dll-md23 is a suppressor of planar polarity defective phenotype of in¹ (Lee and Adler, 2002)
Other
Statement Reference Scer\GAL4^en-e16E, fz^Scer\UAS.cAa, zip^{Rod.Scer\UAS.T:Avic\GFP} has planar polarity defective phenotype (Franke et al., 2010)
Phenotype Manifest In
Enhanced by
Statement Reference fz^Scer\UAS.cAa has ommatidium phenotype, enhanceable by Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa (Weber et al., 2012, Weber et al., 2012) Scer\GAL4^dpp.blk1, fz^Scer\UAS.cAa has wing hair \| anterior \| P-stage phenotype, enhanceable \| somatic clone by ft^G-rv (Ma et al., 2003) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, enhanceable by tow^Scer\UAS.cCa/Scer\GAL4^hs.2sev (Chung et al., 2007) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, enhanceable by VhaM8.9^{Scer\UAS.T:Disc\RFP-mCherry}/Scer\GAL4^hs.2sev (Hermle et al., 2010)
Suppressed by
Statement Reference Scer\GAL4^dpp.blk1, fz^Scer\UAS.cAa has wing hair phenotype, suppressible by Wnt4^Scer\UAS.cGa/Scer\GAL4^dpp.blk1 (Lim et al., 2005) Scer\GAL4^dpp.PS, fz^Scer\UAS.cAa has wing hair phenotype, suppressible \| partially by VhaM8.9^5-HA-1890 (Buechling et al., 2010) Scer\GAL4^dpp.PS, fz^Scer\UAS.cAa has wing hair phenotype, suppressible \| partially by VhaM8.9^EY03616 (Buechling et al., 2010) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has eye phenotype, suppressible \| partially by Nhe2^{dsRNA.Scer\UAS.WIZ}/Nhe2[+]/Nhe2¹, Scer\GAL4^hs.2sev (Simons et al., 2009) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, suppressible \| partially by +/Df(2R)E73 (Weber et al., 2000) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, suppressible \| partially by In(3L)tow^fz/+ (Chung et al., 2007) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, suppressible \| partially by Jra^76-19/Jra[+] (Weber et al., 2000) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, suppressible \| partially by Jra^IA109/Jra[+] (Weber et al., 2000) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, suppressible \| partially by tow[+]/tow⁷⁵⁴ (Chung et al., 2007) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, suppressible \| partially by VhaM8.9^EY03616/CG8444[+] (Hermle et al., 2010) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, suppressible \| partially by VhaM8.9^KK107676/Scer\GAL4^hs.2sev (Hermle et al., 2010) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, suppressible by bsk¹ (Strutt et al., 1997) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, suppressible by bsk² (Strutt et al., 1997) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, suppressible by dsh³ (Strutt et al., 1997) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, suppressible by kay^{C-Ala.Scer\UAS}/Scer\GAL4^hs.2sev (Ciapponi et al., 2001) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, suppressible by kay^{pan-Ala.Scer\UAS}/Scer\GAL4^hs.2sev (Ciapponi et al., 2001) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, suppressible by Rho1^k07236 (Strutt et al., 1997) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, suppressible by Rho1^k07903 (Strutt et al., 1997) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, suppressible by Scer\GAL4^hs.2sev/kay² (Ciapponi et al., 2001) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, suppressible by Scer\GAL4^hs.2sev/kay^{N-Ala.Scer\UAS} (Ciapponi et al., 2001) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has photoreceptor cell R4 phenotype, suppressible \| partially by +/Df(2R)E73 (Weber et al., 2000) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has photoreceptor cell R4 phenotype, suppressible \| partially by Jra^76-19/Jra[+] (Weber et al., 2000) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has photoreceptor cell R4 phenotype, suppressible \| partially by Jra^IA109/Jra[+] (Weber et al., 2000)
NOT suppressed by
Statement Reference Scer\GAL4^dpp.PS, fz^Scer\UAS.cAa has wing hair phenotype, non-suppressible by VhaM8.9^{EY03616-excΔ} (Buechling et al., 2010) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, non-suppressible by Scer\GAL4^hs.2sev/kay^Scer\UAS.cEa (Ciapponi et al., 2001) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa has ommatidium phenotype, non-suppressible by VhaM8.9^EY03616-ex (Hermle et al., 2010)
Enhancer of
Statement Reference Scer\GAL4^en-e16E/fz^Scer\UAS.cAa is an enhancer of wing hair \| supernumerary phenotype of Scer\GAL4^en-e16E, zip^{Rod.Scer\UAS.T:Avic\GFP} (Franke et al., 2010) Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa is an enhancer of ommatidium phenotype of fz^Scer\UAS.cAa (Weber et al., 2012, Weber et al., 2012)
Suppressor of
Statement Reference fz^Scer\UAS.cAa/Scer\GAL4^Dll-md23 is a suppressor of wing hair & 1st posterior cell phenotype of in¹ (Lee and Adler, 2002)
Additional Comments
Genetic Interactions
Statement Reference Co-expression of gish[GD10588] with fz[Scer\UAS.cAa] under the control of Scer\GAL4[hs.2sev] enhances the ommatidial rotation defects induced by Scer\GAL4[hs.2sev]>fz[Scer\UAS.cAa]. (Weber et al., 2012) The planar polarity defects in the wing caused by expression of fz[Scer\UAS.cAa] under the control of Scer\GAL4[dpp.PS] are partially suppressed by VhaM8.9[EY03616] or VhaM8.9[5-HA-1890], but are not suppressed by VhaM8.9[EY03616-excΔ]. (Buechling et al., 2010) Co-expression of fz[Scer\UAS.cAa] enhances the penetrance of the multiple wing hair phenotype caused by expression of zip[Rod.Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[en-e16E]. In addition, the double mutant wings also show polarity defects. (Franke et al., 2010) The planar polarity defects in the eye which are caused by expression of fz[Scer\UAS.cAa] under the control of Scer\GAL4[hs.2sev] are partially suppressed by VhaM8.9[EY03616]/+ or by co-expression of VhaM8.9[KK107676], but are not suppressed by VhaM8.9[EY03616-ex]. Co-expression of VhaM8.9[Scer\UAS.T:Disc\RFP-mCherry] enhances the planar polarity defects in the eye which are caused by expression of fz[Scer\UAS.cAa] under the control of Scer\GAL4[hs.2sev]. (Hermle et al., 2010) The planar cell polarity defects in the eye that are caused by expression of fz[Scer\UAS.cAa] under the control of Scer\GAL4[hs.2sev] are partially suppressed if the flies also simultaneously co-express Nhe2[dsRNA.Scer\UAS.WIZ] and carry Nhe2[1]/+. (Simons et al., 2009) The planar polarity defects seen in the eyes of animals expressing fz^Scer\UAS.cAa under the control of Scer\GAL4^hs.2sev are almost completely suppressed by tow⁷⁵⁴/+ (79.7% of ommatidia are correctly rotated) or In(3L)tow^fz/+ (79.0% of ommatidia are correctly rotated). The planar polarity defects seen in the eyes of animals expressing fz^Scer\UAS.cAa under the control of Scer\GAL4^hs.2sev are enhanced by co-expression of tow^Scer\UAS.cCa (only 26.4% of ommatidia are correctly rotated). (Chung et al., 2007) Co-expression of Wnt4^Scer\UAS.cGa suppresses the change in wing hair polarity caused by expression of fz^Scer\UAS.cAa under the control of Scer\GAL4^dpp.blk1. (Lim et al., 2005) fz^Scer\UAS.cAa; Scer\GAL4^dpp.blk1 flies have a zone extending anterior to the dpp expression domain in which wing hairs point away from the fz overexpressing cells. When such wings have somatic clones of ft^G-rv in the anterior of the wing, this zone enlarges to fill the clone. (Ma et al., 2003) The planar polarity defect in dsh¹ wings that are expressing fz^Scer\UAS.cAa under the control of Scer\GAL4^71B is indistinguishable from the dsh¹ single mutant phenotype. (Rulifson et al., 2000) The tissue polarity phenotype caused by expression of fz^Scer\UAS.cAa using Scer\GAL4^hs.2sev is dominantly suppressed by fz¹, dsh³, Rho1^k07236, Rho1^k07903, bsk¹ and bsk², but is not affected by rl¹⁰, pk^pk-sple-13, nmo^E33 or wg^l-17. (Strutt et al., 1997)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescued by	fz^Scer\UAS.cAa is partially rescued by Scer\GAL4^hs.2sev/fz¹ (Strutt et al., 1997)
Rescues	Scer\GAL4^da.G32/fz^Scer\UAS.cAa rescues fz²¹ (Bhanot et al., 1999) Scer\GAL4^da.G32/fz^Scer\UAS.cAa rescues fz²³ (Bhanot et al., 1999)
Comments	Rescues the embryonic cuticle phenotype of double mutants of fz²¹ or fz²³ with Df(3L)fz2. (Bhanot et al., 1999)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	fz^Scer\UAS.cAa fz^UAS.cAa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Adler (Adler, 1997.3.14)
Secondary FlyBase IDs

References ( 31 )

Generate a list of	All references relating to this allele ( 31 )

List References by type	Research paper ( 30 ) Personal communication to FlyBase ( 1 )
Recent research papers ( 2 )
	Hermle et al., 2013, EMBO J. 32(2): 245--259 Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking. [FBrf0220613] Weber et al., 2012, Genetics 191(1): 145--162 Novel regulators of planar cell polarity: a genetic analysis in Drosophila. [FBrf0218210] Show all research papers ...

Allele Dmel\fzScer\UAS.cAa

Allele Dmel\fz^Scer\UAS.cAa