Allele Dmel\fs(1)K10^unspecified

General Information
Symbol	Dmel\fs(1)K10^unspecified	Species	D. melanogaster
Name		FlyBase ID	FBal0060403
Feature type	allele	Associated gene	Dmel\fs(1)K10

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	female sterile \| recessive (Mohler, 1977) lethal \| embryonic stage \| maternal effect (Haenlin et al., 1995)
Phenotype Manifest In
	dorsal appendage (Mohler, 1977, Ghabrial et al., 1998, Zartman et al., 2008, Barth et al., 2011) egg (Mohler, 1977, Ghabrial et al., 1998, Tinker et al., 1998) egg \| ventral (Chang et al., 2001) embryo (Haenlin et al., 1995)
Detailed Description
	Statement Reference fs(1)K10[unspecified] mutants lay eggs containing a mass of chorionic material instead of two dorsal appendages. (Barth et al., 2011) Homozygous mutant eggs are dorsalised. (Chang et al., 2001) Eggs derived from homozygous females are dorsalised, 99% having dorsal appendage material extending around the lateral and ventral side of the egg. Eggs derived from fs(1)K10^unspecified; okr^AA/Df(2L)JS17, fs(1)K10^unspecified; grk³/+ or fs(1)K10^unspecified; spn-B²/spn-B¹ females show a broad spectrum of phenotypes ranging from completely dorsalised to completely ventralised. (Ghabrial et al., 1998) Homozygous females lay dorsalised eggs. This phenotype is not altered if the females also carry vas^6356-001/vas^6356-005. (Tinker et al., 1998) Fate-mapping experiments show that fs(1)K10^unspecified embryos do possess dorso-ventral polarity, but the dorsoventral and anteroposterior axes lie parallel to each other in these mutant embryos. (Haenlin et al., 1995) Homozygous females lay eggs with abnormal dorsal appendages. (Mohler, 1977)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Statement Reference fs(1)K10^unspecified has egg \| ventral phenotype, non-enhanceable by orb^mel/orb^mel (Chang et al., 2001)
Suppressed by
Statement Reference fs(1)K10^unspecified has phenotype, suppressible \| partially by grk³/grk³ (Haenlin et al., 1995)
NOT suppressed by
Statement Reference fs(1)K10^unspecified has egg \| ventral phenotype, non-suppressible by orb^mel/orb^mel (Chang et al., 2001)
Other
Statement Reference fs(1)K10^unspecified, orb^mel has egg \| ventral phenotype (Chang et al., 2001, Chang et al., 2001, Chang et al., 2001)
Additional Comments
Genetic Interactions
Statement Reference orb^mel/orb^mel, fs(1)K10^unspecified/fs(1)K10^unspecified eggs are dorsalised. (Chang et al., 2001) The misorientation of the dorsoventral and anteroposterior axes is partly corrected if the number of wild-type copies of grk is reduced (using grk³). (Haenlin et al., 1995)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	fs(1)K10^unspecified is rescued by fs(1)K10^+tcos9 (Haenlin et al., 1985) fs(1)K10^unspecified is rescued by fs(1)K10^+tHb (Haenlin et al., 1987) fs(1)K10^unspecified is rescued by fs(1)K10^+tHc (Haenlin et al., 1987) fs(1)K10^unspecified is rescued by fs(1)K10^+tHd (Haenlin et al., 1987) fs(1)K10^unspecified is rescued by fs(1)K10^+tKpn13 (Haenlin et al., 1985) fs(1)K10^unspecified is rescued by fs(1)K10^+tXba15 (Haenlin et al., 1985)
Not rescued by	fs(1)K10^unspecified is not rescued by fs(1)K10^tHa (Haenlin et al., 1987)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	fs(1)K10 (Barth et al., 2011) fs(1)K10^unspecified unspecified (Haenlin et al., 1995)
Name Synonym
Secondary FlyBase IDs

References ( 12 )
Research paper	Barth et al., 2011, Cell Death Differ. 18(6): 915--924 Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis. [FBrf0213616] Zartman et al., 2008, Dev. Biol. 322(2): 289--301 Cad74A is regulated by BR and is required for robust dorsal appendage formation in Drosophila oogenesis. [FBrf0207291] Chang et al., 2001, Development 128(16): 3169--3177 Functioning of the Drosophila orb gene in gurken mRNA localization and translation. [FBrf0139629] Zhao et al., 2000, Dev. Genes Evol. 210(8-9): 449--457 The Mirror transcription factor links signalling pathways in Drosophila oogenesis. [FBrf0131435] Zhao et al., 2000, J. Cell Sci. 113(21): 3781--3794 Expression of fringe is down regulated by Gurken/Epidermal growth factor receptor signalling and is required for the morphogenesis of ovarian follicle cells. [FBrf0130273] Ghabrial et al., 1998, Genes Dev. 12(17): 2711--2723 okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis. [FBrf0104438] Tinker et al., 1998, Dev. Biol. 199(1): 1--10 Requirement for the vasa RNA helicase in gurken mRNA localization. [FBrf0103384] Haenlin et al., 1995, Mech. Dev. 49(1-2): 97--106 The angle of the dorsoventral axis with respect to the anteroposterior axis in the Drosophila embryo is controlled by the distribution of gurken mRNA in the oocyte. [FBrf0080074] Haenlin et al., 1987, EMBO J. 6(3): 801--807 Oocyte-specific transcription of fs(1)K10: a Drosophila gene affecting dorsal-ventral developmental polarity. [FBrf0046138] Haenlin et al., 1985, Cell 40: 827--837 A 43 kilobase cosmid P transposon rescues the fs(1)K10 morphogenetic locus and three adjacent Drosophila developmental mutants. [FBrf0042056] Mohler, 1977, Genetics 85: 259--272 Developmental genetics of the Drosophila egg. [FBrf0030136]
Stock list	The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Russia, 1997, D. I. S. 80: 109--130 Stock list. [FBrf0098381]

Allele Dmel\fs(1)K10unspecified

Allele Dmel\fs(1)K10^unspecified